Skeletal muscle mass in gastroesophageal cancer and associated factors

Authors

DOI:

https://doi.org/10.33448/rsd-v12i3.40316

Keywords:

Skeletal Muscle; Body Composition; Stomach Neoplasms; Esophageal Neoplasms; Sarcopenia.

Abstract

Purpose: The aim of this study was to estimate skeletal muscle mass in patients with gastroesophageal cancer. Methods: A cross-sectional study was conducted with male and female patients with gastroesophageal cancer in treatment at the Pernambuco Cancer Hospital in 2015. Data on socioeconomic, lifestyle, clinical, eating and anthropometric [body mass index (BMI) characteristics as well as percentage of weight loss (%WL)] were evaluated. Skeletal muscle mass (SMM) and the muscle mass index (MMI) were calculated. Results: One hundred patients participated in the study (62% male; mean age: 58.30 ± 10.90 years). Gastric cancer was more prevalent (61%), followed by esophageal cancer (24%). Based on the BMI, 30% were underweight and 71% had a severe %WL. SMM was 22.69 ± 6.02 kg, which is lower than that of healthy adults and elderly individuals. SMM was low in elderly individuals, females, those who did not use alcohol and those with a low BMI. Type of cancer was not associated with either SMM or the MMI. Conclusion: In the sample studied, skeletal muscle mass was lower than that found in healthy adults and elderly individuals and was associated with anthropometric variables, sex, age and lifestyle. A high rate of malnutrition was found, as evidenced by the percentage of weight loss.

References

Alexandre, T.da S., Duarte, Y. A., Santos, J. L., Wong, R., & Lebrão, M. L. (2014). Prevalence and associated factors of sarcopenia among elderly in Brazil: findings from the SABE study. The journal of nutrition, health & aging, 18(3), 284–290.

American Diabetes Association and American Heart Association. (2007). Primary prevention of cardiovascular disease in people with diabetes mellitus. Diabetes Care. 30, 162-72.

Awad, S., Tan, B. H., Cui, H., Bhalla, A., Fearon, K. C., Parsons, S. L., Catton, J. A., & Lobo, D. N. (2012). Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clinical nutrition. 31(1), 74–77.

Azevedo, I. G., Carneiro, I. C. L. M., Tomiya, M. T. O., & Burgos, M. G. P. A. (2015). Gastric cancer and associated factors in hospitalized patients. Nutricion hospitalaria, 32(1), 283–290.

Blackburn, G. L., Bristian, B. R., Maini, B.S., Schlamm, H. T., & Smith, M. F. (1977). Nutritional and metabolic assessment of the hospitalized patient. Journal of Parenteral and Enteral Nutrition. 1, 11-22.

Boer, R. B., Jones, K. I., Ash, S., Boxel, G. I., Gillies, R. S., et al. (2020). Impact on postoperative complications of changes in skeletal muscle mass during neoadjuvant chemotherapy for gastro-oesophageal cancer. BJS Open. 4(5), 847-854.

Carvalho, J. B., Salgado, N. A., Silva, A. C. M., Ramos, E. M. L. S., Demachki, S., & Araújo, M. S. (2011). Fatores de risco socioambientais e nutricionais envolvidos na carcinogênese gástrica. Revista Paraense de Medicina. 25(2).

Chen, Y., Chaohui, Y., & Youming, L. (2014). Physical activity and risks of esophageal and gastric cancers: a meta-analysis. PLoS ONE. 2014;9(2): e88082. 10.1371/journal.pone.0088082.

Firme, L.E., & Gallon, C .W. (2010). Perfil nutricional de pacientes com carcinoma esofágico de um hospital público de Caxias do Sul. Revista Brasileira de Cancerologia. 56(4), 443-51.

Fukuda, Y., Yamamoto, K., Hirao, M., Nishikawa, K., Nagatsuma, Y., Nakayama, T., et al. (2015). Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy. Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 19(3), 986–993

Gobbo, L. A., Cyrino, E. S., Petroski, E. L., Cardoso, J. R., Carvalho, F. O., Romanzini, M., et al. (2008). Validação de equações antropométricas para a estimativa da massa muscular por meio de absortometria radiológica de dupla energia em universitários do sexo masculino. Revista Brasileira de Medicina do Esporte. 14(4), 376-80.

Gonzalez, M. C., Pastore, C. A., Orlandi, S. P., & Heymsfield, S. B. (2014). Obesity paradox in cancer: new insights provided by body composition. The American Journal of Clinical Nutrition. 99, 999-05.

Hill A., Kiss, N., Hodgson, B., Crowe, T. C., & Walsh, A. D. (2011) Associations between nutritional status, weight loss, radiotherapy treatment toxicity and treatment outcomes in gastrointestinal cancer patients. Clinical Nutrition. 30(1), 92-8.

INCA. Instituto Nacional de Câncer José Alencar Gomes da Silva (Brasil). Estimativa 2014: incidência de câncer no Brasil. Rio de Janeiro: INCA, 2014.

Järvinen, T., Ilonen, I., Kauppi, J., Salo, J., & Räsänen, J. (2018). Loss of skeletal muscle mass during neoadjuvant treatments correlates with worse prognosis in esophageal cancer: a retrospective cohort study. World journal of surgical oncology, 16(1), 27.

Ko, K-P., Park, S. K., Yang, J. J., Ma, S. H., Gwack, J., Shin, A., et al. (2013). Intake of soy products and other foods and gastric cancer risk: a prospective study. Journal of Epidemiology. 23(5), 337-43.

Laviano, A., Meguid, M. M., Preziosa, I., & Fanelli, F. R. (2007). Oxidative stress and wasting in cancer. Current Opinion in Clinical Nutrition & Metabolic Care. 10, 449-456.

Lee, R. C., Wang, Z., Heo, M., Ross, R., Janssen, I., & Heymsfield, S. B. (2000). Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. American Journal of Clinical Nutrition. 72, 796-803.

Lipschitz, D.A. (1994). Screening for nutritional status in the elderly. Primary care. 1994;21:55-67.

Magalhaes, L. P., Oshima, C. T. F., Souza, L. G., Lima, J. M., Carvalho, L., & Forones, N. M. (2008). Variação de peso, grau de escolaridade, saneamento básico, etilismo, tabagismo e hábito alimentar pregresso em pacientes com câncer de estômago. Arquivos de Gastroenterologia. 45, 111-6.

Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J.M., Biolo, G., et al. (2010). Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clinical Nutrition. 29(2), 154-9.

Oliveira, F. L., Vieira, R. F. F. A., Melhem, A. R. F., Schiessel, D. L., Franco, S., & Cavagnar, M. A. V. (2020). Métodos para avaliação da sarcopenia em pacientes hospitalizados com câncer do trato gastrointestinal. Braspen Journal. 35(4), 371-6.

Pinto, C. E., Fernandes, D., Accetta, A. C., Almeida, H. I. B., & Zanatto, R.M (2013). Câncer do Esôfago. Em: Figueiredo, E.M.A., Correia, M.M., Oliveira, A.F., coordenadores. Tratado de oncologia. Revinter; 2013. p.775.

Rech, C. R., Dellagrana, R. A., Marucci, M. F. N., & Petroski, E. L. (2012). Validade de equações antropométricas para estimar a massa muscular em idosos. Rev Bras Cineantr Desem Hum. 14(1), 23-31.

Rêgo, M. A.V., & Fonseca, A. A. (2014). Tendência da Mortalidade por Câncer de Esôfago na Cidade de Salvador e no Estado da Bahia, Brasil, 1980 a 2012. Revista Brasileira de Cancerologia. 60(1), 25-33.

Silva, M.A.D., Sousa, A.G.M.R, & Schargodsky, H. (1998). Fatores de risco para infarto do miocárdio no Brasil: Estudo FRICAS. Arquivos Brasileiros de Cardiolog ia. 71(5):667-75.

Tan, B. H. L., Brammer, K., Randhawa, N., Welch, N. T., Parsons, S. L., James, E. J., et al. (2015). Sarcopenia is associated with toxicity in patients undergoing neo-adjuvant chemotherapy for oesophago-gastric cancer. European Journal of Surgical Oncology. 41, 333-8.

World Health Organization. Physical status: the use and interpretation of anthropometry. Geneva: World Health Organization 1997;p.6-29.

Downloads

Published

17/02/2023

How to Cite

SANTOS, E. C. M. dos .; LEAL, I. C. .; CALADO, C. K. M. .; SILVA, J. J. da .; BURGOS, M. G. P. de A. . Skeletal muscle mass in gastroesophageal cancer and associated factors. Research, Society and Development, [S. l.], v. 12, n. 3, p. e1212340316, 2023. DOI: 10.33448/rsd-v12i3.40316. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40316. Acesso em: 26 nov. 2024.

Issue

Vol. 12 No. 3

Section

Health Sciences

License

Copyright (c) 2023 Eveline Cássia Meira dos Santos; Isabel Cristina Leal; Cinthia Katiane Martins Calado; Josimário João da Silva; Maria Goretti Pessoa de Araújo Burgos

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.