Regeneration of lesions in the grade II furca area through the use of autologous platelet concentrates: A narrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i9.43325

Keywords:

Platelet Rich Fibrin; Furcation defects; L-PRF; Periodontitis.

Abstract

The furcation defects is related to the presence of bone resorption and loss of attachment in the interradicular region as a consequence of periodontal disease. They are difficult places of immunity and with several treatment options. Objective: to verify, through a narrative review, the applicability of platelet-rich fibrin in the treatment of grade II furcation defects. Methodology: studies in English were selected, from 2012 to 2022, indexed in PubMed / Medline and Lilacs and Cochrane databases that used PRF to treat grade II furcation defects alone or combined with other materials. First, a screening was performed by title followed by reading the abstracts. After verifying a relationship with the theme, the articles were viewed in full by a single researcher. Discussion: studies report that the use of PRF adjuvant to other biomaterials in class II furcation defects seems to be significantly (p<0.01) beneficial for reducing probing depth and gain in clinical hospitalization compared to bone grafts and too much materials when they are used alone. Conclusion: PRF has been identified as a promising biomaterial in the process of tissue immunity in grade II furcation defects.

References

Agarwal, A., Manjunath, R.G.S., Sethi, P. & Shankar, G.S. (2019). Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial. Singapore Dent J. 39(1), 33-40. doi.org/10.1142/S2214607519500032

Avila-Ortiz, G., De Buitrago, J. G., & Reddy, M. S. (2015). Periodontal regeneration - furcation defects: a systematic review from the AAP Regeneration Workshop. Journal of periodontology, 86(2 Suppl), S108–S130. doi.org/10.1902/jop.2015.130677

Bajaj, P., Pradeep, A. R., Agarwal, E., Rao, N. S., Naik, S. B., Priyanka, N., & Kalra, N. (2013). Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. Journal of periodontal research, 48(5), 573–581. doi.org/10.1111/jre.12040

Bernardo, W. M., Nobre, M. R., & Jatene, F. B. (2004). A prática clínica baseada em evidências. Parte II--Buscando as evidências em fontes de informação [Evidence-based clinical practice. Part II--Searching evidence databases]. Revista da Associacao Medica Brasileira (1992), 50(1), 104–108. doi.org/10.1590/s0104-42302004000100045

Bouchard, P., Carra, M. C., Boillot, A., Mora, F., & Rangé, H. (2017). Risk factors in periodontology: a conceptual framework. Journal of clinical periodontology, 44(2), 125–131. doi.org/10.1111/jcpe.12650

Carvalho Dutra, B., Oliveira, A. M. S. D., Oliveira, P. A. D., Miranda Cota, L. O., Silveira, J. O., & Costa, F. O. (2019). Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial. Journal of periodontology, 90(10), 1079–1087. doi.org/10.1002/JPER.19-0160

Castro, A. B., Herrero, E. R., Slomka, V., Pinto, N., Teughels, W., & Quirynen, M. (2019). Antimicrobial capacity of Leucocyte-and Platelet Rich Fibrin against periodontal pathogens. Scientific reports, 9(1), 8188. doi.org/10.1038/s41598-019-44755-6

Choukroun, J., Diss, A., Simonpieri, A., Girard, M. O., Schoeffler, C., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Dohan, D. M. (2006). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 101(3), e56–e60. doi.org/10.1016/j.tripleo.2005.07.011

Del Corso, M., Vervelle, A., Simonpieri, A., Jimbo, R., Inchingolo, F., Sammartino, G., & Dohan Ehrenfest, D. M. (2012). Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Current pharmaceutical biotechnology, 13(7), 1207–1230. doi.org/10.2174/138920112800624391

Jepsen, S., Gennai, S., Hirschfeld, J., Kalemaj, Z., Buti, J., & Graziani, F. (2020). Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials. Journal of clinical periodontology, 47 Suppl 22, 352–374. doi.org/10.1111/jcpe.13238

Hamp, S. E., Nyman, S., & Lindhe, J. (1975). Periodontal treatment of multirooted teeth. Results after 5 years. Journal of clinical periodontology, 2(3), 126–135. doi.org/10.1111/j.1600-051x.1975.tb01734.x

Kawase, T., Kamiya, M., Kobayashi, M., Tanaka, T., Okuda, K., Wolff, L. F., & Yoshie, H. (2015). The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. Journal of biomedical materials research. Part B, Applied biomaterials, 103(4), 825–831. doi.org/10.1002/jbm.b.33262

Loureiro, A.T. (2018). Regeneração periodontal de defeitos de furca com fibrina rica em plaquetas e leucócitos (L-PRF) [dissertação]. Coimbra: Faculdade de Medicina, Universidade de Coimbra. Retrieved dezembro, 2022, de https://estudogeral.uc.pt/handle/10316/82191?mode=full

Matarasso, M., Iorio-Siciliano, V., Blasi, A., Ramaglia, L., Salvi, G. E., & Sculean, A. (2015). Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis. Clinical oral investigations, 19(7), 1581–1593. doi.org/10.1007/s00784-015-1491-7

Miron, R. J., Moraschini, V., Fujioka-Kobayashi, M., Zhang, Y., Kawase, T., Cosgarea, R., Jepsen, S., Bishara, M., Canullo, L., Shirakata, Y., Gruber, R., Ferenc, D., Calasans-Maia, M. D., Wang, H. L., & Sculean, A. (2021). Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Clinical oral investigations, 25(5), 2461–2478. doi.org/10.1007/s00784-021-03825-8

Nasirzade, J., Kargarpour, Z., Hasannia, S., Strauss, F. J., & Gruber, R. (2020). Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro. Journal of periodontology, 91(2), 244–252. doi.org/10.1002/JPER.19-0216

Panda, S., Karanxha, L., Goker, F., Satpathy, A., Taschieri, S., Francetti, L., Das, A. C., Kumar, M., Panda, S., & Fabbro, M. D. (2019). Autologous Platelet Concentrates in Treatment of Furcation Defects-A Systematic Review and Meta-Analysis. International journal of molecular sciences, 20(6), 1347. doi.org/10.3390/ijms20061347

Pepelassi, E., & Deligianni, M. (2022). The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis. Materials (Basel, Switzerland), 15(6), 2088. doi.org/10.3390/ma15062088

Rodrigues, A.L., Souza. A.C., Melo, J.G.A. & Soares, D.M. (2020). Lesões em áreas de furca: fatores etiológicos, diagnóstico e tratamento. Archives of Health Investigation, 9(6), 635–640. doi.org/10.21270/archi.v9i6.5110

Sanz, M., Jepsen, K., Eickholz, P., & Jepsen, S. (2015). Clinical concepts for regenerative therapy in furcations. Periodontology 2000, 68(1), 308–332. doi.org/10.1111/prd.12081

Serroni, M., Paolantonio, M., Romano, L., Santamaria, P., Rexhepi, I., Sinjari, B., Paolantonio, G., Secondi, L., De Ninis, P., & Femminella, B. (2022). Added benefit of L-PRF to autogenous bone grafts in the treatment of degree II furcation involvement in mandibular molars. Journal of periodontology, 93(10), 1486–1499. doi.org/10.1002/JPER.21-0369

Swami, R. K., Kolte, A. P., & Kolte, R. A. (2022). Clinico-radiographic comparative evaluation of 1% metformin gel plus platelet-rich fibrin over platelet-rich fibrin alone in the treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial. Journal of periodontology, 93(5), 644–655. doi.org/10.1002/JPER.21-0233

Tarallo, F., Mancini, L., Pitzurra, L., Bizzarro, S., Tepedino, M., & Marchetti, E. (2020). Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis. Journal of clinical medicine, 9(7), 2104. doi.org/10.3390/jcm9072104

Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018). Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of periodontology, 89 Suppl 1, S159–S172. doi.org/10.1002/JPER.18-0006

Troiano, G., Laino, L., Dioguardi, M., Giannatempo, G., Lo Muzio, L., & Lo Russo, L. (2016). Mandibular Class II Furcation Defect Treatment: Effects of the Addition of Platelet Concentrates to Open Flap: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of periodontology, 87(9), 1030–1038. doi.org/10.1902/jop.2016.160058

Vargas. R, Quiroz, V. F., Lins-Candeiro, C. L., Oliveria, S. W. & Magalhães, D. (2020). Terapia periodontal associando plasma rico em fibrina (PRF) no tratamento de dentes com lesão de furca grau II: revisão de literatura. Revista Digital APO, 3(2), 32–37. doi.org/10.5935/2526-8155.20190010

Wanikar, I., Rathod, S., & Kolte, A. P. (2019). Clinico-radiographic evaluation of 1% alendronate gel as an adjunct and smart blood derivative platelet rich fibrin in grade II furcation defects. Journal of periodontology, 90(1), 52–60. doi.org/10.1002/JPER.18-0146

Zhang, J., Yin, C., Zhao, Q., Zhao, Z., Wang, J., Miron, R. J., & Zhang, Y. (2020). Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. Journal of biomedical materials research. Part A, 108(1), 61–68. doi.org/10.1002/jbm.a.36792

Published

26/09/2023

How to Cite

VITOR, G. P. .; MIRANDA, J. A. M. de .; DAMASCENO, L. S. . Regeneration of lesions in the grade II furca area through the use of autologous platelet concentrates: A narrative review. Research, Society and Development, [S. l.], v. 12, n. 9, p. e13212943325, 2023. DOI: 10.33448/rsd-v12i9.43325. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/43325. Acesso em: 22 nov. 2024.

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Section

Health Sciences