Perfil lipídico y estado nutricional de una población pediátrica con enfermedad de células falciformes: diferencias entre sexo y asociación con marcadores de gravedad
DOI:
https://doi.org/10.33448/rsd-v10i10.18934Palabras clave:
Enfermedad de células falciformes; Dislipidemia; Apolipoproteína A1; Estado nutricional; Vitamina A; Vitamina D.Resumen
Objetivo: El objetivo de este artículo es investigar las asociaciones entre el estado nutricional y el perfil lipídico con biomarcadores de hemólisis y inflamación en la ECF, además de considerar diferencias de género. Material y métodos: Este estudio transversal analizó datos nutricionales y bioquímicos de pacientes pediátricos con ECF. Resultados: Vitamina A, apolipoproteína B, colesterol total, LDL-C y colesterol no HDL-C fueron menores en los niños. La hemoglobina fue significativamente menor y los glóbulos blancos (WBC) y desidrogenasa láctica (LDH) fueron mayores en los niños. El escore Z del índice de masa corporal para edad (escore z do IMC), vitamina A y triglicéridos fueron asociados a los niveles de hemoglobina, mientras la apolipoproteína A-I fue asociada a leucócitos y bilirrubina total. Además de eso, el escore z del IMC y la vitamina A fueron asociados al LDH. La vitamina A mostro poder predictivo significativo en la alteración de la hemoglobina y LDH, entretanto apolipoproteína A-I fue capaz de predecir valores elevados de leucócitos y bilirrubina total. Conclusión: Este estudio encontró en la población pediátrica con ECF que IMC, vitamina A, triglicéridos y apolipoproteína A-I fueron asociados a biomarcadores de hemólisis y inflamación. Lo niños exhibieron el maior déficit nutricional y gravedad de la enfermedad.
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Derechos de autor 2021 Nilcemar Rodrigues Carvalho Cruz; Thaisa Netto Souza Valente ; Fernanda Oliveira Ferreira; Leandro Roberto de Macedo; Andreza da Silva Brito Rocha; Dayenne Paula Nascimento; Antônio Frederico de Freitas Gomides; Maria Anete Santana Valente; Jacqueline Isaura Alvarez-Leite; Cibele Velloso-Rodrigues
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