Perspective of pharmaceutical practice in adrenal insufficiency: An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i7.16197

Keywords:

Adrenal insufficiency; Pharmaceutical services; Pharmacology.

Abstract

An integrating review of the literature about the perspectives of the pharmaceutical practices in Adrenal Insufficiency (AI) was carried out. Researches were done on the LILACS database, Medline (Pubmed), and Scientific Electronic Library OnLine-SCIELO.  Articles published between January 2007 and February 2021, written in Portuguese, English, and Spanish, were included. A total of 43 articles were selected to compose the review. A great deal of the studies considers patient education fundamental for the treatment and AI control. Among the education measures found in these studies, which can subside the service routines are: guidelines on the precipitating factors, signs and disease symptoms, dose adjustment, drug interaction, and condition identification cards. Relevant interventions of clinic management reported hospital discharge plans, management of AI acute and chronic phases, home care management, and routine outpatient follow-up. For an effective self-care support system, patient-centered assistance must be the core of the health care standards model. The review establishes that the AI patient follow-up must be performed regularly by a multidisciplinary team. It also allowed the identification of health measures that a pharmacist integrated with the healthcare team should perform.

References

Aguirre, Miguel A, Luna, Magda, Reyes, Yubriangel, Gómez-Pérez, Roald, & Benítez, Isabel. (2013). Diagnóstico y Manejo de la Insuficiencia Adrenal. Revista Venezolana de Endocrinología y Metabolismo, 11(3), 157-167. http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S1690-31102013000300007&lng=es&tlng=es

Alexandraki K.I. & Grossman A. (2019). Management of Hypopituitarism. J Clin Med., 8(12), 2153. doi:10.3390/jcm8122153.

Alves, C., Robazzi, T. C. V. & Mendonça, M. (2008). Retirada da corticoterapia: recomendações para a prática clínica. Jornal de Pediatria, 84(3), 192-202. https://doi.org/10.2223/JPED.1773.

Bensing, S., Hulting, A., Husebye, E. S., Kämpe, O., & Løvås, K. (2016). MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review, European Journal of Endocrinology, 175(3), R107-R116. https://eje.bioscientifica.com/view/journals/eje/175/3/R107.xml

Björnsdottir S., Sundström A., Ludvigsson J.F., Blomqvist P., Kämpe O. & Bensing S. (2013). Drug prescription patterns in patients with Addison's disease: a Swedish population-based cohort study. J Clin Endocrinol Metab, 98(5), 2009-2018. doi: 10.1210/jc.2012-3561.

Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., & Torpy, D. J. (2016). Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism, 101(2), 364–389. https://doi.org/10.1210/jc.2015-1710

Bowden S.A., Connolly A. M., Kinnett K. & Zeitler P.S. (2019). Management of Adrenal Insufficiency Risk After Long-term Systemic Glucocorticoid Therapy in Duchenne Muscular Dystrophy: Clinical Practice Recommendations. J Neuromuscul Dis, 6(1), 31-41. doi:10.3233/JND-180346.

Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. (2013). Diretrizes para o cuidado das pessoas com doenças crônicas nas redes de atenção à saúde e nas linhas de cuidado prioritárias. Brasília: Ministério da Saúde.

Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. (2014). Cuidado farmacêutico na atenção básica. Caderno 1: Serviços farmacêuticos na atenção básica à saúde. Brasília: Ministério da Saúde.

Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. (2014). Diretrizes para Atenção Integral às Pessoas com Doenças Raras no Sistema Único de Saúde – SUS Brasília: Ministério da Saúde.

Brasil. Ministério da saúde. (2015). Protocolo Clínico e Diretrizes Terapêuticas – Insuficiência Adrenal Primária (Doença de Addison). Portaria SAS/MS nº 1170, de 19 de novembro de 2015. Brasília: Ministério da Saude.

Broersen, L. H., Pereira, A. M., Jørgensen, J. O., & Dekkers, O. M. (2015). Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis. The Journal of clinical endocrinology and metabolism, 100(6), 2171–2180. https://doi.org/10.1210/jc.2015-1218

González Calero, Teresa Margarita, & González Padilla, Katrine. (2014). La educación terapéutica en pacientes con insuficiencia adrenal crónica. Revista Cubana de Endocrinología, 25(3), 231-236. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532014000300011&lng=es&tlng=es

Castro, M. & Elias, L. L. K. (2003). Insuficiência adrenal crônica e aguda. Medicina, 36(-4), 375-379. https://doi.org/10.11606/issn.2176-7262.v36i2/4p375-379

Conselho Federal de Farmácia (CFF). (2008). O papel do farmacêutico comunitário no aconselhamento ao paciente. Boletim Farmacoterapêutico. Ano XIII. n. 4 e 5 Jul./out. Brasília: Conselho Federal de Farmácia.

Conselho Federal de Farmácia (CFF). (2013). Resolução nº 585 de 29 de agosto de 2013. Ementa: Regulamenta as atribuições clínicas do farmacêutico e dá outras providências. Brasília. https://www.cff.org.br/userfiles/file/resolucoes/585.pdf

Conselho Federal de Farmácia (CFF). (2016). Serviços farmacêuticos diretamente destinados ao paciente, à família e à comunidade: contextualização e arcabouço conceitual. Brasília: Conselho Federal de Farmácia.

Dineen, R., Thompson, C. J., & Sherlock, M. (2019). Adrenal crisis: prevention and management in adult patients. Therapeutic advances in endocrinology and metabolism, 10, 2042018819848218. https://doi.org/10.1177/2042018819848218

Dinsen S., Baslund B., Klose M., Rasmussen A.K., Friis-Hansen L., Hilsted L. & Feldt-Rasmussen U. (2013). Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself. Eur J Intern Med, 24(8), 714-20. doi: 10.1016/j.ejim.2013.05.014.

Elshimy, G., Alghoula, F., & Jeong, J. M. (2020). Adrenal Crisis. In StatPearls. StatPearls Publishing.

Ekman, B., Fitts, D., Marelli, C., Murray, R. D., Quinkler, M., & Zelissen, P. M. (2014). European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy. BMC endocrine disorders, 14, 40. Retrieved from https://doi.org/10.1186/1472-6823-14-40

Fares A. B. & Dos Santos, R. A. (2016). Conduct protocol in emergency: Acute adrenal insufficiency. Rev. Assoc. Med. Bras., 62(8), 728-734. https://www.scielo.br/j/ramb/a/dvmW3zdbhSmFYQrjQvYD5NL/?lang=en 42302016000800728&lng=en. https://doi.org/10.1590/1806-9282.62.08.728

Franco, L., Vieira, H., Vieira, P. & Rabelo, I. (2012). Doença de Addison em idade pediátrica: um caso clínico. Nascer e Crescer, 21(2), 96-98. https://repositorio.chporto.pt/bitstream/10400.16/1333/1/06_CasosClinicos-1_21-2.indd.pdf

Harsch I.A., Schuller A., Hahn E.G. & Hensen J. (2010). Cortisone replacement therapy in endocrine disorders - quality of self-care. J Eval Clin Pract., 16(3), 492-498. doi: 10.1111/j.1365-2753.2009.01149.

Hittle, K., Hsieh, S., & Sheeran, P. (2010). Acute adrenal crisis masquerading as septic shock in a healthy young woman. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners, 24(1), 48–52. https://doi.org/10.1016/j.pedhc.2009.09.007

Huecker, M.R., Bhutta, B.S., Dominique, E. & Bossuah, K. A. (2021). Insuficiência adrenal (nursing). Treasure Island (FL): StatPearls Publishing. Retrieved from https://fs53slaq3neykuquxervhfvj5a-adv7ofecxzh2qqi-www-ncbi-nlm-nih-gov.translate.goog/books/NBK568707/

Husebye, E. S., Allolio, B., Arlt, W., Badenhoop, K., Bensing, S., Betterle, C., Falorni, A., Gan, E. H., Hulting, A. L., Kasperlik-Zaluska, A., Kämpe, O., Løvås, K., Meyer, G., & Pearce, S. H. (2014). Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. Journal of internal medicine, 275(2), 104–115. https://doi.org/10.1111/joim.12162

Inder, W. J., Meyer, C., & Hunt, P. J. (2015). Management of hypertension and heart failure in patients with Addison's disease. Clinical endocrinology, 82(6), 789–792. https://doi.org/10.1111/cen.12592

Jones, D. A., Miras, A., & Tringham, J. R. (2008). Addison's disease: a diagnostic challenge. British journal of hospital medicine (London, England : 2005), 69(12), M192–M195. https://doi.org/10.12968/hmed.2008.69.sup12.31945

Kampmeyer, D., Lehnert, H., Moenig, H., Haas, C. S., & Harbeck, B. (2016). A strong need for improving the education of physicians on glucocorticoid replacement treatment in adrenal insufficiency: An interdisciplinary and multicentre evaluation. European journal of internal medicine, 33, e13–e15. https://doi.org/10.1016/j.ejim.2016.04.006

Kluger, N., Matikainen, N., Sintonen, H., Ranki, A., Roine, R. P., & Schalin-Jäntti, C. (2014). Impaired health-related quality of life in Addison's disease--impact of replacement therapy, comorbidities and socio-economic factors. Clinical endocrinology, 81(4), 511–518. https://doi.org/10.1111/cen.12484

Marques, L. F. G. & Romano-Lieber, N. S.(2014). Segurança do paciente no uso de medicamentos após a alta hospitalar: um estudo exploratório. Saúde e Sociedade [online], 23(4), 1431-1444. https://doi.org/10.1590/S0104-12902014000400025

Martínez, A., & Heinrich, J. (2010). Emergencia pediátrica: insuficiencia suprarrenal aguda Pediatric emergency: adrenal insufficiency and adrenal crisis. Arch Argent Pediatr, 108(2), 167-170. doi: 10.1590/S0325-00752010000200018

Molimard, M., Girodet, P. O., Pollet, C., Fourrier-Réglat, A., Daveluy, A., Haramburu, F., Fayon, M., & Tabarin, A. (2008). Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation. Drug safety, 31(9), 769–774. https://doi.org/10.2165/00002018-200831090-00005

Moloney, Sinéad, & Dowling, Maura. (2012). Early intervention and management of adrenal insufficiency in children. Nursing Children and Young People, 24(7), 25-28. doi: 10.7748/ncyp.24.7.25.s23.

Moloney, S., Murphy, N., & Collin, J. (2015). An overview of the nursing issues involved in caring for a child with adrenal insufficiency. Nursing children and young people, 27(7), 28–36. https://doi.org/10.7748/ncyp.27.7.28.e609

Munir, S., Quintanilla Rodriguez, B. S., & Waseem, M. (2021). Addison Disease. In StatPearls. StatPearls Publishing.

Napier, C., & Pearce, S. H. (2012). Autoimmune Addison's disease. Presse medicale (Paris, France : 1983), 41(12 P 2), e626–e635. https://doi.org/10.1016/j.lpm.2012.09.010

Nieman, L. K. (2021). Patient education: Adrenal insufficiency (Addison's disease) (Beyond the Basics). UpToDate. https://www.uptodate.com/contents/adrenal-insufficiency-addisons-disease-beyond-the-basics

O'Connell, S., & Siafarikas, A. (2010). Addison disease - diagnosis and initial management. Australian family physician, 39(11), 834–837. https://pubmed.ncbi.nlm.nih.gov/21301655/

Odenwald, B., Nennstiel-Ratzel, U., Dörr, H., Schmidt, H., Wildner, M., & Bonfig, W. (2016). Children with classic congenital adrenal hyperplasia experience salt loss and hypoglycemia: evaluation of adrenal crises during the first 6 years of life, European Journal of Endocrinology, 174(2), 177-186. https://eje.bioscientifica.com/view/journals/eje/174/2/177.xml

Oprea, A., Bonnet, N., Pollé, O., & Lysy, P. A. (2019). Novel insights into glucocorticoid replacement therapy for pediatric and adult adrenal insufficiency. Therapeutic advances in endocrinology and metabolism, 10. https://doi.org/10.1177/2042018818821294

Palacio, A.V., González, B.V. & Maya, G.C. (2013). Evaluation of hypothalamic-pituitary-adrenal axis function in children treated with steroids. Medicina & Laboratorio, 19(03-04), 111-125 https://www.medigraphic.com/pdfs/medlab/myl-2013/myl133-4b.pdf

Pereira, A. S. et al. (2018). Metodologia da pesquisa cientifica. [free e-book]. Santa Maria: UAB/NTE/UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence.

Quinkler, M., Hahner, S., Johannsson, G., & Stewart, P. M. (2014). Saving lives of patients with adrenal insufficiency: a pan-European initiative?. Clinical endocrinology, 80(3), 319–321. https://doi.org/10.1111/cen.12378

Puar, T. H., Stikkelbroeck, N. M., Smans, L. C., Zelissen, P. M., & Hermus, A. R. (2016). Adrenal Crisis: Still a Deadly Event in the 21st Century. The American journal of medicine, 129(3), 339.e1–339.e3399. https://doi.org/10.1016/j.amjmed.2015.08.021

Reddy P. (2011). Clinical approach to adrenal insufficiency in hospitalised patients. International journal of clinical practice, 65(10), 1059–1066. https://doi.org/10.1111/j.1742-1241.2011.02718.x

Repping-Wuts, H. J., Stikkelbroeck, N. M., Noordzij, A., Kerstens, M., & Hermus, A. R. (2013). A glucocorticoid education group meeting: an effective strategy for improving self-management to prevent adrenal crisis. European journal of endocrinology, 169(1), 17–22. https://doi.org/10.1530/EJE-12-1094

Romanholi, D. J. P. C. & Salgado, L. R. (2007). Exogenous Cushing’s Syndromeand Glucocorticoid Withdrawal. ArqBrasEndocrinolMetab, 51(8),1280-1292. https://www.scielo.br/j/abem/a/KVfdmqMxwtGx5KFtkfVByKM/?lang=pt&format=pdf

Rushworth, R. L., & Torpy, D. J. (2014). A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections. BMC endocrine disorders, 14, 79. https://doi.org/10.1186/1472-6823-14-79

Shepherd, L. M., Tahrani, A. A., Inman, C., Arlt, W., & Carrick-Sen, D. M. (2017). Exploration of knowledge and understanding in patients with primary adrenal insufficiency: A mixed methods study. BMC Endocrine Disorders, 17(1). https://doi.org/10.1186/s12902-017-0196-0

Silva, R. C., Castro, M. De, Kater, C. E., Cunha, A. A., Moraes, A. M., Alvarenga, D. B., Moreira, A. C. & Elias, L. L. K. (2004). Insuficiência adrenal primária no adulto: 150 anos depois de Addison. ArqBrasEndocrinolMetab, 48(5), 724-738. https://www.scielo.br/j/abem/a/Z3HMNsNKKYLmBbZ3jrY9QTn/?lang=pt#

Van Eck, J. P., Gobbens, R. J., Beukers, J., Geilvoet, W., van der Lely, A. J., & Neggers, S. J. (2016). Much to be desired in self-management of patients with adrenal insufficiency. International journal of nursing practice, 22(1), 61–69. https://doi.org/10.1111/ijn.12368

Nuez Vilar, Marisela. (2014). Tratamiento sustitutivo en la insuficiencia suprarrenal crónica. Revista Cubana de Endocrinología, 25(3), 191-197. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532014000300007&lng=es&tlng=es

Araújo, S. Q., Costa, K. S., Luiza, V. L., Lavras, C., Santana, E. A. & Tavares, N. U. L. (2017). Organização dos serviços farmacêuticos no Sistema Único de Saúde em regiões de saúde. Ciência & Saúde Coletiva, 22(4), 1181-1191. https://www.scielo.br/pdf/csc/v22n4/1413-8123-csc-22-04-1181.pdf

Rathbun, K. M., Nguyen, M., & Singhal, M. (2020). Addisonian Crisis. In StatPearls. StatPearls Publishing.

Bowden, S.A., Henry, R. (2018). Pediatric Adrenal Insufficiency: Diagnosis, Management, and New Therapies. Int J Pediatr, 2018 (1), 1-8. doi: 10.1155/2018/1739831.

Miller, B. S., Spencer, S. P., Geffner, M. E., Gourgari, E., Lahoti, A., Kamboj, M. K., Stanley, T. L., Uli, N. K., Wicklow, B. A., & Sarafoglou, K. (2020). Emergency management of adrenal insufficiency in children: advocating for treatment options in outpatient and field settings. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 68(1), 16–25. https://doi.org/10.1136/jim-2019-000999

Alexandraki, K.I. & Grossman, A. (2018). Adrenal Insufficiency. South Dartmouth (MA): MDText.com, Inc., South Dartmouth (MA). https://www.ncbi.nlm.nih.gov/books/NBK279087/?report=reader

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13/06/2021

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CAETANO, J. D. S. .; CASTILHO, S. R. de .; SANTOS, V. dos . Perspective of pharmaceutical practice in adrenal insufficiency: An integrative review. Research, Society and Development, [S. l.], v. 10, n. 7, p. e5610716197, 2021. DOI: 10.33448/rsd-v10i7.16197. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16197. Acesso em: 22 dec. 2024.

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Health Sciences