¿El uso de la terapia fotodinámica en comparación con el hidróxido de calcio reduce los microorganismos intracanal en los dientes con necrosis pulpar? una revisión sistemática y un metanálisis
DOI:
https://doi.org/10.33448/rsd-v10i12.20058Palabras clave:
dientes permanentes; metaanálisis, necrosis pulpar; revisión sistemática; tratamiento de conducto; Dentición permanente; Metaanálisis; Necrosis pulpar; Revisión sistemática; Tratamiento del conducto radicular.Resumen
Se realizó una revisión sistemática para evaluar la reducción de microorganismos intracanal en dientes con necrosis pulpar mediante terapia fotodinámica (TFD) en comparación con hidróxido de calcio (HC). La investigación buscó ensayos clínicos aleatorios que utilizaran la TFD para ayudar en la desinfección intracanal en dientes con necrosis pulpar en comparación con el uso de HC. La búsqueda se realizó en PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library y literatura gris. También se realizaron búsquedas en resúmenes de IADR, registros de ensayos inéditos, disertaciones y tesis. Se aplicó la herramienta de análisis de riesgo de sesgo de la colaboración Cochrane para evaluar la calidad de los estudios. Se identificaron 121 artículos. Sólo 5 estudios permanecieron en la síntesis cualitativa, uno de los cuales se consideró con riesgo de sesgo "bajo" y 4 se consideró que tenían un riesgo de sesgo "indefinido" en los dominios clave. Los 5 artículos se incluyeron en el metanálisis. La reducción de microorganismos en dientes con necrosis pulpar comparando TFD con HC fue de 0,01 (intervalo de confianza [IC] = -0,04 a 0,07, p = 0,59). Este resultado demuestra que no hubo diferencia entre las terapias. Se puede concluir que no hubo diferencia entre el uso de TFD o HC en la desinfección intracanal de dientes con necrosis pulpar.
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Afkhami, F., Akbari, S., & Chiniforush, N. (2017). Entrococcus faecalis Elimination in Root Canals Using Silver Nanoparticles, Photodynamic Therapy, Diode Laser, or Laser-activated Nanoparticles: An In Vitro Study. Journal of Endodontics, 43(2), 279–282. https://doi.org/10.1016/j.joen.2016.08.029
Ahangari, Z., Mojtahed Bidabadi, M., Asnaashari, M., Rahmati, A., & Tabatabaei, F. S. (2017). Comparison of the Antimicrobial Efficacy of Calcium Hydroxide and Photodynamic Therapy Against Enterococcus faecalis and Candida albicans in Teeth With Periapical Lesions; An In Vivo Study. Journal of Lasers in Medical Sciences, 8(2), 72–78. https://doi.org/10.15171/jlms.2017.13
Asnaashari, M., Ashraf, H., Rahmati, A., & Amini, N. (2017). A comparison between effect of photodynamic therapy by LED and calcium hydroxide therapy for root canal disinfection against Enterococcus faecalis: A randomized controlled trial. Photodiagnosis and Photodynamic Therapy, 17, 226–232. https://doi.org/10.1016/j.pdpdt.2016.12.009
Barbosa-Ribeiro, M., Arruda-Vasconcelos, R., de-Jesus-Soares, A., Zaia, A. A., Ferraz, C., de Almeida, J., & Gomes, B. (2019). Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis. Clinical Oral Investigations, 23(6), 2759–2766. https://doi.org/10.1007/s00784-018-2719-0
Bonsor, S. J., Nichol, R., Reid, T. M., & Pearson, G. J. (2006). Microbiological evaluation of photo-activated disinfection in endodontics (an in vivo study). British Dental Journal, 200(6), 337–329. https://doi.org/10.1038/sj.bdj.4813371
Brito, P. R., Souza, L. C., Machado de Oliveira, J. C., Alves, F. R., De-Deus, G., Lopes, H. P., & Siqueira, J. F., Jr (2009). Comparison of the effectiveness of three irrigation techniques in reducing intracanal Enterococcus faecalis populations: an in vitro study. Journal of Endodontics, 35(10), 1422–1427. https://doi.org/10.1016/j.joen.2009.07.001
Burns, T., Wilson, M., & Pearson, G. J. (1993). Sensitisation of cariogenic bacteria to killing by light from a helium-neon laser. Journal of Medical Microbiology, 38(6), 401–405. https://doi.org/10.1099/00222615-38-6-401
Calzavara-Pinton, P., Rossi, M. T., Sala, R., & Venturini, M. (2012). Photodynamic antifungal chemotherapy. Photochemistry and Photobiology, 88(3), 512–522. https://doi.org/10.1111/j.1751-1097.2012.01107.x
da Frota, M. F., Guerreiro-Tanomaru, J. M., Tanomaru-Filho, M., Bagnato, V. S., Espir, C. G., & Berbert, F. L. (2015). Photodynamic therapy in root canals contaminated with Enterococcus faecalis using curcumin as photosensitizer. Lasers in Medical Science, 30(7), 1867–1872. https://doi.org/10.1007/s10103-014-1696-z
da Silva, C. C., Chaves Júnior, S. P., Pereira, G., Fontes, K., Antunes, L., Póvoa, H., Antunes, L. S., & Iorio, N. (2018). Antimicrobial Photodynamic Therapy Associated with Conventional Endodontic Treatment: A Clinical and Molecular Microbiological Study. Photochemistry and Photobiology, 94(2), 351–356. https://doi.org/10.1111/php.12869
Dalton, B. C., Orstavik, D., Phillips, C., Pettiette, M., & Trope, M. (1998). Bacterial reduction with nickel-titanium rotary instrumentation. Journal of Endodontics, 24(11), 763–767. https://doi.org/10.1016/S0099-2399(98)80170-2
de Carvalho Leonel, L., Carvalho, M. L., da Silva, B. M., Zamuner, S., Alberto-Silva, C., & Silva Costa, M. (2019). Photodynamic Antimicrobial Chemotherapy (PACT) using methylene blue inhibits the viability of the biofilm produced by Candida albicans. Photodiagnosis and Photodynamic Therapy, 26, 316–323. https://doi.org/10.1016/j.pdpdt.2019.04.026
Dostálová, T., Jelínková, H., Housová, D., Sulc, J., Nemeć, M., Dusková, J., Miyagi, M., & Krátky, M. (2002). Endodontic treatment with application of Er:YAG laser waveguide radiation disinfection. Journal of Clinical Laser Medicine & Surgery, 20(3), 135–139. https://doi.org/10.1089/104454702760090218
Figueiredo, R. A., Anami, L. C., Mello, I., Carvalho, E., Habitante, S. M., & Raldi, D. P. (2014). Tooth discoloration induced by endodontic phenothiazine dyes in photodynamic therapy. Photomedicine and Laser Surgery, 32(8), 458–462. https://doi.org/10.1089/pho.2014.3722
Fonseca, M. B., Júnior, P. O., Pallota, R. C., Filho, H. F., Denardin, O. V., Rapoport, A., Dedivitis, R. A., Veronezi, J. F., Genovese, W. J., & Ricardo, A. L. (2008). Photodynamic therapy for root canals infected with Enterococcus faecalis. Photomedicine and Laser Surgery, 26(3), 209–213. https://doi.org/10.1089/pho.2007.2124
Garcez, A. S., Arantes-Neto, J. G., Sellera, D. P., & Fregnani, E. R. (2015). Effects of antimicrobial photodynamic therapy and surgical endodontic treatment on the bacterial load reduction and periapical lesion healing. Three years follow up. Photodiagnosis and Photodynamic Therapy, 12(4), 575–580. https://doi.org/10.1016/j.pdpdt.2015.06.002
Garcez, A. S., Nuñez, S. C., Hamblim, M. R., Suzuki, H., & Ribeiro, M. S. (2010). Photodynamic therapy associated with conventional endodontic treatment in patients with antibiotic-resistant microflora: a preliminary report. Journal of Endodontics, 36(9), 1463–1466. https://doi.org/10.1016/j.joen.2010.06.001
Garcez, A. S., Nuñez, S. C., Hamblin, M. R., & Ribeiro, M. S. (2008). Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. Journal of Endodontics, 34(2), 138–142. https://doi.org/10.1016/j.joen.2007.10.020
Haapasalo, H. K., Sirén, E. K., Waltimo, T. M., Ørstavik, D., & Haapasalo, M. P. (2000). Inactivation of local root canal medicaments by dentine: an in vitro study. International Endodontic Journal, 33(2), 126–131. https://doi.org/10.1046/j.1365-2591.2000.00291.x
Hecker, S., Hiller, K. A., Galler, K. M., Erb, S., Mader, T., & Schmalz, G. (2013). Establishment of an optimized ex vivo system for artificial root canal infection evaluated by use of sodium hypochlorite and the photodynamic therapy. International Endodontic Journal, 46(5), 449–457. https://doi.org/10.1111/iej.12010
Karakov, K. G., Gandylyan, K. S., Khachaturyan, E. E., Vlasova, T. N., Oganyan, A. V., & Eremenko, A. V. (2018). Comparative Characteristics of the Methods of Treatment of Chronic Periodontitis Using Antibacterial Photodynamic Therapy (Per One Visit) and Calasept Preparation. Journal of the National Medical Association, 110(1), 73–77. https://doi.org/10.1016/j.jnma.2017.01.013
Konopka, K., & Goslinski, T. (2007). Photodynamic therapy in dentistry. Journal of Dental Research, 86(8), 694–707. https://doi.org/10.1177/154405910708600803
Krug, R., Krastl, G., & Jahreis, M. (2017). Technical quality of a matching-taper single-cone filling technique following rotary instrumentation compared with lateral compaction after manual preparation: a retrospective study. Clinical Oral Investigations, 21(2), 643–652. https://doi.org/10.1007/s00784-016-1931-z
Martins, M. R., Carvalho, M. F., Pina-Vaz, I., Capelas, J. A., Martins, M. A., & Gutknecht, N. (2014). Outcome of Er,Cr:YSGG laser-assisted treatment of teeth with apical periodontitis: a blind randomized clinical trial. Photomedicine and Laser Surgery, 32(1), 3–9. https://doi.org/10.1089/pho.2013.3573
Martins, M. R., Carvalho, M. F., Vaz, I. P., Capelas, J. A., Martins, M. A., & Gutknecht, N. (2013). Efficacy of Er,Cr:YSGG laser with endodontical radial firing tips on the outcome of endodontic treatment: blind randomized controlled clinical trial with six-month evaluation. Lasers in Medical Science, 28(4), 1049–1055. https://doi.org/10.1007/s10103-012-1172
Meirinhos, J., Martins, J., Pereira, B., Baruwa, A., Gouveia, J., Quaresma, S. A., Monroe, A., & Ginjeira, A. (2020). Prevalence of apical periodontitis and its association with previous root canal treatment, root canal filling length and type of coronal restoration - a cross-sectional study. International Endodontic Journal, 53(4), 573–584. https://doi.org/10.1111/iej.13256
Metzger Z, Solomonov M, Kfir A. (2013). The role of mechanical instrumentation in the cleaning of root canals. Endodontic Topics. 46(7):681-7.
Mohammadi, Z., Shalavi, S., & Yazdizadeh, M. (2012). Antimicrobial activity of calcium hydroxide in endodontics: a review. Chonnam Medical Journal, 48(3), 133–140. https://doi.org/10.4068/cmj.2012.48.3.133
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097
Nagata, J. Y., Hioka, N., Kimura, E., Batistela, V. R., Terada, R. S., Graciano, A. X., Baesso, M. L., & Hayacibara, M. F. (2012). Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. Photodiagnosis and Photodynamic Therapy, 9(2), 122–131. https://doi.org/10.1016/j.pdpdt.2011.11.006
Nagayoshi, M., Nishihara, T., Nakashima, K., Iwaki, S., Chen, K. K., Terashita, M., & Kitamura, C. (2011). Bactericidal effects of diode laser irradiation on enterococcus faecalis using periapical lesion defect model. ISRN Dentistry, 2011, 870364. https://doi.org/10.5402/2011/870364
Nair, P. N., Henry, S., Cano, V., & Vera, J. (2005). Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after "one-visit" endodontic treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 99(2), 231–252.
Pagonis, T. C., Chen, J., Fontana, C. R., Devalapally, H., Ruggiero, K., Song, X., Foschi, F., Dunham, J., Skobe, Z., Yamazaki, H., Kent, R., Tanner, A. C., Amiji, M. M., & Soukos, N. S. (2010). Nanoparticle-based endodontic antimicrobial photodynamic therapy. Journal of Endodontics, 36(2), 322–328. https://doi.org/10.1016/j.joen.2009.10.011
Plotino, G., Grande, N. M., & Mercade, M. (2019). Photodynamic therapy in endodontics. International Endodontic Journal, 52(6), 760–774. https://doi.org/10.1111/iej.13057
Pourhajibagher, M., & Bahador, A. (2018). An in vivo evaluation of microbial diversity before and after the photo-activated disinfection in primary endodontic infections: Traditional phenotypic and molecular approaches. Photodiagnosis and Photodynamic Therapy, 22, 19–25. https://doi.org/10.1016/j.pdpdt.2018.02.016
Prada, I., Micó-Muñoz, P., Giner-Lluesma, T., Micó-Martínez, P., Collado-Castellano, N., & Manzano-Saiz, A. (2019). Influence of microbiology on endodontic failure. Literature review. Medicina Oral, Patologia Oral y Cirugia Bucal, 24(3), e364–e372. https://doi.org/10.4317/medoral.22907
Rabello, D., Corazza, B., Ferreira, L. L., Santamaria, M. P., Gomes, A., & Martinho, F. C. (2017). Does supplemental photodynamic therapy optimize the disinfection of bacteria and endotoxins in one-visit and two-visit root canal therapy? A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, 19, 205–211. https://doi.org/10.1016/j.pdpdt.2017.06.005
Ramalho, K. M., Cunha, S. R., Mayer-Santos, E., Eduardo, C. P., Freitas, P. M., Aranha, A., & Moura-Netto, C. (2017). In vitro evaluation of methylene blue removal from root canal after Photodynamic Therapy. Photodiagnosis and Photodynamic Therapy, 20, 248–252. https://doi.org/10.1016/j.pdpdt.2017.10.024
Rôças, I. N., Lima, K. C., & Siqueira, J. F., Jr (2013). Reduction in bacterial counts in infected root canals after rotary or hand nickel-titanium instrumentation--a clinical study. International Endodontic Journal, 46(7), 681–687. https://doi.org/10.1111/iej.12045
Ruiz-Linares, M., Aguado-Pérez, B., Baca, P., Arias-Moliz, M. T., & Ferrer-Luque, C. M. (2017). Efficacy of antimicrobial solutions against polymicrobial root canal biofilm. International Endodontic Journal, 50(1), 77–83. https://doi.org/10.1111/iej.12598
Schilder H. (1974). Cleaning and shaping the root canal. Dental Clinics of North America, 18(2), 269–296.
Seal, G. J., Ng, Y. L., Spratt, D., Bhatti, M., & Gulabivala, K. (2002). An in vitro comparison of the bactericidal efficacy of lethal photosensitization or sodium hyphochlorite irrigation on Streptococcus intermedius biofilms in root canals. International Endodontic Journal, 35(3), 268–274. https://doi.org/10.1046/j.1365-2591.2002.00477.x
Shahravan, A., Haghdoost, A. A., Adl, A., Rahimi, H., & Shadifar, F. (2007). Effect of smear layer on sealing ability of canal obturation: a systematic review and meta-analysis. Journal of Endodontics, 33(2), 96–105. https://doi.org/10.1016/j.joen.2006.10.007
Sharwani, A., Jerjes, W., Salih, V., MacRobert, A. J., El-Maaytah, M., Khalil, H. S., & Hopper, C. (2006). Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy. Journal of Photochemistry and Photobiology. B, Biology, 83(1), 27–33. https://doi.org/10.1016/j.jphotobiol.2005.11.007
Shrestha, A., Shi, Z., Neoh, K. G., & Kishen, A. (2010). Nanoparticulates for antibiofilm treatment and effect of aging on its antibacterial activity. Journal of Endodontics, 36(6), 1030–1035. https://doi.org/10.1016/j.joen.2010.02.008
Shuping, G. B., Orstavik, D., Sigurdsson, A., & Trope, M. (2000). Reduction of intracanal bacteria using nickel-titanium rotary instrumentation and various medications. Journal of Endodontics, 26(12), 751–755. https://doi.org/10.1097/00004770-200012000-00022
Siddiqui, S. H., Awan, K. H., & Javed, F. (2013). Bactericidal efficacy of photodynamic therapy against Enterococcus faecalis in infected root canals: a systematic literature review. Photodiagnosis and Photodynamic Therapy, 10(4), 632–643. https://doi.org/10.1016/j.pdpdt.2013.07.006
Silva, L. A. B. D., Silva, R. A. B. D., Nelson‐Filho, P., & Cohenca, N. (2014). Intracanal Medication in Root Canal Disinfection. Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis, 247-276.
Siqueira, J. F., Jr, Lima, K. C., Magalhães, F. A., Lopes, H. P., & de Uzeda, M. (1999). Mechanical reduction of the bacterial population in the root canal by three instrumentation techniques. Journal of Endodontics, 25(5), 332–335. https://doi.org/10.1016/S0099-2399(06)81166-0
Siqueira, J. F., Jr, Rôças, I. N., Santos, S. R., Lima, K. C., Magalhães, F. A., & de Uzeda, M. (2002). Efficacy of instrumentation techniques and irrigation regimens in reducing the bacterial population within root canals. Journal of Endodontics, 28(3), 181–184. https://doi.org/10.1097/00004770-200203000-00009
Sjögren, U., Figdor, D., Spångberg, L., & Sundqvist, G. (1991). The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. International Endodontic Journal, 24(3), 119–125. https://doi.org/10.1111/j.1365-2591.1991.tb00117.x
Souza, L. C., Brito, P. R., de Oliveira, J. C., Alves, F. R., Moreira, E. J., Sampaio-Filho, H. R., Rôças, I. N., & Siqueira, J. F., Jr (2010). Photodynamic therapy with two different photosensitizers as a supplement to instrumentation/irrigation procedures in promoting intracanal reduction of Enterococcus faecalis. Journal of Endodontics, 36(2), 292–296. https://doi.org/10.1016/j.joen.2009.09.041
Takasaki, A. A., Aoki, A., Mizutani, K., Schwarz, F., Sculean, A., Wang, C., & Izumi, Y. (2009). Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontology 2000, 51(1), 109-140.
Tennert, C., Drews, A. M., Walther, V., Altenburger, M. J., Karygianni, L., Wrbas, K. T., Hellwig, E., & Al-Ahmad, A. (2015). Ultrasonic activation and chemical modification of photosensitizers enhances the effects of photodynamic therapy against Enterococcus faecalis root-canal isolates. Photodiagnosis and Photodynamic Therapy, 12(2), 244–251. https://doi.org/10.1016/j.pdpdt.2015.02.002
Wainwright M. (1998). Photodynamic antimicrobial chemotherapy (PACT). The Journal of Antimicrobial Chemotherapy, 42(1), 13–28. https://doi.org/10.1093/jac/42.1.13
Zancan, R. F., Vivan, R. R., Milanda Lopes, M. R., Weckwerth, P. H., de Andrade, F. B., Ponce, J. B., & Duarte, M. A. (2016). Antimicrobial activity and physicochemical properties of calcium hydroxide pastes used as intracanal medication. Journal of Endodontics, 42(12), 1822–1828. https://doi.org/10.1016/j.joen.2016.08.017
Zanin, I. C., Lobo, M. M., Rodrigues, L. K., Pimenta, L. A., Höfling, J. F., & Gonçalves, R. B. (2006). Photosensitization of in vitro biofilms by toluidine blue O combined with a light-emitting diode. European Journal of Oral Sciences, 114(1), 64–69. https://doi.org/10.1111/j.1600-0722.2006.00263.x
Zavattini, A., Cowie, J., Niazi, S., Giovarruscio, M., Sauro, S., & Foschi, F. (2020). Reduction of an in vitro Intraradicular Multispecies Biofilm Using Two Rotary Instrumentation Sequences. European Journal of Dentistry, 14(1), 1–7. https://doi.org/10.1055/s-0040-1701541
Zorita-García, M., Alonso-Ezpeleta, L. Ó., Cobo, M., Del Campo, R., Rico-Romano, C., Mena-Álvarez, J., & Zubizarreta-Macho, Á. (2019). Photodynamic therapy in endodontic root canal treatment significantly increases bacterial clearance, preventing apical periodontitis. Quintessence International 50(10), 782–789. https://doi.org/10.3290/j.qi.a43249
Zorzela, L., Loke, Y. K., Ioannidis, J. P., Golder, S., Santaguida, P., Altman, D. G., Moher, D., Vohra, S., & PRISMAHarms Group (2016). PRISMA harms checklist: improving harms reporting in systematic reviews. BMJ (Clinical Research ed.), 352, i157. https://doi.org/10.1136/bmj.i157
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Derechos de autor 2021 Milena Stuber; Paulo Fernando Otoni da Fonseca Filho; Carlla Sloane Alberton; Valéria Custódio dos Santos; Bruno Marques da Silva; Marina da Rosa Kaizer; Letícia Maíra Wambier; Flávia Sens Fagundes Tomazinho
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