Use of low intensity laser and LED in the wound healing process: review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27722

Keywords:

Laser; Rats; Laboratory.

Abstract

The healing of cutaneous wounds is a challenge in clinical surgery, requiring new therapeutic methods for the process to be optimized and performed adequately. In this aspect, photobiomodulation with low intensity laser light (LLLT) has been studied and applied as an adjuvant treatment in this process.  Studies have evaluated that lasers can be used satisfactorily, optimizing the repair process of these wounds. The objective of this integrative review was to review the use of photobiomodulation with led light and laser in the process of wound healing. As a search strategy, a bibliographic search was made in electronic databases: PubMed, Lilacs and Web of Science, and selected studies performed in humans and in vivo laboratory with rats, between the years 2010 and 2021. A combination of the following keywords was used: LED light, laser, in vivo, human and laboratory. Fifty-two studies were selected, of these, forty were eliminated as duplicates and fourteen were included for the purpose of qualitative analysis. In all the studied articles, the laser therapy obtained positive results, acting satisfactorily to the objectives. After the analysis of the studies, it can be concluded that photobiomodulation with low intensity laser and LED have shown to be effective, satisfactorily improving the entire process of tissue repair. However, there is a need for more knowledge and studies for the therapy to be really incorporated into clinical practice.

References

Amadio, E. M., Marcos, R. L., Serra, A. J., Santos, S. A., Chaires, J. A., Fernandes, G. H. C., Junior, E. C. L., Ferrari, J. C. C. & Carvalho, P. T. C. (2021). Efeitos da terapia de fotobiomodulação na fase de proliferação de e cicatrização de feridas cutâneas em ratos alimentados com dieta hipoprotéica. Lasers Med Sci. 37(7), 1427-35.

Amadio, E. M., Marcos, R. L., Serra, A. J., Santos, S. A., Chaires, J. A., Fernandes, G. H. C., Junior, E. C. L., Ferrari, J. C. C. & Carvalho, P. T. C. (2021). Efeitos da terapia de fotobiomodulação na fase de proliferação de e cicatrização de feridas cutâneas em ratos alimentados com dieta hipoprotéica. Lasers Med Sci. 37(7), 1427-35.

Asghari, M., Kanonisabet, K., Safakhah, M., Azimzadeh, Z., Mostafavinia, A., Taheri, S., Amini, A., Ghorish, S.K & Bayat, M. (2017). The effect of combined photobiomodulation and metformin on open skin wound healing in a non-genetic model of type II diabetes. J Photochem Photobiol B. 169(2), 63-69.

Catão, M.H.V., Nonaka, C.F., De Albuquerque, J.R., Bento, P.M & De Oliveira, C.R. (2015). Effects of red laser, infrared, photodynamic therapy, and green LED on the healing process of third-degree burns: clinical and histological study in rats. Lasers Med Sci. 30(1), 421-8. http://dx.doi.org/10.1007/s10103-014-1687-0;

De Medeiros, M.L., Filho, I.A., Silva, E.F.M., Queiroz, W.S.S., Soares, C.D., Carvalho, M.G.F & Maciel, M.A.M. (2017). Effect of low-level laser therapy on angiogenesis and matrix metalloproteinase-2 immunoexpression in wound repair. Lasers Med Sci. 32(1), 35-43.

Eissa, M & Salih W.H.M. (2017). The influence of low-intensity he-ne laser on the wound healing in diabetic rats. Lasers Med Sci. 32(6), 1261-1267.

Firouzi, A., Norozian, M., Amini. A., Abdollalifar, M.A., Abbaszadeh H.A & Fathabadi, F.F. (2018) Combined effect of low-level laser treatment and levothyroxine on wound healing in rats with hypothyroidism. Lasers Med Sci. 9(4), 268-273.

Lopez, A & Brundage, C. Wound Photobiomodulation Treatment Outcomes in Animal Models. (2019). J Vet Med. 28(3), 123-137.

Soleimani, H., Amini, A., TaherI, S., Sajadi, E., Shafikahani, S., Shuger, L.A., Veddy, B.V., Ghoreishi, S.K., Pouriran, R., Chien S & BAYAT, M. (2018). The effect of combined photobiomodulation and curcumin on skin wound healing in type I diabetes in rats. J Photochem Photobiol B. 18(1), 23-30.

Lima, F.J.C., De Oliveira, O.B., Barbosa, F.T., Do Nascimento, G.A.M., Ramos, F.W.S & De Lima, C.C.F. (2016). Is there a protocol in experimental skin wounds in rats using low-level diode laser therapy (LLDLT) combining or not red and infrared wavelengths? Systematic review. Lasers Med Sci. 31(4), 779–787.

Mortazavi H., Baharvand M & Rahmanini, S. (2016). Diagnostic features of common oral ulcerative lesions: An updated decision tree. Int J Dent. 1(3), 257.

Medeiros, M.L. (2017). Effect of low-level laser therapy on angiogenesis and matrix metalloproteinase-2 immunoexpression in wound repair. Lasers Med Sci. 32(1), 35-43.

Suzuki, R & Takakuda K. (2016). Wound healing efficacy of a 660-nm diode laser in a rat incisional wound model. Lasers Med Sci, 31(8), 1683–1689.

Pereira, A.S., Shitsuka, D.M., Parreira, F.J & Shitsuka, R. (2018). Metodologia da pesquisa científica. Santa Maria, RS, Ed.UAB/NTE/UFSM.

Sant'anna, E.F. (2017). Aplicação do laser de alta intensidade em Ortodontia. Dente. Pressione J. Orthod. 22(2), 99-100.

Shi, M., Sadegh, M., Akhoundi, A., Javadi, E., Kamali a & Motahhari, P. (2020). Os efeitos do laser de diodo (660 nm) na taxa de movimentação dentária: um estudo animal. Lasers Med Sci. 30(2), 713-718. Doi.org/10.1590/1807-2577.14418.

Smith K.C. (2005). Laser (and LED) therapy is phototherapy. Photomed Laser Surg. 23(1), 78-80. http://dx.doi.org/10.1089/pho.2005.23.7

Solmaz, H., Ulgen, Y & Gulsoy,M. (2017). Photobiomodulation of wound healing via visible and infrared laser irradiation. Lasers Med Sc. 32(4), 903-910.

Sousa, M.V. (2013). Avaliação do efeito do laser de baixa intensidade como recurso de ancoragem, J Photochem Photobiol B. 10(1), 10-20.

Woessner, A.E., Mcgee, J.D., Jones, J.D & Quinn, K. (2019). Characterizing differences in the collagen fiber organization of skin wounds using quantitative polarized light imaging. Wound repair regen. 27(6), 711-714.

Published

26/03/2022

How to Cite

FARIAS, L. G. de .; CATÃO, M. H. C. de V. Use of low intensity laser and LED in the wound healing process: review. Research, Society and Development, [S. l.], v. 11, n. 4, p. e55811427722, 2022. DOI: 10.33448/rsd-v11i4.27722. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27722. Acesso em: 23 nov. 2024.

Issue

Section

Review Article