Bioactivities of spilanthes acmella: a review
DOI:
https://doi.org/10.33448/rsd-v10i14.22035Keywords:
Biological activities; Natural products; Spilanthes acmella.Abstract
The purpose of the work is to present a bibliographic review on biological activities in plants of the species Spilanthes acmella (L.). The research was carried out from September to November 2019 and consisted of a search of the SciFinder database, considering the articles published between January 1959 and August 2019 and using the keywords: Acmella oleracea, Spilanthes acmella, antioxidant, antipyretic and anti-inflammatory. Through this process resulted in 32 articles found endorsing the biological activities that are attributed to the species Spilanthes acmella (L.), such as insecticidal and anti-inflammatory activities. Many activities that are attributed to the plant Spilanthes acmella could be proven, as well as the biologically active substances and their mechanisms of action, in particular the insecticidal activity, which demonstrated great potential against several species of invertebrates.
References
Ahmed, S., Rahman, A., Muslim, T., Sohrab, M. H. (2012). Antimicrobial, cytotoxicity and phytochemical activities of spilanthes acmella, Bangladesh Journal of Scientific and Industrial Research, 47(4), 437-440.
Ansari, A. H.; Mukharya, D. K. & Saxena, V. K. (1988). Analgésic study of n-isobutyl-4,5-decadienamide isolated from the flowers of Spilanthes acmella (Murr.), Indian Journal of Pharmaceutical Sciences, 50(2), 106.
Arora, S., Vijay, S. & Kumar, D. (2011). Phytochemical and antimicrobial studies on the leaves of Spilanthes acmella, Journal of Chemical and Pharmaceutical Research, 3(5), 145-150.
Benelli, G., Pavela, R. & Drenaggi, E., Maggi, F. (2019). Insecticidal efficacy of the essential oil jambú (Acmella oleracea (L.) R.K. Jansen) cultivated in central Italy against filariasis mosquito vectors, houseflies and moth pests, Journal of Ethnopharmacology, 229, 272-279.
Bringel Jr, J. B. A. (2007). A tribo Heliantheae Cassini (Asteraceae) na bacia do rio Paranã (Go, TO), Dissertação, Universidade de Brasilia, Brasil.
Chakraborty, A. Devi, B. R. K., Sanjebam, R. & Khumbong, S., Thokchom, I. S. (2010). Preliminary studies on local anesthesic and antipyretic activities of Spilanthes acmella Murr. Indian journal of pharmacology, 42(5), 277-9.
Cho, Y. C., Tran, B., Kim, B. R. Voung, H. L. & Cho, S. (2017). Spilanthes acmella inhibits inflammatory responses via inhibition of NF-kB and MAPK signaling pathways in RAW 264.7 macrophages, Molecular Medicine Reports, 16(1), 339-346.
Cruz, P. B., Barbosa, A. F., Zeringóta, V., Melo, D. Novato, T. Fidelis, Q. C., Fabri, R. L., de Carvalho, M. G., Oliveira Sabaa-Srur, A. U., Daemon, E. & Monteiro, C. M. O. (2016). Acaricidal activity of metanol extract of Acmella oleracea L. (Asteraceae) and spilanthol on Rhipicephalus microplus (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodiae), Veterinary Parasitology, 228, 137-143.
Di Stasi, L. C. & Hiruma-Lima, C. A. (2002). Plantas medicinais na Amazônia e na Mata Atlântica. São Paulo, Brasil: Editora UNESP.
Franca, J. V.; Queiroz, M. S. R., do Amaral, B. P., Simas, N. K., da Silva, N. C. B. & Leal, I. C. R. (2016). Distinct growth and extractive methods of Acmella oleracea (L.) R. K. Jansen rising different concentrations of spilanthol: An important bioactive compound in human dietary, Food Research International, 89, 781-789.
Freitas-Blanco, V. S., Michalak, B., Zelioli, I. A. M., de Oliveira, A. S. S., Rodrigues, M. V. N., Ferreira, A. G., Garcia, V. L., Cabral, F. A., Kiss, A. K. & Rodrigues, R. A. F. (2018). Isolation of spilanthol from Acmella oleracea based on Green Chemistry and evaluation its in vitro anti-inflamatory activity, Journal of Supercritical Fluids, 140, 372-379.
Freitas-Blanco, V. S., Monteiro, K. M., de Oliveira, P. R., de Oliveira, E. C. S. Braga, L., de Carvalho, J. E. & Rodrigues, R. A. F. (2019). Spilanthol, the principal alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Planta Medica, 85(3), 203-209.
Gerbino, A., Giorgia S., Milano, S., Milella, L., Franco-Barbosa, A., Armentano, F., Procino, G., Svelto, M. & Carmosino, M. (2016). Spilanthol from Acmella Oleracea lowers the intracellular levels of camp impairing NKCC2 phosphorylation and water channel AQP2 membrane expression in mouse kidney, PLoS One, 11(5), e0156021/1-e0156021/22. Retirado de: https://doi.org/10.1371/journal.pone.0156021
Huang, W. C., Wu, L. Y., Hu, S. & Wu, S. J. (2018) Spilanthol Inhibits COX-2 and ICAM–1 Expression via Suppression of NF-kB and MAPK Signaling in Interleukin–1β-Stimulated Human Lung Epithelial Cells, Inflammation, 41(5), 1934–1944.
Judd, W. S., Campbell, C. S., Kellogg E. A., Stevens, P. F., Donoghue, M. J., Simões, A. O., Singer, R. J., Singer, R. F. & Chies, T. T. S. (2009). Sistemática vegetal: Um Enfoque Filogenético. Porto Alegre, Brasil: Artmed.
Kadir, H. A, Zakaria, M., Kechil, A. A. & Azirun, M. S. (1989). Toxicity and electrophysiological effects of Spilanthes acmella Murr. extracts on Periplaneta americana L, Pesticide Science, 25(4), 329-335.
Kavya, M. D. & Pattar, P. V. (2016). Antibacterial activity and phytochemical screening of Spilanthes acmella Murr. Against selected pathogenic microorganisms, International Journal of Pharma and Bio Sciences, 7(2), 310-314.
Kawaree, R. Okonogi, S., Chowwanapoompohn, S. & Phutdhawong, W. (2007). Chemical composition and antioxidant evaluation of volatile oils from Thai medicinal plants. Acta Horticulturae, 786, 209-215.
Leng, T. C., Ping, N. S., Lim, B. P. & Keng, C. L. (2011). Detection of bioactive compounds from Spilanthes acmella (L.) plantas and its various in vitro culture products. Journal of Medicinal Plant Research. 5(3).
Cruz, P., Barbosa, A. F., Franco, C., Novato, T. P. L., Sanches, M. N. G., de Carvalho, M. G., Fabri, R., Daemon, E. & Monteiro, C. M. O. (2018). Activity of the extract of Acmella oleracea on immature stages of Amblyomma sculptum (Acari: Ixodidae), Veterinary parasitology, 254, 147-150.
Mbeunkui, F., Grace, M. H., Lategan, C., Smith, P., Raskin, I. & Lila, M. A. (2011). Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 879(21), 1886-1892.
Medeiros-Neves, B., Teixeira, H. F. & von POSER, G. L. (2018). The genus Pterocaulon (Asteraceae) – A review on traditional medicinal uses, chemical constituents and biological properties. Journal of Ethnopharmacology, 224, 451–464.
Nabi, N. G. & Shrivastava, M. (2016). Estimation of total flavonoids and antioxidant activities of Spilanthes acmella leaves. UK journal of pharmaceutical and Biosciences, 4(6), 29-34.
Nascimento de Alcantara, B. N., Kobayashi, Y. T., Barroso, K. F., da Silva, I. D. R., de Almeida, M. B. & Barbosa, W. L. R. (2015). Pharmacognostic analyses and evaluation of the in vitro antimicrobial activity of Acmella oleracea (L.) RK Jansen (Jambu) floral extract and fractions, Journal of Medicinal Plants Research, 9(4), 91-96.
Oliver-Bever, B. (2008). Medicinal plants in tropical West Africa. Cambridge University Press.
Pacheco-Soares, C., Lemos, V. R., da Silva, A. G., Campoy, R. M., da Silva, C. A. P., Menegon, R. F., Rojahn. I. & Joaquim, W. M. (2014). Effect of Spilanthes acmella hydroetanolic extract activity on tumor cell actin cytoskeleton. Cell Biology International, 38(1), 131–135.
Prachayasittikul, S., Suphapong, S., Worachartcheewan, A., Lawung, R. Ruchirawat, S. & Prachayasittikul, V. (2009). Bioactive metabolites from Spilanthes acmella Murr., Molecules, 14(2), 850-867.
Ramsewak, R. S., Erickson, A. J. & Nair, M. G. (1999). Bioactive N-isobutylamides from the flower buds of Spilanthes acmella, Phytochemistry, 51(6), 729-732.
Ratnasooriya, W. D., Pieris, K. P. P., Samaratunga, U. & Jayakody, A. (2004). Diuretic activity of Spilanthes acmella flowers in rats. Journal of etnopharmacology, 91(2-3), 317-20.
Rondanelli, M., Fossari, F., Vecchio, V., Braschi, V., Riva, A., Allegrini, P., Petrangolini, G., Iannello, G., Faliva, M. A., Peroni, G., Nichetti, M., Gasparri, C., Spadaccini, D., Infantino, V., Mustafa, S., Alalwan, T. & Perna, S. (2020). Acmella oleracea for pain management, Fitoterapia, 140, 0367-326X.
Savitha, S.; Bijosh, J. & Sharath, C. H. (2015). Antimicrobial and antifúngico efficacy of Spilanthes acmella as an intracanal medicament in comparison to calcium hydroxide: An in vitro study, Indian Journal of dental research: official publication of Indian Society for Dental Research, 26(5), 528-32.
Saraf, D. K. & Dixit, V. K. (2002). Spilanthes acmella Murr.: study on its extract spilanthol as larvicidal compound, Asian Journal of Experimental Sciences, 16(1-2), 9-19.
Sharma, A., Kumar, V., Rattan, R., Kumar, N. & Singh, B. (2012). Insecticidal toxicity of spilanthol from Spilanthes acmella Murr. against Plutella xylostella L, American Journal of Plant Sciences, 3(11), 1568-1572.
Da Silva, M. P., Barbosa, F. S. Q. & de Barros, R. F. M. (2014). Estudo taxonômico e etnobotânico sobre a família Asteraceae (Dumortier) em uma comunidade rural no Nordeste do Brasil. Gaia Scientia, Volume Especial Populações Tradicionais, 110 – 123.
Spelman, K., Depoix, D., McCray, M., Mouray, E. & Grellier, P. 2011. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo antimalarial activity, Phytotherapy Research, 25(7), 1098-1101.
The Plant List. (2013). A working list of all plant species. Retirado em Março, 10, 2021, de http://www.theplantlist.org/
Veerashekhar, T., Kuppast, I. J. & Mankini, K. L. (2010). Study of anti-inflammatory activities of the plant Spilanthes acmella var; oleracea in rats, International Journal of Chemical Sciences, 8(4), 2708-2716.
Vitto, L. A. & Petenatti, E. (2009). Asteráceas de importância económica y ambiental: Primera parte. Sinopsis morfológica y taxonómica, importancia ecológica y plantas de interés industrial. Multequina, 18, 87-115.
Wongsawatkul, O., Prachayasittikul, S., Isarankura-Na-Ayudhya, C., Satayavivad, J., Ruchirawat, S. & Prachayasittikul, V. (2008). Vasorelaxant and antioxidant activities of Spilanthes acmella Murr. International Journal of Molecular Sciences, 9(12), 2724-2744.
Wu, L. C., Fan, N. C., Lin, M. H., Chu, I. R., Huang, S. J., Hu, C. Y. & Han, S. Y. (2008). Anti-inflammatory Effect of Spilanthol from Spilanthes acmella on Murine Macrophage by Down-Regulating LPS-Induced Inflammatory Mediators, Journal of Agricultural and Food Chemistry, 56(7), 2341-2349.
Yinusa, I., George, N. I., Shuaibu, U. O. & Ayo, R. G. (2014). Bioactivity of stigmasterol isolated from the aerial part of Spilanthes acmella (Murr.) on selected microorganism, International Journal of Current Microbiology and Applied Sciences, 3(2), 475-479.
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