Management of chronic infectious and chronic degenerative endometritis in mares: A narrative review of the literature
DOI:
https://doi.org/10.33448/rsd-v13i10.47089Keywords:
Endometritis; Mares; Reproduction; Chronic.Abstract
Endometritis is one of the main causes of infertility in mares and is characterized by inflammation of the uterine endometrium, usually caused by bacteria such as Streptococcus zooepidemicus and Escherichia coli or by fungi. The aim of this study is to review the management of chronic infectious and degenerative endometritis in mares, addressing the pathogens involved, diagnostic methods, treatments and new therapies. The methodology used involved a narrative review of the literature, searching databases such as Google Scholar, PubMed and Scielo, as well as regulations from organizations such as the OIE. The results highlight the complexity of chronic endometritis, which can be infectious, caused by bacteria and fungi, or degenerative, as in chronic endometriosis, which affects fertility irreversibly. Diagnosis is made using bacterial culture, cytology and biopsy of the uterus. Treatment includes the use of antibiotics and antifungals, as well as uterine washings to remove secretions. Recently, alternative therapies, such as immunomodulators and probiotics, have been studied to combat antimicrobial resistance and improve the local immune response. Endometritis represents a significant challenge in equine reproduction, especially in chronic cases. Integrating traditional treatments with innovative approaches can improve the chances of reproductive success, but more studies are needed to assess the long-term effectiveness of these therapies.
References
Aguiar, D. M., Ribeiro, M. G., Ueno, T. E., et al. (2021). Etiologia e sensibilidade in vitro de microrganismos aeróbicos isolados de endometrite eqüina. Arquivos do Instituto Biológico, São Paulo, 88(1), 1-6.
Ávila, A. C. A., Diniz, N. C., Serpa, R. T., Chaves, M. M. B. C., Viu, M. A. O., & de Oliveira, R. A. (2022). Effectiveness of Ozone Therapy in The Treatment of Endometritis in Mares. J Equine Vet Sci, 112, 103900. https://doi.org/10.1016/j.jevs.2022.103900.
Boni, R., & Cecchini Gualandi, S. (2022). Relationship between Oxidative Stress and Endometritis: Exploiting Knowledge Gained in Mares and Cows. Animals (Basel), 12(18), 2403. https://doi.org/10.3390/ani12182403
Botelho, J. H. V., Pessoa, G. O., Caixeta, E. S., Sales, G., de Oliveira, K. R., Nascimento Neto, J. D. P., Ferreira, R. D., & Palhão, M. P. (2024). Does the uterine ozone therapy alter the transcript profile of anti- and proinflammatory genes in mares with endometritis? Reproduction in Domestic Animals, 59(9), e14718. doi: 10.1111/rda.14718. PMID: 39253801
Casarin, S. T., Porto, A. R., Gabatz, R. I. B., Bonow, C. A., Ribeiro, J. P., & Mota, M. S. (2020). Tipos de revisão de literatura: considerações das editoras do Journal of Nursing and Health/Types of literature review: considerations of the editors of the Journal of Nursing and Health. Journal of Nursing and Health,10
Cavalcante, L. T. C., & Oliveira, A. A. S. (2020). Métodos de revisão bibliográfica nos estudos científicos. Psicol. Rev., 26(1). https://doi.org/10.5752/P.1678-9563.2020v26n1p82-100.
Cruz Júnior, J. A. (2016). Manejo da endometrite crônica em éguas: uma revisão de literatura. Trabalho de Conclusão de Curso (Graduação em Medicina Veterinária) – Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Patos.
Franco, L. A. (2023). Endometrite equina: revisão de literatura.
Godoi Bacaro, V. B. (2023). Endometrite equina. Brazilian Journal of Veterinary
Köhne, M., Hofbauer, L., Böttcher, D., Tönissen, A., Hegger, A., Görgens, A., Ulrich, R., & Sieme, H. (2023). Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice. Front Vet Sci, 10, 1102149. https://doi.org/10.3389/fvets.2023.1102149.
LeBlanc, M. M. (2010). Advances in the diagnosis and treatment of chronic infectious and post-mating-induced endometritis in the mare. Reprod Domest Anim, 45(Suppl 2), 21-27. https://doi.org/10.1111/j.1439-0531.2010.01634.x.
Mattos, R. C., Malschitzky, E., & Jobim, M. I. M. (2003). Endometrite na égua. Revista Brasileira de Reprodução Animal, Belo Horizonte, 27(2), 150-157.
Mazzuchini, M. P., Lisboa, F. P., Segabinazzi, L. G., & Canisso, I. F. (2024). Equine uterine sanitizer: in vitro inhibition of endometritis-causing microorganisms and its stability to dilute antibiotics. Journal of Equine Veterinary Science, 141, 105163. doi: 10.1016/j.jevs.2024.105163. Epub 2024 Aug 12. PMID: 39142617.
Morrell, J. M., & Rocha, A. (2022). A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State. Front Vet Sci, 8, 799619. https://doi.org/10.3389/fvets.2021.799619.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Ribeiro, T. J. E. (2019). Abordagem à Adaptação da Citocentrifugação no Diagnóstico Citológico de Endometrite Equina.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm., 20(2). https://doi.org/10.1590/S0103-21002007000200001
Scoggin, C. F. (2016). Endometritis: Nontraditional Therapies. Vet Clin North Am Equine Pract, 32(3), 499-511. https://doi.org/10.1016/j.cveq.2016.08.002.
Sikora, M., Król, J., Nowak, M., Stefaniak, T., Aubertsson, G., & Kozdrowski, R. (2016). The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares. Acta Vet Scand, 58(1), 50. doi: https://doi.org/10.1186/s13028-016-0233-4.
Tyrnenopoulou, P., & Fthenakis, G. C. (2023). Clinical aspects of bacterial distribution and antibiotic resistance in the reproductive system of equids. Antibiotics (Basel), 12(4), 664. doi: 10.3390/antibiotics12040664. PMID: 37107026; PMCID: PMC10135018.
Virendra, A., Gulavane, S. U., Ahmed, Z. A., Reddy, R., Chaudhari, R. J., Gaikwad, S. M., Shelar, R. R., Ingole, S. D., Thorat, V. D., Khanam, A., & Khan, F. A. (2024). Metagenomic analysis unravels novel taxonomic differences in the uterine microbiome between healthy mares and mares with endometritis. Vet Med Sci, 10(2), e1369. https://doi.org/10.1002/vms3.1369.
Watson, E. D. (2000). Post-breeding endometrites in the mare. Animal Reproduction Science, 60-61, 221-232
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Andreia Oliveira Santos; Lídia Ketry Moreira Chaves; Lavínia Soares de Sousa; Danilo Lourenço de Albuquerque; George Estêfano dos Santos Pereira; Janilson Olegário de Melo Filho; Mateus de Melo Lima Waterloo

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.