Research on the relationship between Mozart's Sonata K448 and the extinction of fear of sound memory

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36379

Keywords:

Animal models; Extinction; Psychological; Memory; Music.

Abstract

Introduction: The process of memory occurs through phases due to various stimuli. Sound is an important source of such stimulation. Extinction, with which previously established information is suppressed, represents a new learning process. Objective: To investigate the interference of Mozart's Sonata K448 in the extinction of the memory of fear of the sound. Methods: C57BL/6J mice were used, divided into: G1: Mozart (n=7); G2: Environment (n=6); and G3: Control (n=6). Only the G1 group was exposed to music from intrauterine life onwards. On days 50 to 53 after birth, the animals were subjected to Habituation. On the 54th day, an Aversive Training was performed only with G1 and G2. On the 55th day, the Extinction Test started, lasting twelve consecutive days with the three groups. On the 81st day, all groups passed the Recall Test. The tests were videotaped for analysis. Data were analyzed using the repeated measures ANOVA test, with p≤0.05 being considered significant. Results: There was no groups main effect (F(2;16)=2,70; p=0,098), nor an interaction between groups x days (F(2,16;17,30)=1,58; p=0,147). Conclusion: Although no statistically significant difference was observed between the groups, future studies with larger samples may be opportune to better elucidate the influence of music on memory.

References

Angelucci, F., Ricci, E., Padua, L., Sabino, A., & Tonali, P. (2007). Music exposure differentially alters the levels of brain-derived neurotrophic factor and nerve growth factor in the mouse hypothalamus. Neurosci Lett, 429,152–155.

Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R., Izquierdo, I., & Medina, J. H. (2007). Persistence of long-term memory storage requires a late protein synthesis- and BDNFdependent phase in the hippocampus. Neuron, 53(2), 261–277.

Bergstrom, H. C. (2016). The neurocircuitry of remote cued fear memory. Neurosci Biobehav Rev., 71, 409-417.

Chen, S., Liang, T., Zhou, F. H., Cao, Y., Wang, C., Wang, F., et. al (2019). Regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood. Biomed Res Int., 8740674.

Chikahisa, S., Sano, A., Kitaoka, K., Miyamoto, K., & Sei, H. (2007). Anxiolytic effect of music depends on ovarian steroid in female mice. Behav Brain Res., 16, 179(1).

Chroilli, M., Michelin, D. C., Salgado, H. R. N. (2007). Animais de laboratório: o camundongo. Rev Ciênc Farm Básica Apl., 28(1), 11-23.

Costa, P. (2012). A memória e a sua influência no processo de aprendizagem. https://www.webartigos.com/artigos/a-memoria-e-a-sua-influencia-no-processo-de-aprendizagem/83381/.

Diehl, F. (2010). Plasticidade de receptores colinérgicos muscarínicos M4 hipocampais decorrente de uma consolidação da memória com o possível marcador sináptico do engrama: ensaios farmacológico-comportamentais [tese]. Porto Alegre, Universidade Federal do Rio Grande do Sul.

Faria, R. S., Sartori, C. R., Canova, F., Ferrari, E. A. M. (2013). Classical aversive conditioning induces increased expression of mature-BDNF in the hippocampus and amygdala of pigeons. Neuroscience, 26, 122-133.

Faria, R. S., Bereta, A. L. B., Reis, G. H. T., dos Santos, L. B. B., Pereira, M. S. D. G., Cortez, P. J. O., et al (2018). Effects of the swimming exercise on the extinction of fear memory in rats. Journal of Neurophysiology, 120(5), 2649-2653.

Goldstein, R. B., Smith, S. M., Chou, S. P., et al (2016). The epidemiology of DSM-5 posttraumatic stress disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Soc Psychiatry Psychiatr Epidemiol, 51, 1137.

Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., & EhrlichI, L. A. (2010). Neuronal circuits off ear extinction. Eur J Neurosci, 31(4), 599-612.

Inda, M. C., Delgado-García, J. M., & Carrión, A. M. (2005). Acquisition, consolidation, reconsolidation, and extinction of eyelid conditioning responses require de novo protein synthesis. J. Neurosci, 25(8), 2070 –2080.

Izquierdo, I. (1989). Memórias. Estud. av., 3(6), 89-112.

Izquierdo, I., & Medina, J. H. (1993). Role of the amygdala, hippocampus and entorhinal cortex in memory consolidation and expression. Braz J Med Biol Res., 26(6), 573-589.

Izquierdo, I. A., Myskiw, J. C., Benetti, F., & Furini, C. R. G. (2013). Mémoria: tipos e mecanismos – achados recentes. Revista USP, (98), 9-16.

Kessler, R. C., Berglund, P., Demler, O., et al (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry, (62), 593.

Kessler, R. C., Chiu, W. T., Demler, O., et al (2005). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry, (62), 617.

Kim, J. J., Fanselow, M. S. (1992). Modality-specific retrograde amnesia of fear. Science, 256(5057), 675-7.

Koenen, K. C., Ratanatharathorn, A., N. L., et al. (2017). Posttraumatic stress disorder in the World Mental Health Surveys. Psychol Med, (47), 2260.

Maren, S., & Holmes, A. (2016). Stress and Fear Extinction. Neuropsychopharmacol, 41(1), 58–79.

Matsuda, S., Matsuzawa, D., Ishii, D., Tomizawa, H., & Shimizu, E. (2014). Effects of memory age and interval of fear extinction sessions on contextual fear extinction. Neurosci Lett., (5780, 139-423.

Meng, B., Zhu, S., Li, S., Zeng, Q., & Mei, B. (2009). Global view of the mechanisms of improved learning and memory capability in mice with music-exposure by microarray. Brain Res Bull., 80(1-2), 36-44.

Pant, U., Frishkopf, M., Park, T., Norris, C. M., & Papathanassoglou, E. (2022). A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors. Int J Environ Res Public Health., 19(5), 3113.

Parker, A. M., Sricharoenchai, T., Raparla, S., et al (2015). Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med., (43), 1121.

Quirk, G. J. (2002). Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery. Learning & Memory., 9(6), 402-407.

Rauscher, F., Robinson, D., & Jens, J. (1998). Improved maze learning through early music exposure in rats. Neurol Res., 20(5), 427- 432.

Sanyal, T., Kumar, V., Nag, T. C., Jain, S., Sreenivas, V., & Wadhwa, S. (2013). Prenatal Loud Music and Noise: Differential Impact on Physiological Arousal, Hippocampal Synaptogenesis and Spatial Behavior in One Day-Old Chicks. Rogers LJ, ed. PLoS ONE, 8 (7).

Sareen, J. (2022). Posttraumatic stress disorder in adults: Epidemiology, pathophysiology, clinical manifestations, course, assessment, and diagnosis. https://www.uptodate.com/contents/posttraumatic-stress-disorder-in-adults-epidemiology-pathophysiology-clinical-manifestations-course-assessment-and-diagnosis?search=transtorno%20de%20estresse%20p%C3%B3s-traum%C3%A1tico&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H1824470698.

Van Ameringen, M., Mancini, C., Patterson, B., Boyle, M. H. (2008). Post-traumatic stress disorder in Canada. CNS Neurosci Ther., (14), 171.

Xing, Y., Qin, Y., Jing, W., Zhang, Y., Wang, Y., Guo, D. (2016). Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats. Cogn Neurodyn., 10 (1), 23-30.

Xing, Y., Xia, Y., Kendrick, K., Liu, X., Wang, M., Wu, D., et al (2016). Mozart, Mozart Rhythm and Retrograde Mozart Effects: Evidences from Behaviours and Neurobiology Bases. Sci Rep., (6), 18744.

Published

29/10/2022

How to Cite

CARDOSO, J. P. G. A. .; FERNANDES, F. T. .; TRZESNIAK, C.; FARIA, R. S. de . Research on the relationship between Mozart’s Sonata K448 and the extinction of fear of sound memory. Research, Society and Development, [S. l.], v. 11, n. 14, p. e347111436379, 2022. DOI: 10.33448/rsd-v11i14.36379. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36379. Acesso em: 18 apr. 2024.

Issue

Section

Health Sciences