Impact of bariatric surgery on non-alcoholic fatty liver disease: an integrative review
DOI:
https://doi.org/10.33448/rsd-v10i13.21437Keywords:
Non-alcoholic fatty liver disease; Bariatric surgery; Diagnostic techniques and procedures; Digestive system diseases.Abstract
The present study aims to demonstrate the results of the impact of bariatric surgery on non-alcoholic fatty liver disease through secondary sources available in the literature. A literature review was carried out with the descriptors "Non-alcoholic Fatty Liver Disease" OR "NAFLD" AND "Bariatric Surgery"; “Doença Hepática Gordurosa não Alcoólica” OR “DHGNA” AND “Cirurgia Bariátrica” in the databases: Latin American and Caribbean Health Sciences Literature, through the Virtual Health Library, and Medical Literature Analysis and Retrieval System Online (Medline), through PubMed. Cohort-type studies addressing the effects of bariatric surgery on non-alcoholic fatty liver disease published in the last 5 years were included in the review. Thirty-one studies were identified, of which 10 were excluded for not performing postoperative evaluation and 8 were excluded for not containing the methodological criteria, totaling 13 studies. The current literature presents data suggestive of the association between bariatric surgery and the regression of non-alcoholic fatty liver disease, however, the studies observed present wide variations in methodological applications and samples with heterogeneous profiles, which makes it difficult to generalize the results. More studies are needed so that it is possible to document with greater evidence and reproducibility the action of different types of bariatric surgery on the rate of this liver disease regression.
References
Angulo, P., Hui, J. M., Marchesini, G., Bugianesi, E., George, J., Farrell, G. C., Enders, F., Saksena, S., Burt, A. D., Bida, J. P., Lindor, K., Sanderson, S. O., Lenzi, M., Adams, L. A., Kench, J., Therneau, T. M., & Day, C. P. (2007). The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology (Baltimore, Md.), 45(4), 846–854. https://doi.org/10.1002/hep.21496
Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica. Diretrizes Brasileiras de Obesidade. (4a ed.). https://abeso.org.br/diretrizes/.
Bhala, N., Younes, R., & Bugianesi, E. (2013). Epidemiology and natural history of patients with NAFLD. Current pharmaceutical design, 19(29), 5169–5176. https://doi.org/10.2174/13816128113199990336 Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005). Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology (Baltimore, Md.), 42(5), 987–1000. https://doi.org/10.1002/hep.20920
Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016). The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism: clinical and experimental, 65(8), 1038–1048. https://doi.org/10.1016/j.metabol.2015.12.012
Cazzo, E., Jimenez, L. S., Pareja, J. C., & Chaim, E. A. (2015). Effect of Roux-en-Y gastric bypass on nonalcoholic fatty liver disease evaluated through NAFLD fibrosis score: a prospective study. Obesity surgery, 25(6), 982–985. https://doi.org/10.1007/s11695-014-1489-2
Cazzo, E., Pareja, J. C., & Chaim, E. A. (2017). Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review. Sao Paulo medical journal = Revista paulista de medicina, 135(3), 277–295. https://doi.org/10.1590/1516-3180.2016.0306311216
Chaim, F., Pascoal, L. B., Chaim, F., Palma, B. B., Damázio, T. A., da Costa, L., Carvalho, R., Cazzo, E., Gestic, M. A., Utrini, M. P., Milanski, M., Chaim, E. A., & Leal, R. F. (2020). Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study. Scientific reports, 10(1), 8496. https://doi.org/10.1038/s41598-020-65556-2
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018). The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.), 67(1), 328–357. https://doi.org/10.1002/hep.29367
Cherla, D. V., Rodriguez, N. A., Vangoitsenhoven, R., Singh, T., Mehta, N., McCullough, A. J., Brethauer, S. A., Schauer, P. R., & Aminian, A. (2020). Impact of sleeve gastrectomy and Roux-en-Y gastric bypass on biopsy-proven non-alcoholic fatty liver disease. Surgical endoscopy, 34(5), 2266–2272. https://doi.org/10.1007/s00464-019-07017-0
Espinet Coll, E., Vila Lolo, C., Díaz Galán, P., Gómez Valero, J. A., Bacchiddu, S., Quintana Tomás, C., Irigoyen, D., Gunnard, K., & Juan-Creix Comamala, A. (2019). Bariatric and metabolic endoscopy in the handling of fatty liver disease. A new emerging approach? Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva, 111(4), 283–293. https://doi.org/10.17235/reed.2019.5949/2018
Day, C. P., & James, O. F. (1998). Steatohepatitis: a tale of two "hits"? Gastroenterology, 114(4), 842–845. https://doi.org/10.1016/s0016-5085(98)70599-2
De Luca, M., Angrisani, L., Himpens, J., Busetto, L., Scopinaro, N., Weiner, R., Sartori, A., Stier, C., Lakdawala, M., Bhasker, A. G., Buchwald, H., Dixon, J., Chiappetta, S., Kolberg, H. C., Frühbeck, G., Sarwer, D. B., Suter, M., Soricelli, E., Blüher, M., Vilallonga, R., & Shikora, S. (2016). Indications for Surgery for Obesity and Weight-Related Diseases: Position Statements from the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO). Obesity surgery, 26(8), 1659–1696. https://doi.org/10.1007/s11695-016-2271-4
Esquivel, C. M., Garcia, M., Armando, L., Ortiz, G., Lascano, F. M., & Foscarini, J. M. (2018). Laparoscopic Sleeve Gastrectomy Resolves NAFLD: Another Formal Indication for Bariatric Surgery? Obesity surgery, 28(12), 4022–4033. https://doi.org/10.1007/s11695-018-3466-7
Fabbrini, E., Sullivan, S., & Klein, S. (2010). Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (Baltimore, Md.), 51(2), 679–689. https://doi.org/10.1002/hep.23280
Froylich, D., Corcelles, R., Daigle, C., Boules, M., Brethauer, S., & Schauer, P. (2016). Effect of Roux-en-Y gastric bypass and sleeve gastrectomy on nonalcoholic fatty liver disease: a comparative study. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 12(1), 127–131. https://doi.org/10.1016/j.soard.2015.04.004
Kalinowski, P., Paluszkiewicz, R., Ziarkiewicz-Wróblewska, B., Wróblewski, T., Remiszewski, P., Grodzicki, M., & Krawczyk, M. (2017). Liver Function in Patients With Nonalcoholic Fatty Liver Disease Randomized to Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy: A Secondary Analysis of a Randomized Clinical Trial. Annals of surgery, 266(5), 738–745. https://doi.org/10.1097/SLA.0000000000002397
Khorgami, Z., Shoar, S., Andalib, A., Aminian, A., Brethauer, S. A., & Schauer, P. R. (2017). Trends in utilization of bariatric surgery, 2010-2014: sleeve gastrectomy dominates. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 13(5), 774–778. https://doi.org/10.1016/j.soard.2017.01.031
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y. C., Torbenson, M. S., Unalp-Arida, A., Yeh, M., McCullough, A. J., Sanyal, A. J., & Nonalcoholic Steatohepatitis Clinical Research Network (2005). Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.), 41(6), 1313–1321. https://doi.org/10.1002/hep.20701
Laursen, T. L., Hagemann, C. A., Wei, C., Kazankov, K., Thomsen, K. L., Knop, F. K., & Grønbæk, H. (2019). Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects. World journal of hepatology, 11(2), 138–149. https://doi.org/10.4254/wjh.v11.i2.138
Ledoux, S., Sami, O., Calabrese, D., Le Gall, M., Flamant, M., & Coupaye, M. (2019). Gastric bypass specifically impairs liver parameters as compared with sleeve gastrectomy, independently of evolution of metabolic disorders. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 15(2), 220–226. https://doi.org/10.1016/j.soard.2018.10.035
Milić, S., Lulić, D., & Štimac, D. (2014). Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. World journal of gastroenterology, 20(28), 9330–9337. https://doi.org/10.3748/wjg.v20.i28.9330
Nascimento, T. M., Alves-Júnior, A., Nunes, M. A., de Freitas, T. R., da Silva, M. A., & Alves, M. R. (2015). Comparison of hepatic profile in pre and postoperative of bariatric surgery: private vs public network. Arquivos brasileiros de cirurgia digestiva: ABCD = Brazilian archives of digestive surgery, 28(4), 274–277. https://doi.org/10.1590/S0102-6720201500040014
Nickel, F., Tapking, C., Benner, L., Sollors, J., Billeter, A. T., Kenngott, H. G., Bokhary, L., Schmid, M., von Frankenberg, M., Fischer, L., Mueller, S., & Müller-Stich, B. P. (2018). Bariatric Surgery as an Efficient Treatment for Non-Alcoholic Fatty Liver Disease in a Prospective Study with 1-Year Follow-up: BariScan Study. Obesity surgery, 28(5), 1342–1350. https://doi.org/10.1007/s11695-017-3012-z
Polyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2017). Adipose tissue, obesity and non-alcoholic fatty liver disease. Minerva endocrinologica, 42(2), 92–108. https://doi.org/10.23736/S0391-1977.16.02563-3
Praveen Raj, P., Gomes, R. M., Kumar, S., Senthilnathan, P., Karthikeyan, P., Shankar, A., & Palanivelu, C. (2015). The effect of surgically induced weight loss on nonalcoholic fatty liver disease in morbidly obese Indians: "NASHOST" prospective observational trial. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 11(6), 1315–1322. https://doi.org/10.1016/j.soard.2015.02.006
Ruiz-Tovar, J., Alsina, M. E., Alpera, M. R., & OBELCHE Group (2017). Improvement of nonalcoholic fatty liver disease in morbidly obese patients after sleeve gastrectomy: association of ultrasonographic findings with lipid profile and liver enzymes. Acta chirurgica Belgica, 117(6), 363–369. https://doi.org/10.1080/00015458.2017.1334858
Ruiz-Tovar, J., & Zubiaga, L. (2019). Validation of biochemical scores for liver steatosis before and 1 year after sleeve gastrectomy. Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 15(9), 1447–1453. https://doi.org/10.1016/j.soard.2019.05.004
Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. einstein (São Paulo), 8(1), 102-106. https://doi.org/10.1590/s1679-45082010rw1134
Simo, K. A., McKillop, I. H., McMillan, M. T., Ahrens, W. A., Walters, A. L., Thompson, K. J., Kuwada, T. S., Martinie, J. B., Iannitti, D. A., Gersin, K. S., & Sindram, D. (2014). Does a calculated "NAFLD fibrosis score" reliably negate the need for liver biopsy in patients undergoing bariatric surgery? Obesity surgery, 24(1), 15–21. https://doi.org/10.1007/s11695-013-1044-6
Von Schönfels, W., Beckmann, J. H., Ahrens, M., Hendricks, A., Röcken, C., Szymczak, S., Hampe, J., & Schafmayer, C. (2018). Histologic improvement of NAFLD in patients with obesity after bariatric surgery based on standardized NAS (NAFLD activity score). Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery, 14(10), 1607–1616. https://doi.org/10.1016/j.soard.2018.07.012
Whittemore, R., & Knafl, K. (2005). The integrative review: Updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
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Copyright (c) 2021 Antônio Alves Júnior; Tereza Virgínia Silva Bezerra do Nascimento; João Augusto Cegarra Quintiliano; Julia Maria Salgado Carvalho; Roberta Kayane Silva Leal; Maria Rosa Melo Alves; Márcio Bezerra Santos; Carlos Anselmo Lima; Marcos Antônio Nunes Prado
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