In vitro analysis of the antifungical activity of plant extracts against yeasts belongimg to the Candida albicans species
DOI:
https://doi.org/10.33448/rsd-v10i10.19075Keywords:
Extracts; Strain; Candida albicans; Efficiency.Abstract
Candidiasis is one of the most common affections, and it is estimated that most women will present, throughout their lives, at least one episode of the infection. And with this the importance of studies on other alternative methods for treatment based on plant extracts, which have ecological potential to replace the use of synthetic products. Thus, the research aimed to analyze the antifungal activity of crude extracts of the vegetables Morinda citrifolia (None), Caryocar brasiliense (Pequi), Annona muricata (Graviola), Morus alba L. (Mora) and Apis mellifera L. (Propolis) in front of the yeast Candida albicans. The vegetables were collected in the municipality of Teresina-PI and dried at room temperature in the shade, with daily exposure of 4 h; milled in knife mills; the extracts were obtained in methanol and the susceptibility tests were carried out in triplicate on agar-agar and Muller-Hinton agar culture media, using the agar diffusion technique. The Candida albicans ATCC-76485 strain was used in the tests. Of the five vegetables used, the extracts of Pequi and Propolis, showed antifungal activity on the strain of C. albicans, with the second extract showing greater power of action on the yeast. Therefore, extracts from Apis melífera L. and Caryocar brasiliense showed anti C. albicans activity, while those from Morus alba L., Morinda citifolia L. and Annona muricata L. did not.
References
Aikawa, N. E., Rosa, D. T., Del Negro, G., Moraes, J. C., Ribeiro, A., Saad, C. G., ... & Bonfá, E. (2016). Infecção sistêmica e localizada por Candida spp. em pacientes reumatológicos em terapia anti-TNF. Revista brasileira de reumatologia, 56, 478-482.
Barani, K., Manipal, S., Prabu, D., Ahmed, A., Adusumilli, P., & Jeevika, C. (2014). Anti-fungal activity of Morinda citrifolia (noni) extracts against Candida albicans: An in vitro study. Indian Journal of Dental Research, 25(2), 188.
Cesar, K. K. F. A., Batista, A. K. R., Paula, L. R., da Silva, R. T., & da Silva, F. L. (2021). Ação antifúngica de extratos e frações de Annona muricata L. sobre Candida spp. Research, Society and Development, 10(5), e28010514938-e28010514938.
de Cabral Sobreira, A. L., de Araújo Silva, M. M., Okamura, L. S., de Souza, J. B. P., & Carmo, E. S. (2020). Atividade antifúngica do extrato etanólico de própolis vermelha contra isolados patogênicos de Candida spp. Revista Verde de Agroecologia e Desenvolvimento Sustentável, 15(4), 429-433.
Barbosa, A. F., Costa, I. C. D. M., Langassner, S. Z., & Giordani, R. B. (2017). Morinda citrifolia: fatos e riscos sobre o uso do noni.
de Carvalho, L. S., Pereira, K. F., & de Araújo, E. G. (2015). Características botânicas, efeitos terapêuticos e princípios ativos presentes no pequi (Caryocar brasiliense). Arquivos de Ciências da Saúde da UNIPAR, 19(2).
de Melo, I. A., & Guerra, R. C. (2014). Candidíase oral: um enfoque sobre a estomatite por prótese. Salusvita, 33(3), 389-414.
de Oliveira, F. C. E., Silva, L. B. P., Abranches, M. V., & Ferreira, A. A. (2018). Efeitos terapêuticos e adversos do noni (morinda citrifolia l.) Na saúde. Revista Saúde & Ciência Online, 7(3), 107-122.
Diniz, D. M. (2015). Atividade anti-inflamatória de microemulsão contendo óleo de pequi (Caryocar coriaceum W.). 2015. 37f. Trabalho de Conclusão de Curso (Graduação em Farmácia)-Universidade Estadual da Paraíba, Campina Grande.
Fernandes Júnior, A., Lopes, M. M. R., Colombari, V., Monteiro, A. C. M., & Vieira, E. P. (2006). Atividade antimicrobiana de própolis de Apis mellifera obtidas em três regiões do Brasil. Ciência Rural, 36, 294-297.
Glehn, E. A. V., & Rodrigues, G. P. S. (2012). Antifungigrama para comprovar o potencial de ação dos extratos vegetais hidroglicólicos sobre Candida sp.(Berkhout). Revista Brasileira de Plantas Medicinais, 14, 435-438.
Lee, J. H., Bae, S. Y., Oh, M., Kim, K. H., & Chung, M. S. (2014). Antiviral effects of mulberry (Morus alba) juice and its fractions on foodborne viral surrogates. Foodborne pathogens and disease, 11(3), 224-229.
Martins, N., Barros, L., Henriques, M., Silva, S., & Ferreira, I. C. (2015). In vivo anti-candida activity of phenolic extracts and compounds: Future perspectives focusing on effective clinical interventions. BioMed research international, 2015.
Moraes-Pinto, M. I. D., & Ferrarini, M. A. G. (2020). Infecções oportunistas em pediatria: quando suspeitar e como abordar. Jornal de Pediatria, 96, 47-57.
Seo, K. H., Lee, D. Y., Jeong, R. H., Lee, D. S., Kim, Y. E., Hong, E. K., ... & Baek, N. I. (2015). Neuroprotective effect of prenylated arylbenzofuran and flavonoids from Morus alba fruits on glutamate-induced oxidative injury in HT22 hippocampal cells. Journal of Medicinal Food, 18(4), 403-408.
Silva, G. C. D. (2015). Morinda Citrifolia L.–investigação científica das propriedades biológicas com base no uso popular (Master's thesis, Universidade Federal de Pernambuco).
Silva, E., DA, M., Rodrigues, L., & Silva Neto, C. D. M. (2017). Avaliação da capacidade inibitória de Caryocar brasiliense E Stryphnodendron adstringens sobre Candida albicans.
Vieira, A. J. H., & Santos, J. I. (2017). Mecanismos de resistência de Candida albicans aos antifúngicos anfotericina B, fluconazol e caspofungina. RBAC, 49(3), 235-9.
Vieira, F., & Nascimento, T. (2017). Candida antifungal resistance and therapeutic approach. Revista Portuguesa de Farmacoterapia, 9(3), 29-36.
Vieira, J. Candidíase-uma revisão de literatura.
Yimam, M., Lee, Y. C., Kim, T. W., Moore, B., Jiao, P., Hong, M., ... & Jia, Q. (2015). UP3005, a botanical composition containing two standardized extracts of Uncaria gambir and Morus alba, improves pain sensitivity and cartilage degradations in monosodium iodoacetate-induced rat OA disease model. Evidence-Based Complementary and Alternative Medicine, 2015.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Lara Vitória de Araújo Costa Pereira; Luciane Costa Silva; Marcela Coelho de Sá ; Mariana de Carvalho Moreira; Gabriel Lima Maia Soares do Nascimento; Thaís Café de Andrade; Vilma Marreiros dos Santos; Francisco Laurindo da Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
