Mucormycosis coinfection and Covid-19 – 2021 scenario: a scope review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i5.28611

Keywords:

Mucormycosis; Covid-19; Teaching; Coinfection.

Abstract

The Covid-19 disease became a pandemic in 2019, starting in China. This disease is being related to opportunistic infections, mainly fungal. One of these co-infections refers to the association with mucormycosis. Objective: In this sense, this study was carried out to evaluate the information available in the literature on the subject and to detect possible clinical conducts. Methodology: For this, the scope review methodology was used to gather information about possible treatments and clinical procedures related to this double infection. Results: 350 articles were found and at the end 13 articles were included in the analysis. Close follow-up of the patients was identified as the clinical procedure to be adopted, in order to identify any facial necrosis, and liposomal amphotericin B was identified as treatment. Conclusion: This knowledge helps the SUS to set up care strategies and robust clinical protocols in relation to this co-infection, which is still little known, as observed in the current literature.

References

Arana, C., Ramírez, R.E.C., Xipell, M., et al. (2021). Mucormycosis associated with covid19 in two kidney transplant patients. Transpl Infect Dis. https://doi: 10.1111/tid.13652. Epub ahead of print. PMID: 34038014.

Arksey H. & O’Malley L. (2005). Scoping studies: towards a methodological framework. Int J Soc Res Methodol.8(1):19-32

Bayram, N., Ozsaygılı, C., Sav, H., et al. (2021). Susceptibility of severe COVID-19 patients to rhino-orbital mucormycosis fungal infection in different clinical manifestations. Jpn J Ophthalmol. https://doi: 10.1007/s10384-021-00845-5. Epub ahead of print. PMID: 34057620; PMCID: PMC8165350.

Bhatt, K., Agolli, A., Patel, M.H., et al. (2021). High mortality co-infections of COVID-19 patients: mucormycosis and other fungal infections. Discoveries (Craiova). https://doi: 10.15190/d.2021.5. PMID: 34036149; PMCID: PMC8137279.

Garg, D., Muthu, V., Sehgal, I.S., et al. (2021). Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature. Mycopathologia. https://doi: 10.1007/s11046-021-00528-2. Epub 2021 Feb 5. PMID: 33544266; PMCID: PMC7862973.

Honavar, S.G. (2021). Code Mucor: Guidelines for the Diagnosis, Staging and Management of Rhino-Orbito-Cerebral Mucormycosis in the Setting of COVID-19. Indian J Ophthalmol. https://doi: 10.4103/ijo.IJO_1165_21. PMID: 34011699.

Kanwar, A., Jordan, A., Olewiler, S., et al. (2021). A Fatal Case of Rhizopus azygosporus Pneumonia Following COVID-19. J Fungi (Basel). https://doi: 10.3390/jof7030174. PMID: 33670842; PMCID: PMC7997212.

Khatri, A., Chang, K.M., Berlinrut, I., et al. (2021) Mucormycosis after Coronavirus disease 2019 infection in a heart transplant recipient - Case report and review of literature. J Mycol Med. https://doi: 10.1016/j.mycmed.2021.101125. Epub 2021 Apr 2. PMID: 33857916; PMCID: PMC8017948.

Krishna, D.S., Raj, H., Kurup, P., et al. (2021). Maxillofacial Infections in Covid-19 Era-Actuality or the Unforeseen: 2 Case Reports. Indian J Otolaryngol Head Neck Surg. https://doi: 10.1007/s12070-021-02618-5. Epub ahead of print. PMID: 34026593; PMCID: PMC8127475.

Kubin, C. J., McConville, T. H., Dietz, D., et al. (2021). Characterization of Bacterial and Fungal Infections in Hospitalized Patients with COVID-19 and actors Associated with Healthcare-associated Infections. Open Forum infectious Diseases. ofab201. https://doi.org/10.1093/ofid/ofab201

Maini, A., Tomar, G., Khanna, D., et al. (2021). Sino-orbital mucormycosis in a COVID-19 patient: A case report. Int J Surg Case Rep. https://doi: 10.1016/j.ijscr.2021.105957. Epub 2021 May 4. PMID: 33964720; PMCID: PMC8093005.

Mehta, S. & Pandey, A. (2020). Rhino-Orbital Mucormycosis Associated With COVID-19. Cureus. https://doi: 10.7759/cureus.10726. PMID: 33145132; PMCID: PMC7599039.

Mekonnen, Z.K., Ashraf, D.C., Jankowski, T., et al. (2021). Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome. Ophthalmic Plast Reconstr Surg. https://doi: 10.1097/IOP.0000000000001889. PMID: 33229953; PMCID: PMC7927902.

Moher, D., Liberati, A., Tetzlaff, J., et al. (2009). The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and MetaAnalyses: The PRISMA Statement. PLoS Med 6(7): e1000097.

Moorthy, A., Gaikwad, R., Krishna, S., et al. (2021). SARS-CoV-2, Uncontrolled Diabetes and Corticosteroids-An Unholy Trinity in Invasive Fungal Infections of the Maxillofacial Region? A Retrospective, Multi-centric Analysis. J Maxillofac Oral Surg. https://doi: 10.1007/s12663-021-01532-1. Epub ahead of print. PMID: 33716414; PMCID: PMC7936599.

Nehara, H.R., Puri, I., Singhal, V., et al. (2021). Rhinocerebral mucormycosis in COVID-19 patient with diabetes a deadly trio: Case series from the northwestern part of India. Indian J Med Microbiol. https://doi: 10.1016/j.ijmmb.2021.05.009. Epub ahead of print. PMID: 34052046; PMCID: PMC8153224.

Ouzzani, M., Hammady, H., Fedorowicz, Z., et al. (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev. https://doi: 10.1186/s13643-016-0384-4.

Pandiar, D., Kumar, N. S., Anand, R., Kamboj, M. & Narwal, A. (2021). Does COVID 19 generate a milieu for propagation of mucormycosis? Medical Hypotheses. v.152. Elsevier.

Reed, C., Bryant, R., Ibrahim, A.S., et al. (2008). Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis. Clin Infect Dis. https://doi: 10.1086/589857. PMID: 18558882; PMCID: PMC2793535.

Saldanha, M., Reddy, R. & Vincent, M.J. (2021). Paranasal Mucormycosis in COVID-19 Patient. Indian J Otolaryngol Head Neck Surg. 2021 Apr 22:1-4. https://doi: 10.1007/s12070-021-02574-0. Epub ahead of print. PMID: 33903850; PMCID: PMC8060684.

Sen, M., Lahane, S., Lahane, TP., et al.. (2021). Mucor in a Viral Land: A Tale of Two Pathogens. Indian J Ophthalmol. https://doi: 10.4103/ijo.IJO_3774_20. PMID: 33463566; PMCID: PMC7933891.

Singh, A. K., Singh, R. & Joshi, S. R. (2021). A Misra. Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India. Diabetes & Metabolic Syndrome. Elsevier.

Song, G., Liang, G. & Liu, W. (2020). Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China. Mycopathologia. https://doi: 10.1007/s11046-020-00462-9. Epub 2020 Jul 31. PMID: 32737747; PMCID: PMC7394275.

The Joanna Briggs Institute – JBI. (2015). Joanna Briggs Institute Reviewers’ Manual edition/supplement, Australia.

Veisi, A., Bagheri, A., Eshaghi, M., et al. (2021). Rhino-orbital mucormycosis during steroid therapy in COVID-19 patients: A case report. Eur J Ophthalmol. https://doi: 10.1177/11206721211009450. Epub ahead of print. PMID: 33843287.

Published

13/04/2022

How to Cite

SILVA, J. C. R. A. da .; PIUVEZAM, G.; BRITO, A. F. S. de . Mucormycosis coinfection and Covid-19 – 2021 scenario: a scope review. Research, Society and Development, [S. l.], v. 11, n. 5, p. e46811528611, 2022. DOI: 10.33448/rsd-v11i5.28611. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28611. Acesso em: 24 nov. 2024.

Issue

Section

Review Article