Ozone therapy as adjuvant treatment in patients with COVID-19
DOI:
https://doi.org/10.33448/rsd-v10i14.21662Keywords:
Ozone; Coronavirus; Prevention; Treatment.Abstract
The new SARS-CoV-2 coronavirus was officially reported in December 2019 in China. Transmission of the virus is by direct and indirect contact, and there are reports of symptomatic and asymptomatic people. It covers serological test, rapid test, testing of blood and respiratory samples as diagnosis. The recommended preventive measures include hand washing, use of alcohol, use of masks, cleaning of surfaces, isolation for positive or exposed people, and the search for complementary measures, such as the use of ozone therapy. Ozone O3 is composed of three oxygen atoms, and is a viable ally as an adjuvant for the treatment of COVID-19, because it has an oxidizing active that decreases the possible complications due to lung inflammation. It has been shown to be beneficial as a disinfectant and sterilizer for medical instruments and environments. This work aims to show the benefits of ozone, and its efficacy as an aid in the treatment of coronavirus. A review of narrative literature on the subject was carried out, using as reference bases articles available in online platforms such as Pubmed and Scielo, in English and Portuguese (Brazil), where the use of the most current articles was prioritized. Ozone therapy in combination with other antiviral drugs may be effective and useful in patients with COVID-19. However, it is evident that studies to clarify the utilities of ozone are still needed in order to improve the proposals for protocol and effective therapeutic applications in the treatment of COVID-19.
References
Hernández, A., Viñals, M., Isidoro, T., & Vilás, F. (2020). Potential Role of Oxygen-Ozone Therapy in Treatment of COVID-19 Pneumonia. The American journal of case reports, 21, e925849.
Ranaldi, G. T., Villani, E. R., & Franza, L. (2020). Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review. Medical gas research, 10(3), 134–138.
Porsse, A. A., Souza, K. B., Carvalho, T. S., Vale. V. A. (2020). Impactos Econômicos da COVID-19 no Brasil. Nedur. (1)4-21.
Oganização Mundial da Saúde. (2021). Weekly operational update on COVID-19 - 16 August 2021.
Souto M. Covid-19: aspectos gerais e implicações globais. (2020). Revista de Educação, Ciência e Tecnologia de Almenara/MG. 2(1)13-25.
Bocci, V., Zanardia, I., Valacchi, G., Borrelli, E., & Travagli, V. (2015). Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases. Cardiovascular & hematological disorders drug targets, 15(2), 127–138.
Valdenassi, L., Franzini, M., Ricevuti, G., Rinaldi, L., Galoforo, A. C., & Tirelli, U. (2020). Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. European review for medical and pharmacological sciences, 24(8), 4059–4061.
Smith, N. L., Wilson, A. L., Gandhi, J., Vatsia, S., & Khan, S. A. (2017). Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Medical gas research, 7(3), 212–219.
Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa.Porto Alegre: Artes Médicas.
Velavan, T. P., & Meyer, C. G. (2020). The COVID-19 epidemic. Tropical medicine & international health : TM & IH, 25(3), 278–280.
Mohamadian, M., Chiti, H., Shoghli, A., Biglari, S., Parsamanesh, N., & Esmaeilzadeh, A. (2021). COVID-19: Virology, biology and novel laboratory diagnosis. The journal of gene medicine, 23(2), e3303.
Wölfel, R., Corman, V. M., Guggemos, W., Seilmaier, M., Zange, S., Müller, M. A., Niemeyer, D., Jones, T. C., Vollmar, P., Rothe, C., Hoelscher, M., Bleicker, T., Brünink, S., Schneider, J., Ehmann, R., Zwirglmaier, K., Drosten, C., & Wendtner, C. (2020). Virological assessment of hospitalized patients with COVID-2019. Nature, 581(7809), 465–469.
Su, J. W., Wu, W. R., Lang, G. J., Zhao, H., & Sheng, J. F. (2020). Transmission risk of patients with COVID-19 meeting discharge criteria should be interpreted with caution. Journal of Zhejiang University. Science. B, 21(5), 408–410.
Cui, X., Zhao, Z., Zhang, T., Guo, W., Guo, W., Zheng, J., Zhang, J., Dong, C., Na, R., Zheng, L., Li, W., Liu, Z., Ma, J., Wang, J., He, S., Xu, Y., Si, P., Shen, Y., & Cai, C. (2021). A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19). Journal of medical virology, 93(2), 1057–1069.
Amanat, F., & Krammer, F. (2020). SARS-CoV-2 Vaccines: Status Report. Immunity, 52(4), 583–589.
Martins, A., Silva, J. T. da, Graciola, L., Fréz, A. R., Ruaro, J. A., & Marquetti, M. da G. K. (2012). Efeito bactericida do gerador de alta frequência na cultura de Staphylococcus aureus. Fisioterapia E Pesquisa, 19(2), 153-157.
Tylicki, L., & Rutkowski, B. (2004). Ozone therapy seems to be safe, but is it really clinically effective?. The International journal of artificial organs, 27(8), 731–733.
Hernández, O.D., González, R. C. (2001). Ozonoterapia en úlceras flebostáticas. Rev. Cubana Cir. v.40, p.123-129.
Jyoti, P., Nagathan, V. M., Rao, S. M., Bheemappa, F. B. (2013) Ozone in Dental Therapy : An Outlook. International Journal of Clinical Dental Science. v. 4, n. 1, p. 4-8.
Ferreira, M. B. (2012). Efeito na reparação óssea periapical da ozonioterapia como coadjuvante ao tratamento endodôntico. Estudo clínico-radiográfico. Tese de Doutorado, Faculdade de Odontologia, Universidade de São Paulo, São Paulo.
Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of natural science, biology, and medicine, 2(1), 66–70.
Bocci, V., Zanardi, I., & Travagli, V. (2011). Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects. Medical gas research, 1(1), 6.
Di Mauro, R., Cantarella, G., Bernardini, R., Di Rosa, M., Barbagallo, I., Distefano, A., Longhitano, L., Vicario, N., Nicolosi, D., Lazzarino, G., Tibullo, D., Gulino, M. E., Spampinato, M., Avola, R., & Li Volti, G. (2019). The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases. International journal of molecular sciences, 20(3), 634.
Cattel, F., Giordano, S., Bertiond, C., Lupia, T., Corcione, S., Scaldaferri, M., Angelone, L., & De Rosa, F. G. (2021). Ozone therapy in COVID-19: A narrative review. Virus research, 291, 198207.
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Copyright (c) 2021 Paula Teles Rezende; Verônica Alves Pereira Melo; Cláudia Maria de Oliveira Andrade; Taís Alves dos Reis; Lia Dietrich
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