The influence of vitamin D on cancer: an integrative review
DOI:
https://doi.org/10.33448/rsd-v10i1.11388Keywords:
Oncology; Neoplasm; Calcitriol; Prevention of diseases.Abstract
Theoretical framework: cancer is a group of more than one hundred diseases, of which have intrinsic and/or extrinsic factors, modifiable and non-modifiable for its onset. Vitamin D, in turn, is a steroid hormone that has its biological actions mediated by the vitamin D receptor, consequently developing roles related to the control of cell growth, differentiation and proliferation, in which, the administration of its active metabolites or analogues can result in inhibition of angiogenesis, delegating effects antiproliferative and activation of apoptotic mechanisms. Objective: Present the influence of vitamin D action on cancers that affect the gastrointestinal tract and distinct organs. Methodology: It is an integrative review, with a qualitative approach. Based on research on BVS and PubMed databases, 19 articles were selected that were consistent with the theme and the inclusion and exclusion criteria, through the association of descriptors and keywords. Results: 84.62% and 71.43% of the studies demonstrated a positive correlation of vitamin D in the anti-carcinogenesis process of cancers that affect the gastrointestinal tract and different organs, respectively. The carcinogenesis process can be influenced by vitamin D deficiency, polymorphisms in the vitamin D receptor gene and other changes and relationships with underlying pathways. Conclusion: This study highlights the positive influence of vitamin D in the prevention of carcinogenesis that affects the gastrointestinal tract and different organs.
References
Albanes, D. (2015). Vitamin D and cancer: Diversity, complexity, and still a ways to go. Cancer Prevention Research, 8(8), 657–661. doi: 10.1158/1940-6207.CAPR-15-0207
Brasil. Ministério da Saúde. Instituto Nacional do Câncer José Alencar Gomes da Silva (INCA). (2020). ABC do câncer: abordagens básicas para o controle do câncer / Instituto Nacional (6ª ed.). Rio de Janeiro: INCA. Recuperado de https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//livro-abc-6-edicao-2020.pdf
Bray, F., Ferlay, J., Soerjomataram, I, Siegel, R. L., Torre, L. A., & Jernal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394-424. doi: https://doi.org/10.3322/caac.21492
Chen, L., Yang, R., Qiao, W., Yuan, S., Goltzman, D., & Miao, D. (2018). 1,25-Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice. International Journal of Cancer, 143(2), 368–382. doi: https://doi.org/10.1002/ijc.31317
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L. & Carmeliet, G. (2015). Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews, 96(1), 365-408. doi: https://doi.org/10.1152/physrev.00014.2015
Deeb, K. K., Trump, D. L. & Johnson, C. S. (2007). Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics. Nature Reviews Cancer, 7(9), 684–700. doi: https://doi.org/10.1038/nrc2196
Eliassen, A. H., Warner, E. T., Rosner, B., Collins, L. C., Beck, A. H., Quintana, L. M., ... Hankinson, S. E. (2016). Plasma 25-Hydroxyvitamin D and Risk of Breast Cancer in Women Followed over 20 Years. Cancer Research, 76(18), 5423–5430. doi: https://doi.org/10.1158/0008-5472.can-16-0353
El-Sharkawy, A. & Malki, A. (2020). Vitamin D signaling in inflammation and cancer: Molecular mechanisms and therapeutic implications. Molecules, 25(14), 1-31. doi: https://doi.org/10.3390/molecules25143219
Eom, S. Y., Yim, D.H., Kim, D. H., Yun, H. Y.., Song, Y. J., Youn, S., ... Kim, H. (2018). Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea. Journal of Biomedical Research, 32(4), 257-263. doi: https://doi.org/10.7555/JBR.32.20170089
Haznadar, M., Krausz, K. W., Margono, E., Diehl, C. M., Bowman, E. D., Manna, S. k., ... Harris, C. C. (2018). Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation. Cancer Medicine, 7(6), 2764–2775. doi: https://doi.org/10.1002/cam4.1444
Holick, M. F. (2007). Medical progress: Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281. doi: https://doi.org/10.1056/NEJMra070553
Horas, K., Zheng, Y., Fong-Yee, C., Macfarlane, E., Manibo, J., Chen, Y., ... Seibel, M. J. (2019). Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization. Journal of Bone and Mineral Research, 34(9), 1721–1732. doi: https://doi.org/10.1002/jbmr.3744
Kim, J. S., Jung, M., Yoo, J., Choi, E. H., Park, B. C., Kim, M. H., & Hong, S. P. (2016). Protective effect of topical Vitamin D3 against photocarcinogenesis in a murine model. Annals of Dermatology, 28(3), 304–313. doi: https://doi.org/10.5021/ad.2016.28.3.304
Kwak, J. H. & Paik, J. K. (2020). Vitamin D Status and Gastric Cancer: A Cross-Sectional Study in Koreans. Nutrients, 12(7), 1-9. doi: https://doi.org/10.3390/nu12072004
Makarova, A. M., Fracari, F., Davari, P., Gorouhi, F., Dutt, P., Wang, L., ... Epstein Jr, E. H. (2018). Ultraviolet radiation inhibits mammary carcinogenesis in an ER-negative murine model by a mechanism independent of Vitamin D3. Cancer Prevention Research, 11(7), 383–391. doi: https://doi.org/10.1158/1940-6207.CAPR-17-0195
Margolis, R. N. & Christakos, S. (2010). The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation: An update. Annals of the New York Academy of Sciences, 1192, 208–214. doi: https://doi.org/10.1111/j.1749-6632.2009.05227.x
McCullough, M. L., Zoltick, E. S., Weinstein, S. J., Fedirko, V., Wang, M., Cook, N. R., ... Smith-Warner, S. A. (2019). Circulating Vitamin D and colorectal cancer risk: An international pooling project of 17 cohorts. Journal of the National Cancer Institute, 111(2), 158–169. doi: https://doi.org/10.1093/jnci/djy087
Messaritakis, I., Koulouridi, A., Sfakianaki, M., Vogiatzoglou, K., Gouvas, N., Athanasakis, E., ... Souglakos, J. (2020). The role of vitamin D receptor gene polymorphisms in colorectal cancer risk. Cancers, 12(6), 1–16. doi: https://doi.org/10.3390/cancers12061379
Orlow, I., Reiner, A. S., Thomas, N. E., Roy, P., Kanetsky, P. A., Luo, L., ... Berwick, M. (2016). Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: A population-based study. Carcinogenesis, 37(1), 30–38. doi: https://doi.org/10.1093/carcin/bgv157
Park, S. M., Li, T., Wu, S., Li, W. Q., Qureshi, A. A., & Cho, E. (2016). Vitamin D intake and risk of skin cancer in US women and men. PLoS ONE, 11(8), 1–14. doi: https://doi.org/10.1371/journal.pone.0160308
Pereira, A. S., Shitsuka, D. M., Pereira, F. J., & Shitsuka, R. (Orgs.) (2018). Metodologia da pesquisa científica. Santa Maria, RS: UFSM. Recuperado de https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Schöttker, B., Jorde, R. Peasey, A., Thorand, B., Jansen, E. H. J. M., Groot, L., ... Brenner, H. (2014). Vitamin D and mortality: Meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ, 348, 1–15. doi: https://doi.org/10.1136/bmj.g3656
Spath, L., Ulivieri, A., Lavra, L., Fidanza, L., Carlesimo, M., Giubettini, ... Bartolazzi, A. (2017). Antiproliferative Effects of 1α-OH-vitD 3 in Malignant Melanoma: Potential Therapeutic implications. Scientific Reports, 7(1), 1–12. doi: https://doi.org/10.1038/srep40370
Souza, M. T., Silva, M. D. D. & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-6. doi: https://doi.org/10.1590/s1679-45082010rw1134
Suksawatamnuay, S., Sriphoosanaphan, S., Aumpansub, P., Aniwan, S., Thanapirom, K., Tanasanvimon, S., ... Komolmit, P. (2020). Association between Vitamin D Receptor Single-Nucleotide Polymorphisms and Colorectal Cancer in the Thai Population: A Case-Control Study. BioMed Research International, 1-9. doi: https://doi.org/10.1155/2020/7562958
Tian, X. Q., Chen, T. C., Matsuoka, L. Y., Wortsman, J., & Holick, M. F. (1993). Kinetic and thermodynamic studies of the conversion of previtamin D3 to vitamin D3 in human skin. Journal of Biological Chemistry, 268(20), 14888-14892. Recuperado de https://www.jbc.org/content/268/20/14888.long
Verma, A., Vincent-Chong, V. K., Dejong, H., Gershberger, P. A., & Sashadri, M. (2020). Impact of dietary vitamin D on initiation and progression of oral cancer. Journal of Steroid Biochemistry and Molecular Biology, 199, 105603. doi: https://doi.org/10.1016/j.jsbmb.2020.105603
Vincent-Chong, V. K., DeJong, H., Attwood, K., Hershberger, P. A. & Seshadri, M. (2019). Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis. Neoplasia, 21(4), 376–388. doi: https://doi.org/10.1016/10.1016/j.neo.2019.02.002
Wacker, M. & Holick, M. F. (2013). Sunlight and Vitamin D: A global perspective for health. Dermato-Endocrinology, 5(1), 51-108. doi: https://doi.org/10.1016/10.4161/derm.24494
Xin, Y., He, L., Phil, M., Luan, Z., Lv, H., Yang, H., ... Qian, J. (2017). E-cadherin Mediates the Preventive Effect of Vitamin D 3 in Colitis-associated Carcinogenesis. Inflammatory Bowel Diseases, 23(9), 1535–1543. doi: https://doi.org/10.1097/MIB.0000000000001209
Yang, L., Chen, H., Zhao, M. & Peng, P. (2017). Prognostic value of circulating vitamin D binding protein, total, free and bioavailable 25-hydroxy vitamin D in patients with colorectal cancer. Oncotarget, 8(25), 40214–40221. doi: https://doi.org/10.18632/oncotarget.16597
Zella, L. A., Kim, S., Shevde, N. K., & Pike, J. W. (2006). Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Molecular Endocrinology, 20(6), 1231–1247. doi: https://doi.org/10.1210/me.2006-0015
Zhang, Y. G., Lu, R., Wu, S., Chatterjee, I., Zhou, D., Xia, Y., & Sun, J. (2020). Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine. Cellular and Molecular Gastroenterology and Hepatology, 10(4), 1–18. doi: https://doi.org/10.1016/j.jcmgh.2020.05.010
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