Elderberry, garlic and ginger: antivirals and/or immunostimulants?

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.6158

Keywords:

Virus; Pathogens; Coronavirus; Functional foods; Medicinal plants.

Abstract

Introduction: Viral diseases affect the world population several times during their lives, and are considered a serious public health problem. Medicinal plants and functional foods have a beneficial influence on human and animal health, due to the bioactive compounds present in plants and foods, which are able to modulate the action of pathogens and reduce the risk of diseases. Although some medicinal plants have their widespread use in folk medicine as antivirals and / or immunostimulants, scientific information is needed to validate their benefits. Objective: To review in scientific journals and describe the antiviral effects and immunomodulatory properties of elderberry (Sambucus sp.), Garlic (Allium sativum) and Ginger (Zingiber officinale) species. Methodology: This review was developed from an exploratory review of articles selected on the Scielo, Google Scholar and PubMed database platforms. Results: The journals reviewed in this study showed that some species of the genus Sambucus, Allium sativum L. and Zingiber officinale R., have potential antivirals and immunostimulants, being able to reinforce protection against pathogens even against the Coronavirus. Final considerations: The plants evaluated in this study can be considered as an alternative in the treatment of viral infections and / or conditions that need to stimulate the immune system. It is emphasized, however, that more research must be carried out to further evaluate the spectrum of action and their respective dosages, in order to standardize their uses.

References

Ali, B. H., Bluden, G., & Tanira, M. O. (2008). A Some phytochemical, pharmacological and toxicological property of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chemical. Toxicology, 46(2), 409-420. https://doi.org/10.1016/j.fct.2007.09.085

Aly, S. M., Atti, N. M., & Mohamed, M. F. (2008). Effect of garlic on the survival, growth, resistance and quality of Oreochromis niloticus. In: From the pharaohs to the future. Retrieved from https://www.cabdirect.org/cabdirect/abstract/20133318682

Atanasov, A. G., Waltenberger, B., Wenzig, E. M. P., Linder, T., Wawrosch, C., Uhrin, P., Stuppne, H. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 33(8), 1582–1614. https://doi.org/ 10.1016/j.biotechadv.2015.08.001.

Ayaz, E., & Alposy, H. C. (2007). Garlic (Allium sativum) and traditional medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17594659.

Badal, D. S., Dwivedi, A. K., Kumar, V., Singh, S., Prakash, A., Verma, S., & Kumar, J. (2019). Effect of organic manures and in organic fertilizer son growth, yield and its attributing traits in garlic (Allium sativum L.). Journal of Pharmacognosy and Phytochemistry, 8(3), 587-590. https://doi.org/10.3390/nu12030872.

Batilha, G. E. S., Beshbishy, A. M., Wasef, L. G., Elewa, Y. H. A., Al-Sagan, A. A., Mohamed, E. A. E. H., & Devkota, H. P. (2020). Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review. Nutrients, 12(3). https://doi.org/10.3390/nu12030872.

Botas, J. C. S. (2017) Caracterização química e propriedades bioativas de Allium sativum L. com diferentes proveniências e processamentos. Dissertação de mestrado em Farmácia e Química de Produtos Naturais. Bragança.

Brasil. Ministério da Saúde (2020). O que é COVID-19. Retrieved from https://coronavirus.saude.gov.br/sobre-a-doenca#o-que-e-covid.

Chakraborty, B., & Sengupta, M. (2012). Boosting of nonspecific host response by aromatics pices turmeric and ginger in immunocompromised mice. Cellular Immunology, 280(1), 92-100. https://doi.org/10.1016/j.cellimm.2012.11.014

Chang, J. S., Wang, K. C., Yeh, C. F., Shieh, D. E., & Chiang, L. C. (2013). Fresh ginger (Zingiber officinale) has anti-viral active it against human respiratory syncytial virus in human respiratory tract cell lines. Journal Ethnopharmacology, 145(5), 146-151. DOI: 10.1016 / j.jep.2012.10.043

Chen, C., Zuckerman, D. M., Brantley, S., Sharpe, M., Childress, K., Hoiczyk, E., & Pendlenton, A. R. (2014). Sambucus nigra extract sinhibit infectious bronchitis virus atanearly point during replication. BMC Veterinary Research, 10 (24), 2-12. https://doi.org/10.1186/1746-6148-10-24.

Conceição, S. F. S. M. (2013). Efeitos do Gengibre, do Alho e do Funcho na Saúde. Dissertação de mestrado em Ciências Farmacêuticas. Porto.

Cunha, A. P., Ribeiro, J. A., & Roque, O. R. (2009). Plantas aromáticas em Portugal: caracterização e utilizações. (2a ed.), Lisboa: Fundação Calouste Gulbenkian.

Cunha, A. P., Roque, O. R., & Silva, A. P. (2006). Plantas e produtos vegetais em fitoterapia. (2a ed.), Lisboa: Fundação Calouste Gulbenkian.

Fintelmann, V., & Weiss, R. F. (2010). Manual de fitoterapia. (11a ed.), Rio de Janeiro: Guanabara Koogen.

Fratianni, F., Ombra, M. N., Cozzolino, A., Riccardi, R., Spigno, P., Tremonte, P., & Nazzaro, F. (2016). Constituintes fenólicos, atividade antioxidante, antimicrobiana e antiproliferativa de diferentes variedades endêmicas italianas de alho (Allium sativum L.). Journal of Functional Foods, 21, 240-248. doi: 10.1016/j.jff.2015.12.019.

Gil, A. C. (2008). Métodos e Técnicas de Pesquisa Social. (6a ed.), São Paulo: Atlas.

Há, S. K, Moon, E., Ju, M. S., Kim, D. H., Ryu, J. H., Oh, M. S., & Kim, S. Y. (2012). 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuro protection. Neupharmacologic, 63(2), 211-223. https://doi.org/10.1016/ j.neuropharm.2012.03.016

Khalid, N., Ahmed, I., Latif, M. S. Z., Rafique, T., & Fawad, A. S. (2014). Comparison of antimicrobial activity, phytochemical profile and minerals composition of garlic Allium sativum and Allium tuberosum. Journal of the Korean Society for Applied Biological Chemistry, 57(3), 311-317. https://doi.org/10.1007/s13765-014-4021-4

Khan, A. M., Shahzad, M., Razaasim, M. B., Imran, M., & Shabbir, A. (2014). Zingiber officinale ameliorates allergicas thma via suppression of Th2-mediated immune response. Pharmaceutical Biology, 53(3), 359, 367. https://doi.org/10.310 9/13880209.2014.920396

Kock, S., Reichling, J., Schneele, J., & Schitzler, P. (2008). lInhibitory effect of essential oils against herpes simplex virus type 2. Phytomed, 15(1,2), 71-80. https://doi.org/10.1016/j.phymed.2007.09.003

Labh, S. N., Shakya, S. R., & Shakya, R. (2014). Medicinal uses of garlic (Allium sativum) improves fish health and acts as an immunostimulant in aquaculture. European Journal of Biotechnology and Bioscience, Retrieved from https://api.semanticschola r.org/CorpusID:55987602

Lee, J. Y., & Gao, Y. (.2012). Review of the application of garlic, Allium sativum, in aquaculture. Journal of the World Aquaculture Society, 43(4), 447-458. https://doi.org/10.1111/j.1749-7345.2012.00581.x

Lemos, H. P. J., & Lemos, A. L. A. (2010). Gengibre. Revista Diagnostico & Tratamento. Retrieved from http://files.bvs.br/upload/S/1413-9979/2010/v15n4/a1701.pdf

Li, W. Q., Zhou, H., Zhou, M. Y., Hu, X. P., Ou, S. Y., Yan, R. A., & Fu, L. (2015). Characterization of phenolic constituents inhibiting the formation of sulfur-containing volatiles produced during garlic processing. Journal of agricultural and food chemistry, 63(3), 787-794. https://doi.org/10.1021/jf505982f

Matte, A. K., & Mata, P. T. G. (2015). Triagem fitoquímica e avaliação da atividade antibacteriana de extratos das flores de Sambucus nigra L. (Caprifoliaceae). Revista brasileira de plantas medicinais, 17(4),1049-1054. https://doi.org/10.1590/1983-084x/14_154

Moraes-Pinto, M. I., & Ferrarini, M. A. G. (2020). Infecções oportunistas em pediatria: quando suspeitar e como abordar. Jornal de Pediatria, 96(1), 47-57. https://doi.org/10.1016/j.jped.2019.09.008

Nascimento, J. H. P., Gomes, B. F. O., Jurnior, C. P. R., Petriz, J. L. F., Rizk, S. I., Costa, I. B. S. S., & Oliveira, G. M. M. (2020). COVID-19 e Estado de Hipercoagulabilidade: Uma Nova Perspectiva Terapêutica. Arquivo brasileiro de cardiologia, 114 (5), 829-833. Recuperado de http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X202 0000600829&lng=en

Nicacio, G. L. S., Moura, S. C., Costa, J. V. J., Sena, C. R., Cruz, T. B. F., Lopes, G. N. M., & Cecílio, A. B. (2018). Breve revisão sobre as propriedades fitoterápicas do Zingibe rofficinale Roscoe o gengibre. Sinapse múltipla, 7(2),74-80.

Nunes, E., Scopel, M., Vignoli-Silva, M., Vendruscolo G. S., Henriques, A. T., & Mentz, L. A. (2007). Caracterização farmacobotânica das espécies de Sambucus (Caprifoliaceae) utilizadas como medicinais no Brasil: Parte II. Sambucus australis Cham. & Schltdl. Revista brasileira de farmacognosia, 17(3), 414-425. https://doi.org/10.1590/S0102-695X20 07000300017.

Nya, E. J., & Austin, B. (2009). Use of garlic, Allium sativum, to control Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Fish Diseases, 32(11), 963-970. https://doi.org/10.1111/j.1365-2761.2009.01100.x

Ohaeri, O., & Adoga, G. I. (2006). Anticoagulant modulation of blood cells and platelet reactivity by garlic oil in experimental diabetes mellitus. Bioscience reports, 26(1), 1-6. https://doi:10.1007/s10540-006-9004-1.

Oudit, G. Y., Kassiri, Z., Jiang, C., Liu, P. P., Poutanen, S. M., Penninger, J. M., & Butany, J. (2009). SARS-corona virus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Europen journal of clinical investigation, 39(7), 618-625. https://doi.org/10.1111/j.1365-2362.2009.02153.x

Owczarek, K., Szczepanski, A., Milewska, A., Baster, Z., Rajfur, Z., Sarna, M., & Pyrc, k. (2018). Early events during human corona virus OC43 entry to the cell. Natureresearch Journal, 8(7124). https://doi.org/10.1038/s41598-018-25640-0

Pascoal, D. B., Carvalho, A. C. S., Mata, L. E. L. F. S., Lopes, T. P., Lopes, L. P., & Cruz, C. M. (2020). Síndrome Respiratória Aguda: uma resposta imunológica exacerbada ao COVID19. Brazilian Journal Heart Revison, 3(2), 2978-2994. https://doi.org/ 10.34119/bjhrv3n2-138.

Patwardhan, M., Morgam, M. T., Dia, V., & D'Souza, D. H. (2020). Heat sensitization of hepatitis A virus and Tulane virus using grapeseed extract, gingerol and curcumin. International Journal Food Microbiology, https://doi.org/10.1016/j.fm.2020.103461

Pereira, A. S., et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado de https://repositorio.ufsm.br/bitstream /handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Quintaes, K. D. (2011). Alho, nutrição e saúde. Revista NutriWeb. Acesso em 20 de 2020, em http://www.nutriweb.org.br/n0302/alho.htm.

Rasool, A., Khan, M., Ali, M., Anjum, A., Amhed, I., Aslam, A., Nawaz, M. (2017). Anti-Avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) & Allium sativum (Garlic) in chick embryos. Pakistan Journal of Pharmaceutical Sciences, 30, 1341-1344.

Reflora – Herbário Virtual. Recuperado de http://www.reflora. jbrj.gov.br/reflora/herbarioVirtual/

Ried, K. (2016). Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. The Journal of nutrition, 146(2), 389S-396S.https://doi.org/10.3945/jn.114.202192

Rodrigues, M L., & Lira, R. K. (2013) Perfil Fitoquímico e Biológico do Extrato Hidroalcoólico dos Rizomas do Gengibre (Zingiber officinale Roscoe). Revista de saúde e Biologia, 8(1), 44-52.

Santos, A. K., C., Araújo, T. A., & Oliveira, F. S. (2020). Farmacoterapia e cuidados farmacêuticos da gripe e resfriado. Journal of Biology & Pharmacy and Agricultural Management., Recuperado de revista.uepb.edu.br/index.php/biofarm.

Schnitzler, P., Kock, C., & Reichling, J. (2007). Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrobial Agents Chemotherapy, 51, 1859-1862.https://doi.org/ 10.1128/AAC.00426-06.

Shojai, T. M., Langeroudi, A G., Karimi, V., Barin, A., & Sadri, N. (2016). The effect of Allium sativum (Garlic) extract on infectious bronchitis virus in specific pathogen free embryonic egg. Avicenna journal of phytomedicine, 6(4), 458-467. Recuperado de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967842/

Silva, A., Martins, H., Silva, M. V., S., Andrade, M. A., Maues, C., Abreu, E., Tomaz, J., Azonsivo, R., & Silva, G. (2017). Propriedades Terapêuticas (Zingiber officinale R.). Pará: Boletim Fitoterápico Gengibre (Zingiber officinale R.).

Silva, E., Bacelar, E., Gonçalves, B., Ferreira, H., Moutinho, J. P., Correia, C., & Nunes, F., M. (2014). Caraterização morfo-fisiológica de populações de Sambucus nigra L. da região do Vale do Varosa. 3º Simpósio Nacional de Fruticultura, Em Vila Real. Recuperado de <https://www.researchgate.net/publication/272490804_Caraterizacao_morfofisiologica_de_populacoes_de_Sambucus_nigra_L_da_regiao_do_Vale_do_Varosa>

Silva, F. M. L., Quental, O. B., Bezerra, I., Freires, M. A., L., Medeiros, A. C., Melo, W. F., & Figueiredo, C. H. A. (2019). Perfil clínico e sintomatológico de pacientes com infecções virais de uma unidade de pronto atendimento no alto sertão paraibano. Revista Brasileira Gestão Ambiental, 13(04), 01-05. Recuperado de https://editoraverde. org/gvaa.com.br/revista/index.php/RBGA/article/view/7467/7063.

Szajdek, A., & Borowska, E. J. (2008). Bioactive compounds and health-promoting properties of berry fruits: a review. Plants Foods Human Nutrition, 63(4),147-56. https://doi.org/10.1007/s11130-008-0097-5.

Tan, B. K. H., & Vanitha, J. (2004). Immunomodulatory and antimicrobial effects of some traditional chines e medicinal herbs: a review. Current Medical Chemistry, 11 (11), 1423-1430.htpps://doi.org/10.2174 / 0929867043365161

Tang, N., Bai, H., Chen, X., Gong, J., Li, D., & Sun, Z. (2020) Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal Thrombosis and Haemostase, 18:1094-1099. https://doi.org/10.1111/jth.14817

Thuy, B. T. P., My, T. T. A., Hai, N. T. T., Hieu, L. T., Hoa, T. T., Loan, H. T. P., Nhung, N. T. A. (2020). Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil. ACS Omega, 5(14), 8312-8320. https://doi.org/10.1021/acsomega.0c00772

Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. Retrieved from https://www.ncbi.nlm. nih.gov/pmc/articles/PMC4848651/

Weng, J. R., Lin, C S., Lai, H C., Lin, Y. P., Wang, C. Y., Lin., C. W. (2019). Antiviral activity of Sambucus Formosana Nakai ethanol extract and related phenolic acid constituents against human coronavirus NL63. Virus Reseach, 273, 197767. https://doi.org/10.1016/j.virusres.2019.197767

Zhang, J., Shen, X., Yan, Y., Wang, Y., & Cheng, Y. (2020). Discovery of anti-SARS-CoV-2 agents from commercially available flavor via docking screening. https://doi.org/10.31219/osf.io/vjch2

Zehsaz, F., Farhangi, N., & Mirheidari, L. (2014). Clinical immunology The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners. Central European Journal of Immunology, 39(2), 174-180. https://doi.org/10.5114/ceji.2014.43719

Zhou, Y., Li, Y., Zhou, T., Zheng, J., Li, S., & Li, H. B. (2016). Dietary natural products for prevention and treatment of liver cancer. Nutrients, 8(3), 156. https://doi.org/10.3390/nu8030156.

Published

09/08/2020

How to Cite

CARVALHO, M. D. G. de S.; BELLINI, J. D. S.; AMARAL, J. L. C.; MORAIS, L. C.; ALVES, L. R. de C.; CARVALHO FILHO, C. G.; PEREIRA, F. H.; OLIVEIRA, F. L. de; GARCIA, E. K. I.; GARCIA, J. A. D. Elderberry, garlic and ginger: antivirals and/or immunostimulants?. Research, Society and Development, [S. l.], v. 9, n. 9, p. e09996158, 2020. DOI: 10.33448/rsd-v9i9.6158. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/6158. Acesso em: 12 nov. 2024.

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Section

Review Article