Effectiveness and safety of surgical antibiotic prophylaxis in dental procedures in patients without underlying cardiac conditions: an overview of systematic reviews
DOI:
https://doi.org/10.33448/rsd-v11i3.26554Keywords:
Antibiotic Prophylaxis; Evidence-Based Dentistry; Preventive Dentistry; Practice patterns, dentists'.Abstract
Objective: This overview of systematic reviews aimed to assess the effectiveness and safety of surgical antibiotic prophylaxis for patients without underlying cardiac conditions undergoing dental surgical procedures. Methods: The searches were carried out at PubMed, Lilacs, Cochrane Library, Web of Science and Scopus databases. Systematic reviews of randomized controlled trials and non-randomized controlled trials that assessed the effectiveness and safety of surgical antibiotic prophylaxis in patients without underlying cardiac conditions undergoing dental surgical procedures were included in the study. A methodological quality assessment was carried out through AMSTAR-2. Results: The search resulted in 1910 studies and 15 systematic reviews were included in the overview. Three surgical procedures were identified: dental implant, dental extraction and endodontic surgery. Most systematic reviews (80%) did not present conclusive results on the effectiveness and safety of surgical antibiotic prophylaxis in procedures performed in patients without underlying cardiac conditions. Eleven studies showed low or critically low quality and four presented moderate methodological quality. Conclusion: The results are inconclusive to state that surgical antibiotic prophylaxis is more effective and safer for patients without underlying cardiac conditions undergoing dental implant, dental extraction and endodontic surgery compared to no intervention, as this overview of systematic review showed evidence that surgical antibiotic prophylaxis should be avoided in healthy patients to minimize the risk of antimicrobial resistance until studies with a lower risk of bias are available to support a favorable decision-making for use.
References
Andrade, E. D. (2014). Terapêutica medicamentosa em odontologia. (3rd. ed). Artes Médicas.
Arteagoitia, I., Rodríguez-Andrés, C., & Rodríguez-Sánchez, F. (2018). Antibiotic prophylaxis habits in dental implant surgery among dentists in Spain. A cross-sectional survey. Medicina Oral, Patologia Oral y Cirugia Bucal, 23(5), e608-e618. https://doi.org/10.4317/medoral.22626
Arteagoitia, M.-I., Barbier, L., Santamaría, J., Santamaría, G., & Ramos, E. (2016). Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and meta-analysis. Medicina Oral, Patologia Oral y Cirugia Bucal, 21(4), e494-504. https://doi.org/10.4317/medoral.21139
Ata-Ali, J., Ata-Ali, F., & Ata-Ali, F. (2014). Do antibiotics decrease implant failure and postoperative infections? A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery, 43(1), 68-74. https://doi.org/10.1016/j.ijom.2013.05.019
Bernardo, W. M., Nobre, M. R. C., & Jatene, F. B. (2004). A prática clínica baseada em evidências: Parte II - buscando as Evidências em Fontes de Informação. Revista Brasileira de Reumatologia., 44(6), 403-409.
Bougioukas, K. I., Liakos, A., Tsapas, A., Ntzani, E., & Haidich, A.-B. (2018). Preferred reporting items for overviews of systematic reviews including harms checklist: A pilot tool to be used for balanced reporting of benefits and harms. Journal of Clinical Epidemiology, 93, 9-24. https://doi.org/10.1016/j.jclinepi.2017.10.002
Bratzler, D. W., Dellinger, E. P., Olsen, K. M., Perl, T. M., Auwaerter, P. G., Bolon, M. K., Fish, D. N., Napolitano, L. M., Sawyer, R. G., Slain, D., Steinberg, J. P., & Weinstein, R. A. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical Infections, 14(1), 73-156. https://doi.org/10.1089/sur.2013.9999
Braun, R. S., Chambrone, L., & Khouly, I. (2019). Prophylactic antibiotic regimens in dental implant failure: A systematic review and meta-analysis. Journal of the American Dental Association (1939), 150(6), e61-e91. https://doi.org/10.1016/j.adaj.2018.10.015
Bryce, G., Bomfim, D. I., & Bassi, G. S. (2014). Pre- and post-operative management of dental implant placement. Part 2: Management of early-presenting complications. British Dental Journal, 217(4), 171-176. https://doi.org/10.1038/sj.bdj.2014.702
Canullo, L., Troiano, G., Sbricoli, L., Guazzo, R., Laino, L., Caiazzo, A., & Pesce, P. (2020). The Use of Antibiotics in Implant Therapy: A Systematic Review and Meta-Analysis with Trial Sequential Analysis on Early Implant Failure. The International Journal of Oral & Maxillofacial Implants, 35(3), 485-494. https://doi.org/10.11607/jomi.7995
Cervino, G., Cicciù, M., Biondi, A., Bocchieri, S., Herford, A. S., Laino, L., & Fiorillo, L. (2019). Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data. Antibiotics (Basel, Switzerland), 8(2). https://doi.org/10.3390/antibiotics8020053
Chen, Z., Chen, D., Zhang, S., Tang, L., & Li, Q. (2017). Antibiotic prophylaxis for preventing dental implant failure and postoperative infection: A systematic review of randomized controlled trials. American Journal of Dentistry, 30(2), 89-95.
de Luca Canto, G. (2020). Revisões sistemáticas da literatura: Guia prático. (1st ed.). Brazil Publishing.
Do, T. A., Le, H. S., Shen, Y.-W., Huang, H.-L., & Fuh, L.-J. (2020). Risk Factors related to Late Failure of Dental Implant-A Systematic Review of Recent Studies. International Journal of Environmental Research and Public Health, 17(11). https://doi.org/10.3390/ijerph17113931
Esposito, M., Grusovin, M. G., Loli, V., Coulthard, P., & Worthington, H. V. (2010). Does antibiotic prophylaxis at implant placement decrease early implant failures? A Cochrane systematic review. European Journal of Oral Implantology, 3(2), 101-110.
Esposito, M., Grusovin, M. G., Talati, M., Coulthard, P., Oliver, R., & Worthington, H. V. (2008). Interventions for replacing missing teeth: Antibiotics at dental implant placement to prevent complications. The Cochrane Database of Systematic Reviews, 3, CD004152. https://doi.org/10.1002/14651858.CD004152.pub2
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). (2021). Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021. www.training.cochrane.org/handbook.
Khouly, I., Braun, R. S., & Chambrone, L. (2019). Antibiotic prophylaxis may not be indicated for prevention of dental implant infections in healthy patients. A systematic review and meta-analysis. Clinical Oral Investigations, 23(4), 1525-1553. https://doi.org/10.1007/s00784-018-2762-x
Lodi, G., Figini, L., Sardella, A., Carrassi, A., Del Fabbro, M., & Furness, S. (2012). Antibiotics to prevent complications following tooth extractions. The Cochrane Database of Systematic Reviews, 11, CD003811. https://doi.org/10.1002/14651858.CD003811.pub2
Marín Escobar, A., Fuentes, R., & Cantín, M. (2013). Uso de Antibióticos en Cirugía de Implantes: Una Revisión Sistemática. International journal of odontostomatology, 7, 59-67.
Mariscal-Cazalla, M. D. M., Manzano-Moreno, F. J., García-Vázquez, M., Vallecillo-Capilla, M. F., & Olmedo-Gaya, M. V. (2021). Do perioperative antibiotics reduce complications of mandibular third molar removal? A double-blind randomized controlled clinical trial. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 131(3), 286-294. https://doi.org/10.1016/j.oooo.2020.08.034
McHugh, M. L. (2012). Interrater reliability: The kappa statistic. Biochemia Medica, 22(3), 276-282.
Menon, R. K., Gopinath, D., Li, K. Y., Leung, Y. Y., & Botelho, M. G. (2019). Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. International Journal of Oral and Maxillofacial Surgery, 48(2), 263-273. https://doi.org/10.1016/j.ijom.2018.08.002
Moreno-Drada, J. A., & García-Perdomo, H. A. (2016). Effectiveness of Antimicrobial Prophylaxis in Preventing the Spread of Infection as a Result of Oral Procedures: A Systematic Review and Meta-Analysis. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons, 74(7), 1313-1321. https://doi.org/10.1016/j.joms.2016.03.006
Mota, L. M., Vilar, F. C., Dias, L. B. A., Nunes, T. F., & Moriguti, J. C. (2010). Uso racional de antimicrobianos. Medicina (Ribeirão Preto), 43(2), 164-172. https://doi.org/10.11606/issn.2176-7262.v43i2p164-172.
O’Neill, J. (2016). Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. [United Kingdom] : Review on Antimicrobial Resistance. https://wellcomecollection.org/works/thvwsuba
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan-a web and mobile app for systematic reviews. Systematic Reviews, 5(1), 210. https://doi.org/10.1186/s13643-016-0384-4
Palma, L. F., Ambrozio, T. B., Smeke, L., Sato, N. M., Yugoshi, L. I., & Kfouri, F. de Á. (2017). Antibióticos sistêmicos diminuem a falha de implantes dentais? Uma revisão da literatura. Revista Odontológica de Araçatuba., 38(2), 36-40.
Pieper, D., Antoine, S.-L., Mathes, T., Neugebauer, E. A. M., & Eikermann, M. (2014). Systematic review finds overlapping reviews were not mentioned in every other overview. Journal of Clinical Epidemiology, 67(4), 368-375. https://doi.org/10.1016/j.jclinepi.2013.11.007
Quirynen, M., De Soete, M., & van Steenberghe, D. (2002). Infectious risks for oral implants: A review of the literature. Clinical Oral Implants Research, 13(1), 1-19. https://doi.org/10.1034/j.1600-0501.2002.130101.x
Romandini, M., De Tullio, I., Congedi, F., Kalemaj, Z., D’Ambrosio, M., Laforí, A., Quaranta, C., Buti, J., & Perfetti, G. (2019). Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta-analysis. Journal of Clinical Periodontology, 46(3), 382-395. https://doi.org/10.1111/jcpe.13080
Santos da Costa, C. M., Pimenta de Mattos, C. A., & Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem [online]., 15(3), 508-511. https://doi.org/10.1590/S0104-11692007000300023
Segura-Egea, J. J., Gould, K., Şen, B. H., Jonasson, P., Cotti, E., Mazzoni, A., Sunay, H., Tjäderhane, L., & Dummer, P. M. H. (2018). European Society of Endodontology position statement: The use of antibiotics in endodontics. International Endodontic Journal, 51(1), 20-25. https://doi.org/10.1111/iej.12781
Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., Moher, D., Tugwell, P., Welch, V., Kristjansson, E., & Henry, D. A. (2017). AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ, 358, j4008. https://doi.org/10.1136/bmj.j4008
Singh Gill, A., Morrissey, H., & Rahman, A. (2018). A Systematic Review and Meta-Analysis Evaluating Antibiotic Prophylaxis in Dental Implants and Extraction Procedures. Medicina (Kaunas, Lithuania), 54(6). https://doi.org/10.3390/medicina54060095
Smeets, R., Henningsen, A., Jung, O., Heiland, M., Hammächer, C., & Stein, J. M. (2014). Definition, etiology, prevention and treatment of peri-implantitis—A review. Head & Face Medicine, 10, 34. https://doi.org/10.1186/1746-160X-10-34
Suda, K. J., Henschel, H., Patel, U., Fitzpatrick, M. A., & Evans, C. T. (2018). Use of Antibiotic Prophylaxis for Tooth Extractions, Dental Implants, and Periodontal Surgical Procedures. Open Forum Infectious Diseases, 5(1), ofx250. https://doi.org/10.1093/ofid/ofx250
Wilson, W., Taubert, K. A., Gewitz, M., Lockhart, P. B., Baddour, L. M., Levison, M., Bolger, A., Cabell, C. H., Takahashi, M., Baltimore, R. S., Newburger, J. W., Strom, B. L., Tani, L. Y., Gerber, M., Bonow, R. O., Pallasch, T., Shulman, S. T., Rowley, A. H., Burns, J. C., … Durack, D. T. (2007). Prevention of infective endocarditis: Guidelines from the American Heart Association: A guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation, 116(15), 1736-1754. https://doi.org/10.1161/CIRCULATIONAHA.106.183095
World Health Organization. (2014). Antimicrobial resistance: Global report on surveillance. World Health Organization.
Yalcin-Ülker, G. M., Cakir, M., & Meral, D. G. (2020). Antibiotic prescribing habits of the clinicians dealing with dental implant surgery in Turkey: A questionnaire study. International Journal of Implant Dentistry, 6(1), 66. https://doi.org/10.1186/s40729-020-00252-4
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Copyright (c) 2022 Joselin Valeska Martinez Sobalvarro; Vinícius Ribeiro Monteiro ; Marcos Luciano Moscardini ; Lucas Borges Pereira; Ricardo Radighieri Rascado ; Tiago Marques dos Reis
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