Implicaciones clínicas de las relaciones celulares en la infección por SARS-CoV-2 y resultados de COVID-19: Una Revisión Bibliográfica Integradora
DOI:
https://doi.org/10.33448/rsd-v10i16.23482Palabras clave:
COVID-19; SARS-CoV-2; Inflamación; Pronóstico.Resumen
Una herramienta prometedora para actuar como biomarcadores circulantes son los ratios celulares, que reflejan la inflamación sistémica, siendo potenciales predictores del pronóstico de mortalidad en diversas poblaciones. Por lo tanto, el objetivo de esta revisión es discutir el cumplimiento de las relaciones celulares y su importancia en la infección por COVID-19. En el presente estudio se realizó una revisión integradora. Tras definir la pregunta guía, localizar y seleccionar los artículos, se identificaron 491 publicaciones potencialmente elegibles. Tras aplicar los criterios de inclusión y exclusión, la muestra quedó compuesta por 35 artículos. Se descubrió que los índices elevados de células sanguíneas periféricas indican un resultado clínico insatisfactorio de COVID-19. Los pacientes con estos índices celulares elevados tenían una mayor incidencia de síndrome de dificultad respiratoria aguda, mayor necesidad de ventilación mecánica y mayores tasas de mortalidad. En conclusión, se encontró que había una asociación entre el valor cuantitativo de los ratios celulares con la evolución del paciente con COVID-19. Se observó que cuanto más altos eran los ratios neutrófilos/linfocitos, plaquetas/linfocitos y linfocitos/monocitos, peor era el pronóstico del paciente infectado por el SARS-CoV 2. Se necesitan más investigaciones para confirmar estos hallazgos y comparar la capacidad predictiva de los ratios en la evolución de la infección por COVID-19.
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Derechos de autor 2021 Mônica Ferreira Silva Cruvinel; Davi de Lima Silva; Thaís Ferreira da Silva; Maria Vitória Pereira Hillades; Tiago Soares Bernardes; Michel Reis Abdalla; Douglas Reis Abdalla
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