Immunonutrition in cancer patients: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i2.2004

Keywords:

Neoplasms; Immunomodulation; Nutrition.

Abstract

Cancer is a denomination that covers more than 100 types of disease and its main feature is the accelerated growth of abnormal cells that affects the other tissues of the body. Its onset may come from several causes, which may act simultaneously or individually to initiate the process of carcinogenesis. The aim of this study is to demonstrate the benefits of immunomodulators in cancer patients. It is an integrative review with a qualitative approach. To perform this research, a bibliographic survey was made to select studies in the online databases: Virtual Health Library (VHL), Pubmed, Science direct. Regarding the results, the selected studies involved the participation of 15 to 776 patients. Most of these studies were performed using enteral immunonutrition. Participant ages ranged from 18 to 75 years. Studies have shown that immunonutrition had a significant effect on patients with cancer, as it had a positive impact on reducing postoperative complications such as infectious and inflammatory processes, increased serum albumin, reduced length of hospital stay and immune system improvement. The results showed that the immunomodulatory diets were effective in the pre and postoperative period, reducing the possible complications, becoming a safe alternative to optimize the results after the surgical procedures. The articles underscored the importance of knowing when to start nutritional support with supplementation before surgery, as this contributes to good results after treatment.

References

Azevedo, D. C., & Bosco, S. M. D. (2011). Perfil nutricional, dietético e qualidade de vida de pacientes em tratamento quimioterápico. Conscientia e Saúde, 10(1), 23 -30.

Barbosa, L. B G., Fortes, R. C., & Toscano, B. A. F. (2013). Efeitos da imunonutrição em pacientes com câncer do trato gastrintestinal: um ensaio clínico randomizado cego e controlado. Rev Bras Nutr Clin, 28(3), 171-178.

Caglayan, K., Oner, I., Gunerhan, Y., Ata, P., Koksal, N., & Ozkara, S. (2012). The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal cancer patients. Instabul Turkey, 204(4), 416-421.

Carvalho, M.D., Moura, L., Prado, R.R., Escalante, J.C., Schmidt M.I., & Duncan B.B. (2014). Mortalidade por doenças crônicas não transmissíveis no Brasil e suas regiões, 2000 a 2011. Rev. Epidemiologia Serv.Saúde, 23(2), 599-608.

Feoli, A.M.P. (2010). Imunonutrição: um novo papel para os nutrientes. Rev. Ciência e saúde, 3(2), 34.

Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., & Mathers, C. (2013). Estimated cancer incidence and mortality worldwide in 2012. Lyon, France 1(11).

Ferraz, L. F., & Campos A. C. F. (2012). Nutrição imunomoduladora pré-operatória em pacientes com cancer gástrico. Nutrición clínica y dietética hospitalaria, 32(3), 43-46.

Fortes R. C., & Waitzberg, D.L. (2011). Efeitos da imunonutrição enteral em pacientes oncológicos submetidos à cirurgia do trato gastrintestinal. Rev. Bras Nutr Clin., 26(4), 255-263.

Gil, A. C. (2008). Como elaborar projetos de pesquisa. 4. ed. São Paulo: Atlas.

Gómez-Candela, C., Sanz, M.V., Horrisberger A., Loria Kohen, V., Bermejo, L.M., & Auñon P.Z. Evaluación de la eficacia de un suplemento oral en polvo enriquecido con ácido eicosapentaenoico en un grupo de pacientes con câncer. Nutr Hosp., 26(6), 85-94.

Guimarães, A. G. C., & Anjos, A. C. Y. (2012). Caracterização Sociodemográfica e Avaliação da Qualidade de Vida em Mulheres com Câncer de Mama em Tratamento Quimioterápico Adjuvante. Revista Brasileira de Cancerologia, 58(4), 581-592.

Hipólito K.P.P., & Ribeiro K.A.R.A. (2014). Importância da Nutrição na Prevenção e no Tratamento de Neoplasias. Rev. Interciência & Sociedade. 3(2), 51-59.

Horie, H., Okada, M., Kojima, M., & Nagai, H. (2006). Favorable effects of preoperative enteral immunonutrition on a surgical site infection in patientes with colorectal cancer without mal nutrition. Surgery Today, 36(12), 1063-8.

Huwe, F.G., Anton, L.M., Eisenhardt, M.F., Foletto, E., Jackisch, S., Severo, B., . . . Possuelo, L. G. (2014). Avaliação das características clínicas e epidemiológicas e sobrevida global de pacientes portadores de câncer colorretal. Rev. Epidemiol Controle Infecç. 3(4), 112-126.

Instituto Nacional de Câncer (INCA). (2014). Incidência de câncer no Brasil. Coordenação de prevenção e vigilância. Rio de Janeiro.

Kamocki, Z.K., Karna, M., Szynaka, B., Kedra, B., & Kemona, H. (2013). Effects of perioperative immunostimulating nutritional therapy on the phagocytic activity of blood platelets in patients with various clinical stages of gastric cancer. Poland, 58(2), 244-250.

Klek, S., Szybinski, P., & Szczepanek, Kinga. (2014). Perioperative Immunonutrition in Surgical Cancer Patients: A Summary of a Decade of Research. Rev. world journal of surgery. Poland, 38(4), 803-812.

Marano, L., Porfidia, R., Pezzella, M., Grassia, M., Petrillo, M., Esposito, G., . . . Di Martino, N. (2013). Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study. Naples, Italy. Ann Surg Oncol., 20(12), 3912-8.

Martin, R.C.G., Agle, S., Schlegel, M., Hayat, M.T., Scoggins, C.R., Masters, K.M., & Philips, P. (2017), Efficacy of preoperative immunonutrition in locally advanced pancreatic cancer undergoing irreversible electroporation (IRE). Eur. J. Surg Oncol., 43(4), 772-779.

Nakamura, M., Iwahashi, M., Takifuji, K., Nakamori, M., Naka, T., Ishida, K., . . . Yamaue, H. (2009). Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. Surg. Today, 39, 855-860.

Okamoto, Y., Okano, K., Izuishi, K., Usuki, H., Wakabayashi, H., & Suzuki, Y. (2009). Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg., 33(9), 115-121.

Patrício, R.S.G. (2010). Desenvolvimento de material educativo digital para divulgação científica da nutrigenômica (Pós-graduação). Universidade de São Paulo, São Paulo.

Pompeo, D.A., Rossi, L. A., & Galvão, C.M. (2009). Revisão integrativa: etapa inicial do processo de validação de diagnóstico de enfermagem. Acta paul. Enferm, 22(4), 434-438.

Read, J. A., Beale, P. J., Volker, D. H., Smith, N., Childs, N., & Clarke, S. J. (2007). Nutrition intervention using an eicosapntaenoic acid (EPA) – containing supplement in patients with advanced colorectal cancer, Effects on nutritional and inflammatory status: a phase II trial. Support Care Cancer, 15(3), 301-307.

Sunpaweravong, S., Puttisak, P., Ruangsin, S., Laohawiriyakamol S., Sangthawan D., Pradutkanchana, J., Geater, A. (2014). Randomized Study of Antiinflammatory and ImmuneModulatory Effects of Enteral Immunonutrition During Concurrent Chemoradiotherapy for Esophageal Cancer. Nutr, Cancer, 66(1), 1-5.

Uscátegui, H.C. (2010). Inmunonutrición: enfoque en el paciente quirúrgico. Rev Chil Cir. 62(1), 80-92.

Yildiz, S.Y., Yazicioğlu, M.B., Tiryaki, C., Çiftçi, A.; Boyacioğlu, Z.; Özyildiz, M., . . . Subaşi, O. (2016). The effect of enteral immunonutrition in upper gastrointestinal surgery for cancer: a prospective study. Rev. Turkish Journal of Medical Sciences, 46, 393-400.

Downloads

Published

01/01/2020

How to Cite

SOUSA, F. das C. A.; SILVA, M. F. da; SILVA, W. C. da; ANDRADE, E. W. O. F.; SILVA, F. D. R. da; SANTOS, M. J. S. dos; SOUSA, K. A. A. de; BEZERRA, A. K. F.; MAGALHÁES, J. M.; ALBUQUERQUE, K. R. de. Immunonutrition in cancer patients: integrative review. Research, Society and Development, [S. l.], v. 9, n. 2, p. e100922004, 2020. DOI: 10.33448/rsd-v9i2.2004. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/2004. Acesso em: 22 nov. 2024.

Issue

Vol. 9 No. 2

Section

Review Article

License

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.