Polydioxanone threads and neocollagenesis in the periorbital region: A narrative review of the literature
DOI:
https://doi.org/10.33448/rsd-v14i2.48287Keywords:
Polydioxanone; Collagen; Face.Abstract
Polydioxanone (PDO) threads have gained popularity in facial aesthetics due to their ability to promote a lifting effect and stimulate neocollagenesis. In the periorbital region, where the skin is more delicate and signs of aging are more pronounced, these threads present a less invasive alternative compared to traditional surgical techniques. This narrative review of the literature aims to explore the efficacy and safety of PDO threads in the periorbital region, focusing on collagen production stimulation, aesthetic outcomes, and possible adverse effects. Through the analysis of various clinical studies and case reports, significant improvements in skin firmness and reduction of fine wrinkles were observed, with a low incidence of serious complications. However, there is still a lack of long-term data regarding the effects of PDO threads, especially in the periorbital region. Thus, further investigation is needed to confirm the durability of results and the safety of the procedure. It is concluded that, although promising, PDO threads require more scientific research to be fully understood in their periorbital application.
References
Alghoul, M., & Codner, M. A. (2013). Retaining ligaments of the face: Review of anatomy and clinical applications. Aesthetic Surgery Journal, 33(6), 769–782.
Cobo, R. (2020). Use of polydioxanone threads as an alternative in nonsurgical procedures in facial rejuvenation. Facial Plastic Surgery, 36(4), 447–452.
Contreras, C., Ariza-Donado, A., & Ariza-Fontalvo, A. (2023). Using PDO threads: A scarcely studied rejuvenation technique. Case report and systematic review. Journal of Cosmetic Dermatology, 22(8), 2158–2165.
Cornelius, C. P., Probst, F., Metzger, M. C., & Gooris, P. J. J. (2021). Anatomy of the orbits: Skeletal features and some notes on the periorbital lining. Atlas of the Oral and Maxillofacial Surgery Clinics of North America, 29(1), 1–18.
Kashkouli, M. B., Abdolalizadeh, P., Abolfathzadeh, N., Sianati, H., Sharepour, M., & Hadi, Y. (2018). Periorbital facial rejuvenation; applied anatomy and pre-operative assessment [Published correction appears in Journal of Current Ophthalmology, 30(2), 188–189].
Khan, G., Ahn, K. H., Kim, S. Y., & Park, E. (2021). Combined press cog type and cog PDO threads in comparison with the cog PDO threads in facial rejuvenation. Journal of Cosmetic Dermatology, 20(10), 3294–3298.
Kim, C. M., Kim, B. Y., Hye Suh, D., Lee, S. J., Moon, H. R., & Ryu, H. J. (2019). The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model. Journal of Cosmetic Dermatology, 18(6), 1893–1898.
Li, K., Zhang, X., Guo, W., Wang, L., Wang, G., & Gao, L. (2022). Polydioxanone thread insertion in combination with radio frequency treatment does not exhibit synergistic efficacy: Animal study with pigs. Journal of Cosmetic Dermatology, 21(8), 3479–3485.
Lots, T. C. C. (2023). Effect of PDO facelift threads on facial skin tissues: An ultrasonographic analysis. Journal of Cosmetic Dermatology, 22(9), 2534–2541.
Miranda, C. R. (2023). Association of PDO threads and technologies—Facial treatment protocols. Journal of Cosmetic Dermatology, 22(3), 804–809.
Myung, Y., & Jung, C. (2020). Mini-midface lift using polydioxanone cog threads. Plastic and Reconstructive Surgery Global Open, 8(6), e2920.
Park, J. H., Jeong, J. W., & Park, J. U. (2024). Advanced facial rejuvenation: Synergistic effects of lower blepharoplasty and ultrasound-guided mid-face lift using polydioxanone (PDO) threads. Aesthetic Plastic Surgery, 48(9), 1706–1714.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm, 20(2).
Shin, J. J., Park, T. J., Kim, B. Y., et al. (2019). Comparative effects of various absorbable threads in a rat model. Journal of Cosmetic and Laser Therapy, 21(3), 158–162.
Unal, M., İslamoğlu, G. K., Ürün Unal, G., & Köylü, N. (2021). Experiences of barbed polydioxanone (PDO) cog thread for facial rejuvenation and our technique to prevent thread migration. Journal of Dermatological Treatment, 32(2), 227–230.
Woodward, J., Cox, S. E., Kato, K., Urdiales-Galvez, F., Boyd, C., & Ashourian, N. (2023). Infraorbital hollow rejuvenation: Considerations, complications, and the contributions of midface volumization. Aesthetic Surgery Journal Open Forum, 5, ojad016.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Vanessa Balbino Libardi; Nicola Felipe Lopez Bempensante; Rafael Pioltine; Regina Ranieri; Raphaella Guimarães; Daniella Pilon Muknicka
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
