Clinical profile, prevalence and mortality of hospitalized patients with chronic liver diseases infected with SARS-COV-2: An integrative review
DOI:
https://doi.org/10.33448/rsd-v10i4.13143Keywords:
Chronic liver disease; Coronavirus infection; Coinfection; Mortality.Abstract
Objective: To analyze scientific evidence on the clinical profile, prevalence and mortality of adult hospitalized patients with chronic liver disease (CLD) infected with SARS-COV-2. Methodology: This is a bibliographic review in the integrative literature review method, carried out in February 2021, in the databases MEDLINE / PubMed, EMBASE and LILACS, using the descriptors / MESH: "COVID-19" AND "chronic liver disease ", combined with the Boolean operator "AND”. Inclusion criteria were: original articles available in full, complete, published between 2019 and January 2021, in Portuguese, English and/or Spanish, and a suitable theme. The exclusion criteria were: incomplete, duplicate articles, unrelated to the topic, in pre-proof, theses, dissertations, monographs and manuals. Results: Seven articles were included. 1693 adult hospitalized patients infected with SARS-COV-2 were analyzed and the frequency was varied between 0.79% and 50%, compared to the hospitalized population infected with COVID-19 with and without CLD. The clinical profile of patients with CLD and COVID-19 was predominantly male, mean age: 55 years, non-alcoholic fatty liver disease as a previous CLD and hypertension as the main comorbidity. The most reported symptoms were cough (80.8%), presence of infection(73.1%), sputum(26.9%), dyspnea(25%), myalgia or fatigue(13.5%). The main laboratory and imaging changes included elevation in liver enzymes, lymphopenia, diffuse opacities and ground-glass. Mortality was more significant in immunosuppressed CLD and COVID-19 patients, ranging from 1.78% to 8.1%. Conclusion: The data propose a trend in clinical profile, prevalence and mortality, but there is a need for further cohort studies or randomized clinical trials with larger samples to confirm hypotheses.
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Copyright (c) 2021 Thyago de Oliveira Afonso; Sarah Maria Soares de Freitas; Douglas Rogério Freitas de Souza; Gabriel Vítor Lima de Andrade; José Erivaldo Gonçalves; Mariana Pereira Barbosa Silva; Samuel Lopes dos Santos; Simone Barroso de Carvalho; Leandro Luiz da Silva Loures; Gustavo Baroni Araujo; Beatriz Cardoso Melo; Yulle Morais Gomes; Luís Eduardo Arcoverde Nogueira Brayner; Natana Maranhão Noleto da Fonseca; Maria Clara Osório Meneses Carvalho; Mariana Magalhães Bergantini Zanovello; Ilana Marjorie Macedo Borges Miranda; Amanda Viana Santos; Amanda Costa Maciel; Yonara Cristiane Ribeiro; Pâmela Ferreira Brito
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