Mucositis oral relacionada con la quimioterapia en pacientes con cáncer de mama: una breve revisión

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i3.13338

Palabras clave:

Estomatitis; Neoplasias de la mama; Quimioterapia; Antineoplásicos.

Resumen

El cáncer de mama puede impactar en distintos ámbitos de la salud de las pacientes, ya que la experiencia con el tratamiento suele estar rodeada de miedos y ansiedades. Es posible observar que los efectos adversos de la quimioterapia son comunes y las mujeres con cáncer de mama pueden tener una alta incidencia de mucositis oral (MO). Por lo tanto, el objetivo de esta revisión fue discutir la relación entre el tratamiento con quimioterapia del cáncer de mama y la aparición de mucositis oral. La MO se caracteriza por la aparición de eritema o úlceras en la cavidad bucal, y su clasificación varía según la escala utilizada. La fisiopatología está asociada a factores de riesgo, ya que el tratamiento administrado y el estilo de vida del paciente pueden impactar directamente en la aparición y progresión de la OM. Aunque la mayoría de los casos son leves o moderados, el impacto de la MO no puede subestimarse, incluso en casos de síntomas bajos o impacto funcional, considerando el dolor bucal y la dificultad para ingerir alimentos. Por ello, es importante que los profesionales estén atentos a la clasificación, los factores de riesgo y los posibles impactos en la salud, incluida la planificación de intervenciones preventivas y curativas en el manejo de este efecto adverso de la quimioterapia. Los profesionales de la salud, incluidos dentistas, enfermeras y médicos, deben estar preparados para atender los casos de OM, promoviendo acciones integradas para reducir el impacto de esta condición en la salud de las mujeres con cáncer de mama.

Citas

Akram, M., Iqbal, M., Daniyal, M., & Khan, A. U. (2017). Awareness and current knowledge of breast cancer. Biological research, 50(1), 1-23.

Al-Ansari, S., Zecha, J. A., Barasch, A., de Lange, J., Rozema, F. R., & Raber-Durlacher, J. E. (2015). Oral mucositis induced by anticancer therapies. Current oral health reports, 2(4), 202-211.

Al Ibraheemi, A. A., & Shamoun, S. (2016). Incidence and risk factors of oral mucositis in patients with breast cancer who receiving chemotherapy in Al-Bashir hospital. International journal of hematology-oncology and stem cell research, 10(4), 217.

Araújo, S. N. M., Luz, M. H. B. A., Silva, G. R. F. D., Andrade, E. M. L. R., Nunes, L. C. C., & Moura, R. O. (2015). Cancer patients with oral mucositis: challenges for nursing care. Revista latino-americana de enfermagem, 23(2), 267-274.

Ariyawardana, A., Cheng, K. K. F., Kandwal, A., Tilly, V., Al-Azri, A. R., Galiti, D., ... & Elad, S. (2019). Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27(10), 3985-3995.

Azamjah, N., Soltan-Zadeh, Y., & Zayeri, F. (2019). Global trend of breast cancer mortality rate: a 25-year study. Asian Pacific journal of cancer prevention: APJCP, 20(7), 2015.

Barasch, A., & Peterson, D. E. (2003). Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral oncology, 39(2), 91-100.

Barbosa-Lima, R., Kameo, S. Y., Amorim, B. F., Ramos, M. J. O., dos Santos Costa, J., Marinho, P. M. L., ... & Silva, G. M. (2020). Occurrence of oral mucositis in women during oncological treatment of breast cancer in the Brazilian Northeast. Health Sciences Journal, 10(4), 144-150.

Brasil. (2019). Estimativa 2020: Incidência de Câncer no Brasil. Instituto Nacional de Câncer - José de Alencar Gomes da Silva. Rio de Janeiro: Ministério da Saúde.

Bonilla, J. M., Tabanera, M. T., & Mendoza, L. R. (2017). Breast cancer in the 21st century: from early detection to new therapies. Radiología (English Edition), 59(5), 368-379.

Chansky, K., Benedetti, J., & Macdonald, J. S. (2005). Differences in toxicity between men and women treated with 5‐fluorouracil therapy for colorectal carcinoma. Cancer: Interdisciplinary International Journal of the American Cancer Society, 103(6), 1165-1171.

Chaveli-López, B., & Bagán-Sebastián, J. V. (2016). Treatment of oral mucositis due to chemotherapy. Journal of clinical and experimental dentistry, 8(2), e201.

Curra, M., Soares Junior, L. A. V., Martins, M. D., & Santos, P. S. D. S. (2018). Chemotherapy protocols and incidence of oral mucositis. An integrative review. Einstein (Sao Paulo), 16(1).

Daugėlaitė, G., Užkuraitytė, K., Jagelavičienė, E., & Filipauskas, A. (2019). Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis. Medicina, 55(2), 25.

Dodd, M. J., Miaskowski, C., Shiba, G. H., Dibble, S. L., Greenspan, D., Macphail, L., ... & Larson, P. (1999). Risk factors for chemotherapy-induced oral mucositis: dental appliances, oral hygiene, previous oral lesions, and history of smoking. Cancer investigation, 17(4), 278-284.

Elad, S., Cheng, K. K. F., Lalla, R. V., Yarom, N., Hong, C., Logan, R. M., ... & Zur, E. (2020). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 126(19), 4423-4431.

Holmes, T. S. V., dos Santos, M. G. C., de Medeiros Nóbrega, D. R., Pereira, J. V., de Castro Gomes, D. Q., & Pereira, M. D. S. V. (2014). Fatores relacionados ao surgimento e gradação da mucosite oral radioinduzida. Rev Cubana Estomatol, 51(1), 45-51.

Hong, B. Y., Sobue, T., Choquette, L., Dupuy, A. K., Thompson, A., Burleson, J. A., ... & Diaz, P. I. (2019). Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis. Microbiome, 7(1), 1-18.

Hong, C. H., Gueiros, L. A., Fulton, J. S., Cheng, K. K. F., Kandwal, A., Galiti, D., ... & Elad, S. (2019). Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27(10), 3949-3967.

Jesus, L. G. D., Cicchelli, M., Martins, G. B., Pereira, M. C. C., Lima, H. S., & Medrado, A. R. A. P. (2016). Oral effects of anticancer drugs: a literature review. RFO UPF, 21(1), 130-135.

Kusiak, A., AlicjaJereczek-Fossa, B., Cichońska, D., & Alterio, D. (2020). Oncological-therapy related oral mucositis as an interdisciplinary problem—Literature review. International journal of environmental research and public health, 17(7), 2464.

Lalla, R. V., Sonis, S. T., Peterson, D. E (2008). Management of Oral Mucositis in Patients with Cancer. Dent Clin North Am, 52(1), 61-77.

McCarthy, G. M., Awde, J. D., Ghandi, H., Vincent, M., & Kocha, W. I. (1998). Risk factors associated with mucositis in cancer patients receiving 5-fluorouracil. Oral oncology, 34(6), 484-490.

Morais, J. R., Vanderley, T. R., Soares, R. D. M., Castro, A. E. D., Araújo, S. N. M., & Luz, M. H. B. A. (2015). Characterization of the patient with chemotherapy-induced oral mucositis/Caracterização do paciente com mucosite oral induzida por quimioterapia/Caracterización de la paciente con mucositis oral inducida por quimioterapia. Revista de Enfermagem da UFPI, 4(1), 26-32.

National Cancer Institute. (2017). Common Terminology Criteria for Adverse Events (CTCAE). United State Department of Health and Human Services, v.5.0.

Park, S. H., & Lee, H. S. (2019). Meta‐analysis of oral cryotherapy in preventing oral mucositis associated with cancer therapy. International journal of nursing practice, 25(5), e12759.

Pereira, I. F., Firmino, R. T., Meira, H. C., Vasconcelos, B. C. D. E., Noronha, V. R. A. D. S., & Santos, V. R. (2019). Radiation-induced oral mucositis in Brazilian patients: Prevalence and associated factors. in vivo, 33(2), 605-609.

Cleverson, P. A. T. U. S. S. I., Laurindo Moacir, S. A. S. S. I., Eduardo Ciliao, M. U. N. H. O. Z., Roberta Targa Stramandinoli, Z. A. N. I. C. O. T. T. I., & Juliana Lucena, S. C. H. U. S. S. E. L. (2014). Clinical assessment of oral mucositis and candidiasis compare to chemotherapic nadir in transplanted patients. Brazilian oral research, 28(1), 1-7.

Pulito, C., Cristaudo, A., La Porta, C., Zapperi, S., Blandino, G., Morrone, A., & Strano, S. (2020). Oral mucositis: the hidden side of cancer therapy. Journal of Experimental & Clinical Cancer Research, 39(1), 1-15.

Raber-durlacher, J. E., Elad, S., Barasch, A. (2010). Oral mucositis. Oral Oncol, 46 (6), 452-456.

Saedi, H. S., Gerami, H., Soltanipour, S., Habibi, A. F., Mirhosseyni, M., Montazeri, S., & Nemati, S. (2019). Frequency of chemoradiotherapy-induced mucositis and related risk factors in patients with the head-and-neck cancers: A survey in the North of Iran. Dental research journal, 16(5), 354.

Scully, C., Sonis, S., Diz, P. D. (2006). Oral mucositis. Oral Dis, 12(3), 229-241.

Seiler, S., Kosse, J., Loibl, S., & Jackisch, C. (2014). Adverse event management of oral mucositis in patients with breast cancer. Breast Care, 9(4), 232-237.

Shankar, A., Roy, S., Bhandari, M., Rath, G. K., Biswas, A. S., Kanodia, R., ... & Sachan, R. (2017). Current trends in management of oral mucositis in cancer treatment. Asian Pacific journal of cancer prevention: APJCP, 18(8), 2019.

Sloan, J. A., Goldberg, R. M., Sargent, D. J., Vargas-Chanes, D., Nair, S., Cha, S. S., ... & Loprinzi, C. L. (2002). Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer. Journal of clinical oncology, 20(6), 1491-1498.

Sonis, S. T. (2009). Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral oncology, 45(12), 1015-1020.

Sonis, S. T., Lieberman, A., & Sonis, A. L. (1978). Oral complications in patients receiving treatment for malignancies other than of the head and neck. The Journal of the American Dental Association, 97(3), 468-472.

Sonis, S., & Clark, J. (1991). Prevention and management of oral mucositis induced by antineoplastic therapy. Oncology (Williston Park, NY), 5(12), 11-8.

Suresh, A. V. S., Varma, P. P., Sinha, S., Deepika, S., Raman, R., Srinivasan, M., ... & Anand, B. B. (2010). Risk-scoring system for predicting mucositis in patients of head and neck cancer receiving concurrent chemoradiotherapy. Journal of cancer research and therapeutics, 6(4), 448.

Watanabe, T., Kuranami, M., Inoue, K., Masuda, N., Aogi, K., Ohno, S., ... & Ohashi, Y. (2017). Comparison of an AC‐taxane versus AC‐free regimen and paclitaxel versus docetaxel in patients with lymph node‐positive breast cancer: Final results of the National Surgical Adjuvant Study of Breast Cancer 02 trial, a randomized comparative phase 3 study. Cancer, 123(5), 759-768.

Wilairat, P., Kengkla, K., Kaewpanan, T., Kaewthong, J., Ruankon, S., Subthaweesin, C., ... & Saokaew, S. (2020). Comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis in adult cancer patients: a systematic review and network meta-analysis. European Journal of Hospital Pharmacy, 27(2), 103-110.

Yu, Y. Y., Deng, J. L., Jin, X. R., Zhang, Z. Z., Zhang, X. H., & Zhou, X. (2020). Effects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials. Medicine, 99(16).

Zhang, X., Sun, D., Qin, N., Liu, M., Zhang, J., & Li, X. (2020). Comparative prevention potential of 10 mouthwashes on intolerable oral mucositis in cancer patients: A Bayesian network analysis. Oral oncology, 107, 104751.

Zhang, X. H., Hao, S., Gao, B., Tian, W. G., Jiang, Y., Zhang, S., ... & Luo, D. L. (2016). A network meta-analysis for toxicity of eight chemotherapy regimens in the treatment of metastatic/advanced breast cancer. Oncotarget, 7(51), 84533-84543.

Publicado

14/03/2021

Cómo citar

MARINHO, P. M. L.; BARBOSA-LIMA, R.; SANTOS, J. C. de O.; SANTOS, D. K. da C.; SOBRAL, G. S.; VASSILIEVITCH, A. C.; AMORIM, B. F.; COSTA , J. dos S.; FONSECA, T. V.; SILVA , G. M.; KAMEO, S. Y.; SAWADA, N. O. Mucositis oral relacionada con la quimioterapia en pacientes con cáncer de mama: una breve revisión. Research, Society and Development, [S. l.], v. 10, n. 3, p. e25610313338, 2021. DOI: 10.33448/rsd-v10i3.13338. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13338. Acesso em: 30 jun. 2024.

Número

Sección

Ciencias de la salud