Medicinais plants in anti-aging: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i5.41813

Keywords:

Phytotherapy; Skin aging; Plants medicinal.

Abstract

Aging occurs due to a cellular functional decline related to intrinsic and extrinsic factors, causing changes in genetic material, an increase in reactive oxygen species, destruction of elastic fibers and collagen, resulting in the characteristic phenotype of aging in terms of dermatology. Therefore, phytotherapy consists of using plants for medicinal purposes, which are studied and used to attenuate the effects of aging, reducing this phenotype and molecular alterations. Thus, the present study aimed to investigate scientific literature regarding the relationship between medicinal plants and aging. The descriptors "Skin Aging," "Medicinal Plants," and "Phytotherapy" were used in the Virtual Health Library, using MEDLINE and LILACS. Twelve articles composed the final sample and brought beneficial results about the use of medicinal plants during the aging process. Through in vitro and in vivo studies, it was demonstrated that certain plants can improve skin appearance, reduce oxidative stress, improve the disposition of matrix proteins, among others. Finally, it is concluded that the application of medicinal plants Acan be an important tool in combating oxidative stress, reducing DNA damage, and biochemical reactions that lead to accelerated skin aging.

References

Alves, G. de A. D., Oliveira de Souza, R., Ghislain Rogez, H. L., Masaki, H., & Fonseca, M. J. V. (2019). Cecropia obtusa extract and chlorogenic acid exhibit anti aging effect in human fibroblasts and keratinocytes cells exposed to UV radiation. PloS One, 14(5), e0216501. https://doi.org/10.1371/journal.pone.0216501

Aryal, S., Baniya, M. K., Danekhu, K., Kunwar, P., Gurung, R., & Koirala, N. (2019). Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal. Plants, 8(4), 96. https://doi.org/10.3390/plants8040096

Boran, R. (2018). Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations. Industrial Crops and Products, 118, 290–295. https://doi.org/10.1016/j.indcrop.2018.03.058

Choi, S. Y., Hong, J. Y., Ko, E. J., Kim, B. J., Hong, S.-W., Lim, M. H., Yeon, S. H., & Son, R. H. (2018). Protective effects of fermented honeybush (Cyclopia intermedia) extract (HU-018) against skin aging: a randomized, double-blinded, placebo-controlled study. Journal of Cosmetic and Laser Therapy, 20(5), 313–318. https://doi.org/10.1080/14764172.2017.1418512

de Lima Silva, E., Danúbia da Silva, M., & Cesar Lima de Vasconcelos, T. (2 C.E., July). Uso do extrato de sementes de uva e suas implicações no processo de envelhecimento da pele [Review of Uso do extrato de sementes de uva e suas implicações no processo de envelhecimento da pele]. Research, Society and Development. doi: https://doi.org/10.33448/rsd-v11i9.31357

Duan, Y., Xiang, Y., Chu, J., Lin, X., He, M., Zhang, C., Sun, S., & Huang, L. (2023). Handelin Reduces Ultraviolet A-Induced Photoaging by Inhibiting Reactive Oxygen Species Generation and Enhancing Autophagy. The Tohoku Journal of Experimental Medicine, 259(3), 189–198. https://doi.org/10.1620/tjem.2022.j108

Fitsiou, E., Pulido, T., Campisi, J., Alimirah, F., & Demaria, M. (2020). Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2020.09.031

Gu, Y., Han, J., Jiang, C., & Zhang, Y. (2020). Biomarkers, oxidative stress and autophagy in skin aging. Ageing Research Reviews, 59, 101036. https://doi.org/10.1016/j.arr.2020.101036

Guo, K., Liu, R., Jing, R., Wang, L., Li, X., Zhang, K., Fu, M., Ye, J., Hu, Z., Zhao, W., & Xu, N. (2022). Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis. Frontiers in Pharmacology, 13, 1036013. https://doi.org/10.3389/fphar.2022.1036013

Ibrahim, N., Abbas, H., El-Sayed, N. S., & Gad, H. A. (2022). Rosmarinus officinalis L. hexane extract: phytochemical analysis, nanoencapsulation, and in silico, in vitro, and in vivo anti-photoaging potential evaluation. Scientific Reports, 12(1), 13102. https://doi.org/10.1038/s41598-022-16592-7

Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Ma’at, & Matsunami, K. (2018). Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition. Journal of Ethnopharmacology, 225, 64–70. https://doi.org/10.1016/j.jep.2018.06.038

Ikehata, H., & Yamamoto, M. (2018). Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation. Toxicology and Applied Pharmacology, 360, 69–77. https://doi.org/10.1016/j.taap.2018.09.038

Kalyana Sundaram, I., Sarangi, D. D., Sundararajan, V., George, S., & Sheik Mohideen, S. (2018). Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging. BMC Complementary and Alternative Medicine, 18(1). https://doi.org/10.1186/s12906-018-2097-9

Khare, R., Upmanyu, N., & Jha, M. (2019). Exploring the potential effect of Methanolic extract of Salvia officinalis against UV exposed skin aging: In vivo and In vitro model. Current Aging Science, 12. https://doi.org/10.2174/1874609812666190808140549

Kim, J.-E., Jang, S.-G., Lee, C. H., Lee, J. Y., Park, H., Kim, J. H., Lee, S., Kim, S. H., Park, E.-Y., Lee, K. W., & Shin, H.-S. (2019). Beneficial effects on skin health using polysaccharides from red ginseng by-product. Journal of Food Biochemistry, 43(8), e12961. https://doi.org/10.1111/jfbc.12961

Kuan, C.-M., Liang, C.-H., Chuang, W.-H., Lin, T.-Y., & Hsu, P.-K. (2022). Ameliorating Effect of Crassocephalum rabens (Asteraceae) Extract on Skin Aging: A Randomized, Parallel, Double-Blind, and Placebo-Controlled Study. Nutrients, 14(13), 2655. https://doi.org/10.3390/nu14132655

Lee, H., Kim, S.-Y., Lee, S. W., Kwak, S., Li, H., Piao, R., Park, H.-Y., Choi, S., & Jeong, T.-S. (2022). Amentoflavone-Enriched Selaginella rossii Protects against Ultraviolet- and Oxidative Stress-Induced Aging in Skin Cells. Life, 12(12), 2106. https://doi.org/10.3390/life12122106

Lee, H. P., Kim, D. S., Park, S. H., Shin, C. Y., Woo, J. J., Kim, J. W., An, R.-B., Lee, C., & Cho, J. Y. (2022). Antioxidant Capacity of Potentilla paradoxa Nutt. and Its Beneficial Effects Related to Anti-Aging in HaCaT and B16F10 Cells. Plants (Basel, Switzerland), 11(7), 873. https://doi.org/10.3390/plants11070873

Li, G.-H., Li, Y.-R., Jiao, P., Zhao, Y., Hu, H.-X., Lou, H.-X., & Shen, T. (2018). Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action. Oxidative Medicine and Cellular Longevity, 2018, 7309073. https://doi.org/10.1155/2018/7309073

Maria Leal Soares, C. (n.d.). Plantas medicinais com potencial anti-idade: uma revisão de literatura (A. Lima Rosa Mendes & A. Gomes Coêlho, Eds.) [Review of Plantas medicinais com potencial anti-idade: uma revisão de literatura]. Revista de Casos e Consultoria.

Mendes, K. D. S., Silveira, R. C. de C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto Enferm, 758–764. https://pesquisa.bvsalud.org/portal/resource/pt/lil-507765

Myung, D.-B., Lee, J.-H., Han, H.-S., Lee, K.-Y., Ahn, H. S., Shin, Y.-K., Song, E., Kim, B.-H., Lee, K. H., Lee, S. H., & Lee, K.-T. (2020). Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients, 12(6), 1588. https://doi.org/10.3390/nu12061588

Nam, G., Kawk, H. W., Kim, S., & Kim, Y. (2020). Solvent fractions of fermented Trapa japonica fruit extract stimulate collagen synthesis through TGF‐β1/GSK‐3β/β‐catenin pathway in human dermal fibroblasts. Journal of Cosmetic Dermatology, 19(1), 226–233. https://doi.org/10.1111/jocd.13253

Oh, S., Zheng, S., Fang, M., Kim, M., Bellere, A. D., Jeong, J., & Yi, T.-H. (2023). Anti-Photoaging Effect of Phaseolus angularis L. Extract on UVB-Exposed HaCaT Keratinocytes and Possibilities as Cosmetic Materials. Molecules (Basel, Switzerland), 28(3), 1407. https://doi.org/10.3390/molecules28031407

Guimarães Rodrigues, F., Luis de Oliveira , J., & Manzini, F. (10 C.E., June). O uso das plantas medicinais no tratamento de situações odontológicas comuns na atenção primária à saúde [Review of O uso das plantas medicinais no tratamento de situações odontológicas comuns na atenção primária à saúde]. Research, Society and Development.

Sandhya Kumari, T. D., & Singara Charya, M. A. (1 C.E., April). PHYTOCHEMISTRY, ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITIES OF SOLVENT LEAF EXTRACTS OF NYCTANTHES ARBOR – TRISTIS [Review of PHYTOCHEMISTRY, ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITIES OF SOLVENT LEAF EXTRACTS OF NYCTANTHES ARBOR – TRISTIS]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH. doi: 10.13040/IJPSR.0975-8232.8(4).1654-63

Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019). Molecular Mechanisms of Dermal Aging and Antiaging Approaches. International Journal of Molecular Sciences, 20(9). https://doi.org/10.3390/ijms20092126

Soleymani, S., Iranpanah, A., Najafi, F., Belwal, T., Ramola, S., Abbasabadi, Z., Momtaz, S., & Farzaei, M. H. (2019). Implications of grape extract and its nanoformulated bioactive agent resveratrol against skin disorders. Archives of Dermatological Research, 311(8), 577–588. https://doi.org/10.1007/s00403-019-01930-z

Published

24/05/2023

How to Cite

SILVA, J. A. B. da .; ASSUNÇÃO, M. F. de .; VASCONCELOS, T. C. L. . Medicinais plants in anti-aging: an integrative review. Research, Society and Development, [S. l.], v. 12, n. 5, p. e23612541813, 2023. DOI: 10.33448/rsd-v12i5.41813. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41813. Acesso em: 21 nov. 2024.

Issue

Section

Review Article