Leydig cell tumor of the ovary: A case report
DOI:
https://doi.org/10.33448/rsd-v12i9.43172Keywords:
Leydig Cell Tumor; Ovarian neoplasms; Virilism; Hyperandrogenism; Hirsutism; Hirsutism.Abstract
Leydig cell tumors of the ovary are classified as benign androgen-secreting neoplasms, which are often related to complaints of virilization in postmenopausal women. However, they represent less than 0.5% of all ovarian tumors and, because of this, their diagnostic description and management are still scarce. The present study aims to contribute to the understanding of the pathology and gather tools to improve care, diagnosis, conduct and contribute to the theoretical collection, introducing debates on its theory and medical conduct, progressing in the quality of care, emergence of hypotheses and adequate management and frame early. We present the case of a patient, female, 34 years old, with complaints of amenorrhea, alopecia, increased libido, deep voice, hirsutism and clitoral hypertrophy. Together, the laboratory evaluation with high levels of total testosterone associated with Magnetic Resonance with oval nodular formation in the left adnexal region, led to surgical treatment. Thus, the patient underwent left salpingo-oophorectomy, which led to the histopathological result in question.
References
Brown, J. G. (2011). Sex cord-stromal tumors. Rare and uncommon gynecological cancers: a clinical guide. New York: Springer, 7, 113-130.
Chambô Filho, A., Scárdua, E. F., Cintra, L. C., Guzzo, T. C., Martinelli, T., Gonçalves, L. D., & Pratti, D. (2008). Tumor Ovariano de Células de Leydig Puro. Revista Brasileira de Cancerologia, 54(3), 245–250. https://doi.org/10.32635/2176-9745.rbc.2008v54n3.1722
Crowe, S., Cresswell, K., Robertson, A., Huby, G., Avery, A. & Sheikh, A. (2011). The case study approach. BMC Medical Research Methodology, 11(100). https://doi.org/10.1186/1471-2288-11-100
Dickerson, R. D., Putman, M. J., Black, M. E., Pinto, K., Diamond, N. G., Marynick, S. P., & Pinto, A. (2005). Selective ovarian vein sampling to localize a Leydig cell tumor. Fertility and Sterility, 84(1), 218–218. https://doi.org/10.1016/j.fertnstert.2004.12.055
Fernandes, C. E., Rennó Jr., J., Nahas, E. A. P., Melo, N. R. de, Ferreira, J. A. de S., Machado, R. B., & Peixoto, S. (2006). Síndrome de insuficiência androgênica: critérios diagnósticos e terapêuticos. Archives of Clinical Psychiatry (São Paulo), 33, 152–161. https://doi.org/10.1590/S0101-60832006000300005
Fracasso, L. B., Morais, N., Muller, T., Audibert, R., Gomez, B. Appel, M., & Magno, V. A. (2016). Tumor de células de Leydig do ovário associado a virilização em paciente na pós-menopausa. Clinical and Biomedical Research, 36(3). https://www.seer.ufrgs.br/index.php/hcpa/article/view/64517
Gershenson, D. M. (2005). Fertility-Sparing Surgery for Malignancies in Women. Journal of the National Cancer Institute Monographs, 2005(34), 43–47. https://doi.org/10.1093/jncimonographs/lgi011
Gershenson, D. M., Hartmann, L. C. & Young, R. H. (2009). Ovarian sex cord-stromal tumors. Principles and practice of gynecologic oncology, 5, 855-874.
Hall, J. E., & Guyton, A. C. (2011). Tratado de fisiología médica: Guyton & Hall (12th ed.). Elsevier, Cop.
Lantzsch, T., Stoerer, S., Lawrenz, K., Buchmann, J., Strauss, H.-G., & Koelbl, H. (2001). Sertoli-Leydig cell tumor. Archives of Gynecology and Obstetrics, 264(4), 206–208. https://doi.org/10.1007/s004040000114
López, A., Francisco, R., Peraza, J., Directores, G., Profesor, Luis, J., Juan, C., & Falcón, A. (2020). Trabajo de Fin de Grado Las células de Leydig del ovario Autores. https://riull.ull.es/xmlui/bitstream/handle/915/19417/Las%20celulas%20de%20Leydig%20del%20ovario.pdf?sequence=1&isAllowed=y
Mandieta, L., Hérnandez, M. E., Sosa, C. & Russi, L. (2022). Tumor de Sertoli – Leydig del Ovario – Reporte de un caso clínico. Archivos de Ginecología y Obstetricia, 60(2), 129-136.
Molina, P. E., & Paolo Beck-Peccoz. (2014). Fisiologia endocrina. Mc-Graw-Hill Libri Italia.
Nunes, C., Barros, J., Henriques, A., Ribeirinho, A. L., & Lourenço, A. V. (2015). Hiperandrogenismo por tumor de Leydig do ovário produtor de testosterona. Revista Portuguesa de Endocrinologia, Diabetes E Metabolismo, 10(1), 18–20. https://doi.org/10.1016/j.rpedm.2014.07.004
Paula, L. C. P. de, Zen, V. L., & Czepielewski, M. A. (2005). Puberdade precoce associada a tumor misto ovariano (células germinativas- estroma-cordão sexual): aspectos clínicos, diagnósticos e manejo de um caso. Arquivos Brasileiros de Endocrinologia & Metabologia, 49(5), 776–783. https://doi.org/10.1590/s0004-27302005000500018
Powell, J. L., Dulaney, D. P., & Shiro, B. C. (2000). Androgen-Secreting Steroid Cell Tumor of the Ovary*. Southern Medical Journal, 93(12), 1201–1204. https://doi.org/10.1097/00007611-200012000-00012
Roth, L. S. W. (1995). Sex cord stromal tumors of the ovary. Haines and Taylor obstetrical and gynaecological pathology, 4, 823.
Serov, S. F., Sobin, L. H., & Scully, R. E. (2013). Histological Typing of Ovarian Tumours in collaboration with. http://apps.who.int/iris/bitstream/10665/41529/1/a28749_eng.pdf
Simões, T., & Guerra, C. (2011). Tumores raros do ovário. http://www.fspog.com/fotos/editor2/cap_25.pdf
Souto, S. B., Baptista, P. V., Braga, D. C., & Carvalho, D. (2014). Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism. Arquivos Brasileiros de Endocrinologia & Metabologia, 58(1), 68–75. https://doi.org/10.1590/0004-2730000002461
Toribio- Membreño, I., Gutiérrez- Miranda, M. R., & Mora- Calderón, A. (2004). Tumor masculinizante de ovario (a propósito de un caso). Acta Médica Costarricense, 46(4), 201–203. https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0001-60022004000400009&lang=pt
Yarak, S., Bagatin, E., Hassun, K., Odete, M., Brasil Parada, A., & Filho, S. (2005). Hiperandrogenismo e pele: síndrome do ovário policístico e resistência periférica à insulina * Hyperandrogenism and skin: polycystic ovary syndrome and peripheral insulin resistance * Artigo de Revisão. An Bras Dermatol, 80(4), 395–410. https://www.scielo.br/j/abd/a/qqSTZ9JDB8bgBjHtsNhSNvB/?format=pdf&lang=pt
Young, R. H. & Shully, R. E. (2003). Steroid cell tumors of the ovary. In: Haines M, Taylor CW, Fox H, Wells M, editor. Haines and Tayler obstetrical and gynaecological pathology, 5, 845-856.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Luiza Garcia de Luca; Júlia Rocha Morão; Ana Cássia Arantes; Roger William Moraes Mendes
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.