Evaluación del efecto farmacológico del extracto etanólico de Stryphnodendron adstringens peel sobre el peristalismo intestinal en Mus musculus
DOI:
https://doi.org/10.33448/rsd-v9i2.2230Keywords:
Barbatimão-verdadeiro; Gastrointestinal tract; Antidiarrheal effect.Abstract
The objective of this work is to analyze the pharmacological activity of the ethanolic extract of the Barbatimão-verdadeiro in the intestinal peristalsis of mice (Mus Musculus). The study is characterized as a quantitative, exploratory and experimental research, in which two pharmacological tests were performed. The animals (n = 35) were treated with a dose of 500mg / kg Stryphnodendron adstringens ethanolic extract and intestinal motility was evaluated following the intestinal transit models (n = 15) and castor oil-induced diarrhea (n = 20). Statistical analysis with one-way ANOVA and Tukey test for significance analysis showed that the group treated with the plant showed significance in relation to the group treated with loperamide (p <0.05). In the induced diarrhea test, the extract showed significance (P = 0.0002) compared with the loperamide treated group and the control group. Therefore, Stryphnodendron adstringens ethanolic extract was effective in reducing intestinal motility.
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