Drug interactions profile of Oral Antineoplastic Agents (OAAs) dispensed for oncologic patients

Authors

DOI:

https://doi.org/10.33448/rsd-v9i8.5369

Keywords:

Neoplasms; Antineoplastic agents; Administration; oral; Drug interactions.

Abstract

The present study aims to list the oral antineoplastic agents (OAAs) most dispensed in an oncology hospital, identifying their doses, indications, contraindications and possible drug interactions (DIs). Documentary, retrospective, analytical and descriptive study, where OAAs dispensation spreadsheets were analyzed, from january to july 2019. Data were obtained from Micromedex® and analyzed by SPSS® (version 20) using descriptive statistics. 22 types of OAAs were dispensed, making a total of 360.703 drugs. Anastrozole was the most prescribed (51,85%) and hormone therapy agents (32%) were considered the main group. Tyrosine kinase inhibitors exposed the highest rates of contraindications (n=64). With regard to serious risk interactions, nilotinib (n=264), dasatinib (n=182) and metotrexate (n=134) were the drugs with the highest number of reports. The OAAs that did not present any type of interaction were anastrozole and diethylstilbestrol. Of the pharmacological agents that most interacted with OAAs, live vaccines (n=11) were the most present in contraindications and warfarin was the one that had the highest rate of serious interactions (n=8). As for the repercussions of DIs, the most frequent indices were the increased risk of prolongation of the QT interval (n=67) and increased exposure to a drug (n=51). Bearing in mind that cancer therapy requires special attention because of the possible interactions with OAAs, these results are shown to be a useful tool for the entire multiprofessional health team, especially the pharmacist, who has an essential role in the pharmaceutical assistance service on an outpatient basis.

Author Biographies

Herlem Silva Rodrigues, Centro Universitário Santo Agostinho

Graduando em Farmácia pelo Centro Universitário Santo Agostinho (UNIFSA). Tem experiência na área de Farmácia Hospitalar, Assistência e Atenção farmacêutica, com ênfase em Manipulação de Quimioterápicos.

Railson Pereira Souza, Universidade Federal do Piauí

Mestrando em Farmacologia de Produtos Naturais da Universidade Federal do Piauí (UFPI) / Núcleo de Pesquisa em Plantas Medicinais (NPPM), Laboratório de Farmacologia Cardiovascular (LAFAC). Farmacêutico graduado pela UFPI. Nutricionista graduado pelo Centro Unificado de Teresina (CEUT). Especialista em Ciências Forenses - Perícia Criminal pelo Instituto Educacional Santa Catarina (IESC) e em Farmacologia pela Faculdade Futura – Instituto de Ciência, Educação e Tecnologia de Votuporanga. Tem experiência na área de Farmácia & Nutrição, com ênfase em Farmacologia antitumoral e cardiovascular de produtos naturais, Farmacoterapia, Desenvolvimento de alimentos e cosméticos, Rotulagem Nutricional e Revisão/escrita de livros e artigos científicos.

Rayran Walter Ramos de Sousa, Universidade Federal do Piauí

Mestrando em Ciências Farmacêuticas pelo Programa de Pós-graduação em Ciências Farmacêuticas na Universidade Federal do Piauí (PPGCF/UFPI), linha de pesquisa Farmacologia e Toxicologia de Produtos Naturais e Sintéticos. Farmacêutico graduado pela UFPI, com experiência em Farmácia Comunitária, Tecnologia Farmacêutica e Cancerologia Experimental.

Layane Carneiro Alves Pereira, Universidade Federal do Piauí

Mestranda em Farmacologia de Produtos Naturais da Universidade Federal do Piauí (UFPI) / Núcleo de Pesquisa em Plantas Medicinais (NPPM). Graduada em Farmácia pela UFPI. Especialista em Farmácia Clínica e Farmacologia Clínica com ênfase em Prescrição Farmacêutica pelo Instituto Brasil de Pós-Graduação, Capacitação e Assessoria (IBRAS) - Faculdade Cathedral. Tem experiência nas áreas de Farmacologia, Fisiologia, Embriologia, Atenção Farmacêutica, Farmacologia Clínica e Pesquisa.

Renata Rodrigues de Oliveira Castelo Branco, Universidade Federal do Piauí

Mestranda em Farmacologia de Produtos Naturais da Universidade Federal do Piauí (UFPI) / Núcleo de Pesquisa em Plantas Medicinais (NPPM). Graduada em Farmácia pela UFPI. Especialista em Farmácia Clínica e Farmacologia Clínica com ênfase em Prescrição Farmacêutica pelo Instituto Brasil de Pós-Graduação, Capacitação e Assessoria (IBRAS) - Faculdade Cathedral. Possui experiência em Farmacologia dos Antimicrobianos e em Farmácia comunitária, prestando serviços de atenção farmacêutica e atendimento ao público.

Pedro Henrique Fernandes Paiva Silveira, Centro Universitário Santo Agostinho

Graduando em Farmácia pelo Centro Universitário Santo Agostinho (UNIFSA).

Maria Helena Rodrigues Mesquita Britto, Centro Universitário Santo Agostinho

Doutora em Farmacologia pela Faculdade de Ciências Médicas da Universidade Estadual de Campinas - UNICAMP.  Mestra em Bioengenharia pela Universidade Vale do Paraíba - UNIVAP. Graduada em Farmácia, com habilitação em Análises Clínicas pela Universidade Federal do Piauí. Docente no Centro Universitário Santo Agostinho (UNIFSA) nos cursos de Farmácia, Odontologia e Estética e cosmética. Atua na área de controle de qualidade de medicamentos, toxicologia e docagem molecular. 

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28/06/2020

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RODRIGUES, H. S.; SOUZA, R. P.; SOUSA, R. W. R. de; PEREIRA, L. C. A.; BRANCO, R. R. de O. C.; SILVEIRA, P. H. F. P.; BRITTO, M. H. R. M. Drug interactions profile of Oral Antineoplastic Agents (OAAs) dispensed for oncologic patients. Research, Society and Development, [S. l.], v. 9, n. 8, p. e145985369, 2020. DOI: 10.33448/rsd-v9i8.5369. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/5369. Acesso em: 27 apr. 2024.

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Vol. 9 No. 8

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Health Sciences

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