Headache due to overuse of analgesics in medical students at a private college
DOI:
https://doi.org/10.33448/rsd-v12i5.41472Keywords:
Headache; Student; Self-medication.Abstract
Medication overuse headache (MEC) is a chronic secondary health condition, occurring on 15 or more days per month, attributed to frequent or regular use of analgesics or acute anti-migraine medications in patients with primary headache. Prolonged medication use can be seen as a lack of adequate coping skills, including insufficient ability to cope with pain. The excessive consumption of these drugs among university students has been a major concern for public health. Based on this, the proposed objectives consisted of analyzing the incidence of headache due to excessive use of analgesics in medical students at a private university in Teresina, Piauí, identifying possible predisposing factors in this group of students. To this end, a cross-sectional, quantitative, exploratory and descriptive study was carried out. Data collection included 324 students, from the 1st to the 12th period of the course. The responses received to the questionnaire were recorded and analyzed using a Microsoft Excel spreadsheet. Based on the results obtained, there was a high percentage of students who make excessive and indiscriminate use of medication for headache (simple analgesics 71.29%, NSAIDs – 23.46%, other medications - 3.09% and opioids – 2 .16%). The immediate relief of symptoms has been the main cause of MEC, due to the cognitive and social impairment that pain can cause, however, such practice reflects in long-term effects, aggravating the condition. In view of this, it is important to carry out more research in order to explore the incidence of headache due to excessive use of analgesics among students.
References
Alshogran, O. Y. (2018). Patterns of self-medication among medical and nonmedical University students in Jordan. Risk Management and Healthcare Policy, 169–176.
Argyriou, A. A. (2021). Uma breve visão geral atualizada sobre cefaléia pós-traumática e uma revisão sistemática das intervenções não farmacológicas para seu manejo. Expert Review of Neurotherapeutics, 4, 475–490.
Carlsen, L. (2020). Comparison of 3 treatment strategies for medication overuse headache: a randomized clinical trial. JAMA neurology, 9, 1069–1078.
Carneiro, E. G. V., Melo, M. G. R., Fachin, L. P., & Bastos, M. C. (2021). Cefaleia por uso excessivo de medicamentos entre os estudantes de medicina. Revista Eletrônica Acervo Saúde, 13(1), e5401. https://doi.org/10.25248/reas.e5401.2021
Cevoli, S., Giannini, G., Favoni, V., Terlizzi, R., Sancisi, E., Nicodemo, M., Zanigni, S., Bacchi Reggiani, M. L., Pierangeli, G., & Cortelli, P. (2017). Treatment of withdrawal headache in patients with medication overuse headache: a pilot study. The Journal of Headache and Pain, 18(1). https://doi.org/10.1186/s10194-017-0763-9
Chen, P.-K., & Wang, S.-J. (2019). Medication overuse and medication overuse headache: Risk factors, comorbidities, associated burdens and nonpharmacologic and pharmacologic treatment approaches. Current Pain and Headache Reports, 23(8), 60. https://doi.org/10.1007/s11916-019-0796-7
Curone, M. (2022). Overview on effectiveness of erenumab, fremanezumab, and galcanezumab in reducing medication overuse headache in chronic migraine patients. Neurological Sciences, 9, 5759–5761.
Diener, H.-C. (2020). European Academy of Neurology guideline on the management of medication-overuse headache. European journal of neurology, 7, 1102–1116.
Diener, H.-C. (2019). Pathophysiology, prevention, and treatment of medication overuse headache. The Lancet Neurology, 18, 891–902.
Diener, H.-C., Donoghue, S., Gaul, C., Holle-Lee, D., Jöckel, K.-H., Mian, A., Schröder, B., & Kühl, T. (2022). Prevention of medication overuse and medication overuse headache in patients with migraine: a randomized, controlled, parallel, allocation-blinded, multicenter, prospective trial using a mobile software application. Trials, 23(1), 382. https://doi.org/10.1186/s13063-022-06329-2
Tabeeva, G. R., Osipova, V. V., Filatova, E. G., Azimova, Y. E., Amelin, A. V., Artyomenko, A. R., Vorobyeva, Y. D., Ekusheva, E. V., Koreshkina, M. I., Lebedeva, E. R., Latysheva, N. V., Naprienko, M. V., Sergeev, A. V., Skorobogatykh, K. V., Golovacheva, V. A., Rachin, A. P., & Parfenov, V. A. (2022). Evaluation and treatment of medication-overuse headache: Russian experts’ guidelines. Neurology neuropsychiatry Psychosomatics, 14(1), 4–13. https://doi.org/10.14412/2074-2711-2022-1-4-13
Grazzi, L., Sansone, E., Raggi, A., D’Amico, D., De Giorgio, A., Leonardi, M., De Torres, L., Salgado-García, F., & Andrasik, F. (2017). Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up. The Journal of Headache and Pain, 18(1). https://doi.org/10.1186/s10194-017-0728-z
The International Classification of Headache Disorders. (2018). Headache Classification Committee Of The International Headache Society (IHS), 38, 1–211.
Ibrahim, N. (2017). Prevalence, predictors and triggers of migraine headache among medical students and interns in King Abdulaziz University, Jeddah, Saudi Arabia. Pakistan Journal of Medical Sciences, 33(2), 270–275.
Ioannis-Alexios, & Dimos, D. (2022). Therapies targeting CGRP signaling for medication overuse headache. Current Opinion in Neurology, 353–359.
Kopruszinski, C. (2017). Prevention of stress-or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. Cephalalgia, 6, 560–570.
Krymchantowski, A. V. (2020). Medication overuse headache: an overview of clinical aspects, mechanisms, and treatments. Expert Review of Neurotherapeutics, 20, 591–600.
Kulkarni, G. (2021). Medication overuse headache. Neurology India, 7.
Lagman-Bartolome, A., Marissa, Valerie, & Lay, C. (2018). Headache Education Active-Waiting Directive: A Program to Enhance Well-Being During Long Referral Wait Times. Headache: The Journal of Head and Face Pain. 109–117
Lundqvist, C. (2019). Severity of analgesic dependence and medication-overuse headache. Journal of Addiction Medicine, 5.
Mose, L. (2022). Use of coping strategies in the management of medication overuse headache. Patient Education and Counseling, 2, 390–397.
Munksgaard, S. B., Madsen, S. K., & Wienecke, T. (2019). Treatment of medication overuse headache-a review. Acta Neurologica Scandinavica, 5, 405–414.
Nacazume, J. (2019). Tratamento e profilaxia de enxaqueca no Brasil: cenário atual e novas perspectivas.
Nation, K. M. (2019). Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia, 5, 617–625.
Pereira, AS, Shitsuka, DM, Parreira, FJ, & Shitsuka, R. (2018). Metodologia da Pesquisa Científica.
Pijpers, J. A. (2018). Medication-overuse headache. Nederlands Tijdschrift Voor Geneeskunde, 162, D1749–D1749.
Pijpers, J. A. (2019). Acute withdrawal and botulinum toxin A in chronic migraine with medication overuse: a double-blind randomized controlled trial. Brain, 5, 1203–1214.
Russell, M. (2019). Epidemiology and management of medication-overuse headache in the general population. Neurological Sciences, 1, 23–26.
Santos, P., Miranda, Janaína, & Gomides, L. (2021). Mindfulness na terapia complementar da cefaleia. Journal of Applied Pharmaceutical Sciences, 7, 77–88.
Schwedt, T. J. (2018). Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study. The journal of headache and pain, 1–9.
Solomon, S. & Fraccaro, S. (1991). O livro da dor de cabeça. União da United Inc. Yonkers.
Sun-Edelstein, C. (2021). The evolution of medication overuse headache: history, pathophysiology and clinical update. CNS drugs, 5, 545–565.
Tarley, M. G. (2018). Estudo comparativo do uso da automedicação entre universitários da área da saúde e universitários de outras áreas não relacionados à saúde na universidade de Marília-SP. Brazilian Journal of Surgery and Clinical Research, 1, 22–27.
Vong, S., Kei, Lifeng, & Stephen, R. (2022). Consumers’ self-reported adherence to directions for non-prescription medicines and the role of risk perception. Research in Social and Administrative Pharmacy, 3929–3938.
Wakerley, B. R. (2019). Medication-overuse headache. Practical neurology, 5, 399–403.
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