Neuroprogression and depression: a literature review
Keywords:Depressive disorder; Neuropsychiatry; Biological psychiatry; Neurodegenerative diseases.
This review aims to show evidence of possible neuroprotective agents, and to identify new avenues for possible intervention, in search of neuroprotection in patients affected by depression. It is a narrative review that used PubMed, Lilacs, Scielo, Cochrane and Latindex as a database, in the period between 2015 to 2020, resulting in 1009 articles and 19 different articles using selection criteria. Neuropsychiatric disorders, including depression, often exhibit a neuroprogressive course from the prodrome to chronicity. There are a variety of agents exhibiting the ability to attenuate biological mechanisms associated with neuroprogression. Signs of evidence of clinical neuroprotection are evident when evaluating studies by different authors. The adjuvant use of multiple drug agents may present a viable path for the clinical realization of neuroprotection. Definitive prospective studies on neuroprotection with multimodal assessment are needed.
Bansal, Y., Singh, R., Parhar, I., Kuhad, A., & Soga, T. (2019). Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression. Frontiers in Pharmacology. DOI: 10.3389/fphar.2019.00452
Baxter, P. S., & Hardingham, G. E. (2016). Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes. Free Radical Biology and Medicine, 100, 147-152. DOI: 10.1016/j.freeradbiomed.2016.06.027
Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P.,Márkus, N.M, Baxter, P., Deighton, R, F., Serio, A.,Bilican, B., Chowdhry, S., Meakin, P.J., Ashford, M. L. J., Wyllie, D. J. A., Scannevin, R. H., Chandran, S., Hayes, J. D., & Hardingham, G. E. (2015). Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications, 6, 1-15. DOI:10.1038/ncomms8066
Ignácio Z. M., Réus, G. Z., Abelaira, H. M., Moura, A. B., Souza, T. G., Matos, D., Goldin, M. P, Mathias, K., Garbossa, L., Petronilho, F., Quevedo, J. (2017). Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain. Metabolic Brain Disease, 32(4), 1195-1208. DOI: 10.1007/s11011-017-0028-y
Krivoy A., Hochman, E., Sendt, K.-V., Hollander, S., Vilner, Y., Selakovic, Weizman, A., M.Taler, M. (2018). Association between serum levels of glutamate and neurotrophic factors and response to clozapine treatment. Schizophrenia Research, 192, 226-231. DOI: 10.1016/j.schres.2017.05.040
Leonard B. E., & Wegener G. (2019). Inflammantion, insulin resistance and neuroprogression in depression. Acta Neuropsychiatrica, 32(1) 1-19. Acesso em 8 setembro, em https://doi.org/ 10.1017/neu.2019.17. DOI: 10.1017/neu.2019.17
Meine, I. R., Cheiram, M. C., Jaeger, F. P. (2019). Depressão e suicídio: o adolescente frente a fatores de risco socioculturais. Research, Society and Development; 8(12), 1-15. Acesso em 8 setembro. DOI: 10.33448/rsd-v8i12.1882
Mendoza, C., Perez-Urrutia, N., Alvarez-Ricartes, N., Barreto, G. E., Pérez-Ordás, R., Iarkov, A., & Echeverria, V. (2018). Cotinine plus krill oil decreased depressive behavior, and increased astrocytes survival in the hippocampus of mice subjected to restraint stress. Frontiers in Neuroscience, 12, 1-11. DOI: 10.3389/fnins.2018.00952
Morris, G., Puri, B. K., Walker, A. J., Maes, M., Carvalho, A. F., Bortolasci, C. C.,Walder, K., Berk, M. (2019). Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders. Neuroscience and Biobehavioral Reviews, 107, 862-882. DOI: 10.1016/j.neubiorev.2019.09.025
Ogyu, K., Kubo, K., Noda, Y., Iwata, Y., Tsugawa, S., Omura, Y., Wada, M., Tarumi, R., Graff-Guerrero, A., Mimura, M. & Nakajima, S. (2018). Kynurenine pathway in depression: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 90, 16-25. DOI: 10.1016/j.neubiorev.2018.03.023
Oliveira, E. N., Carvalho, A. G., Moreira, R. M. M., Melo, B. T., Lima, G. F., & Ximenes Neto, F. R. G. (2020). Interfaces entre o uso abusivo de substâncias psicoativas, presença de comorbidades e risco de suicídio. Research, Society and Development, 9(7), 1-18. DOI: 10.33448/rsd-v9i7.4172
Poletti, S., Aggio, V., Hoogenboezem, T. A., Ambrée, O., Wit, H., Wijkhuijs, Locatelli, C., Colombo, C., Arolt, V., Drexhage, H. A., & Benedetti, F.. (2017). Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder. European Psychiatry, 40, 33-37. DOI: 10.1016/j.eurpsy.2016.06.008
Robertson, O. D., Coronado, N. G., Sethi, R., Berk, M. & Dodd, S. (2019). Putative neuroprotective pharmacotherapies to target the staged progression of mental illness. Early Intervention In Psychiatry, 13(5), 1032-1049. DOI: 10.1111/eip.12775
Ruiz, N. A. L., Ángel, D. S., Olguín, H. J. & Silva, M. L. (2018). Neuroprogression: the hidden mechanism of depression. Neuropsychiatric Disease and Treatment, 14, 2837-2845. DOI: 10.2147/NDT.S177973
Savitz, J., Drevets, W. C., Wurfel, B. E, Ford, B. N., Bellgowan, P. S. F, Victor, T. A., Bodurka, J., Teague, T. K., & Dantzer, R. (2015). Reduction of kynurenic acid Victor to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain, Behavior, and Immunity, 46, 55-59. DOI: 10.1016/j.bbi.2015.02.007
Schmidt, M., Brandwein, C., Luoni, A., Sandrini, P., Calzoni, T., Deuschle, M., Cirulli, F. Riva M. A., & Gass, P. (2016). Morc1 knockout evokes a depression-like phenotype in mice. Behavioural Brain Research, 296, 7-14. DOI: 10.1016/j.bbr.2015.08.005
Sotelo, J. L., & Nemeroff, C. B. (2017). Depression as a systemic disease. Personalized Medicine in Psychiatry, 1(2), 11-25. DOI:https://doi.org/10.1016/j.pmip.2016.11.002
World Health Organization. (2018). Depression. WHO. Recuperado de https://bit.ly/3bxfHZz.
Yao, W., Zhang, J.-C., Ishima, T., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, Jin, Suganuma, H., Ishida, Y., Yamamoto, M. & Hashimoto, K. (2016). Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Scientific Reports, 6, 1-13. DOI: 10.1038/srep30659
How to Cite
Copyright (c) 2020 Matheus Gonçalves Chaves Mello, José Carlos Rosa Pires Souza, José Carlos Rosa Pires Souza, Vinicius Oliveira Andrade, Vinicius Oliveira Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.