Comorbilidades aumentan el riesgo de gravedad y mortalidad en pacientes con COVID-19: una revisión sistemática y metanálisis
DOI:
https://doi.org/10.33448/rsd-v10i2.12533Palabras clave:
Coronavirus; COVID-19; Comorbilidades; Enfermedades crónicas; SARS-CoV-2.Resumen
Introducción: Varios estudios han demostrado que los pacientes con comorbilidades presenten un mal pronóstico clínico de COVID-19, pero las conclusiones aún no están consolidadas. Realizamos un metanálisis para evaluar la relación entre las condiciones preexistentes (comorbilidades) en pacientes infectados con SARS-CoV-2 y el resultado de COVID-19. Métodos: Se examinaron las bases de datos PubMed, Science Direct, ISI Web of Science y Scopus hasta noviembre de 2020. Nosotros calculamos el odds ratio (OR) con un intervalo de confianza del 95%, utilizando modelos de efectos fijos o de efectos aleatorios. Resultados: Se incluyeron en el metanálisis un total de 48 estudios de cohorte retrospectivos con 344,290 pacientes con COVID-19. Los resultados combinados mostraron que la hipertensión, la diabetes, las enfermedades cardiovasculares, pulmonares crónicas, renales crónicas y cerebrovasculares aumentan el riesgo de gravedad y mortalidad en los pacientes con COVID-19. Además, la malignidad se asoció con un mayor riesgo de muerte por COVID-19. Conclusiones: Las comorbilidades mencionadas anteriormente pueden ser importantes predictores de mala evolución del COVID-19, contribuyendo al pronóstico de los casos graves de la enfermedad.
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Derechos de autor 2021 Edilson Leite de Moura; Jean Moises Ferreira; Ana Caroline Melo dos Santos ; Denise Macedo da Silva ; Maria Lidiane Ferreira da Silva ; Gleyce Kelly Marques de Oliveira Silva; Pedro Henrique Nobre Silva ; José Anderson dos Santos; Marcos Antônio da Silva Barbosa Junior ; Abel Barbosa Lira Neto ; Aline Cristine Pereira e Silva; Carlos Alberto de Carvalho Fraga; Karol Fireman de Farias; Elaine Virginia Martins de Souza Figueiredo
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