Alternative treatment of premenstrual syndrome with chamomile, apple and passion fruit




Behavior; Hormonal fluctuation; Medicinal plants; Menstrual cycle; Flavonoids; Vascular disorder.


The great achievements of women on the social, family and socioeconomic scale also bring to the public a picture of signs and symptoms experienced in their fertile life, which used to be between them and their gynecologists, which is the Premenstrual Tension Syndrome (STPM). The search for effective and safe alternative therapies capable of acting on the psychological and physical symptoms avoiding loss of work days and better family, social and work relationships can bring socioeconomic benefits and quality of life for women suffering from this great inconvenience. The aim of the present study was to investigate patients diagnosed with STPM with the associated use of chamomile (Matricaria recutita), apple (Malus domestica) and passion fruit (Passiflora edulis) in the 10 days prior to menstruation in tea form of said plants. For this purpose, 43 patients of childbearing age (between 18 and 49 years old) with a diagnosis of STPM in a private doctor's office in the city of Umuarama, PR, who answered a questionnaire about the prevalence of the most frequent symptoms related to STPM, and the results observed in our study showed that the parameters: 1) Irritability and Nervousness, 2) Anxiety and 7) Increased desire for sweet eating were the most affected in relation to alternative therapy with 91%, 81% and 67%, respectively. In addition, 93% of patients reported having more than 4 in up to 10 affected parameters. This reflected the level of satisfaction with the therapy performed with 79.1% satisfaction of the women evaluated in relation to this percentage of parameters reached (91%), where the predominant age group was between 18 and 23 years of age 35% participation in said research. In this way, it was verified that the central events related to this Syndrome are the most positively affected by this proposed therapy, and that the peripheral complaints were also softened. These effects are due to the general activities of the flavonoids contained in these natural products (Passion fruit, Chamomile and Apple) acting on central receptors, similar to the activities of Gaba (gamma amino butyric acid) and its actions modulating the inflammatory process reducing the synthesis of prostaglandins and metalloproteinases respectively. Thus, it was concluded that this therapy generally improved the most frequent symptoms of this syndrome (irritability and nervousness, anxiety, and desire to eat sweets) and the quality of life of these women when using alternative therapies.


Alberti, A. (2014). Compostos fenólicos da maçã. Tese de Doutorado (Programa de pós-graduação em Engenharia de Alimentos do Setor de Tecnologia) Universidade Federal do Paraná.

Al-Dabbagh, B., Elhaty, I. A., Elhaw, M., Murali, C., Al Mansoori, A., Awad, B., & Amin, A. (2019). Antioxidant and anticancer activities of chamomile (Matricaria recutita L.). BMC research notes, 12(1), 1-8.

Almeida, M. A. B, Gutierrez, G. L, & Marques, R. (2012). Qualidade de vida. Definição, Conceitos e Interfaces Com Outras Áreas de Pesquisa. São Paulo, Escola de Artes, Ciências e Humanidade.

Baracat, E. C. (2015). Manual de Ginecologia Endócrina. Federação Brasileira das Sociedades de Ginecologia e Obstetrícia.

Barbosa, S. R., Liberali, R., & Coutinho, V. F. (2010). Relação dos aspectos nutricionais na tensão pré-menstrual (TPM): revisão sistemática. RBONE-Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 4(19), 31-38.

Bortoluzzi, M. M., Schmitt, V., & Mazur, C. E. (2020). Efeito fitoterápico de plantas medicinais sobre a ansiedade: uma breve revisão. Research, Society and Development, 9(1), e02911504.

Bouzas, I., Braga, C., & Leão, L. (2010). Ciclo menstrual na adolescência. Adolescência e Saúde, 7(3), 59-63.

Brilhante, A. V. M., Bilhar, A. P. M., Carvalho, C. B., Karbage, S. A. L., Pequeno Filho, E. P., & Rocha, E. S. D. (2010). Síndrome pré-menstrual e síndrome disfórica pré-menstrual: aspectos atuais. Revista Femina, 38, 373-378.

Bryant, M., Truesdale, K. P., & Dye, L. (2006). Modest changes in dietary intake across the menstrual cycle: implications for food intake research. British Journal of Nutrition, 96(5), 888-894.

Busso, N. E., Acosta, A. A., &. Remohi, J. (1999). Indução da Ovulação. São Paulo. Editora Atheneu. 8-18 p.

Demarque, R., Rennó Jr, J., Lobo Ribeiro, H., Pires Cavalsan, J., Rocha, R., & Cantilino, A. (2013). Transtorno Disfórico Pré-Menstrual: um breve panorama. Revista Debates em Psiquiatria, (5), 6-13.

Ebrahimi, F., Farzaei, M. H., Bahramsoltani, R., Heydari, M., Naderinia, K., & Rahimi, R. (2019). Plant-derived medicines for neuropathies: a comprehensive review of clinical evidence. Reviews in the Neurosciences, 30(6), 671-684.

Goutman, J. D., Waxemberg, M. D., Doñate-Oliver, F., Pomata, P. E., & Calvo, D. J. (2003). Flavonoid modulation of ionic currents mediated by GABAA and GABAC receptors. European Journal of Pharmacology, 461(2-3), 79-87.

Hanrahan, J. R., Chebib, M., & Johnston, G. A. (2011). Flavonoid modulation of GABAA receptors. British Journal of Pharmacology, 163(2), 234-245.

Losi, G., & Puia, G. (2004). Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons. European Journal of Pharmacology, 502, 41-46.

Medina, J., & Salvatore C. A. (1977). Fisiopatologia Menstrual. São Paulo. Editora Manole, p. 384.

MINISTÉRIO DA SAÚDE. (2018). Práticas Integrativas Complementares em Saúde, PICS. Brasília, Distrito Federal.

Miroddi, M., Calapai, G., Navarra, M., Minciullo, P. L., & Gangemi, S. (2013). Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Journal of Ethnopharmacology, 150(3), 791-804.

Moghadam, Z. B., & Rezaei, E. (2016). The effect of valerian root extract on the severity of pre menstrual syndrome symptoms. Journal of Traditional and Complementary Medicine, 6, 309-315.

Muramatsu, C. H., Vieira, O. C. S., Simões, C. C., Katayama, D. A., & Nakagawa, F. H. (2001). Consequências da síndrome da tensão pré-menstrual na vida da mulher. Revista da Escola de Enfermagem da USP, 35(3), 205-213.

Sharifi, F., Simbar, M., Mojab, F., & Majd, H. A. (2014). Comparison of the effects of Matricaria chamomila (Chamomile) extract and mefenamic acid on the intensity of premenstrual syndrome. Complementary Therapies in Clinical Practice, 20(1), 81-88.

Silva, S. M. C. S. D., Silva, B. F. C., Farina, B. V., Spinoza, E. D., & Breda, S. M. (2012). A influência da tensão pré-menstrual sobre os sintomas emocionais e o consumo alimentar. Nutrire, 37(1), 13-21.

Viola, H., Wasowski, C., De Stein, M. L., Wolfman, C., Silveira, R., Dajas, F., Medina, J. H., & Paladini, A. C. (1995). Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Medica, 61(3), 213-216.

Zeraik, M. L., Pereira, C. A. M., Zuin, V. G., & Yariwake, J. H. (2010). Maracujá: um Alimento Funcional? Revista brasileira de farmacognosia, 20(3), 459-471.



How to Cite

SANTOS , C. C. D. .; ALBERTON, O.; BELETTINI, S. T. .; DONADEL, G.; DALMAGRO, M.; OTENIO, J. K. .; PINC, M. M. .; SABEC, G. Z. .; LOURENÇO, E. L. B. . Alternative treatment of premenstrual syndrome with chamomile, apple and passion fruit. Research, Society and Development, [S. l.], v. 9, n. 10, p. e2929108702, 2020. DOI: 10.33448/rsd-v9i10.8702. Disponível em: Acesso em: 28 sep. 2022.



Health Sciences