Laboratory patterns related to dengue fatality: A literature review
DOI:
https://doi.org/10.33448/rsd-v13i7.46425Keywords:
Dengue; Blood tests; Mortality.Abstract
Introduction: Dengue, the main arbovirus in the world, although manifesting as a mild viral illness in most patients, has been a cause for concern due to the increasing number of deaths. The analysis of laboratory tests is one of the main tools to predict the patient's poor evolution, since some hematological patterns are altered from the beginning. Objective: Therefore, the objective was to analyze what these laboratory alterations are in patients fatal from dengue. Methodology: The descriptors "dengue", "blood tests", "mortality", "severe dengue" were searched in the LILACS, PubMED and SciELO databases, using the boolean term AND. A total of 1338 studies were found, of which 13 were selected as a sample, after selection based on inclusion and exclusion criteria previously defined by the authors. The main alterations related to dengue mortality were elevation of liver enzymes, bilirubin, creatinine, urea, and leukocytes, as well as anemia with increased hematocrit and a sharp drop in platelet count. Final considerations: Laboratory values should be analyzed together, used as a tool to predict dengue severity, avoiding progression to a poor prognosis and fatality.
References
Abas, S. S. S., et al. (2022). Correlation of dengue warning signs during febrile phase with rotational thromboelastometry, cortisol and ferritin. International Journal of Environmental Research and Public Health, 19(2), 807.
Agrawal, V. K., et al. (2018). Clinical profile and predictors of severe dengue disease: a study from South India. Caspian Journal of Internal Medicine, 9(4), 334-340.
Anwat, F., et al. (2022). Epidemiological and hematological investigation of dengue virus infection. Microbiology and Immunology, 66(9), 426-432.
Arora, S. K., et al. (2021). Predictors of severe dengue amongst children as per the revised WHO classification. Journal of Vector Borne Diseases, 58(4), 329-334.
Baitha, U., et al. (2021). Leucocytosis and early organ involvement as risk factors of mortality in adults in dengue fever. Drug Discovery and Therapy, 14(6), 313-318.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. (2016). Dengue: diagnóstico e manejo clínico: adulto e criança (5th ed.). Brasília: Ministério da Saúde.
Chagas, G. C. L., et al. (2022). Risk factors for mortality in patients with dengue: a systematic review and meta-analysis. Tropical Medicine & International Health, 27(8), 656-668.
Ghetia, C., et al. (2022). Association of dengue virus non-structural-1 protein with disease severity: a brief review. Transactions of the Royal Society of Tropical Medicine and Hygiene, 116(11), 986-995.
Gupta, M., et al. (2020). Study of utility of basic arterial blood gas parameter and lactate as predictors of severe dengue amongst children. Reviews in Medical Virology, 31(1), 1-9.
Harapan, H., et al. (2020). Dengue: a minireview. Viruses, 12(8), 829.
John, K. J., et al. (2019). Predictors of major bleeding and mortality in dengue infection: a retrospective observational study in a tertiary care center in South India. Interdisciplinary Perspectives on Infectious Diseases, 2019, 482379.
Kularatnam, G. A. M., et al. (2019). Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study. BMC Pediatrics, 19, 87.
Lee, I.-K., et al. (2018). Prognostic factors in adult patients with dengue: developing risk scoring models and emphasizing factors associated with death ≤7 days after illness onset and ≤3 days after presentation. Journal of Clinical Medicine, 7(11), 396.
Melnyk, B. M., et al. (2011). Evidence-based practice in nursing & healthcare: a guide to best practice. Philadelphia: Lippincott Williams & Wilkins.
Moher, D., et al. (2010). PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. International Journal of Surgery, 8, 336-341.
Md-Sani, S. S., et al. (2018). Prediction of mortality in severe dengue cases. BMC Infectious Diseases, 18(1), 232.
Mourad, O., et al. (2016). Rayyan - a web and mobile app for systematic reviews. Systematic Reviews, 5, 210.
Nandwani, S., et al. (2021). Early hematological parameters as predictors for outcomes in children with dengue in northern India: a retrospective analysis. Revista da Sociedade Brasileira de Medicina Tropical, 54, e05192020.
Rojas, E., et al. (2019). Clinical indicators of fatal dengue in two endemic areas of Colombia: a hospital-based case-control study. American Journal of Tropical Medicine and Hygiene, 100(2), 411-419.
Rosenberg, M. L., et al. (2018). Hemofagocitosis secundaria a dengue. Medicina (Buenos Aires), 78(1), 37-40.
Sachdev, A., et al. (2021). Early predictors of mortality in children with severe dengue fever: a prospective study. The Pediatric Infectious Disease Journal, 40(9), 797-801.
Singhal, T., & Kothari, V. (2020). Clinical and laboratory profile of fatal dengue cases at a tertiary care private hospital in Mumbai, India. American Journal of Tropical Medicine and Hygiene, 103(3), 1223-1227.
Sirisena, P. D. N. N., et al. (2021). Concurrent dengue infections: epidemiology & clinical implications. Indian Journal of Medical Research, 154(5), 669-679.
Tayal, A., et al. (2023). Management of dengue: an updated review. Indian Journal of Pediatrics, 90(2), 168-177.
Teerasarntipan, T., et al. (2020). Acute liver failure and death predictors in patients with dengue-induced severe hepatitis. World Journal of Gastroenterology, 26(33), 4983-4885.
Teixeira, A. C. Q., et al. (2022). Platelets in dengue infection: more than a numbers game. Platelets, 33(2), 176-183.
World Health Organization. (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva.
Yeh, C.-Y. (2015). Trajectories of hepatic and coagulation dysfunctions related to a rapidly fatal outcome among hospitalized patients with dengue fever in Tainan. PLoS Neglected Tropical Diseases, 13(12), e0007817.
Yuan, K., et al. (2019). Risk and predictive factors for severe dengue infection: a systematic review and meta-analysis. PLoS One, 17(4), e0267186.
Wong, J. M., et al. (2022). Dengue: a growing problem with new interventions. Pediatrics, 149(6), e2021055522.
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