Lectinas antibacterianas y antibiofilms vegetales - una revision
DOI:
https://doi.org/10.33448/rsd-v10i15.22595Palabras clave:
Resistencia bacteriana; Biopelícula; Infección; Proteínas; Productos vegetales.Resumen
Ha aumentado el número de bacterias multirresistentes que afectan a la salud pública y los recursos terapéuticos para hacer frente a estos patógenos son limitados. La formación de biopelículas por bacterias dificulta aún más la terapia. En este sentido, los productos naturales se han utilizado cada vez más como fuente de nuevos antimicrobianos y las lectinas se han destacado como una opción prometedora. Así, este trabajo tiene como objetivo revisar las lectinas vegetales con propiedades antibacterianas y antibiofilm frente a microorganismos patógenos. Varias lectinas, extraídas de Punica granatum (PgTeL), Portulaca elatior (PeRol), Curcuma longa L. (CLA), Sterculia foetida L. (SfL), Apuleia leiocarpa (ApulSL), Schinus terebinthifolius (SteLL), Archidendron jiringa Nielsen (AjLL) y Phthirusa pyrifolia (PpyLL) demostraron actividad antibacteriana. Canavalia ensiformis (ConA), Calliandra surinamensis (Casul), Solanum tuberosum (StL-20), Canavalia maritime (ConM) demostraron actividad antibiofilm. Además, las lectinas de Alpinia purpurata (ApuL) y Moringa oleifera (WSMoL) demostraron ambos potenciales. Por lo tanto, esta revisión ha reunido evidencia sustancial de que estas lectinas pueden ser una alternativa terapéutica para el tratamiento de infecciones causadas por bacterias Gram positivas y Gram negativas resistentes a múltiples fármacos y productoras de biopelículas en el futuro.
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Derechos de autor 2021 Zion Nascimento de Souza; João Victor de Oliveira Santos; José Manoel Wanderley Duarte Neto; Wagner Roberto Cirilo da Silva; Ylanna Larissa Alves Ferreira; Isabella Macário Ferro Cavalcanti
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