Renal replacement therapy in patients affected by Covid-19 in an Intensive Care Unit in the countryside of Rondônia

Authors

DOI:

https://doi.org/10.33448/rsd-v10i17.23921

Keywords:

Covid-19; Intensive Care Units; Acute Kidney Injury.

Abstract

The research was carried out from the analysis of medical records of patients who acquired Acute Kidney Injury (AKI) and needed Kidney Replacement Therapy (RRT) in admissions to Covid Intensive Care Units of the Hospital Regional de Cacoal (HRC) in the countryside of Rondônia . It is a descriptive, cross-sectional, retrospective study with a quantitative approach. After applying the exclusion criteria, 188 medical records were able to be analyzed from June 2020 to June 2021. Of the 188 patients, 108 were male (57%), with a mean age of 62.44, minimum age 23 and maximum 94 years. Diabetes, hypertension and obesity were the most prevalent pre-existing diseases in the study with 84%, and 6% of patients developed AKI without having any declared comorbidity. In this study, there is a high rate of patients who evolved to hemodialysis with a high mortality outcome with altered laboratory tests, totaling 93% of deaths and 7% of discharges. AKI in patients hospitalized with Covid-19 is intertwined with a poor prognosis with a high mortality rate, that the hyperinflammatory state affects the renal cells, causing the need for renal replacement therapy.

References

Alvarez, G., Chrusch, C., Hulme, T., & Posadas-Calleja, J. G. (2019). Renal replacement therapy: a practical update. Traitement substitutif de l’insuffisance rénale: une mise à jour pratique. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 66(5), 593–604. https://doi.org/10.1007/s12630-019-01306-x

Chen, L., & Guo, C. (2020). Focus on kidney disease among the coronavirus disease 2019 patients: A comparative perspective between China, Italy and the United States. International journal of clinical practice, 74(9), e13561. https://doi.org/10.1111/ijcp.13561

Costa, R. L., Sória, T. C., Salles, E. F., Gerecht, A. V., & Corvisier, M. F. (2021). Acute kidney injury in patients with Covid-19 in a Brazilian ICU: incidence, predictors and in-hospital mortality. Braz. J. Nephrol. (J. Bras. Nefrol.) 2021;43(3):349-358. https://doi.org/10.1590/2175- 8239-JBN-2020-0144

Wei-jie Guan, P. D., Zheng-yi Ni, M. D., Yu Hu, M. D et al. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China..The New England Journal of Medicine , 382 (18), 1708–1720. https://doi.org/10.1056/NEJMoa2002032

Pei, G., Zhang, Z., Peng, J., Liu, L., Zhang, C et al. (2020). Renal Involvement and Early Prognosis in Patients with Covid-19 Pneumonia. Journal of the American Society of Nephrology. 31(6),1157–1165. https://doi.org/10.1681/ASN.2020030276

Hidalgo-Blanco, M. A., Andreu-Periz, D., & Moreno-Arroyo, M. C. (2020). Covid-19en el enfermo renal. Revisión breve. Enfermería Nefrológica, 23(2), 122-131. https://dx.doi.org/10.37551/s2254-28842020013

Hirsch, J. S., Ng, J. H., Ross, D. W., Sharma, P., Shah, H. H., et al. Acute kidney injury in patients hospitalized with Covid-19. Kidney international , 98 (1), 209–218. https://doi.org/10.1016/j.kint.2020.05.006

Holshue, M. L., Chas DeBolt, C., Lofy, K, H., Wiesman, J., Bruce, H et al. (2020). First Case of 2019 Novel Coronavirus in the United States. The New England Journal of Medicine, 382 (10), 929–936. https://doi.org/10.1056/NEJMoa2001191

Kunutsor, S. K., & Laukkanen, J. A. (2020). Renal complications in Covid-19: a systematic review and meta-analysis. Annals of medicine, 52(7), 345–353. https://doi.org/10.1080/07853890.2020.1790643

Martins, H; Brandão-Neto, R. A; Scalabrini-Neto, A, Velasco, I. Emergências Clínicas – Abordagem Prática. (9a ed.). Manole, 2014.

Moitinho, M. S., Belasco, A. G. S., Barbosa, D. A., & Foncesa C. D. (2020). Acute Kidney Injury by SARS-CoV-2 virus in patients with Covid-19: an integrative review. Revista Brasileira de Enfermagem, 73 (2). https://doi.org/10.1590/0034-7167-2020-0354.

Nunes, L., & Lima, T. (2021). Use of medicines for Covid-19 treatment in patients with loss of kidney function: a narrative review. Brazilian Journal of Nephrology, 43 (2), 2175-8239. https://doi.org/10.1590/2175-8239-JBN-2020-0105.

Pecly, I. M. D., Azevedo, R. B., Muxfeldt, E. S., Botelho, B. G., Albuquerque G. G., et al (2021). A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results. Brazilian Journal of Nephrology., 43(4), 551-571. https://doi.org/10.1590/2175-8239-JBN-2020-0204.

Portolés, J., Marques, M., Sánchez, P. L., Valdenebro, M., Muñez, E et al. (2020). Doença renal crônica e lesão renal aguda no surto espanhol Covid-19, Transplante de diálise em nefrologia., 35 (8), 1353–1361. https://doi.org/10.1093/ndt/gfaa189

Queiroz A. G. S., Souza, R. Z., Sottocornola, S. F., Barbosa, S. J., Pinheiro, F. A., et al. (2020). Diagnósticos de enfermagem segundo a taxonomia da NANDA internacional para sistematização da assistência de enfermagem a Covid-19. J Health Biol Sci. 8(1):1-6. 10.12662/2317-3206jhbs.v8i1.3352.p1-6.2020

Scholz, J. R., Lopes, M. A. C. Q., Saraiva, J. F. K., & Colombo, F. C. (2020). Covid-19, Sistema Renina-Angiotensina, Enzima Conversora da Angiotensina 2 e Nicotina: Qual é a Inter-relação?. Arq. Bras. Cardiol., 115 (4), 708-711. https://doi.org/10.36660/abc.20200653.

Sodré, F. L., Costa., J. C. B., & Lima, J. C. C. (2007). Avaliação da função e da lesão renal: um desafio laboratorial. J. Bras. Patol. Med. Lab. 43 (5). https://doi.org/10.1590/S1676-24442007000500005

Sociedade Brasileira de Nefrologia. Insuficiência Renal Aguda. São Paulo: SN, 2007. https://www.sbn.org.br/fileadmin/user_upload/sbn/2020/01/0 4/Diretrizes_Insuficiencia_Renal_Aguda.pdf

Sosa-García, J. O., Gutiérrez-Villaseñor, A. O., García-Briones, A., Romero-González, J. P., Juárez-Hernández, E., & González-Chon, O. (2020). Experience in the management of severe Covid-19 patients in an intensive care unit. Cirugia y cirujanos, 88(5), 569–575. https://doi.org/10.24875/CIRU.20000675

Suassuna, J. H. R., Lima, E. Q., Rocha, E., Castro, A., Burdmann, E. A., et al. Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine. Braz. J. Nephrol, 42(2 Supl. 1):22-31. https://doi.org/10.1590/2175-8239-JBN-2020-S107.

Tandukar, S., & Palevsky, P. M. (2019). Continuous Renal Replacement Therapy: Who, When, Why, and How. Chest, 155(3), 626–638. https://doi.org/10.1016/j.chest.2018.09.004

Wang, X., Fang, X., Cai, Z., Wu, X., Gao, X., Min, J., & Wang, F. (2020). Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. Research (Washington, D.C.), 2402961. https://doi.org/10.34133/2020/2402961

Younes-Ibrahim, M. (2021). O rim: função, células e biomarcadores. Braz. J. Nephrol., 43 (1), 3-4. https://doi.org/10.1590/2175-8239- JBN-2020-0215

Published

24/12/2021

How to Cite

SOTTOCORNOLA, S. F. .; SILVA, R. R. da .; BARBOSA, S. J. .; QUEIROZ, A. G. S. .; SOUZA, R. Z. de .; BULGARELLI, Érico M. N. . Renal replacement therapy in patients affected by Covid-19 in an Intensive Care Unit in the countryside of Rondônia. Research, Society and Development, [S. l.], v. 10, n. 17, p. e188101723921, 2021. DOI: 10.33448/rsd-v10i17.23921. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/23921. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences