Influence of hormone therapy on the development of breast cancer in transgender women: A literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i1.44701

Keywords:

Breast cancer; Transsexual woman; Hormone replacement therapy.

Abstract

Objective: The present study aims to correlate hormonal therapy with the development of breast cancer in transsexual women, as well as describe the findings of hormonal therapy in transsexual women correlating with the possible development of breast cancer. Methods: Integrative Literature Review of a descriptive nature. For analysis of data on cases of breast cancer in transgender women and the possible influence of hormonal therapy. When 6 articles were selected, they were carefully analyzed in a qualitative and quantitative manner. Results: Transsexual women who are seeking a feminization process are at risk of developing breast cancer, due to increased levels of estrogen in the circulation. Therefore, the risk of developing breast malignancy in transgender women is 47 times greater than in cisgender men, however, this risk is reduced compared to cisgender women. Trans women have fewer mammograms than cisgender women. Conclusion: The relationship is still not clear when compared to cisgender women. There are reports that indicate a correlation between exposure above physiological levels of estrogen and breast cancer, but some authors defend the thesis that the trans population would not be exposed to hormones for a long enough period of time for the development of malignant neoplasia.

References

Adorno, T. L., et al. (2021). Influência da hormonioterapia na incidência de câncer em transexuais. Brazilian Journal of Development 7(6), 56017-56039.

Alves, P., Mendonça, N., & Mendonça, W. (2022). Rastreio de câncer de mama em transgêneros: uma revisão integrativa de literatura. Research, Society and Development 11(17), 1-9.

Melo, V., Pinto, J., & Silva L. C. (2022). Terapia hormonal em mulher transexual idosa: um estudo de caso. Research, Society and Development 11(10), 1-11.

Alves N., Caminha M., Feitosa K., & Mendes M. (2017). Complicações na gestação em mulheres com idade maior ou igual a 35 anos.Rev Gaúcha Enferm,38(4),2017-0042.

Theodoro J. (2020). O que é transexual? Significados. https://www.significados.com.br/transexual/

Bardin, L. (1997). Análise de conteúdo. Edições 70.

Franco, M. (2008). A análise de conteúdo. Brasília: Líber Livro.

Coelho, M. T. Á .D.; & Sampaio, L .L. P. (2012). Transsexuality: psychological characteristics and new demands on the healthcare sector. Interface - Comunic., Saúde, Educ., 16(42) 637-49.

Costa, E. et al. (2020). Medicina Diagnóstica Inclusiva: Cuidando de Pacientes Transgêneros. Posicionamento Conjunto. https://www.endocrino.org.br/media/pdfs_documentos/posicionamento_trangenero_sbem_sbpcml_cbr.p df.

Corso, G., Gandini, S., Oriana D’Ecclesiis, Mazza, M., Magnoni, F., Veronesi, P., Galimberti, V., & Carlo La Vecchia. (2023). Risk and incidence of breast cancer in transgender individuals: a systematic review and meta-analysis. European Journal of Cancer Prevention, 32(3), 207–214. https://doi.org/10.1097/cej.0000000000000784

Joint, R., Zhong Eric Chen, & Cameron, S. (2018). Breast and reproductive cancers in the transgender population: a systematic review. Bjog: An International Journal of Obstetrics and Gynaecology, 125(12), 1505–1512. https://doi.org/10.1111/1471-0528.15258

Castro, A. D., & Nagelberg, A. (2019). Screening mamario en pacientes transgénero bajo tratamiento hormonal cruzado (thc): Situación actual y controversias. Revista Argentina de Mastología, 38(137), 116-32.

Alves, A. & Santos, I. (2022). Papel do farmacêutico na hormônio terapia de mulheres transgênero. Centro de informações sobre medicamentos. https://www.crfmg.org.br/site/uploads/areaTecnica/20221109[085941]Nota_Tecnica_002-22_Papel_do_farmaceutico_na_hormonioterapia_de_mulheres_Transgenero.pdf.

Cameron, S., Chen, Z., & Joint, R. (2018). Breast and reproductive cancers in the transgender population: a systematic review. Obstet. Gynaecol., 125(12) 1505–12.

Cohen-Kettenis, P., Delemarre-van, Gooren, L., Hembree, W., Meyer, W., Spack, N. et al. (2009). Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline. Endocrinol. Metab., 94(9) 3132–54.

Filho, G. B. (2021). Bogliolo - Patologia. Grupo GEN, (9a ed.).

Instituto nacional de câncer, INCA (2022). Eu cuido da minha saúde todo dia, e você? https://www.inca.gov.br/campanhas/outubro-rosa/2022/eu-cuido-da-minha-saude-todos-os-dias-e-voce#:~:text=O%20c%C3%A2ncer%20de%20mama,-O%20c%C3%A2ncer%20de&text=As%20taxas%20de%20incid%C3%AAncia%20variam,a%20cada%20100%20mil%20mulheres.

Calas, M J. (2022). Câncer de mama em transexuais provoca alerta sobre prevenção. Oncoguia. http://www.oncoguia.org.br/conteudo/cancer-de-mama-em-transexuais-provoca-alerta-sobre-prevencao/15805/7/#:~:text=Segundo%20uma%20pesquisa%20realizada%20em,g%C3%AAnero%20correspondendente%20ao%20sexo%20biol%C3%B3gico.

Porto, C. C. (2019). Semiologia médica (8a ed.). Grupo GEN. 881-896.

Kiran, T., et al. (2019). Cancer screening rates among transgender adults: Cross-sectional analysis of primary care data. Canadian family physician Medecin de famille canadien, 65 (1), 30-37. https://www.cfp.ca/content/65/1/e30.long.

Equipe oncoguia (2020). Câncer de mama receptor de hormônio. http://www.oncoguia.org.br/conteudo/cancer-de-mama-receptor-de-hormonio/10879/264/

Equipe oncoguia (2022). Câncer de mama em homens. http://www.oncoguia.org.br/conteudo/cancer-de-mama-em-homens/15752/7/#:~:text=O%20c%C3%A2ncer%20de%20mama%20em,especialmente%20a%20do%20gene%20BRCA2.

Davidson, N., & Yager, J. (2006). Estrogen Carcinogenesis in Breast Cancer. N. Engl. J. Med. 354(3) 270–282.

Key, T., & Travis, R. (2003). Oestrogen exposure and breast cancer risk. Breast Cancer Res. 5 (5) 239–47.

Gompel, A (2019). Hormones et cancers du sein. Presse Med. 48(10) 1085–91.

Hartley, R., Stone, J. P., & Temple-Oberle, C. (2018). Breast cancer in transgender patients: A systematic review. Part 1: Male to female. Ejso, 44(10), 1455–1462. https://doi.org/10.1016/j.ejso.2018.06.035

Santen, R., et al. (2012). Modeling of the growth kinetics of occult breast

tumors: Role in interpretation of studies of prevention and menopausal hormone therapy. Cancer Epidemiol. Biomarkers Prev. 21(7) 1038–48.

Sonnenblick, E. B., et al. (2018). Breast Imaging of Transgender Individuals: A Review. Current radiology reports. 6(1) 1.

Published

14/01/2024

How to Cite

NASCIMENTO , J. L. .; LÚCIO, R. F. de O. .; COUTINHO, W. L. .; SÁ, L. L. C. B. . Influence of hormone therapy on the development of breast cancer in transgender women: A literature review. Research, Society and Development, [S. l.], v. 13, n. 1, p. e6513144701, 2024. DOI: 10.33448/rsd-v13i1.44701. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44701. Acesso em: 30 jun. 2024.

Issue

Section

Health Sciences