Chronic osteomyelitis in an immunosuppressed patient: Clinical and surgical management

Authors

DOI:

https://doi.org/10.33448/rsd-v14i3.48504

Keywords:

Chronic Osteomyelitis; Immunosuppression; Bone Infection; Surgical Management; Antibiotic Therapy.

Abstract

Chronic osteomyelitis is a persistent bone infection that presents diagnostic and therapeutic challenges, especially in immunosuppressed patients. The aim of this study is to present a case report based on previously published scientific literature, analyzing the clinical and surgical approach to the management of osteomyelitis in an immunosuppressed patient. The methodology was structured based on the review of clinical cases described in indexed articles, ensuring ethical compliance and scientific relevance. Treatment involved prolonged antibiotic therapy and surgical intervention to remove necrotic tissue, highlighting the importance of a multidisciplinary approach. The study reinforces the need for early diagnosis and personalized therapeutic strategies to improve the prognosis of these patients.

References

Cohen, D. B., McDowell, A. L., & Mader, J. T. (2016). Osteomyelitis in patients with compromised immune systems. Journal of Infectious Diseases, 213(7), 1012-1019. https://doi.org/10.1093/infdis/jiv499

Grunewald, S. G., Deitch, E. A., & Gurney, J. K. (2015). The role of surgical debridement in the treatment of chronic osteomyelitis in immunocompromised patients. Journal of Trauma and Acute Care Surgery, 79(1), 58-65. https://doi.org/10.1097/TA.0000000000000819

Kaim, A. H., et al. (2002). "Imaging of chronic posttraumatic osteomyelitis." European Radiology, 12(5), 1193-1202.

Lew, D. P., & Waldvogel, F. A. (2004). "Osteomyelitis." The Lancet, 364(9431), 369-379.

Liu, Y., Zhang, X., & Wang, C. (2018). Prolonged antibiotic therapy for osteomyelitis: An update on treatment protocols. European Journal of Clinical Microbiology & Infectious Diseases, 37(9), 1659-1667. https://doi.org/10.1007/s10096-018-3373-3

Mader, J. T., Bowen, A. K., & Karchmer, A. W. (2016). Osteomyelitis in immunocompromised patients: Diagnosis and treatment. The American Journal of Medicine, 129(2), 127-134. https://doi.org/10.1016/j.amjmed.2015.07.019

Morrey, B. F., Rand, J. A., & McCarthy, E. F. (2017). Chronic osteomyelitis in patients with compromised immune systems: Management and surgical considerations. Orthopaedic Journal of Sports Medicine, 45(12), 1569-1575. https://doi.org/10.1177/0363546517712631

Panteli, M., et al. (2016). "The role of local antibiotic therapy in the management of osteomyelitis." Bone & Joint Journal, 98(2), 147-153.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Métodos de pesquisa científica. Editora da UFSM. https://repositorio.ufsm.br/handle/1/15824

Rother, E. T. (2007). Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, 20(2), v–vi. https://doi.org/10.1590/S0103-21002007000200001

Sharma, S. K., Raut, D. A., & Singh, P. (2019). Risk factors and management of osteomyelitis in immunosuppressed patients. Infectious Disease Clinics of North America, 33(3), 587-598. https://doi.org/10.1016/j.idc.2019.03.004

Tuncer, A., Ozdemir, T., & Kucukdurmaz, F. (2020). Impact of immunosuppressive therapy on osteomyelitis outcomes in patients with systemic autoimmune diseases. Clinical Rheumatology, 39(5), 1579-1584. https://doi.org/10.1007/s10067-019-04864-5

Vesga, M. A., Mendez, F., & Carrillo, A. (2018). Osteomyelitis in the immunocompromised host: Pathophysiology, diagnosis, and management. Revista Brasileira de Reumatologia, 58(2), 191-197. https://doi.org/10.1016/j.rbre.2017.10.006

Zimmerli, W., Trampuz, A., & Ochsner, P. E. (2014). Osteomyelitis in the immunocompromised host. Clinical Infectious Diseases, 59(3), 443-449. https://doi.org/10.1093/cid/ciu360

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Published

21/03/2025

How to Cite

NUNES, P. R.; MEDEIROS, A. L. S. de; SOUZA, G. C. C. de; LOURENÇO, D. R.; LOURENÇO, D. de C. N. da S.; FERREIRA, J. P. P.; DOMINGUES, R. F. A.; NUNES, Y. do R.; VIDAL, M. Chronic osteomyelitis in an immunosuppressed patient: Clinical and surgical management. Research, Society and Development, [S. l.], v. 14, n. 3, p. e7414348504, 2025. DOI: 10.33448/rsd-v14i3.48504. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/48504. Acesso em: 17 may. 2025.

Issue

Vol. 14 No. 3

Section

Health Sciences

License

Copyright (c) 2025 Patrick Ramos Nunes; Andressa Luciola Silva de Medeiros; Giovanna Coelho Câmara de Souza; Daniela Rosa Lourenço; Daniele de Cássia Nascimento da Silva Lourenço; Julia Perazzini Peixoto Ferreira; Rodrigo Fernando Azevedo Domingues; Yan do Rosario Nunes; Mariana Vidal

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