Influence of sleep quality on clinical and laboratory parameters in women with polycystic ovary syndrome
DOI:
https://doi.org/10.33448/rsd-v13i10.47118Keywords:
Polycystic Ovary Syndrome; Sleep; Gynecology; Life style.Abstract
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age, characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Objective: To describe the influence of sleep quality on clinical and laboratory parameters in women with polycystic ovary syndrome. Methodology: Integrative review, carried out in the Public Medline (PubMed) database, with DeCS/MESH descriptors “Polycystic Ovary Syndrome” and “Sleep”. Freely available articles were included, with research carried out on women with PCOS of any age group, published in the last five years, in Portuguese or English. Results: 66 studies were found and, after methodological screening, 5 were included in the review. In total, 279 women of varying ages were evaluated, of which those with PCOS and sleep disorders showed changes in body mass index, insulin resistance, liver fat and higher triglycerides (TG). Conclusion: The presence of sleep disorders in women with PCOS is associated with changes in symptoms and laboratory parameters. It is suggested, however, that more studies are needed to prove this relationship and the specific mechanisms.
References
Bertolazi, A. N. (2008). Tradução, adaptação cultural e validação de dois instrumentos de avaliação do sono: Escala de Sonolência de Epworth e Índice de Qualidade de Sono de Pittsburgh (Doctoral dissertation). Universidade Federal do Rio Grande do Sul.
Chasens, E. R., Imes, C. C., Kariuki, J. K., Luyster, F. S., Morris, J. L., DiNardo, M. M., et al. (2021). Sleep and metabolic syndrome. Nursing Clinics of North America, 56(2), 203-217. https://doi.org/10.1016/j.cnur.2020.10.012
Deans, R. (2019). Polycystic ovary syndrome in adolescence. Medicina (Basel), 7(10), 101. https://doi.org/10.3390/medsci7100101
Garcia, S. A., Neves, J. D., Vicentini, S. C., Nogueira, G. A., Marques, J. M., & Barreiros, R. N., et al. (2020). Actigrafia versus polissonografia para identificar alterações nos padrões de sono de adultos com insônia. Revista Neurociências, 28. https://doi.org/10.34024/rnc.2020.v28.10600
Hachul, H., Polesel, D. N., Tock, L., Carneiro, G., Pereira, A. Z., Zanella, M. T., et al. (2019). Sleep disorders in polycystic ovary syndrome: Influence of obesity and hyperandrogenism. Revista da Associação Médica Brasileira, 65(3), 375-383.
Humer, E., Pieh, C., & Brandmayr, G. (2020). Metabolomics in sleep, insomnia and sleep apnea. International Journal of Molecular Sciences, 21(19), 7244. https://doi.org/10.3390/ijms21197244
Kahal, H., Tahrani, A. A., Kyrou, I., Dimitriadis, G. K., Kimani, P. K., Barber, T. M., et al. (2020). The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: A cross-sectional study. Therapeutic Advances in Endocrinology and Metabolism, 21, 2042018820906689. https://doi.org/10.1177/2042018820906689
Kumarendran, B., Sumilo, D., O'Reilly, M. W., Toulis, K. A., Gokhale, K. M., Wijeyaratne, C. N., et al. (2019). Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: A population-based cohort study. European Journal of Endocrinology, 180(4), 265-272. https://doi.org/10.1530/EJE-18-0693
Li, H., Liu, M., & Zhang, C. (2022). Women with polycystic ovary syndrome (PCOS) have reduced melatonin concentrations in their follicles and have mild sleep disturbances. BMC Women's Health, 22(1), 79. https://doi.org/10.1186/s12905-022-01661-w
Martins, A. B., Tufik, S., & Moura, S. M. G. P. (2007). Síndrome da apnéia-hipopnéia obstrutiva do sono: Fisiopatologia. Jornal Brasileiro de Pneumologia, 33(1), 93-100.
Melo, M. H. A., Neves, D. D., Ferreira, L. V. M. V., Moreira, M. L. V., Nigri, R., & Simões, S. M. G. (2016). Questionários e escalas úteis na pesquisa da síndrome da apneia obstrutiva do sono. Revista HUPE, 15(1). https://doi.org/10.12957/rhupe.2016.22368
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM
Rocha, A. L., Oliveira, F. R., Azevedo, R. C., Silva, V. A., Peres, T. M., Cândido, A. L., & et al. (2019). Recent advances in the understanding and management of polycystic ovary syndrome. F1000Research, 8, 565. https://doi.org/10.12688/f1000research.15318.1
Rosa-e-Silva, A. C. (2018). Conceito, epidemiologia e fisiopatologia aplicada à prática clínica. In Síndrome dos ovários policísticos (Cap. 1, pp. 1-15). Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo).
Sanchez-Garrido, M. A., & Tena-Sempere, M. (2020). Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies. Molecular Metabolism, 35, 100937. https://doi.org/10.1016/j.molmet.2020.01.001
Simon, S., Rahat, H., Carreau, A. M., Garcia-Reyes, Y., Halbower, A., Pyle, L., et al. (2020). Poor sleep is related to metabolic syndrome severity in adolescents with PCOS and obesity. The Journal of Clinical Endocrinology & Metabolism, 105(4), e1827-e1834. https://doi.org/10.1210/clinem/dgz285
Simon, S. L., McWhirter, L., Diniz Behn, C., Bubar, K. M., Kaar, J. L., Pyle, L., et al. (2019). Morning circadian misalignment is associated with insulin resistance in girls with obesity and polycystic ovarian syndrome. The Journal of Clinical Endocrinology & Metabolism, 104(8), 3525-3534.
Sen, A., & Tai, X. Y. (2023). Sleep duration and executive function in adults. Current Neurology and Neuroscience Reports, 23(11), 801-813. https://doi.org/10.1007/s11910-023-01309-8
Sousa, L. M. M., Vieira, C. M. A. M., Severino, S. S. P., & Antunes, A. V. (2017). A metodologia de revisão integrativa da literatura em enfermagem. Revista Investigação em Enfermagem, 17-26.
Zielinski, M. R., & Gibbons, A. J. (2022). Neuroinflammation, sleep, and circadian rhythms. Frontiers in Cellular and Infection Microbiology, 12, 853096. https://doi.org/10.3389/fcimb.2022.853096
Zhang, J., Ye, J., Tao, X., Lu, W., Chen, X., & Liu, C. (2022). Sleep disturbances, sleep quality, and cardiovascular risk factors in women with polycystic ovary syndrome: Systematic review and meta-analysis. Frontiers in Endocrinology, 13, 971604. https://doi.org/10.3389/fendo.2022.971604
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Luane Mascarenhas Magalhães; Hanna Vitória da Cruz Correia ; Luana Teles de Resende

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.