Depressive disorders in women during climateric: A systematic review
DOI:
https://doi.org/10.33448/rsd-v13i12.47871Keywords:
Climacteric; Depression; Menopause.Abstract
The climacteric, the period between the reproductive and non-reproductive phases in females, is characterized by significant hormonal changes that can have a profound impact on women's mental health, being related to depression, irritability, and anxiety. Thus, the objective of this study is to understand the state of the art of psychic changes resulting from endocrine changes related to the climacteric and their reflections on women's quality of life. This is a systematic literature review based on the PRISMA protocol, guided by the research question: "What are the repercussions of depression in the climacteric?" conducted from June 2024 to December 2024. Twelve studies were analyzed, mostly of high quality, describing various findings related to menopausal depressive symptoms, such as age, nutritional changes, influence of hormone levels, neurotrophic factors, changes in neurotransmitter levels, and use of contraceptives. Hormonal changes in women during the climacteric lead to significant physiological changes, such as alterations in neurotrophic levels and neurotransmissions. These changes can result in psychiatric complaints, with the most reported involving mood lability and being related to hormone replacement therapy, although there is no consensus. The great variability in mood is not caused solely by the direct action of hormones but also by indirect effects such as on sleep. Detailing the pathophysiological mechanisms may enable the development of individualized therapeutic plans, resulting in more effective management for patients.
References
Albert, K. M., et al. (2021). Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder. Journal of Affective Disorders, 293, 355-362.
Alblooshi, S., Taylor, M., & Gill, N. (2023). Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review. Australasian Psychiatry, 31(2), 165-173.
Alsugeir, D., et al. (2024). Common mental health diagnoses arising from or coinciding with menopausal transition and prescribing of SSRIs/SNRIs medications and other psychotropic medications. Journal of Affective Disorders, 364, 259-265.
Balan, A., et al. (2020). Hormonal fluctuations related to depressive symptoms in menopause. Bulletin of the Transilvania University of Brasov. Medical Sciences. Series VI, 13(2).
Bayram, S., et al. (2024). Sleep, mood, and nutrition patterns of postmenopausal women diagnosed with Major Depressive Disorder by menopause periods. Life, 14, 775.
Chu, K., et al. (2022). Biopsychosocial risk factors of depression during menopause transition in southeast China. BMC Women's Health, 22(273), 1-10.
Conde, D. M., et al. (2021). Menopausa e comprometimento cognitivo: uma revisão narrativa do conhecimento atual. Revista Mundial de Psiquiatria, 11(8), 412-428.
Curta, J. C., & Weissheimer, A. M. (2020). Percepções e sentimentos sobre as alterações corporais de mulheres climatéricas. Rve Gaúcha Enferm, 41, 1-9.
Feng, P., et al. (2022). Impacts of menopause hormone therapy on mood disorders among postmenopausal women. Climacteric, 25, 579-585.
Galdino, V. S. (2021). Climatério e depressão: análise de prevalência em mulheres climatéricas e fatores associados. (Trabalho de Conclusão de Curso, Universidade Federal da Paraíba, Centro de Ciências Médicas, João Pessoa).
Gomes, I. S & Caminha, I. O. (2014). Guia para estudos de revisão sistemática: uma opção metodológica para as ciências do Movimento humano. Movimento.
Harder, et al. (2023). Brain-derived neurotrophic factor and mood in perimenopausal depression. Journal of Affective Disorders, 300, 145-149.
Harper-Harrison, G., Carlson, K., & Shanahan, M. M. (2024). Hormone Replacement Therapy, Estados Unidos.<https://www.ncbi.nlm.nih.gov/books/NBK493191/.
Hernández-Muñoz, A. E., et al. (2019). Riesgo para el desarrollo de Trastorno Depresivo Mayor al existir alteraciones en la sintomatología menopaúsica en mujeres de Guadalajara, Jalisco. Revista Chilena de Obstetricia y Ginecología, 84, 297-306.
Instituto JB. (2020). Ferramentas de Avaliação Crítica. Disponível em: https://jbi.global/critical-appraisal-tools.Acesso em: 11 de novembro de 2024.
Joffe, H., et al. (2020). Impact of estradiol variability and progesterone on mood in perimenopausal women with depressive symptoms. The Journal of Clinical Endocrinology & Metabolism, 105, e642-e650.
Lee, D. Y., et al. (2023). Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study. European Psychiatry: The Journal of the Association of European Psychiatrists, 66(1), e80.
Martins, K. S. M., et al. (2021). O climatério e suas implicações psicológicas na saúde da mulher: uma revisão bibliográfica. Revista Científica Multidisciplinar, 2(11), 1-7.
Meijsen, J. J., et al. (2023). Shared genetic influences on depression and menopause symptoms. Psychological Medicine, 53, 2241-2251.
Negreiros, B. A., et al. (2021). Transtornos psicóticos associados ao período do climatério. Research, Society and Development, 10(10), -8.
Pertesi, S., et al. (2019). Menopause, cognition and dementia - a review. Post Reproductive Health, 25(4), 200-206.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book). Editora UAB/NTE/UFSM.
Ryu, K. J., et al. (2022). Age at Menopause and Suicidal Ideation in Menopausal Women: A Study of Korea National Health and Nutrition Examination Survey Data. Journal of Korean Medical Science, 37(45), 1-9.
Santos, M. A., et al. (2021). Sleep quality and its association with menopausal and climacteric symptoms. Revista Brasileira de Enfermagem, 74, 1-7.
Silva, M. S. (2024). Fatores biopsicossociais relacionados com a disfunção sexual e depressão ao longo da vida. (Dissertação de Mestrado, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto).
Sourouni, M., et al. (2021). Assessment of the climacteric syndrome: a narrative review. Archives of Gynecology and Obstetrics, 304, 855-862.
Tran, K. H., et al. (2023). Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study. International Journal of Neuropsychopharmacology, 26(1), 32-41.
Wenzel, E. S., et al. (2021). Mental health during the COVID-19 pandemic and beyond: The importance of the vagus nerve for biopsychosocial resilience. Neuroscience and Biobehavioral Reviews, 125, 1-10.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Pedro Henrique Lago de Oliveira ; Fernando Gabriel dos Santos Santiago; Cleberson Dias Rodrigues; Lucas Alves Leão; José Mauro de Almeida Leão; Pedro Murilo Moreira Pantoja
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
