Potential of photobiomodulation therapy in the treatment of skeletal muscle atrophy





Phototherapy; Lasers; Muscle atrophy; Rehabilitation.


Atrophy of striated skeletal muscle tissue is a complex process caused by an imbalance between the degradation and synthesis of myofibrillar proteins, leading to a reduction in muscle strength and, consequently, influencing the emotional behavior, mental health and quality of life of individuals. Thus, the attenuation of the atrophy and stimulus for the formation of new muscle tissue is a challenge for rehabilitation. Considerable efforts have been devoted to the establishment of new treatments, however, reliable experimental and clinical data are still lacking for its clinical application. Among the therapeutic resources available, photobiomodulation therapy (PBMT, from the English photobiomodulation therapy) has great potential, as it is often used as a promising therapeutic strategy for the rehabilitation of skeletal muscle tissue. Within this context, the aim of this study is to provide, through a narrative review, an understanding of the current available evidence on the importance of PBMT in the treatment of skeletal muscle atrophy. The searches were performed in the bibliographic databases of PubMed / MEDLINE, Virtual Health Library (VHL), Web of Science and SciELO. The evidence found in this study points out that PBMT can be proposed as an effective therapeutic intervention in the treatment of muscle atrophy, due to the potential to stimulate myogenic regulatory factors that promote the activation and proliferation of satellite cells and the consequent increase in the formation of muscle fibers, as well as how to attenuate and cellular apoptosis the proteolysis pathways of muscle fiber.

Author Biographies

Silma Rodrigues Gonçalves, Universidade Brasil

Mestrado em Ciências Morfofuncionais pelo ICBIII/USP com bolsa CNPQ

Professora Universitária de Anatomia e Morfologia Humana desde 2004.

Doutoranda em Engenharia Biomédica com enfase em Fotobiomodulação - Lasers

Bolsista da Capes

Lívia Assis Garcia, Universidade Brasil

Profa Dra Livia Assis

Orientadora do trabalho " Fotobiomodulação na Atrofia Muscular"


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How to Cite

GONÇALVES, S. R.; TIM, C. R. .; MARTIGNAGO, C. C. S. .; SILVA, M. C. P. .; ANARUMA, C. A.; GARCIA, L. A. . Potential of photobiomodulation therapy in the treatment of skeletal muscle atrophy. Research, Society and Development, [S. l.], v. 10, n. 1, p. e931018527, 2021. DOI: 10.33448/rsd-v10i1.8527. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/8527. Acesso em: 20 jan. 2021.



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