Increased cardiovascular risk in patients with fibromyalgia: An integrative review of the literature
DOI:
https://doi.org/10.33448/rsd-v13i6.45894Keywords:
Fibromyalgia; Heart disease risk factors; Chronic pain; Rheumatic diseases; Coronary heart disease.Abstract
Introduction: Fibromyalgia is a chronic pain syndrome that affects approximately 5% of the world's population. In addition to the physical and mental impact, fibromyalgia may be associated with an increased cardiovascular risk in these patients. Objective: To evaluate the association between increased cardiovascular risk in patients with fibromyalgia. Methodology: This is an integrative review of the literature, carried out in May 2024, with data collected from the Virtual Health Library. In total, 18 articles were found, of which 4 (n = 4) were selected to compose this study. Results: It was observed that patients with fibromyalgia may have a higher cardiovascular risk when compared to patients without fibromyalgia. The mechanisms that lead to this susceptibility are diverse, such as increased interleukin 6, metabolic and inflammatory changes and increased thrombogenic predisposition. As a result, cardiovascular complications, such as coronary disease, stroke, transient ischemic attack, end up increasing in patients with fibromyalgia, especially in those individuals in whom fibromyalgia is associated with other cardiovascular risk factors. Conclusion: It is important to reinforce knowledge about this association, in order to expand prevention and health education for patients with fibromyalgia. Furthermore, a better understanding of this association broadens the perspective in relation to the systemic outcomes caused by fibromyalgia, which go beyond its classic pain condition.
References
Akkaya, H., Güntürk, E. E., Kaydok, E., & Özdemir, B. (2020). Determination of the increased risk of developing atrial fibrillation in fibromyalgia syndrome. Advances in Rheumatology, 60(1).
Alberti, F., Blatt, C., & Pilger, D. (2021). Custos diretos e indiretos da fibromialgia: uma revisão de escopo. Jornal Brasileiro de Economia Da Saúde, 13(3), 388–344.
Almanza, A. P. M. C., Cruz, D. S. da, Oliveira-Júnior, S. A. de, & Martinez, P. F. (2023). Etiology and pathophysiology of fibromyalgia. REVISTA CIÊNCIAS EM SAÚDE, 13(3), 3–9.
Atzeni, F., Cirillo, M., D’Amico, V., Rodríguez-Carrio, J., Corda, M., & Alciati, A. (2023). Cardiovascular Risk Factors and Events in Fibromyalgia Patients. The Israel Medical Association Journal: IMAJ, 25(9), 627–630.
Avila, L. A., de Araujo Filho, G. M., Guimarães, E. F. U., Gonçalves, L. C. S., Paschoalin, P. N., & Aleixo, F. B. (2014). Caracterização dos padrões de dor, sono e alexitimia em pacientes com fibromialgia atendidos em um centro terciário brasileiro. Revista Brasileira de Reumatologia, 54(5), 409–413.
Costa, S. R. M. R. da, Pedreira Neto, M. da S., Tavares-Neto, J., Kubiak, I., Dourado, M. S., Araújo, A. C. de, Albuquerque, L. C. de, & Ribeiro, P. C. (2005). Características de pacientes com síndrome da fibromialgia atendidos em hospital de Salvador-BA, Brasil. Revista Brasileira de Reumatologia, 45(2), 64–70.
Fernandes, L. G. R., Wenceslau, C. M. de G., Santos, A. A. M. dos, Lima, D. V. G., Dieckmann, L. H. J., Haddad, M., Mansani, F. P., & Schafranski, M. D. (2023). Correlation between levels of perceived stress and depressive symptoms in the functional disability of patients with fibromyalgia. Revista Da Associação Médica Brasileira, 69(11).
Gressler, F. Z., Milani, P. D., da Silva, T. A. F. G., Kahlow, B. S., Skare, T. L., Cuenca, R. M., Andreollo, N. A., & Torres, O. J. M. (2023). Estudo comparativo da qualidade de vida de doentes com lúpus, artrite reumatoide e fibromialgia. BioSCIENCE, 81(2), 1.
Heymann, R. E., Paiva, E. dos S., Helfenstein Junior, M., Pollak, D. F., Martinez, J. E., Provenza, J. R., Paula, A. P., Althoff, A. C., Souza, E. J. R. e, Neubarth, F., Lage, L. V., Rezende, M. C., Assis, M. R. de, Lopes, M. L. L., Jennings, F., Araújo, R. L. C. da C., Cristo, V. V., Costa, E. D. G., Kaziyama, H. H. S., & Fonseca, M. C. M. (2010). Consenso brasileiro do tratamento da fibromialgia. Revista Brasileira de Reumatologia, 50(1), 56–66.
Mansour, M., Ehrenberg, S., Mahroum, N., Tsur, A. M., Fisher, L., & Amital, H. (2024). The existence of a bidirectional link between ischemic heart disease and fibromyalgia. Coronary Artery Disease, 35(2), 99–104.
Marcadenti, A., Machado, R. H. V., Santos, R. H. N., Kasai, C. C. D. S., Kovacs, C., Bello, A., de Matos, C. H., Bertacco, R. T. A., Souza, G. C., Schirmann, G. da S., Nagano, F. E. Z., Poloni, S., Kik, R. M. el, Feres, N. H., Rodrigues, I. G., Sousa, A. C. S., Pinheiro, J. M. F., Vasconcelos, S. M. L., Carlos, D. M. de O., … Bersch-Ferreira, Â. C. (2024). Adequação do Consumo de Ácidos Graxos entre Pacientes em Prevenção Cardiovascular Secundária. Arquivos Brasileiros de Cardiologia, 121(3), e20230487.
Passinho, R. S., Bressan, J., Hermsdorff, H. H. M., de Oliveira, F. L. P., & Pimenta, A. M. (2023). 30-Year High Cardiovascular Risk Incidence and its Determinants: CUME Study. Revista Brasileira de Enfermagem, 76(6).
Ricardo De Toledo Gagliardi, A., Augusto, P., Ii, A., Ribeiro, L., Iii, S., Costa, R., Iii, H., Rodrigues, E., Filho, A., Focaccia, F., & Iii, P. (2009). Clínica médica Fibromialgia e síndrome metabólica: alterações neuroendócrinas em comum. In Diagn Tratamento (Vol. 14, Issue 3).
Souza, J. B. de, & Perissinotti, D. M. N. (2018). The prevalence of fibromyalgia in Brazil – a population-based study with secondary data of the study on chronic pain prevalence in Brazil. Brazilian Journal Of Pain, 1(4), 345–348.
Souza Fialho Silva, D. da. (n.d.). I Casa de Oswaldo Cruz-FIOCRUZ Programa de Pós-Graduação em História das Ciências e da Saúde “o alarme que precisa ser regulado”: os debates médicos sobre a fibromialgia na sociedade brasileira de reumatologia entre as décadas de 1990 e 2010 Rio de Janeiro 2014.
Su, C. H., Chen, J. H., Lan, J. L., Wang, Y. C., Tseng, C. H., Hsu, C. Y., & Huang, L. (2015). Increased risk of coronary heart disease in patients with primary fibromyalgia and those with concomitant comorbidity - A Taiwanese population-based cohort study. PLoS ONE, 10(9).
Surendran, S., Mithun, C. B., Moni, M., Tiwari, A., & Pradeep, M. (2021). Cardiovascular risk assessment using ASCVD risk score in fibromyalgia: a single-centre, retrospective study using “traditional” case control methodology and “novel” machine learning. Advances in Rheumatology, 61(1).
Tavares De Souza, M., Dias Da Silva, M., & de Carvalho, R. (2010). Revisão integrativa: o que é e como fazer Integrative review: what is it? How to do it? (Vol. 8, Issue 1).
Zanetti, C. B., Pontes, M. A. G., de Moura, E. G. H., & Domiciano, D. S. (2023). High frequency of gastrointestinal complaints, but insignificant prevalence of gluten-sensitive enteropathies in Brazilian fibromyalgia patients. Reumatología Clínica (English Edition), 19(7), 374–378.
Zanetti, H. R., Facioli, T. de P., Furlanetto Júnior, R., Haddad, E. G., Lopes, L. T. P., & Gonçalves, A. (2015). Cardiovascular risk factors in patients with fibromyalgia. Acta Fisiátrica, 22(4).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Gabriel Rodrigues de Carvalho Melo; Sarah Maria do Nascimento Britto Neto; Luciene Oliveira Souza ; Márcio Duarte Carvalho Alves; Síntique Laísa da Silva Valença; Wesley Dias Cordeiro; Úrsula Maria Moreira Costa Burgos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
