Papel de los antioxidantes en el tratamiento del carcinoma hepatocelular: Revisión integrativa
DOI:
https://doi.org/10.33448/rsd-v10i1.12028Palabras clave:
Carcinoma hepatocelular; Antioxidante; Estrés oxidativo.Resumen
Marco teórico: el carcinoma hepatocelular es un cáncer singular que suele surgir en el context de una enfermedad hepatica crónica dependiente de la interacción entre el huésped, los factores ambientales y la capacidad de desarrolar la enfermedad. Desafortunadamente, con el tratamiento actual, los pacientes con carcinoma hepatocelular Avanzado tienen pocas opciones de tratamiento y el pronóstico es malo. Objetivo: evaluar el papel de los antioxidantes en el tratamiento del carcinoma hepatocelular. Metodología: se trata de una revision integradora, con enfoque cualitativo. A partir de búsquedas en las bases de datos ScienceDirect y PubMed, se seleccionaron 12 artículos que fueron consistentes con la temática y los criterios de inclusion y exclusion, mediante la asociación de descriptors y palabras clave. Resultados: Los estudios realizados in vivo han demonstrado una correlación positiva en el uso de antioxidantes en el tratamiento del carcinoma hepatocelular. Los antioxidantes fueron capaces de promover la inhibición del desarrollo tumoral al disminuir las citocinas proinflamatorias IL-1 e IL-6 y alterar la relación entre Bax/Bcl2 que apoyan la apoptosis, además de dirigir la eliminación de especies reactivas. Entre los principals antioxidantes con evidencia preclínica avanzada en el tratamiento del carcinoma hepatocelular se encuentra la curcumina con pruebas en humanos, ácido gálico, quercetina y resveratrol con varias pruebas in vitro e in vivo. Conclusión: Este studio destaca que los antioxidantes pueden ser una terapia prometedora en el tratamiento del carcinoma hepatocelular.
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Derechos de autor 2021 Claudriana Locatelli; Joyce Kelly Busolin Jardim; Vilmair Zancanaro
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