Medicina alternativa a base de hierbas para el tratamiento del acné

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i2.12153

Palabras clave:

Acné; Propionibacterium acnes; Fitoterapia; Plantas medicinales.

Resumen

El acné se considera una inflamación crónica de la piel que afecta a jóvenes y adultos de diferentes grupos de edad. Su etiología es multifactorial y se desencadena desde lesiones leves hasta lesiones comedogénicas que pueden producir cicatrices en ocasiones antiestéticas. Las terapias convencionales tienen varias limitaciones, ampliando la búsqueda de los afectados por terapias alternativas. La medicina alternativa se basa en el uso de plantas medicinales y sus derivados, y se ha utilizado con frecuencia en el acné. El objetivo del presente trabajo es analizar cómo la fitoterapia puede ayudar en el tratamiento alternativo del acné. Así, se realizó una búsqueda bibliográfica exhaustiva en las plataformas Scielo, PubMed, Science Direct y Scholar Google con investigaciones entre los años 2010 a 2020. De los 250 artículos seleccionados según la aplicabilidad del tema, 30 fueron utilizados para esta revisión. El resultado de la investigación mostró una diversidad de plantas medicinales con un potencial significativo en el tratamiento del acné, entre ellas Camellia sinensis, Orthosiphon stamineus y Rosmarinus officinalis. Las plantas con potencial para actuar en el tratamiento del acné presentaron compuestos bioactivos como el polifenol Epigalocatequina-3-galato, Strictinina, Aloemodina, Crisopanol y Aloína, que realizan actividad en las diferentes fisiopatologías del acné, pudiendo ser un tratamiento alternativo para el acné en relación a las terapias convencionales.

Biografía del autor/a

Verônica Marin Cubas, Universidade Positivo

Universidade Positivo, Brasil

Citas

Almela, L., Sánchez-Muñoz, B., Fernández-López, J. A., Roca, M. J., & Rabe, V. (2006). Liquid chromatograpic-mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material. Journal of Chromatography A, 1120, 221-229. 10.1016 / j.chroma.2006.02.05

Bhambri, S., Rosso, J. Q. D., & Bhambri, A. (2009). Pathogenesis of acne vulgaris: recent advances. Journal of Drugs in Dermatology, 8(7), 615-618.

Brasil. (2015). Ministério da Saúde, Secretaria de Atenção à Saúde. Portaria nº. 1159, de 18 de novembro de 2015. Brasília.

Buffon, M. C. M., Lima, M. L. C., Galarda, I., & Cogo, L. (2001). Avaliação da eficácia dos extratos de Malva sylvestris, Calendula officinalis, Plantago major e Curcuma zedoarea no controle do crescimento das bactérias da placa dentária. Estudo “in vitro”. Revista Visão Acadêmica, 2(1). 31-38.

Canavan, T. N., Chen, E., & Elewski, B. E. (2016). Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review. Dermatologic Therapy (Heidelb), 6(4), 555-578. 10.1007 / s13555-016-0138-1

Carson, C. F., Mee, B. J., & Riley, T. V. (2002). Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrobial Agents and Chemotherapy, 46(6), 1914-1920. 10.1128 / aac.46.6.1914-1920.2002

Castillo, D. E., Nanda, S., & Keri, J. E. (2019). Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives. Dermatologia e Terapia, 9(1), 19-31. 10.1007 / s13555-018-0275-9

Chahal, D. S., Sivamani, R. K., Isseroff, R. R., & Dasu, M. R. (2013). Plant-Based Modulation of Toll-like Receptors: An Emerging Therapeutic Model. Phytotherapy Research, 27(10), 1423-1438. https://doi.org/10.1002/ptr.4886

Chen, W., Wyk, Ben-Erik. V., Vermaak, I., & Viljoen, A. M. (2012). Cape aloes - A review of the phytochemistry, pharmacology and commercialisation of Aloe ferox. Phytochemistry Letters, 5(1), 1-12. 10.1016 / j.phytol.2011.09.001

Choo, B. K. M., Kundap, U. P., Kumari, Y., Hue, S. M., Othman, I., & Shaikh, M. F. (2018). Orthosiphon stamineus Leaf Extract Affects TNF-α and Seizures in a Zebrafish Model. Frontiers in Pharmacology, 9, 1-11. https://doi.org/10.3389/fphar.2018.00139

Daglia, M. (2012). Polyphenols as antimicrobial agents. Current Opinion in Biotechnology, 23(2), 174-181. https://doi.org/10.1016/j.copbio.2011.08.007

Dessinioti, C., & Katsambas, A. D. (2010). The role of Propionibacterium acnes in acne pathogenesis: facts and controversies. Clinics In Dermatology, 28(1), 2-7. 10.1016 / j.clindermatol.2009.03.012

Dhillon, KS., & Varshney, K. R. (2013). Study of Microbiological Spectrum in Acne Vulgaris: An In Vitro Study. Scholars Journal of Applied Medical Sciences, 1(6), 724-727.

Dreno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D., Bettoli, V.,Torres, V., & Leyden, J. (2015). Understanding innate immunity and inflammation in acne: implications for management. Journal Of The European Academy Of Dermatology And Venereology, 29(Suppl 4), 3-11. 10.1111 / jdv.13190

Dreno, B., Poli, F., Pawin, H., Beylot, C., Faure, M., Chivot, M., Auffret, N., Moyse, D., Ballanger, F., & Revuz, J. (2011). Development and evaluation of a Global Acne Severity Scale (GEA Scale) suitable for France and Europe. Journal of the European Academy of Dermatology and Venereology, 25(1), 43-48. 10.1111 / j.1468-3083.2010.03685.x

Enioutina, E. Y., Teng, L., Fateeva, T. V., Brown, J. CS., Job, K. M., Bortnikova, V. V., Krepkova, L. V., Gubarev, M. I., & Sherwin, C. MT. (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert Review of Clinical Pharmacology, 10(11), 1203-1214. 10.1080 / 17512433.2017.1371591

Eumkeba, G., Sakdarat, S., & Siriwonga, S. (2010). Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime. Phytomedicine, 18 (1), 40-45. 10.1016 / j.phymed.2010.09.003

Feldman, S. R., Tan, J., Poulin, Y., Dirschka, T., Kerrouche, N., & Manna, V. (2011). The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions. Journal of the American Academy of Dermatology, 64(6), 1085-1091. 10.1016 / j.jaad.2010.03.036

Fisk, W. A., Lev-Tov, H. A., & Sivamani, R. K. (2014). Botanical and Phytochemical Therapy of Acne: A Systematic Review. Phytotherapy Research, 28(8), 1137-1152. 10.1002 / ptr.5125

Food and drug administration. (2018). Contains Nonbinding Recommendations: Draft Guidance on Adapalene; Benzoyl peroxide. Recuperado 2020, de https://www.accessdata.fda.gov/drugsatfda_docs/psg/Adapalene_Benzoyl_Peroxide_Gel_NDA_207917_RV_Nov_2018.pdf.

Fox, L., Csongradi, C., Aucamp, M., Plessis, J. D.,& Gerber, M. (2016). Treatment Modalities for Acne. Molecules, 21(8), 1-20. 10.3390 / moléculas21081063

González-Gallego, J., García-Mediavilla, M. V., Sánchez-Campos, S., & Tuñón, M. J. (2010). Fruit polyphenols, immunity and inflammation. British Journal of Nutrition, 104, S15-27.

Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., Bouffard, G. G., Blakesley, R. W., Murray, P. R., Green, E. D., Turner, M. L., & Segre, J. A. (2009). Topographical and temporal diversity of the human skin microbiome. Science, 324(5931), 1190-1192. 10.1126 / science.1171700

Han, R., Blencke, H. M., Cheng, H., & Li, C. (2018). The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. Peptides, 99, 36-43. 10.1016 / j.peptides.2017.11.001

Hou, H. S., Bonku, E. M., Zhai, R., Zeng, R., Hou, Y. L., Yang, Z. H., & Quan, C. (2019). Extraction of essential oil from Citrus reticulate Blanco peel and its antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes). Heliyon, 5(12), e02947. https://doi.org/10.1016/j.heliyon.2019.e02947

Hsieh, S. K., Xu, J. R., Lin, N. H., Li, Y. C., Chen, G. H., Kuo, P. C., Chen, W. Y., & Tzen, J. TC. (2016). Antibacterial and laxative activities of strictinin isolated from Pu‘er tea (Camellia sinensis). Journal of Food and Drug Analysis, 24(4), 722-729.

Issabeagloo, E., Kermanizadeh, P., Taghizadieh, M., & Forughi, R. (2012). Antimicrobial effects of rosemary (Rosmarinus officinalis L.) essential oils against Staphylococcus spp. African Journal of Microbiology Research, 6(23), 5039-5042. https://doi.org/10.5897/AJMR12.741

Jasson, F., Nagy, I., Knol, A. C., Zuliani, T., Khammari, A., & Dréno, B. (2013). Different strains of Propionibacterium acnes modulate differently the cutaneous innate immunity. Experimental Dermatology, 22(9), 587-592. 10.1111 / exd.12206

Jeong, W. Y., & Kim, K. (2017). Anti-Propionibacterium acnes and the Anti-Inflammatory Effect of Aloe ferox Miller Components. Journal of Herbal Medicine, 9, 53-59. https://doi.org/10.1016/j.hermed.2017.03.009

Kim, J. (2005). Review of the Innate Immune Response in Acne vulgaris: Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. Dermatology, 211(3), 193-198. 10.1159 / 000087011

Kim, J., Lee, K. W., & Lee, H. J. (2014). Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease. Polyphenols in Human Health and Disease, 1, 393-408. 10.1016 / B978-0-12-398456-2.00029-3

Kim, J., Ochoa, M., Krutzik, S. R., Takeuchi, O., Uematsu, S., Legaspi, A. J., Brightbill, H. D., Holland, D., Cunliffe, W. J., Akira, S., Sieling, P. A., Godowski , P. J., & Modlin, R. L. (2002). Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. The Journal of Immunology, 169(3), 1535-1541. 10.4049 / jimmunol.169.3.1535

Kim, S. Y., & Ochsendorf, F. R. (2016). New Developments in Acne Treatment: Role of Combination Adapalene-Benzoylperoxide. Therapeutics and Clinical Risk Managemen, 12, 1497-1506. https://doi.org/10.2147/TCRM.S94062

Kistowska, M., Gehrke, S., Jankovic, D., Kerl, K., Fettelschoss, A., Feldmeyer, l., Fenini, G., Kolios, A., Navarini, A., Ganceviciene, R., Schauber, J., Contassot, E., & Francês, L. E. (2014). IL-1β drives inflammatory responses to Propionibacterium acnes in vitro and in vivo. Journal of Investigative Dermatology, 134(3), 677-685. 10.1038 / jid.2013.438

Lamarão, R. C., & Fialho, E. (2009). Functional aspects of green tea catechins in the cellular metabolism and their relationship with body fat reduction. Revista de Nutrição, 22(2), 257-269. 10.1590/S1415-52732009000200008

Leal, C. A. E., & Lara, S. G. (2019). Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications. Planta médica, 85(7), 535-551. 10.1055 / a-0857-6633

Lee, Y. B., Byun, E. J., & Kim, H. S. (2019). Potential Role of the Microbiome in Acne: A Comprehensive Review. Journal of Clinical Medicine, 8(7), 1-25. 10.3390 / jcm8070987

Leyden, J. J. (2003). A review of the use of combination therapies for the treatment of acne vulgaris. Journal of the American Academy of Dermatology, 49(Suppl 3), 200-210. 10.1067 / s0190-9622 (03) 01154-x

Leyden, J. J. (2012). In vivo antibacterial effects of tretinoin-clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory. Journal of Drugs in Dermatology, 11(12), 1434-1438.

Li, Z., Summanen, P. H., Downes, J., Corbett, K., Komoriya, T., Henning, S. M., Kim, J., & Finegold, S. M. (2015). Antimicrobial Activity of Pomegranate and Green Tea Extract on Propionibacterium acnes, Propionibacterium granulosum, Staphylococcus aureus and Staphylococcus epidermidis. Journal of Drugs in Dermatology, 14(6), 574-578.

Liao, S. (2001). The medicinal action of androgens and green tea epigallocatechin gallate. Hong Kong Medical Journal, 7(4), 369-374.

Lomholt, H. B., & Kilian, M. (2010). Population Genetic Analysis of Propionibacterium acnes Identifies a Subpopulation and Epidemic Clones Associated With Acne. PLoS One, 5(8), e12277. 10.1371 / journal.pone.0012277

Maeda-Yamamoto, M., Nagai, H., Asai, K., Tachibana, H., Miyase, T., San, M., Moriwaki, S., Horie, H., & Kohata, K. (2004). Changes in Epigallocatechin-3-O-(3-O-methyl) Gallate and Strictinin Contents of Tea (Camellia sinensis L.) Cultivar ‘Benifuki’ in Various Degrees of Maturity and Leaf Order. Food Science and Technology Research, 10(2), 186-190.

Mahmood, T., Akhtar, N., & Moldavo, C. (2013). A comparison of the effects of topical green tea and lotus on facial sebum control in healthy humans. Hippokratia, 17(1), 64-67.

Mahmood, T., Akhtar, N., Khan, B. A., Khan, H. M. S., & Saeed, T. (2010). Outcomes of 3% green tea emulsion on skin sebum production in male volunteers. Bosnian Journal Of Basic Medical Sciences, 10(3), 260-264. 10.17305 / bjbms.2010.2697

Mansu, S. S. Y., Coyle, M., Wang, K., May, B., Zhang, A. L., & Xue, C. C. L. (2018). Herbal medicine Eriobotrya japonica formula for acne vulgaris: A systematic review. Journal of Herbal Medicine, 11, 12-23. https://doi.org/10.1016/j.hermed.2017.09.001

Marzocchella, L., Fantini, M., Benvenuto, M., Masuelli, L., Tresoldi, I., Modesti, A., & Bei, R. (2011). Dietary flavonoids: molecular mechanisms of action as anti- inflammatory agents. Recent Patents on Inflammation & Allergy Drug Discovery, 5(3), 200-220. 10.2174 / 187221311797264937

Matsuchita, H. L. P., & Matsuchita, A. S. P. (2014). Uso da Própolis na Prevenção e Tratamento da Acne Vulgar. Uniciências, 18(1), 19-23.

Mcinturff, J. E., & Kim, J. (2005). The Role of Toll-Like Receptors in the Pathophysiology of Acne. Seminars in Cutaneous Medicine and Surgery, 24(2), 73-78. 10.1016 / j.sder.2005.03.002.

Mcinturff, J. E., Modlin, R. L., & Kim, J. (2005). The Role of Toll-like Receptors in the Pathogenesis and Treatment of Dermatological Disease. The Journal of Investigative Dermatology, 125(1), 1-8. 10.1111 / j.0022-202X.2004.23459.x

Melnik, B. C. (2015). Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clinical, Cosmetic and Investigational Dermatology, 8, 71-388. 10.2147 / CCID.S69135

Melnik, B. C., & Schmitz, G. (2013). Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?. Experimental Dermatology, 22, 502-504.

Melnik, B. C., & Zouboulis, C. C. (2013). Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Experimental Dermatology, 22, 311-315. https://doi.org/10.1111/exd.12172

Melnik, C. B. (2018). Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle. Clinics In Dermatology, 36(1), 29-40. 10.1016 / j.clindermatol.2017.09.006

Michael, C. A., Dominey-Howes, D., & Maurizio, L. (2014). The Antimicrobial Resistance Crisis: Causes, Consequences, and Management. Frontiers in Public Health, 2, 1-8. https://doi.org/10.3389/fpubh.2014.00145

Montagner, S., & Costa, A. (2010). Diretrizes modernas no tratamento da acne vulgar: da abordagem inicial à manutenção dos benefícios clínicos. Surgical & Cosmetic Dermatology, 2(3), 205-213.

Mukherjeea, P. K., Maity, N., Nema, N. K., & Sarkar, B. K. (2011). Bioactive compounds from natural resources against skin aging. Phytomedicine, 19(1), 64-73. 10.1016 / j.phymed.2011.10.003

Nasri, H., Bahmani, M., Shahinfard, N., Nafchi, A. M., Saberianpour, S., & Kopaei, M. R. (2015). Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences. Jundishapur Journal of Microbiology, 8(11), e25580. 10.5812 / jjm.25580

Nichols, J. A., & Katiyar, S. K. (2010). Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Archives of Dermatology, 302(2), 71- 83. 10.1007 / s00403-009-1001-3

O’neill A. M., & Gallo, R. L. (2018). Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome, 6(1), 177. 10.1186 / s40168-018-0558-5

Pathak, R., Kasama, N., Kumar, R., & Gautam, H. K. (2013). Staphylococcus epidermidis in Human Skin Microbiome associated with Acne: A Cause of Disease or Defence?. Research Journal Of Biotechnology, 8(12), 78-82.

Pecastaings, S., Roque, C., Nocera, P. C., Mengeaud, V., Khammari, A., & Dréno, B. (2018). Characterisation of Cutibacterium acnes phylotypes in acne and in vivo exploratory evaluation of Myrtacine. Journal of the European Academy of Dermatology and Venereology, 32(Suppl 2), 15-23. 10.1111 / jdv.15042

Poomanee, W., Chaiyana, W., Mueller, M., Viernstein, H., Khunkitti, W., & Leelapornpisid, P. (2018). In-vitro investigation of anti-acne properties of Mangifera indica L. kernel extract and its mechanism of action against Propionibacterium acnes. Anaerobe, 52, 64-74. 10.1016 / j.anaerobe.2018.05.004

Porstmann, T., Santos, C.R., Lewis, C., Griffiths, B., & Schulze, A. (2009). A New Player in the Orchestra of Cell Growth: SREBP Activity Is Regulated by mTORC1 and Contributes to the Regulation of Cell and Organ Size. Biochemical Society Transactions, 37, 78-283. 10.1042 / BST0370278

Quinn, W. J., & Birnbaum, M. J. (2012). Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c. Proceedings of the National Academy of Sciences of the United States America, 109(40), 15974-15975. https://doi.org/10.1073/pnas.1214113109

Ramli, R., Malik, A. S., Hani, A. F. M., & Jamil, A. (2012). Acne analysis, grading and computational assessment methods: an overview. Skin Research and Technology, 18(1), 1-14. 10.1111 / j.1600-0846.2011.00542.x

Rathee, P., Chaudhary, H., Rathee, S., Rathee, D., Kumar, V., & Kohli, K. (2009). Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflammation & Allergy - Drug Targets, 8(3), 229-235. 10.2174 / 187152809788681029

Ruiz, A. C. A., Hernández, O.M., Torres-Tobar, L., Garzón, M. G., Reverend, C., Ayala, C. A., Rueda, J. C., & Díaz, A. T. (2019). Caracterización de las cepas de Cutibacterium acnes en pacientes con diagnóstico de acné en una población colombiana. Piel: Formación continuada en dermatología, 34(4), 204-211.

Sadhasivam, S., Sinha, M., Saini, S., Kaur, S. P., Gupta, T., Sengupta, S., Ghosh, S., & Sardana, K. (2016). Heterogeneity and antibiotic resistance in Propionibacterium acnes isolates and its therapeutic implications: blurring the lines between commensal and pathogenic phylotypes. Dermatologic Therapy, 29(6), 451-454. https://doi.org/10.1111/dth.12391

Saewan, N., & Jimtaisong, A. (2015). Natural products as photoprotection. Journal of Cosmetic Dermatology, 14(1), 47-63. https://doi.org/10.1111/jocd.12123

Saha, R. (2012). Cosmeceuticals and herbal drugs: practical uses. International Journal of Pharmaceutical Sciences and Research, 3(1), 59-65.

Sand, F. L., & Thomsen, S. F. (2013). Adalimumab for the Treatment of Refractory Acne Conglobata. JAMA Dermatology, 149(11), 1306-1307. 10.1001 / jamadermatol.2013.6678

Silva, A. F., Costa, F.P., & Moreira, M. (2014). Acne vulgar: diagnóstico e manejo pelo médico de família e comunidade. Revista Brasileira de medicina de família e comunidade, 9(30), 54-63. https://doi.org/10.5712/rbmfc9(30)754

Silva, A. M. O., Andrade-Wartha, E. R. S., Carvalho, E. B. T., Lima, A., Novoa, A. V., & Filho-Mancini, J. (2011). Effect of aqueous rosemary extract (Rosmarinus officinalis L.) on the oxidative stress of diabetic rats. Revista de Nutrição, 24(1), 121-130.

Thiboutot, D. (2011). Dermatologists Do Not Yet Fully Understand the Clinical Significance of Antibiotic Use and Bacterial Resistance in Patients With Acne. Archives of Dermatology, 147(8), 921-922. 10.1001 / archdermatol.2011.201

Thiboutot, D., Gollnick, H., Vincenzo, B., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. R., Lozada, V. T., Berson, D., Finlay, A., Goh, C. L., Herane, M. I., Kaminsky, A., Kubba, R., Layton, A., Miyachi, Y., Perez, M., Martin, J. P., Silva, M. R., See, J. A., Shear, N., & Jr, J. W. (2009). New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group. Journal of the American Academy of Dermatology, 60(Suppl 5), 1-50. 10.1016 / j.jaad.2009.01.019

Totté, JEE., Feltz, WT, V., Bode, LGM., Belkum, A. V., Zuuren, EJ. V., & Pasmans, SGMA. (2016). A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea. European Journal of Clinical Microbiology & Infectious Diseases, 35(7), 1069-1077. 10.1007 / s10096-016-2647-3

Tsai, P, J., Huang, W. C., Hsieh, M. C., Sung, P. J., Kuo, Y. H., & Wu, W. H. (2016). Flavones Isolated from Scutellariae radix Suppress Propionibacterium Acnes - Induced Cytokine Production In Vitro and In Vivo. Molecules, 21(1), 1-11. 10.3390 / moléculas21010015

Tuñón, MJ., García-Mediavilla, MV., Sánchez-Campos, S., & González-Gallego, J. (2009). Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways. Current Drug Metabolism, 3, 256-271.

Upadhyay, A., Upadhyaya, I., Kollanoor-Johny, A., & Venkitanarayanan, K. (2014). Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis. BioMed Research International, 2014, 1-18. https://doi.org/10.1155/2014/761741

Vogelgesang, B., Malak, N. A., Reymermier., Altobelli, C., & Saget, J. (2011). On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. International Journal of Cosmetic Science, 33(1), 44-52. 10.1111 / j.1468-2494.2010.00581.x

Vora, J., Srivastava, A., & Modi, H. (2018). Antibacterial and antioxidant strategies for acne treatment through plant extracts. Informatics in Medicine Unlocked, 13, 128-132. https://doi.org/10.1016/j.imu.2017.10.005

Williams, H. C., Dellavalle, R. P., & Garner, S. (2012). Acne vulgaris. Lanceta, 379(9813), 361-372. 10.1016 / S0140-6736 (11) 60321-8

Wolff, K., Johnson, R. A., Saavedra, A. P., & Roh, E. K. (2019). Dermatologia de Fitzpatrick. Porto Alegre: (8 ed). AMGH.

Yam, M. F., Lim, V., Salman, I. M., Ameer, O. Z., Ang, L. F., Rosidah, N., Abdulkarim, M. F., Abdullah, G. Z., Basir, R., Sadikun, A., & Asmawi, M. Z. (2010). HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves. Molecules, 15(6), 4452-4466. 10.3390 / moléculas15064452

Yoon, J. Y., Know, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H. (2013). Epigallocatechin-3-Gallate Improves Acne in Humans by Modulating Intracellular Molecular Targets and Inhibiting P. acnes. Journal of Investigative Dermatology, 133(2), 429-440. 10.1038 / jid.2012.292

Zouboulis, CC., Jourdan, E., & Picardo, M. (2014). Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. Journal of The European Academy of Dermatology And Venereology, 28(5), 527-532. 10.1111 / jdv.12298

Publicado

07/02/2021

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CUBAS, V. M.; RIBAS, J. L. C. Medicina alternativa a base de hierbas para el tratamiento del acné. Research, Society and Development, [S. l.], v. 10, n. 2, p. e12810212153, 2021. DOI: 10.33448/rsd-v10i2.12153. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12153. Acesso em: 21 dic. 2024.

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