Clinical and epidemiological profile of patients with migraine treated at the neurology clinic of a university hospital

Authors

DOI:

https://doi.org/10.33448/rsd-v13i9.46753

Keywords:

Migraine disorders; Epidemiology; Chronic pain.

Abstract

The present study aimed to evaluate the clinical and epidemiological profile of patients with migraine treated at the neurology outpatient clinic of a University Hospital. It was a quantitative, descriptive, observational, and retrospective study involving adult patients diagnosed with migraine, treated from 1st January to 31st December 2021. Sociodemographic and clinical information was collected from medical records. A total of 247 patients were included, predominantly women (93.5%), with an average age of 43.7 years, married (48.6%), with no family history (56.0%) or previous treatment (57.7%). About 74.9% reported comorbidities, with hypertension (26.2%) and psychiatric disorders (12.6%) being the most prevalent. There was a significant association between the number of migraine days per month and the presence of comorbidities (p< 0.05) and between chronic migraine and comorbidities (OR 2.65). This research characterised the clinical and epidemiological profile of the patients, confirming that comorbidities are associated with the chronification of migraine and interfere with daily activities.

References

Academia Brasileira de Neurologia, Departamento Científico de Cefaleia, Sociedade Brasileira de Cefaleia. (2018). Protocolo nacional para diagnóstico e manejo das cefaleias nas unidades de urgência do Brasil. Disponível em https://sbcefaleia.com.br/images/protocolo%20cefaleia%20urgencia.pdf

Ashina, M. (2020). Migraine. The New England Journal of Medicine, 383(19), 1866-1876.

Barbanti, P., Aurilia, C., Egeo, G., Fofi, L. (2010). Hypertension as a risk factor for migraine chronification. Neurol Sci, 31(1), S41-3.

Benatto, M. T., Florencio, L. L., Carvalho, G. F., Dach, F., Bigal, M. E., Chaves, T. C., Bevilaqua-Grossi, D. (2017). Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease. Arq Neuropsiquiatr, 75(3), 153-159.

Bo, D. E. B., & Rocha, E. de M. C. (2022). Comorbidity between chronic headache and depression treated with botulinum toxin: Literature review. Brazilian Journal of Pain, 5(2), 154–160.

Brasil. Conselho Nacional de Saúde, Ministério da Saúde. (2012). Resolução nº 466, de 12 de dezembro de 2012. Brasília: Conselho Nacional de Saúde. Recuperado em 25 de dezembro de 2022, de https://bvsms.saude.gov.br/bvs/saudelegis/cns/2013/res0466_12_12_2012.html

Bron, C., Sutherland, H. G., & Griffiths, L. R. (2021). Exploring the hereditary nature of migraine. Neuropsychiatric Disease and Treatment, 17, 1183-1194.

Burch, R. C., Buse, D. C., & Lipton, R. B. (2019). Migraine: Epidemiology, burden, and comorbidity. Neurologic Clinics, 37(4), 631-649.

Charles, A. (2018). The pathophysiology of migraine: Implications for clinical management. The Lancet Neurology, 17(2), 174-182.

Cruz, M. C. da, Camargo, R. P. de, Cruz, L. C. da, Schiefelbein, N., Cruz, D. M. da, & Cruz, M. C. C. da. (2020). Migrânea: Revisão de literatura. Archives of Health Investigation, 10(2), 307-314.

Dantas, M. I. O., Pereira, T. A. B., & DeSantana, J. M. (2021). Chronic migraine patients have low level of knowledge about pain neurophysiology. Brazilian Journal of Pain, 4(4), 339–343.

Ferreira, K. S., Teixeira, C. T., Cáfaro, C., Oliver, G. Z., Carvalho, G. L. P., Carvalho, L. A. S. D., Silva, B. G., Haes, F. B. B., & Ciciarelli, M. C. (2018). Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment. Arquivos de Neuro-Psiquiatria, 76(9), 582-587.

Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553-622.

Hauser, S. L., & Josephson, S. A. (2018). Neurologia clínica de Harrison (5th ed.). AMGH.

Jurno, M. E., Felipe, B. L. de, Souza, M. G. da C., Matoso, A. A., Barreto, E. F., & Martins da Costa, M. C. M. (2016). Impacto da solicitação de tomografias computadorizadas cranianas na investigação diagnóstica da migrânea. HU Revista, 42(3), 185-190.

Kang, L. L., Chen, P. E., Tung, T. H., Chien, C. W. (2021). Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies. Front Allergy, 1;2,741135.

Lipton, R. B., Adams, A. M., Buse, D. C., Fanning, K. M., & Reed, M. L. (2016). A comparison of the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study and American Migraine Prevalence and Prevention (AMPP) Study: Demographics and headache-related disability. Headache, 56(8), 1280-1289.

Lipton, R. B., Fanning, K. M., Buse, D. C., Martin, V. T., Hohaia, L. B., Adams, A. M., Reed, M. L., & Goadsby, P. J. (2019). Migraine progression in subgroups of migraine based on comorbidities: Results of the CaMEO study. Neurology, 93(24), e2224-e2236.

Nedel, W. L., & Silveira, F. da. (2016). Os diferentes delineamentos de pesquisa e suas particularidades na terapia intensiva. Revista Brasileira De Terapia Intensiva, 28(3), 256–260.

Parreira, E., Luzeiro, I., & Monteiro, J. M. (2020). Chronic and refractory migraine: How to diagnose and treat. Acta Médica Portuguesa, 33(11), 753-760.

Radat, F. (2021). What is the link between migraine and psychiatric disorders? From epidemiology to therapeutics. Rev Neurol (Paris), 177(7), 821-826.

Rivera-Mancilla, E., Al-Hassany, L., Villalón, C. M., MaassenVanDenBrink, A. (2021). Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus. Front Neurol, 12, 686398.

Scher, A. I., Buse, D. C,. Fanning, K. M., Kelly, A. M, Franznick, D. A., Adams, A. M. & Lipton, R. B. (2017). Comorbid pain and migraine chronicity: The Chronic Migraine Epidemiology and Outcomes Study. Neurology, 89(5), 461-468.

Scher, A. I., Wang, S. J., Katsarava, Z., Buse, D. C., Fanning, K. M., Adams, A. M., & Lipton, R. B. (2019). Epidemiology of migraine in men: Results from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study. Cephalalgia, 39(2), 296-305.

Silva, L. R., Santos, G. E. S., Neto, M. G. A., & Gonçalves, M. C. (2021). Frequência de cefaleia e atividade física na população dos povoados de Aranha e Bonfim do município de Arari-MA. Revista CEUMA Perspectivas, 37(2).

Steiner, T. J., Stovner, L. J., Vos, T., Jensen, R., & Katsarava, Z. (2018). Migraine is first cause of disability in under 50s: Will health politicians now take notice? The Journal of Headache and Pain, 19(1), 17.

World Health Organization. (2020). ATLAS of Headache Disorders and Resources in the World 2020. World Health Organization. Disponível em https://www.who.int/publications/i/item/9789240020294

Yu, S., Kim, B. K., Wang, H., Zhou, J., Wan, Q., Yu, T., Lian, Y., Arkuszewski, M., Ecochard, L., Wen, S., Yin, F., Li, Z., Su, W., & Wang, S. J. (2022). A phase 3, randomised, placebo-controlled study of erenumab for the prevention of chronic migraine in patients from Asia: The DRAGON study. The Journal of Headache and Pain, 23(1), 146.

Zampieri, M. A., Tognola, W. A., & Galego, J. C. (2014). Patients with chronic headache tend to have more psychological symptoms than those with sporadic episodes of pain. Arquivos de Neuro-Psiquiatria, 72(8), 598-602.

Published

08/09/2024

How to Cite

ANDRADE, M. H. de .; MARQUES FILHO, R. N. .; RIBEIRO, S. M. de L. .; BARROS, L. S. B. .; MORAIS, D. B. .; RORIZ, L. C. de S. .; MOURA, Y. L. L. de .; SILVA, M. G. da .; BISPO, F. M. . Clinical and epidemiological profile of patients with migraine treated at the neurology clinic of a university hospital. Research, Society and Development, [S. l.], v. 13, n. 9, p. e1113946753, 2024. DOI: 10.33448/rsd-v13i9.46753. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46753. Acesso em: 27 sep. 2024.

Issue

Section

Health Sciences