The use of tricyclic antidepressants in the treatment of fibromyalgia: a literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i13.34850

Keywords:

Fibromyalgia; Tricyclic Antidepressants; Pharmacokinetics.

Abstract

Introduction: Tricyclic antidepressants (TCAs) are widely used as analgesics for chronic low back pain and neuropathic pain. Antidepressants do not significantly influence the normal organism in its basal state, they only correct anomalous conditions. Antidepressants with different chemical structures have in common the ability to acutely increase the synaptic availability of one or more neurotransmitters, through action on several specific receptors and enzymes. Objective: The objective of this work is to demonstrate the mechanism of action of antidepressants and their reactions. Methodology: the research was developed through searches on the Scielo (Electronic Library Scientifc Electronic Library Online) and Google academic platforms. Based on a literature review, according to Cunha, Cunha & Alves, (2014). The following descriptors were used: Fibromyalgia; Tricyclic Antidepressants; Pharmacokinetics. Conclusion: The treatment of fibromyalgia is individualized, and does not propose a cure. The objective is to reduce the suffering of its patients, improve functionality and, as far as possible, personal autonomy and quality of life. Most conducts and recommendations have a lot in common, but they are not totally congruent, showing dynamism and changes as knowledge accumulates on a subject on which consensus is still far from occurring.

References

Atzeni, F., Gerardi, M. C., Masala, I. F., Alciati, A., Batticciotto, A., & Sarzi-Puttini, P. (2017). Na update on emerging drugs for fibromyalgia treatment. Expert opinion on emerging drugs, 22(4), 357-367.

Azevedo, P. M. (2018). A ciência da dor: Sobre fibromialgia e outras síndromes dolorosas persistente e sobre a natureza humana. São Paulo: Editora Unesp Digital.

Atsak, P., Guenzel, F. M., Kantar-Gok, D., Zalachoras, I., Yargicoglu, P., Meijer, O. C., Quirarte, G. L., Lobo, O.T., Schwabe, L., & Roozendaal, B. (2016). Glucocorticoids mediate stress-induced impairment of Retrieval of stimulus-response memory. Psychoneuroendocrinology, 67(1),207-215.

Barceló-Martinez, E., Gelves-Ospina, M., Navarro Lechuga, E., Allegri , R. F., Orozco- Acosta, E., Benítez-Agudelo, J. C., León-Jacobus, A., & Román, N. F. (2018). Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia. Actas Esp Psiquiatr, 46 (1), 1-11.

Benlidayi, I. C. (2019). Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatology international, 39(5), 781-791.

Chang, J. E., Torres, J. C., & Yoshida, Y. C. (2017). Programa para la atención com abordaje psicológi¬co en pacientes con síndrome de fibromialgia em un hospital público de la Ciudad de Chiclayo. Tzhoecoen. 9(2).

Cunha, P. L. P., Cunha, C. S., & Alves, P. F. (2014). Revisão bibliográfica sistemática integrativa: a pesquisa baseada em evidências. Revista Anima Educação, 6(3), 1-63.

Fischer, S., Doerr, J. M., Strahler, J., Mewes, R., Thieme, K., & Nater, U. M. (2016). Stress exacerbates pain in the everyday lives of women with fibromyalgia syndrome - the role of cortisol and alpha-amylase. Psychoneuroendocrinology, 63(1), 68-77.

Halpern, R., Shah, S. N., Cappelleri, J. C., Masters, E. T., & Clair, A. (2016). Evaluating guideline‐recommended pain medication use among patients with newly diagnosed fibromyalgia. Pain Practice, 16 (8), 1027-1039.

Katzung, B. G. (2014) Farmacologia básica e clínica. (12ª edição): AMGH.

Lawson, K. (2017). Emerging pharmacological strategies for the treatment of fibromyalgia. World J Pharmacology. 6(1):1-10.

Martinez, J. E., Paiva, E. S., Rezende, M. C., Heymann, R. E., Helfenstein, M. J., Ranzolin, A., Provenza, J. R., Ribeiro, L. S., Souza, E. J., Feldman, D. P., & Assis, M. R. (2017). EpiFibro (Registro Brasileiro de Fibromialgia): dados sobre a classificac¸ão do ACR e preenchimento dos critérios diagnósticos preliminares e avaliacão de seguimento. Rev Bras Reumatol, 57(2), 129–133.

Metyas, S., Rezk, T., Arkfeld, D., & Leptich, T. (2017). Autoinflammation and immunomodulation in inflammatory fibromyalgia syndrome-a review. Current rheumatology reviews, 13(2), 98-102.

Moraczewski, J., & Aedma, K. K. (2022) Tricyclic Antidepressants. In: StatPearls [Internet] https://www.ncbi.nlm.nih.gov/books/NBK557791

Morales, K. O., Passarelli, B. S., Casimiro, E. F., Pereira, J. C., Deliberato, P. C. P., & Santos, B. R. M. (2019). O uso da técnica manual shiatsu no alívio dos sintomas decorrentes da fibromialgia. Unisanta Health Science, 3(1), 1-17.

Oliveira, J. O., & Almeida, M. B. (2018). O tratamento atual da fibromialgia. Br J Pain. São Paulo, 1(3), 255-62.

Pernambuco, A. P., Schetino, L. P., Carvalho, L. S. C., & Reis, D. A. (2016). Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. Journal of Pain & Relief, 5 (3), 1-7.

Salvat-Pujol, N., Labad, J., Urretavizcaya, M., de Arriba-Arnau, A., Segalàs, C., Real, E., Ferre, A., Cresco, J. M., Jiménez-Murcia, S., Soriano-Mas, C., Menchón, J. M., & Soria, V. (2017). Hypothalamic-pituitary-adrenal axis activity and cognition in major depression: the role of remission status. Psychoneuroendocrinology, 76(1),38-48.

Steudte-Schmiedgen, S., Wichmann, S., Stalder, T., Hilbert, K., Muehlhan, M., Lueken, U. & Beesdo-Baum, K. (2017). Hair cortisol concentrations and cortisol stress reactivity in generalized anxiety disorder, major depression and their comorbidity. Journal of psychiatric research, 84 (1), 184-190.

Tanwar, M. S., Jain, S., Kumar, U., Dada, R., & Bhatia, R. (2016). Reproductive Hormones in Pathophysiology of Fibromyalgia Syndrome. Indian Obstetrics and Gynaecology, 6(3), 35-42.

Tsilioni, I., Russell, I. J., Stewart, J. M., Gleason, R. M., & Theoharides, T. C. (2016). Neuropeptides CRH, SP, HK-1, and inflammatory cytokines IL-6 and TNF are increased in serum of patients with fibromyalgia syndrome, implicating mast cells. Journal of Pharmacology and Experimental Therapeutics, 356(3), 664-672.

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Published

07/10/2022

How to Cite

SILVA, F. G. C. da; LADISLAU, R. S.; SILVA, G. L. da S. e .; OLIVIERA, A. B. T. de; MAGALHÃES, E. Q. de; RODRIGUES JUNIOR, O. M. The use of tricyclic antidepressants in the treatment of fibromyalgia: a literature review. Research, Society and Development, [S. l.], v. 11, n. 13, p. e02111334850, 2022. DOI: 10.33448/rsd-v11i13.34850. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/34850. Acesso em: 22 nov. 2024.

Issue

Vol. 11 No. 13

Section

Review Article

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Copyright (c) 2022 Francisco Gabriel Carvalho da Silva; Rebeca Simão Ladislau; Gerson Luiz da Silva e Silva; Antônio Bartolomeu Texeira de Oliviera; Edivane Queiroz de Magalhães; Omero Martins Rodrigues Junior

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