Association of serum vitamin D3 levels and oral diseases - Systematic Review
DOI:
https://doi.org/10.33448/rsd-v10i15.23019Keywords:
Colecalciferol; Vitamin D3; Mouth diseases.Abstract
The active metabolite of vitamin D3, cholecalciferol, is a multifunctional hormone that acts in the regulation of calcium and phosphorus homeostasis and which, in addition, has shown promising results as an immunomodulator, an antitumor agent, among other functions. Therefore, this systematic review aims to review in the scientific literature how cholecalciferol acts as a hormonal modulator and what is its role in oral pathologies. A search was carried out in the PubMed (MEDLINE), Scopus, Embase, Google Scholar and The Cochrane Library databases, having as inclusion criteria studies which will use issues related to oral health associated with the use of cholecalciferol. We found several oral pathologies that are associated with cholecalciferol, and we verified its role in inflammation, chemoprevention and as an antitumor agent, we also revealed that low levels of this vitamin are associated with the appearance and/or predisposition of oral pathologies. We conclude that maintaining optimal serum cholecalciferol levels is very important for the preservation and maintenance of oral health as well as systemic health.
References
Abbassy, M. A., Watari, I., Bakry, A. S., Ono, T., & Hassan, A. H. (2016). Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth. International journal of oral science, 8(1), 39–44. https://doi.org/10.1038/ijos.2015.47
Abe, K., Ooshima, T., Lily, T. S., Yasufuku, Y., & Sobue, S. (1988). Structural deformities of deciduous teeth in patients with hypophosphatemic vitamin D-resistant rickets. Oral surgery, oral medicine, and oral pathology, 65(2), 191–198. https://doi.org/10.1016/0030-4220(88)90165-x
Abe, M., Akeno, N., Ohida, S., & Horiuchi, N. (1998). Inhibitory effects of 1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid on parathyroid hormone-related protein expression by oral cancer cells (HSC-3). The Journal of endocrinology, 156(2), 349–357. https://doi.org/10.1677/joe.0.1560349
Abe, K., Ooshima, T., Sobue, S., & Moriwaki, Y. (1989). The crystallinity of human deciduous teeth in hypophosphataemic vitamin D-resistant rickets. Archives of oral biology, 34(5), 365-372.
Aerden, T., Grisar, K., Nys, M., & Politis, C. (2018). Secondary hyperparathyroidism causing increased jaw bone density and mandibular pain: a case report. Oral surgery, oral medicine, oral pathology and oral radiology, 125(3), e37–e41. https://doi.org/10.1016/j.oooo.2017.11.020
Agha-Hosseini, F., Mirzaii-Dizgah, I., & Mirjalili, N. (2013). Unstimulated whole saliva 25-hydroxycholecalciferol in patients with xerostomia in menopausal women. Aging clinical and experimental research, 25(2), 147–151. https://doi.org/10.1007/s40520-013-0023-z
Anand, S., Rollakanti, K. R., Horst, R. L., Hasan, T., & Maytin, E. V. (2014). Combination of oral vitamin D3 with photodynamic therapy enhances tumor cell death in a murine model of cutaneous squamous cell carcinoma. Photochemistry and photobiology, 90(5), 1126–1135. https://doi.org/10.1111/php.12286
Andrukhov, O., Andrukhova, O., Hulan, U., Tang, Y., Bantleon, H. P., & Rausch-Fan, X. (2014). Both 25-hydroxyvitamin-D3 and 1,25-dihydroxyvitamin-D3 reduces inflammatory response in human periodontal ligament cells. PloS one, 9(2), e90301. https://doi.org/10.1371/journal.pone.0090301
Aral, K., Alkan, B. A., Saraymen, R., Yay, A., Şen, A., & Önder, G. Ö. (2015). Therapeutic effects of systemic vitamin k2 and vitamin d3 on gingival inflammation and alveolar bone in rats with experimentally induced periodontitis. Journal of periodontology, 86(5), 666–673. https://doi.org/10.1902/jop.2015.140467
Bahramian, A., Falsafi, P., Abbasi, T., Ghanizadeh, M., Abedini, M., Kavoosi, F., Kouhsoltani, M., Noorbakhsh, F., Dabbaghi Tabriz, F., Rajaeih, S., & Rezaei, F. (2018). Comparing Serum and Salivary Levels of Vitamin D in Patients with Recurrent Aphthous Stomatitis and Healthy Individuals. Journal of dentistry (Shiraz, Iran), 19(4), 295–300.
Baldini, C., Delle Sedie, A., Luciano, N., Pepe, P., Ferro, F., Talarico, R., Tani, C., & Mosca, M. (2014). Vitamin D in "early" primary Sjögren's syndrome: does it play a role in influencing disease phenotypes?. Rheumatology international, 34(8), 1159–1164. https://doi.org/10.1007/s00296-013-2872-3
Bashutski, J. D., Eber, R. M., Kinney, J. S., Benavides, E., Maitra, S., Braun, T. M., Giannobile, W. V., & McCauley, L. K. (2011). The impact of vitamin D status on periodontal surgery outcomes. Journal of dental research, 90(8), 1007–1012. https://doi.org/10.1177/0022034511407771
Beltes, C., & Zachou, E. (2012). Endodontic management in a patient with vitamin D-resistant Rickets. Journal of endodontics, 38(2), 255–258. https://doi.org/10.1016/j.joen.2011.10.025
Bender, I. B., & Naidorf, I. J. (1985). Dental observations in vitamin D-resistant rickets with special reference to periapical lesions. Journal of endodontics, 11(11), 514–520. https://doi.org/10.1016/S0099-2399(85)80225-9
Berdal, A., Balmain, N., Cuisinier-Gleizes, P., & Mathieu, H. (1987). Histology and microradiography of early post-natal molar tooth development in vitamin-D deficient rats. Archives of oral biology, 32(7), 493–498. https://doi.org/10.1016/s0003-9969(87)80010-9
Bi, C. S., Wang, J., Qu, H. L., Li, X., Tian, B. M., Ge, S., & Chen, F. M. (2019). Calcitriol suppresses lipopolysaccharide-induced alveolar bone damage in rats by regulating T helper cell subset polarization. Journal of periodontal research, 54(6), 612–623. https://doi.org/10.1111/jre.12661
Bothwell, K. D., Shaurova, T., Merzianu, M., Suresh, A., Kuriakose, M. A., Johnson, C. S., Hershberger, P. A., & Seshadri, M. (2015). Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer. Cancer prevention research (Philadelphia, Pa.), 8(9), 765–776. https://doi.org/10.1158/1940-6207.CAPR-14-0454
Chantarangsu, S., Sura, T., Mongkornkarn, S., Donsakul, K., & Torrungruang, K. (2016). Vitamin D receptor gene polymorphism and smoking in the risk of chronic periodontitis. Journal of periodontology, 87(11), 1343-1351.
Chaussain‐Miller, C., Sinding, C., Septier, D., Wolikow, M., Goldberg, M., & Garabedian, M. (2007). Dentin structure in familial hypophosphatemic rickets: benefits of vitamin D and phosphate treatment. Oral diseases, 13(5), 482-489.
Dalirsani, Z., Farajnia, S., Javadzadeh, Y., Mehdipour, M., & Koozegari, S. (2012). The effects of 5-fluorouracil alone and in combination with 13-cis retinoic acid and vitamin D3 on human oral squamous cell carcinoma lines. The journal of contemporary dental practice, 13(3), 345–350. https://doi.org/10.5005/jp-journals-10024-1149
Dawson, S. J., Murray, R. M., & Rischin, D. (2006). Hypocalcemia associated with bone metastases in a patient with salivary-gland carcinoma. Nature clinical practice. Oncology, 3(2), 104–107. https://doi.org/10.1038/ncponc0405
DeSantis, K. A., Robilotto, S. L., Matson, M., Kotb, N. M., Lapierre, C. M., Minhas, Z., Leder, A. A., Abdul, K., Facteau, E. M., & Welsh, J. (2020). VDR in salivary gland homeostasis and cancer. The Journal of steroid biochemistry and molecular biology, 199, 105600. https://doi.org/10.1016/j.jsbmb.2020.105600
Descroix, V., Kato, S., Lézot, F., & Berdal, A. (2010). Physiopathology of dental rickets in vitamin D receptor-ablated mice. Journal of dental research, 89(12), 1427–1432. https://doi.org/10.1177/0022034510379603
Do, J. E., Kwon, S. Y., Park, S., & Lee, E. S. (2008). Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford, England), 47(6), 840–848. https://doi.org/10.1093/rheumatology/ken109
Du, J., Li, R., Yu, F., Yang, F., Wang, J., Chen, Q., Wang, X., Zhao, B., & Zhang, F. (2017). Experimental study on 1,25(OH)2 D3 amelioration of oral lichen planus through regulating NF-κB signaling pathway. Oral diseases, 23(6), 770–778. https://doi.org/10.1111/odi.12659
Dudding, T., Johansson, M., Thomas, S. J., Brennan, P., Martin, R. M., & Timpson, N. J. (2018). Assessing the causal association between 25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization. International journal of cancer, 143(5), 1029–1036. https://doi.org/10.1002/ijc.31377
Fanidi, A., Muller, D. C., Midttun, Ø., Ueland, P. M., Vollset, S. E., Relton, C., Vineis, P., Weiderpass, E., Skeie, G., Brustad, M., Palli, D., Tumino, R., Grioni, S., Sacerdote, C., Bueno-de-Mesquita, H. B., Peeters, P. H., Boutron-Ruault, M. C., Kvaskoff, M., Cadeau, C., Huerta, J. M., Johansson, M. (2016). Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Scientific reports, 6, 36017. https://doi.org/10.1038/srep36017
Femiano, F., Gombos, F., Scully, C., Battista, C., Belnome, G., & Esposito, V. (2001). Oral leukoplakia: open trial of topical therapy with calcipotriol compared with tretinoin. International journal of oral and maxillofacial surgery, 30(5), 402–406. https://doi.org/10.1054/ijom.2001.0107
Ferguson, H. W., & Hartles, R. L. (1964). The effect of vitamin D on the dentine of the incisor teeth and on the alveolar bone of young rats maintained on diets deficient in calcium or phosphorus. Archives of oral biology, 9(4), 447-IN19.
Fink M. (2011). Vitamin D deficiency is a cofactor of chemotherapy-induced mucocutaneous toxicity and dysgeusia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(4), e81–e82. https://doi.org/10.1200/JCO.2010.31.5317
Fügl, A., Gruber, R., Agis, H., Lzicar, H., Keibl, C., Schwarze, U. Y., & Dvorak, G. (2015). Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats. Journal of clinical periodontology, 42(1), 96–103. https://doi.org/10.1111/jcpe.12342
Gao, W., Tang, H., Wang, D., Zhou, X., Song, Y., & Wang, Z. (2020). Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial. Journal of periodontal research, 55(3), 354–362. https://doi.org/10.1111/jre.12719
Ge, X., Wang, L., Li, M., Xu, N., Yu, F., Yang, F., Li, R., Zhang, F., Zhao, B., & Du, J. (2019). Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway. Cell communication and signaling : CCS, 17(1), 18. https://doi.org/10.1186/s12964-019-0331-9
Gedlicka, C., Hager, G., Weissenböck, M., Gedlicka, W., Knerer, B., Kornfehl, J., & Formanek, M. (2006). 1,25(OH)2Vitamin D3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck. Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 35(8), 472–478. https://doi.org/10.1111/j.1600-0714.2006.00407.x
Gümüş, P., Öztürk, V. Ö., Bozkurt, E., & Emingil, G. (2016). Evaluation of the gingival inflammation in pregnancy and postpartum via 25-hydroxy-vitamin D3, prostaglandin E2 and TNF-α levels in saliva. Archives of oral biology, 63, 1–6. https://doi.org/10.1016/j.archoralbio.2015.11.018
Hamidieh, A. A., Sherafatmand, M., Mansouri, A., Hadjibabaie, M., Ashouri, A., Jahangard-Rafsanjani, Z., Gholami, K., Javadi, M. R., Ghavamzadeh, A., & Radfar, M. (2016). Calcitriol for Oral Mucositis Prevention in Patients With Fanconi Anemia Undergoing Hematopoietic SCT: A Double-Blind, Randomized, Placebo-Controlled Trial. American journal of therapeutics, 23(6), e1700–e1708. https://doi.org/10.1097/MJT.0000000000000269
Han, J., Cheng, C., Zhu, Z., Lin, M., Zhang, D. X., Wang, Z. M., & Wang, S. (2019). Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. Journal of oral science, 61(1), 53–60. https://doi.org/10.2334/josnusd.17-0357
Hartles, R. L., & Shapiro, I. M. (1966). Changes in the rat incisor teeth in response to dietary deficiencies of calcium or phosphorus in the presence and absence of added vitamin D. Archives of oral biology, 11(1), 21-29.
Hiremath, V. P., Rao, C. B., Naik, V., & Prasad, K. V. (2013). Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral health & preventive dentistry, 11(1), 61–69. https://doi.org/10.3290/j.ohpd.a29377
Hokugo, A., Christensen, R., Chung, E. M., Sung, E. C., Felsenfeld, A. L., Sayre, J. W., Garrett, N., Adams, J. S., & Nishimura, I. (2010). Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 25(6), 1337–1349. https://doi.org/10.1002/jbmr.23
Hosokawa, Y., Hosokawa, I., Shindo, S., Ozaki, K., & Matsuo, T. (2015). Calcitriol Suppressed Inflammatory Reactions in IL-1β-Stimulated Human Periodontal Ligament Cells. Inflammation, 38(6), 2252–2258. https://doi.org/10.1007/s10753-015-0209-y
Huang, Z., Zhang, Y., Li, H., Zhou, Y., Zhang, Q., Chen, R., Jin, T., Hu, K., Li, S., Wang, Y., Chen, W., & Huang, Z. (2019). Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3. Cell death & disease, 10(12), 936. https://doi.org/10.1038/s41419-019-2177-x
Jabbar, S., Drury, J., Fordham, J., Datta, H. K., Francis, R. M., & Tuck, S. P. (2011). Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis. Journal of periodontal research, 46(1), 97–104. https://doi.org/10.1111/j.1600-0765.2010.01317.x
Jagur, O., Kull, M., Leibur, E., Kallikorm, R., Loorits, D., Lember, M., & Voog-Oras, U. (2011). Relationship between radiographic changes in the temporomandibular joint and bone mineral density: a population based study. Stomatologija, 13(2), 42–48.
Ketharanathan, V., Torgersen, G. R., Petrovski, B. É., & Preus, H. R. (2019). Radiographic alveolar bone level and levels of serum 25-OH-Vitamin D3 in ethnic Norwegian and Tamil periodontitis patients and their periodontally healthy controls. BMC oral health, 19(1), 83. https://doi.org/10.1186/s12903-019-0769-6
Kilinç, A., Tepecik, T., Dayi, E., & Gündoğdu, B. (2017). Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency. The Journal of craniofacial surgery, 28(1), 296–297. https://doi.org/10.1097/SCS.0000000000003256
Krall, E. A., Wehler, C., Garcia, R. I., Harris, S. S., & Dawson-Hughes, B. (2001). Calcium and vitamin D supplements reduce tooth loss in the elderly. The American journal of medicine, 111(6), 452-456.
Kribbs P. J. (1992). Two-year changes in mandibular bone mass in an osteoporotic population. The Journal of prosthetic dentistry, 67(5), 653–655. https://doi.org/10.1016/0022-3913(92)90164-6
Kühnisch, J., Thiering, E., Kratzsch, J., Heinrich-Weltzien, R., Hickel, R., Heinrich, J., GINIplus study group, & LISAplus study group (2015). Elevated serum 25(OH)-vitamin D levels are negatively correlated with molar-incisor hypomineralization. Journal of dental research, 94(2), 381–387. https://doi.org/10.1177/0022034514561657
Li, H., Wang, Q., Xiao, Y., Bao, C., & Li, W. (2013). 25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models. AAPS PharmSciTech, 14(2), 880–889. https://doi.org/10.1208/s12249-013-9978-5
Li, H., Xie, H., Fu, M., Li, W., Guo, B., Ding, Y., & Wang, Q. (2013). 25-hydroxyvitamin D3 ameliorates periodontitis by modulating the expression of inflammation-associated factors in diabetic mice. Steroids, 78(2), 115–120. https://doi.org/10.1016/j.steroids.2012.10.015
Li, H., Li, B., Wang, Q., Xiao, Y., Chen, X. M., & Li, W. (2014). Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded polylactic acid microspheres in treatment of periodontitis in diabetic rats. The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 17(2), 91–98.
Li, H., Zhong, X., Li, W., & Wang, Q. (2019). Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model. Journal of applied oral science: revista FOB, 27, e20180713. https://doi.org/10.1590/1678-7757-2018-0713
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., ... & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology, 62(10), e1-e34.
Liu, K., Meng, H., Tang, X., Xu, L., Zhang, L., Chen, Z., & Lu, R. (2009). Elevated plasma calcifediol is associated with aggressive periodontitis. Journal of periodontology, 80(7), 1114-1120.
Liu, K., Meng, H., Lu, R., Xu, L., Zhang, L., Chen, Z., Shi, D., Feng, X., & Tang, X. (2010). Initial periodontal therapy reduced systemic and local 25-hydroxy vitamin D(3) and interleukin-1beta in patients with aggressive periodontitis. Journal of periodontology, 81(2), 260–266. https://doi.org/10.1902/jop.2009.090355
Maher, R., Aga, P., Johnson, N. W., Sankaranarayanan, R., & Warnakulasuriya, S. (1997). Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan. Nutrition and cancer, 27(1), 41–47. https://doi.org/10.1080/01635589709514499
Małodobra-Mazur, M., Paduch, A., Lebioda, A., Konopacka, M., Rogoliński, J., Szymczyk, C., & Dobosz, T. (2012). VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma. Acta Biochimica Polonica, 59(4).
Menzel, L. P., Ruddick, W., Chowdhury, M. H., Brice, D. C., Clance, R., Porcelli, E., Ryan, L. K., Lee, J., Yilmaz, Ö., Kirkwood, K. L., McMahon, L., Tran, A., & Diamond, G. (2019). Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss. Journal of periodontal research, 54(4), 444–452. https://doi.org/10.1111/jre.12646
Montava, M., Garcia, S., Mancini, J., Jammes, Y., Courageot, J., Lavieille, J. P., & Feron, F. (2015). Vitamin D3 potentiates myelination and recovery after facial nerve injury. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 272(10), 2815–2823. https://doi.org/10.1007/s00405-014-3305-y
Morr Verenzuela, C. S., Davis, M., Bruce, A. J., & Torgerson, R. R. (2017). Burning mouth syndrome: results of screening tests for vitamin and mineral deficiencies, thyroid hormone, and glucose levels-experience at Mayo Clinic over a decade. International journal of dermatology, 56(9), 952–956. https://doi.org/10.1111/ijd.13634
Müller, K., Oxholm, P., Sørensen, O. H., Thymann, M., Høier-Madsen, M., & Bendtzen, K. (1990). Abnormal vitamin D3 metabolism in patients with primary Sjögren's syndrome. Annals of the rheumatic diseases, 49(9), 682–684. https://doi.org/10.1136/ard.49.9.682
Murayama, T., Iwatsubo, R., Akiyama, S., Amano, A., & Morisaki, I. (2000). Familial hypophosphatemic vitamin D-resistant rickets: dental findings and histologic study of teeth. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 90(3), 310-316.
Nasreen, S., Ramesh, D., Thriveni, R., Bayatnal, A., Chowdhury, R. M., Kattimani, S., & Saba, R. (2019). Assessment of alveolar bone mass using radio morphometric indices in urban and rural postmenopausal women and their correlation with serum vitamin D3 level. Indian journal of dental research : official publication of Indian Society for Dental Research, 30(5), 722–730. https://doi.org/10.4103/ijdr.IJDR_369_18
Nakashyan, V., Tipton, D. A., Karydis, A., Livada, R., & Stein, S. H. (2017). Effect of 1,25(OH)2 D3 and 20(OH)D3 on interleukin-1β-stimulated interleukin-6 and -8 production by human gingival fibroblasts. Journal of periodontal research, 52(5), 832–841. https://doi.org/10.1111/jre.12452
Penoni, D. C., Torres, S. R., Farias, M. L., Fernandes, T. M., Luiz, R. R., & Leão, A. T. (2016). Association of osteoporosis and bone medication with the periodontal condition in elderly women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 27(5), 1887–1896. https://doi.org/10.1007/s00198-015-3437-y
Qin, X., Shao, L., Zhang, L., Ma, L., & Xiong, S. (2019). Investigation of Interaction between Vitamin D Receptor Gene Polymorphisms and Environmental Factors in Early Childhood Caries in Chinese Children. BioMed research international, 2019, 4315839. https://doi.org/10.1155/2019/4315839
Rosli, S. N., Shintani, T., Toratani, S., Usui, E., & Okamoto, T. (2014). 1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1. In vitro cellular & developmental biology. Animal, 50(9), 802–806. https://doi.org/10.1007/s11626-014-9787-5
Schroth, R. J., Rabbani, R., Loewen, G., & Moffatt, M. E. (2016). Vitamin D and dental caries in children. Journal of dental research, 95(2), 173-179.
Shintani, T., Rosli, S., Takatsu, F., Choon, Y. F., Hayashido, Y., Toratani, S., Usui, E., & Okamoto, T. (2016). Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas. The Journal of steroid biochemistry and molecular biology, 164, 79–84. https://doi.org/10.1016/j.jsbmb.2015.09.043
Shintani, T., Takatsu, F., Rosli, S., Usui, E., Hamada, A., Sumi, K., Hayashido, Y., Toratani, S., & Okamoto, T. (2017). Eldecalcitol (ED-71), an analog of 1α,25(OH)2D3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2. In vitro cellular & developmental biology. Animal, 53(9), 810–817. https://doi.org/10.1007/s11626-017-0183-9
Spolidorio, L. C., Herrera, B. S., Coimbra, L. S., Spolidorio, D. M., Muscará, M. N., & Rossa, C., Jr (2010). Intermittent therapy with 1,25 vitamin D and calcitonin prevents cyclosporin-induced alveolar bone loss in rats. Calcified tissue international, 87(3), 236–245. https://doi.org/10.1007/s00223-010-9380-1
Sundaram, K., Sambandam, Y., Tsuruga, E., Wagner, C. L., & Reddy, S. V. (2014). 1α,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells. Hormones & cancer, 5(2), 90–97. https://doi.org/10.1007/s12672-014-0170-5
Suresh, K. V., Nilesh, K., Mounesh Kumar, C. D., Patil, M. R., & Pramod, R. C. (2014). Brown tumour of posterior maxilla associated with polydactyly, syndactyly and cardiac anomalies: a unique case report. Journal of clinical and diagnostic research: JCDR, 8(8), ZD31.
Thakur M. (2019). Familial Vitamin D-dependent rickets Type 2A: A report of two cases with alopecia and oral manifestations. Journal of oral and maxillofacial pathology : JOMFP, 23(Suppl 1), 130–133. https://doi.org/10.4103/jomfp.JOMFP_309_18
Torrungruang, K., Chantarangsu, S., Sura, T., & Thienpramuk, L. (2020). Interplay between vitamin D receptor FokI polymorphism and smoking influences Porphyromonas gingivalis proportions in subgingival plaque. Journal of clinical periodontology, 47(8), 912–920. https://doi.org/10.1111/jcpe.13307
Vincent-Chong, V. K., DeJong, H., Attwood, K., Hershberger, P. A., & Seshadri, M. (2019). Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis. Neoplasia (New York, N.Y.), 21(4), 376–388. https://doi.org/10.1016/j.neo.2019.02.002
Wang, Q., Zhang, W., Li, H., Aprecio, R., Wu, W., Lin, Y., & Li, Y. (2013). Effects of 25-hydroxyvitamin D3 on cathelicidin production and antibacterial function of human oral keratinocytes. Cellular immunology, 283(1-2), 45–50. https://doi.org/10.1016/j.cellimm.2013.06.007
Wang, Q., Zhou, X., Jiang, J., Zhang, P., Xia, S., Ding, Y., & Wang, Q. (2019). Relationship between serum 25-hydroxyvitamin D3 levels and severity of chronic periodontitis in type 2 diabetic patients: A cross-sectional study. Journal of periodontal research, 54(6), 671–680. https://doi.org/10.1111/jre.12669
Xiao, T. T., Li, X., Feng, J. L., & Li, Y. (2018). Combined effects of aspirin and vitamin D3 on two OSCC cell lines: a preliminary study. Biotechnology letters, 40(3), 551–559. https://doi.org/10.1007/s10529-018-2508-5
Yang, S. W., Tsai, C. Y., Pan, Y. C., Yeh, C. N., Pang, J. H., Takano, M., Kittaka, A., Juang, H. H., Chen, T. C., & Chiang, K. C. (2016). MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells. Drug design, development and therapy, 10, 1995–2002. https://doi.org/10.2147/DDDT.S107256
Yanık, S., Aras, M. H., Erkılıç, S., Bozdağ, Z., Demir, T., & Çetiner, S. (2016). Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation. Archives of oral biology, 65, 59–65. https://doi.org/10.1016/j.archoralbio.2015.10.010
Yuan, F. N., Valiyaparambil, J., Woods, M. C., Tran, H., Pant, R., Adams, J. S., & Mallya, S. M. (2014). Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. International journal of oncology, 44(5), 1625–1633. https://doi.org/10.3892/ijo.2014.2338
Zhang, P., Zhang, W., Zhang, D., Wang, M., Aprecio, R., Ji, N., Mohamed, O., Li, Y., Ding, Y., & Wang, Q. (2018). 25-Hydroxyvitamin D3 -enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus. Journal of periodontal research, 53(3), 467–477. https://doi.org/10.1111/jre.12535
Zhang, X., Meng, H., Sun, X., Xu, L., Zhang, L., Shi, D., Feng, X., Lu, R., & Chen, Z. (2013). Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis. Journal of periodontal research, 48(1), 74–79. https://doi.org/10.1111/j.1600-0765.2012.01505.x
Zhao, B., Xu, N., Li, R., Yu, F., Zhang, F., Yang, F., Ge, X., Li, Y. C., & Du, J. (2019). Vitamin D/VDR signaling suppresses microRNA-802-induced apoptosis of keratinocytes in oral lichen planus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1042–1050. https://doi.org/10.1096/fj.201801020RRR
Zhou, X., Zhang, P., Wang, Q., Xia, S., Ji, N., Ding, Y., & Wang, Q. (2018). 25-Hydroxyvitamin D3 Alleviates Experimental Periodontitis via Promoting Expression of Cathelicidin in Mice with Type 2 Diabetic Mellitus. Journal of nutritional science and vitaminology, 64(5), 307–315. https://doi.org/10.3177/jnsv.64.307
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Stephane Silva Santana; Ivânia Aparecida Pimenta Santos Silva; Gustavo Augusto Santos; Adriano Luís Pulquério de Almeida; Rodrigo Soares de Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
