Efficiency of antibiotic prophylaxis in third molar surgery in healthy patients: a literature review
DOI:
https://doi.org/10.33448/rsd-v9i8.5984Keywords:
Antibiotic Prophylaxis; Oral Surgical Procedures; Third molar.Abstract
Introduction: Dental surgeons routinely deals with third molar extractions in their offices. Then questions about antibiotic prophylaxis in healthy patients start arising. Objective: to verify efficiency of antibiotic prophylaxis during third molar surgery in healthy patients through a literature review. Methods: bibliographic searches were carried out in PUBMED and SCIELO databases. Only case control articles were select, with a range of the last 5 years, resulting in seven articles found at all. Results: Four articles concluded that groups treated without antibiotic prophylaxis obtained the same effects as those who had antibiotics in relation to postoperative infections. One article concluded that antibiotics can be used as antibiotics prophylaxis. Also the achieve that patients who did not have antibiotics are more likely to develop dental alveolitis were concluded in one article. Conclusion: Antibiotic prophylaxis in healthy patients did not present, in most cases, significant results in preventing infections in third molars surgeries. In addition, following the postoperative analgesic and anti-inflammatory medication protocol is sufficient for a good recovery.
References
Andrade, E., (2014). Terapéutica Medicamentosa em Odontología. Porto Alegre: Artes Médicas.
Arteagoitia, I., Ramos, E., Santamaria, G., Barbier, L., Alvarez, J., & Santamaria, J. (2015). Amoxicillin/clavulanic acid 2000/125 mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial. Oral surgery, oral medicine, oral pathology and oral radiology, 119(1), 8-16. doi.org/10.1016/j.oooo.2014.08.014
Ataoğlu, H., Öz, G. Y., Çandirli, C., &Kiziloğlu, D. (2008). Routine antibiotic prophylaxis is not necessary during operations to remove third molars. British Journal of Oral and Maxillofacial Surgery, 46(2), 133-135.doi.org/10.1016/j.bjoms.2006.11.005
Bezerra, T. P., Studart-Soares, E. C., Scaparo, H. C., Pita-Neto, I. C., Batista, S. H. B., &Fonteles, C. S. R. (2011). Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg). Journal of Oral and Maxillofacial Surgery, 69(11), e333-e339.
Blumenthal, K. G., Peter, J. G., Trubiano, J. A., & Phillips, E. J. (2019). Antibiotic allergy. Lancet (London, England), 393(10167), 183–198.doi.org/10.1016/j.joms.2011.03.055
Braimah, R. O., Ndukwe, K. C., Owotade, J. F., & Aregbesola, S. B. (2017). Impact of oral antibiotics on health related quality of life after mandibular third molar surgery: An observational study. Nigerian journal of clinical practice, 20(9), 1189-1194.doi.org/ 10.4103/1119-3077.183235
Cigerim, L., & Eroglu, C. N. (2018). Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium–Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized Double-Blind Study. Journal of Oral and Maxillofacial Surgery, 76(3), 495-502.doi.org/10.1016/j.joms.2017.08.041
Cho, H., Lynham, A. J., & Hsu, E. (2017). Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Australian dental journal, 62(4), 412-419.doi.org/10.1111/adj.12526
Cubas-Jaeger, J. L., &Asmat-Abanto, A. S. (2016). Amoxicilina para prevenir la infección postexodoncia de terceros molares incluidos: ensayo clínico aleatorizado. Revista Española de Cirugía Oral y Maxilofacial, 38(4), 188-192.doi.org/10.1016/j.maxilo.2015.04.001
Deepti, C., Rehan, H. S., &Mehra, P. (2009). Changes in quality of life after surgical removal of impacted mandibular third molar teeth. Journal of maxillofacial and oral surgery, 8(3), 257–260.doi.org/10.1007/s12663-009-0063-2
Gopee, P., & Rikhotso, E. (2017). Impacted mandibular third molars: the efficacy of prophylactic antibiotics and chlorhexidine mouthwash in preventing postoperative infections. South African Dental Journal, 72(5), 213-218.doi.org/10.17159/2519-0105/2017/v72no5a3
Hita-Iglesias, P., Torres-Lagares, D., Flores-Ruiz, R., Magallanes-Abad, N., Basallote-Gonzalez, M., & Gutierrez-Perez, J. L. (2008). Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. Journal of oral and maxillofacial surgery, 66(3), 441-445.doi.org/10.1016/j.joms.2007.06.641
Hupp, J., 2015. Cirurgia Oral E Maxilofacial Contemporânea. Rio de Janeiro: Elsevier Health Sciences.
IJzerman, L. M. (2019). Werktchloorhexidinealspreventieveinterventietegenalveolitis?. Ned TijdschrTandheelkd, 13-15.doi.org/10.5177/ntvt.2019.01.18202
Kaposvári, I., Körmöczi, K., László, Z. B., Oberna, F., Horváth, F., &Joób-Fancsaly, Á. (2017). A preoperatív antibiotikus és antiszeptikus kezelés hatása a műtéti úton eltávolított alsó bölcsességfogak sebgyógyulására–prospektív randomizált vizsgálat. OrvosiHetilap, 158(1), 13-19.doi.org/10.1556/650.2017.30645
Lacasa, J. M., Jiménez, J. A., Ferrás, V., Bossom, M., Sóla-Morales, O., García-Rey, C., &Garau, J. (2007). Prophylaxis versus pre-emptive treatment for infective and inflammatory complications of surgical third molar removal: a randomized, double-blind, placebo-controlled, clinical trial with sustained release amoxicillin/clavulanic acid (1000/62.5 mg). International journal of oral and maxillofacial surgery, 36(4), 321-327.doi.org/10.1016/j.ijom.2006.11.007
Lima, T. C., Bagordakis, E., Falci, S. G. M., dos Santos, C. R. R., & Pinheiro, M. L. P. (2018). Pre-emptive effect of dexamethasone and diclofenac sodium associated with codeine on pain, swelling, and trismus after third molar surgery: a split-mouth, randomized, triple-blind, controlled clinical trial. Journal of Oral and Maxillofacial Surgery, 76(1), 60-66.doi.org/10.1016/j.joms.2017.06.012
Markiewicz, M. R., Brady, M. F., Ding, E. L., & Dodson, T. B. (2008). Corticosteroids reduce postoperative morbidity after third molar surgery: a systematic review and meta-analysis. Journal of oral and maxillofacial surgery, 66(9), 1881-1894.doi.org/10.1016/j.joms.2008.04.022
McGrath, C., Comfort, M. B., Lo, E. C. M., & Luo, Y. (2003). Changes in life quality following third molar surgery–the immediate postoperative period. British dental journal, 194(5), 265-268.doi.org/10.1038/sj.bdj.4809930
Menon, R. K., Gopinath, D., Li, K. Y., Leung, Y. Y., & Botelho, M. G. (2019). Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. International journal of oral and maxillofacial surgery, 48(2), 263–273. https://doi.org/10.1016/j.ijom.2018.08.002
Milani, B. A., Bauer, H. C., Sampaio-Filho, H., Horliana, A. C. R. T., Perez, F. E. G., Tortamano, I. P., & Jorge, W. A. (2015). Antibiotic therapy in fully impacted lower third molar surgery: randomized three-arm, double-blind, controlled trial. Oral and maxillofacial surgery, 19(4), 341-346.doi.org/10.1007/s10006-015-0521-6
Ndukwe, K. C., Braimah, R. O., Owotade, J. F., & Aregbesola, S. B. (2016). Comparative efficacy of amoxicillin/clavulanic acid and levofloxacin in the reduction of postsurgical sequelae after third molar surgery: A randomized, double blind, clinical trial in a Nigerian University Teaching Hospital. NigerianJournalofSurgery, 22(2), 70-76. doi.org/10.4103/1117-6806.179830
Paiva-Oliveira, J. G., Bastos, P. R. H. O., Pontes, E. R. C., da Silva, J. C. L., Delgado, J. A. B., & Oshiro-Filho, N. T. (2016). Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars. Oral and maxillofacial surgery, 20(2), 123-133.doi.org/10.1007/s10006-015-0533-2
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica.[e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Disponível em:https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica. pdf.
Poeschl, P. W., Eckel, D., & Poeschl, E. (2004). Postoperative prophylactic antibiotic treatment in third molar surgery—A necessity?. Journal of oral and maxillofacial surgery, 62(1), 3-8.doi.org/10.1016/j.joms.2003.05.004
Prajapati, A., Prajapati, A., & Sathaye, S. (2016). Benefits of not prescribing prophylactic antibiotics after third molar surgery. Journal of maxillofacial and oral surgery, 15(2), 217-220.doi.org/10.1007/s12663-015-0814-1
Ramos, E., Santamaría, J., Santamaría, G., Barbier, L., & Arteagoitia, I. (2016). Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis. Oral surgery, oral medicine, oral pathology and oral radiology, 122(4), 403-425.doi.org/10.1016/j.oooo.2016.04.016
Rodrigues, W. C., Okamoto, R., Pellizzer, E. P., dos Carrijo, A. C., de Almeida, R. S., & de Melo, W. M. (2015). Antibiotic prophylaxis for third molar extraction in healthy patients: Current scientific evidence. Quintessence international (Berlin, Germany : 1985), 46(2), 149–161.doi.org/10.3290/j.qi.a32825
Sanchez, F. R., Andrés, C. R., & Calvo, I. A. (2017). Does chlorhexidine prevent alveolar osteitis after third molar extractions? Systematic review and meta-analysis. Journal of Oral and Maxillofacial Surgery, 75(5), 901-914.doi.org/10.1016/j.joms.2017.01.002
Xue, P., Wang, J., Wu, B., Ma, Y., Wu, F., & Hou, R. (2015). Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial. British Journalof OralandMaxillofacialSurgery, 53(5), 416-420.doi.org/10.1016/j.bjoms.2015.02.001
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Haniel Laurentino Ferreira dos Santos, Jaqueline Oliveira Barreto, Matheus Simões Medeiros, Thallyson Bandeira de Sá, Julliana Cariry Palhano Freire, Eduardo Dias Ribeiro
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
