Efeito antitumoral do chá verde no carcinoma de células escamosas oral: Revisão integrativa

William José e Silva Filho; Divyashree  Singh; Shalini Singh; Rosilene Calazans  Soares; Débora dos Santos  Tavares

doi:10.33448/rsd-v10i8.17039

Autores/as

William José e Silva Filho Universidade Federal de Sergipe https://orcid.org/0000-0002-2117-3352
Divyashree Singh Universidade Federal de Sergipe https://orcid.org/0000-0003-0077-6039
Shalini Singh Universidade Federal de Sergipe https://orcid.org/0000-0002-8369-5666
Rosilene Calazans Soares Universidade Federal de Sergipe https://orcid.org/0000-0002-8392-9653
Débora dos Santos Tavares Universidade Federal de Sergipe https://orcid.org/0000-0001-5452-0771

DOI:

https://doi.org/10.33448/rsd-v10i8.17039

Palabras clave:

té verde; Camellia sinensis; Cáncer oral; Carcinoma de células escamosas; Animales.

Resumen

Objetivo: Evaluar el efecto antitumoral del té verde y sus compuestos naturales en el carcinoma oral de células escamosas (CCEO). Metodología: Se trata de una revisión integradora de la literatura basada en la pregunta orientadora “¿Tiene el té verde un efecto antitumoral en el desarrollo de CCEO?”. La búsqueda se realizó con los descriptores "Camellia sinensis", "Té verde"; "Cáncer oral"; "Carcinoma de células escamosas"; “Animales” y “agentes anticancerígenos” en las bases de datos PubMed, Science Direct, Scielo y Google Scholar. Los criterios de inclusión fueron artículos científicos sobre el efecto del té verde, en forma de extracto o compuestos aislados, en el CCEO, estudios in vivo, en cualquier idioma. Resultados: Se obtuvieron un total de 1.245 artículos, de los cuales se seleccionaron 11. La mayoría de los estudios (90,9%) fueron realizados por países del este. Epigalocatequina-galato, hámsters y DMBA fueron los compuestos más utilizados, modelo animal y carcinógeno, respectivamente. Hubo varios mecanismos de acción (estrés oxidativo, apoptosis, inhibición de la proliferación y diferenciación celular) y efectos moleculares (alteración en la expresión de glicoconjugados, proteínas precursoras amiloides, metaloproteinasas y formación de invadopodios) en el té verde. Consideraciones finales: El té verde tiene un efecto antitumoral sobre el carcinoma de células escamosas oral, ejerciendo acción tanto quimiopreventiva como terapéutica, por diferentes vías. Al ser un producto natural, biocompatible, seguro y de fácil acceso/bajo costo, se debe explorar su uso para contribuir al tratamiento / prevención del CCEO, el tipo de cáncer oral más frecuente.

Citas

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Efecto antitumoral del té verde en el carcinoma de células escamosas oral: Revisión integradora

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