Profile of patients diagnosed with multiple sclerosis in a city in southern Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.9533

Keywords:

Multiple sclerosis; Diagnosis; Neurologic manifestations; Epidemiology.

Abstract

Multiple Sclerosis (MS) is a chronic disease which leads to demyelination of bundles of central nervous system nerve fibers. Thus, neuronal conduction is no longer saltatory, which results in decreased speed of the nerve impulses. The objective of this research was analyze the profile of MS patients over the past 7 years from 3 care centers located in Cascavel, western Paraná, southern Brazil. This is a descriptive quantitative cross-sectional study with the analysis of medical records of patients in 3 care centers from 2012 to 2018. Data were collected with a questionnaire (script) prepared by the researchers. The information was stored in the SPSS version 20.0 software, obtaining mean, standard deviation, minimum, maximum, interquartile range and absolute and relative frequency values. 24 female and 4 male patients were studied. The sample was diagnosed on average 6.6 years ago. The first reported symptoms were motor / sensory, visual or headache and about 50% were diagnosed within 1 year. The average age of diagnosis was 34.8 years. It was found that 67.9% had been or were under psychological treatment. Regarding the medical treatment for MS, the use of glatiramer acetate, β-interferone 1a and natalizumab has predominated among the patients. Through this study it was found that the majority of people with MS were women, of productive age and with high school education. Regarding the time between the first symptom and the diagnosis, it varied from a few days to 20 years.

Author Biographies

Barbara Biffi Gabardo, FAG

Acadêmica do Curso de Medicina no Centro Universitário da Fundação Assis Gurgacz, Cascavel, PR, Brasil

Everton Paulo Roman, Centro Universitário da Fundação Assis Gurgacz

Doutor em Saúde da Criança e do Adolescente e Docente no Centro Universitário da Fundação Assis Gurgacz, Cascavel, PR, Brasil.

Renatto Endler Iachinski, Centro Universitário da Fundação Assis Gurgacz

Neurologista com residência médica pelo Instituto de Neurologia de Curitiba (INC), especialista em Neurofisiologia Clínica e Docente no Centro Universitário da Fundação Assis Gurgacz, Cascavel, PR, Brasil.

Heboni Sabadin, Universidade do Planalto Catarinense

Médica pela Universidade do Planalto Catarinense (UNIPLAC), Lages, SC, Brasil

Leonardo Silva Grassi, Universidade do Planalto Catarinense

Acadêmico do Curso de Medicina na Universidade do Planalto Catarinense (UNIPLAC), Lages, SC, Brasil

João Pedro Zanatta, Universidade de Passo Fundo

Médico pela Universidade de Passo Fundo, RS, Brasil.

Layane Sanches Fernandes, Centro Universitário da Fundação Assis Gurgacz

Acadêmica do Curso de Medicina no Centro Universitário da Fundação Assis Gurgacz, Cascavel, PR, Brasil

References

Aires A., Barros A., Machado C., Fitas D., Cação G, Pedrosa R, … Andrade C. (2019) Diagnostic Delay of Multiple Sclerosis in a Portuguese Population, Acta Med Port, 32(4):289-294. Recuperado de https://www.actamedicaportuguesa.com/revista/index.php/ amp/article/view/11187. doi: 10.20344/amp.11187

Carmona N. P, Jover E. F, Sempere A. P. (2019) Epidemiología de la esclerosis múltiple en España. Revista de Neurología, 69(01):32-38. Recuperado de https://www.neurologia. com/articulo/2018477. doi:10.33588/rn.6901.2018477.

Cavenaghi V. B, Dobrianskyj F. M, Olival G. S, Carneiro R. P. C. D, Tilbery C. P. (2017) Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study. Sao Paulo Medical Journal, 135(3):222-225. Recuperado de https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222. doi:10.1590/1516-3180.2016.0200270117

Cerqueira, A. C. R., Nardi, A. E. (2011) Depressão e esclerose múltipla: um; a visão geral. Revista Brasileira de Neurologia, 47(4), 11-16. Recuperado de http://files.bvs.br /upload/S/0101-8469/2012/v47n4/a2944.pdf.

Gajofatto, A., Benedetti, M. (2015) Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World Journal of Clinical Cases, 3(7):545. Recuperado de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517331/. doi: 10.12998/wjcc.v3.i7.545.

Mapping Multiple Sclerosis around the World [Internet]. Msif.org. 2013. Recuperado de http://www.msif.org/wp-content/uploads/2014/09/Atlas-of- MS.pdf

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., Wolinsky, J. S. (2001) Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50(1), 121-127. Recuperado de https://pubmed.ncbi.nlm.nih.gov/11456302/. doi: 10.1002/ana.1032.

Mendes, M. F., Balsimelli, S., Stangehaus, G., Tilbery, C. P. (2004) Validação de escala de determinação funcional da qualidade de vida na esclerose múltipla para a língua portuguesa. Arquivos de Neuro-Psiquiatria, 62(1), 108-113. Recuperado de https://www.scielo.br/s cielo.php?script=sci_arttext&pid=S0004-282X2004000100019&lng=en&nrm=iso&tlng=pt. doi: 10.1590/S0004-282X2004000100019

Mendes, M. F., Tilbery, C. P., Balsimelli, S., Moreira, M. A., Barão-Cruz, A. M. (2003) Depressão na esclerose multipla forma remitente-recorrente. Arquivos de Neuro-Psiquiatria, 61(3A), 591-595. Recuperado de https://www.scielo.br/scielo.php?scr ipt=sci_arttext&pid=S0004-282X2003000400012&lng=en&nrm=iso&tlng=pt. doi: 10.1590/S0004-282X2003000400012

Merritt, H., Rowland, L.. (2011) Tratado de neurologia. (12a ed.), Rio de Janeiro (RJ): Guanabara Koogan; 2011.

Miller, D., Barkhof, F., Montalban, X., Thompson, A., Filippi, M. (2005) Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis. The Lancet Neurology, 4(5):281-288. Recuperado de https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(05)70071-5/fulltext. doi: 10.1016/S1474-4422(05)70071-5

Minguetti, G. (2001) Ressonância magnética na esclerose múltipla: análise de 270 casos. Arquivos de Neuro-Psiquiatria, 59(3A):563-569. Recuperado de https://www.scielo. br/scielo.php?script=sci_arttext&pid=S0004-282X2001000400015&lng=en&nrm= iso&tlng =pt. doi: 10.1590/S0004-282X2001000400015

MS Treatments Multiple Sclerosis. MS International Federation. 2018. Recuperado de https://www.msif.org/living-with-ms/treatments/.

Noseworthy, J. H., Lucchinetti, C., Rodriguez, M., Weinshenker, B. G. (2000) Multiple Sclerosis. New England Journal of Medicine, 343(13):938-952. Recuperado de https://www.nejm.org/doi/10.1056/NEJM200009283431307?url_ver=Z39.88-2003&r fr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed doi: 10.1056/NEJM 20000928 3431307.

Oliveira, E., Souza, N. (1998) Esclerose Múltipla. Revista Neurociências, 6(3),114-118. Recuperado de http://www.revistaneurociencias.com.br/edicoes/1998/RN%2006%2003/P ages%20from%20RN%2006%2003-4.pdf

Protocolo Clínico e Diretrizes Terapêuticas Esclerose Múltipla. Conitec.gov.br. 2018 Recuperado de http://conitec.gov.br/images/Relatorios/2018/Relatorio_PCDT_Escle roseMultipla.pdf.

Pugliatti, M., Rosati, G., Carton, H., Riise, T., Drulovic, J., Vecsei, L., et al. (2006) The epidemiology of multiple sclerosis in Europe. European Journal of Neurology, 13 (7), 700-722. Recuperado de https://pubmed.ncbi.nlm.nih.gov/16834700/ doi: 10.1111/j.1468-1331.2006.01342.x

Thompson, A. J., Baranzini, S. E., Geurts, J., Hemmer, B., Ciccarelli, O. (2018) Multiple Sclerosis. Lancet, 391(10130), 1622-1636. Recuperado de https://pubmed.ncbi.nlm.nih.gov/2 9576504/ doi: 10.1016/S0140-6736(18)30481-1

Turner, A. P., Hartoonian, N., Hughes, A. J., Arewasikporn, A., Alschuler, K. N., Sloan, A. P., et al. (2019) Physical activity and depression in MS: The mediating role of behavioral activation. Disability and Health Journal,1-6. Recuperado de https://www.scien cedirect.com/science/article/abs/pii/S1936657419300639?via%3Dihubdoi: 10.1016/j.dhjo.2019.04.004

Wallace, C. J., Seland, T. P., Fong, T. C. (1992) Multiple sclerosis: the impact of MR imaging. American Journal of Roentgenology, 158(4):849-857. Recuperado de https://www.ajronline.org/doi/abs/10.2214/ajr.158.4.1546605. doi: 10.2214/ajr.158.4.1546605

Yadav, S., Mindur, J., Ito, K., Dhib-Jalbut, S. (2015) Advances in the immunopathogenesis of multiple sclerosis. Current Opinion in Neurology, 28(3), 206-219. Recuperado de https://journals.lww.com/co-neurology/Abstract/2015/06000/Advances_in_the_immunopatho genesis_of_multiple.2.aspx. doi: 10.1097/WCO.0000000000000205

Published

06/11/2020

How to Cite

GABARDO, B. B. .; ROMAN, E. P.; IACHINSKI, R. E. .; SABADIN, H. .; GRASSI, L. S. .; ZANATTA, J. P.; FERNANDES, L. S. . Profile of patients diagnosed with multiple sclerosis in a city in southern Brazil. Research, Society and Development, [S. l.], v. 9, n. 11, p. e1169119533, 2020. DOI: 10.33448/rsd-v9i11.9533. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/9533. Acesso em: 27 dec. 2024.

Issue

Section

Health Sciences