Micotoxinas: riesgos para la salud humana por la ingestión diaria de alimentos contaminados y su ocurrencia en muestras clínicas

Autores/as

DOI:

https://doi.org/10.33448/rsd-v9i4.2482

Palabras clave:

Micotoxinas; Comida; Exposición; Salud; Orina.

Resumen

Los hongos toxicogénicos pueden producir micotoxinas en los alimentos cuando se encuentran en codiciones favorables de temperatura y humedad. La ingesta diaria de estas micotoxinas en los alimentos puede causar daños a la salud humana y animal. El objetivo de este estudio fue verificar la exposición del organismo humano a las micotoxinas y su aparición en muestras clínicas. En esta revisíon de la literatura, los artículos se seleccionaron a través de una base de datos utilizando palabras conbinadas para buscar el tema principal, se reclutaron 60 artículos para la revisíon general y 20 se seleccionarion para los datos de exposición a micotoxinas y los resultados en muestras clínicas. Las micotoxinas se encuentran en muchos alimentos, desde cereales, legumbres, frutas y verduras. Son moléculas altamente resistentes que permanecen incluso después del procesamiento en la industria, incluidos sus subproductos. La intoxicación crónica puede ocurrir en individuos, causando daños a la salud. El hallazgo de micotoxinas en muestras clínicas de individuos de una región determinada puede ayudar a saber cuánto está realmente expuesta esta poblacíon, lo que permite diferentes medidas para prevenir posibles enfermedades. La evaluación de la exposición a las micotoxinas es de fundamental importancia para la salud pública, ya que puede ayudar a prevenir o reducir las enfermedades causadas por estas toxinas. Esta revisión puede contribuir a instigar nuevas investigaciones sobre la posible relación entre la exposición a la ingestión de micotoxinas y las enfermedades derivadas de su interacción con el cuerpo.

Biografía del autor/a

Geovana Dagostim Savi, Universidade Federal de Santa Catarina

Brasil

Citas

Aish, J. L., Rippon, E.H., Barlow, T., & Hattersley, S.J. (2004). Ochratoxin A (pp. 307-338). Cambridge: Woodhead Publishing.

Ali, N., Munoz, K., & Degen, G. H. (2017). Ochratoxin A and its metabolites in urines of German adults-An assessment of variables in biomarker analysis. Toxicology Letters, 275, 19-26. doi: 10.1016/j.toxlet.2017.04.013

Alshannaq, A., & Yu, J. H. (2017). Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food. International Journal of Environmental Research and Public Health, 14(6), 632. doi: 10.3390/ijerph14060632

Andrade, G. C. R. M., Pimpinato, R. F., Francisco, J. G., Monteiro, S. H., Calori-Domingues, M. A., & Tornisielo, V. L. (2018). Evaluation of mycotoxins and their estimated daily intake in popcorn and cornflakes using LC-MS techniques. LWT, 95, 240-246. doi: 10.1016/j.lwt.2018.04.073

ANVISA. (2011). Agência Nacional de Vigilância Sanitária. Resolução RDC no. 7, de 18 de fevereiro de 2011. Dispõe sobre limites máximos tolerados (LMT) para micotoxinas em alimentos. Diário Oficial da União. Acesso em 07 outubro 2019. Disponível em: http://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2011/res0007_18_02_2011_rep.html

ANVISA. (2017). Agência Nacional de Vigilância Sanitária. Altera a Resolução da Diretoria Colegiada - RDC nº 7, de 18 de fevereiro de 2011, que dispõe sobre limites máximos tolerados (LMT) para micotoxinas em alimentos. Publicada no DOU nº 29, de 9 de fevereiro de 2017. Diário Oficial da União. Acesso em 07 outubro 2019. Disponível em https://www.jusbrasil.com.br/diarios/136813858/dou-secao-1-09-02-2017-pg-45

Asplin, F. D., & Carnaghan., R.B.A. (1961). The toxicity of certain groundnut meals for poultry with special reference to their effect on ducklings and chickens. Veterinary Record, 73(46), 1215-1219.

Bhat, R., Rai, R. V., & Karim, A. A. (2010). Mycotoxins in Food and Feed: Present Status and Future Concerns. Comprehensive Reviews in Food Science and Food Safety, 9, 57-81. doi: 10.1111/j.1541-4337.2009.00094.x

Blount, W. P. (1961). Turkey "X" disease. Turkeys, 9(7), 52-61.

Brewer, J. H., Thrasher, J. D., Straus, D. C., Madison, R. A., & Hooper, D. (2013). Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome. Toxins, 5(4), 605-617. doi: 10.3390/toxins5040605

Bryden, W. L. (2007). Mycotoxins in the food chain: human health implications. Asia Pacific Journal of Clinical Nutrition, 16 Suppl 1, 95-101. Disponível em http://apjcn.nhri.org.tw/server/APJCN/16%20Suppl%201//95.pdf

Bryden, W. L. (2012). Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Animal Feed Science and Technology, 173(1–2), 134-158. doi: 10.1016/j.anifeedsci.2011.12.014

Cao, X., Li, X., Li, J., Niu, Y., Shi, L., Fang, Z., . . . Ding, H. (2018). Quantitative determination of carcinogenic mycotoxins in human and animal biological matrices and animal-derived foods using multi-mycotoxin and analyte-specific high performance liquid chromatography-tandem mass spectrometric methods. Journal of Chromatography B, 1073, 191-200. doi: 10.1016/j.jchromb.2017.10.006

Demeke, T., Kidane, Y., & Wuhib, E. (1979). Ergotism-a report on an epidemic, 1977-78. Ethiopian Medical Journal, 17(4), 107-113.

Ediage, E. N., Di Mavungu, J. D., Song, S., Wu, A., Van Peteghem, C., & De Saeger, S. (2012). A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry. Analytica Chimica Acta, 741, 58-69. doi: 10.1016/j.aca.2012.06.038

Escrivá, L., Font, G., & Manyes, L. (2015). In vivo toxicity studies of fusarium mycotoxins in the last decade: A review. Food and Chemical Toxicology, 78, 185-206. doi: 10.1016/j.fct.2015.02.005

Ezekiel, C. N., Warth, B., Ogara, I. M., Abia, W. A., Ezekiel, V. C., Atehnkeng, J., . . . Bandyopadhyay, R. (2014). Mycotoxin exposure in rural residents in northern Nigeria: A pilot study using multi-urinary biomarkers. Environment International, 66, 138-145. doi: 10.1016/j.envint.2014.02.003

FAO. (2002). Food and Agriculture Organization. Manual on the application of the HACCP system in mycotoxin prevention and control. Acesso em 04 março 2020. Disponível em http://www.fao.org/3/a-y1390e.pdf

Freire, L., & Sant’Ana, A. S. (2018). Modified mycotoxins: An updated review on their formation, detection, occurrence, and toxic effects. Food and Chemical Toxicology, 111, 189-205. doi: 10.1016/j.fct.2017.11.021

Heyndrickx, E., Sioen, I., Huybrechts, B., Callebaut, A., De Henauw, S., & De Saeger, S. (2015). Human biomonitoring of multiple mycotoxins in the Belgian population: Results of the BIOMYCO study. Environment International, 84, 82-89. doi: 10.1016/j.envint.2015.06.011

IARC. (1993). International Agency for Research on Cancer. Monograph on the Evaluation of Carcinogenic Risk to Humans, 56, 257-263. Acesso em 04 março 2020. Disponível em https://www.ncbi.nlm.nih.gov/books/NBK513574/

IARC. (2002). Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. from World Health Organization. Acesso em 04 março 2020. Disponível em https://www.ncbi.nlm.nih.gov/books/NBK326619/

Iqbal, S. Z., Asi, M. R., Hanif, U., Zuber, M., & Jinap, S. (2016). The presence of aflatoxins and ochratoxin A in rice and rice products; and evaluation of dietary intake. Food Chemistry, 210, 135-140. doi: 10.1016/j.foodchem.2016.04.104

JECFA. (2001). Safety evaluation of certain mycotoxins in food. Prepared by the Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) (pp. 700). Geneva: World Health Organization - WHO. Acesso em 04 março 2020. Disponível em https://apps.who.int/iris/handle/10665/42467

Juan, C., Berrada, H., Manes, J., & Oueslati, S. (2017). Multi-mycotoxin determination in barley and derived products from Tunisia and estimation of their dietary intake. Food and Chemical Toxicology, 103, 148-156. doi: 10.1016/j.fct.2017.02.037

Luo, Y., Liu, X., & Li, J. (2018). Updating techniques on controlling mycotoxins - A review. Food Control, 89, 123-132. doi: 10.1016/j.foodcont.2018.01.016

Marin, S., Ramos, A. J., Cano-Sancho, G., & Sanchis, V. (2013). Mycotoxins: occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology, 60, 218-237. doi: 10.1016/j.fct.2013.07.047

Munoz, K., Blaszkewicz, M., & Degen, G. H. (2010). Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. Journal of Chromatography. B: Analytical Technologies in the Biomedical and Life Sciences, 878(27), 2623-2629. doi: 10.1016/j.jchromb.2009.11.044

Neme, K., & Mohammed, A. (2017). Mycotoxin occurrence in grains and the role of postharvest management as a mitigation strategies. A review. Food Control, 78, 412-425. doi: 10.1016/j.foodcont.2017.03.012

Pascari, X., Ortiz-Solá, J., Marín, S., Ramos, A. J., & Sanchis, V. (2018). Survey of mycotoxins in beer and exposure assessment through the consumption of commercially available beer in Lleida, Spain. LWT, 92, 87-91. doi: 10.1016/j.lwt.2018.02.021

Pereira, A.S., Shitsuka, D.M., Parreira, F.J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book] (pp. 119). 1ª Ed. Santa Maria/RS: UAB/NTE/UFSM. Acesso em 09 fevereiro 2020. Disponível em: https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1

Pestka, J. J., & Smolinski, A. T. (2005). Deoxynivalenol: toxicology and potential effects on humans. Journal of Toxicology and Environmental Health. Part B: Critical Reviews, 8(1), 39-69. doi: 10.1080/10937400590889458

Pitt, J. I. (2000). Toxigenic fungi and mycotoxins. British Medical Bulletin, 56(1), 184-192. doi: 10.1258/0007142001902888

Pozzi, C. R., Correa, B., Xavier, J. G., Direito, G. M., Orsi, R. B., & Matarazzo, S. V. (2001). Effects of prolonged oral administration of fumonisin B1 and aflatoxin B1 in rats. Mycopathologia, 151(1), 21-27. doi: 10.1023/a:1010954119980

Rodriguez-Carrasco, Y., Molto, J. C., Manes, J., & Berrada, H. (2014). Development of a GC-MS/MS strategy to determine 15 mycotoxins and metabolites in human urine. Talanta, 128, 125-131. doi: 10.1016/j.talanta.2014.04.072

Rosa, C. A., Keller, K. M., Oliveira, A. A., Almeida, T. X., Keller, L. A., Marassi, A. C., . . . Oliveira, D. C. (2010). Production of citreoviridin by Penicillium citreonigrum strains associated with rice consumption and beriberi cases in the Maranhao State, Brazil. Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 27(2), 241-248. doi: 10.1080/19440040903289712

Rubert, J., Soriano, J. M., Manes, J., & Soler, C. (2011). Rapid mycotoxin analysis in human urine: a pilot study. Food and Chemical Toxicology, 49(9), 2299-2304. doi: 10.1016/j.fct.2011.06.030

Saladino, F., Quiles, J. M., Mañes, J., Fernández-Franzón, M., Luciano, F. B., & Meca, G. (2017). Dietary exposure to mycotoxins through the consumption of commercial bread loaf in Valencia, Spain. LWT, 75, 697-701. doi: 10.1016/j.lwt.2016.10.029

Savi, G.D., Garcia, L.P., & Scussel, V.M. (2013). Segurança de Grãos: Micotoxinas & Agrotóxicos. Revista Grãos Brasil, 58, 27-32. Acesso em 05 março 2020. Disponível em http://www.graosbrasil.com.br/revista/10/graos-brasil

Savi, G. D., Piacentini, K. C., Marchi, D., & Scussel, V. M. (2016a). Fumonisins B1 and B2 in the corn-milling process and corn-based products, and evaluation of estimated daily intake. Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 33(2), 339-345. doi: 10.1080/19440049.2015.1124459

Savi, G. D., Piacentini, K. C., Tibola, C. S., Santos, K., Sousa Maria, G., & Scussel, V. M. (2016b). Deoxynivalenol in the wheat milling process and wheat-based products and daily intake estimates for the Southern Brazilian population. Food Control, 62, 231-236. doi: 10.1016/j.foodcont.2015.10.029

SCF. (2002). Scientific Committee on Food. Opinion of the Scientific Committee on food on Fusarium Toxins. Acesso em 05 março 2020. Disponível em https://ec.europa.eu/food/sites/food/files/safety/docs/cs_contaminants_catalogue_fusarium_out123_en.pdf

Silva, M. V., Janeiro, V., Bando, E., & Machinski Jr, M. (2015). Occurrence and estimative of aflatoxin M1 intake in UHT cow milk in Paraná State, Brazil. Food Control, 53, 222-225. doi: 10.1016/j.foodcont.2015.01.025

Stevens, A. J. S., Saunders, C.N., Spence, J.B., & Newham, A.G. (1960). Investigations into "diseases" of turkey poults. Veterinary Record, 72(31), 627-628.

Tortora, G. J., Funke, B. R., & Case, C. L. (2012). Microbiologia (10ª ed., pp. 964). Porto Alegre: Artmed.

Wallin, S., Gambacorta, L., Kotova, N., Lemming, E. W., Nalsen, C., Solfrizzo, M., & Olsen, M. (2015). Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis. Food and Chemical Toxicology, 83, 133-139. doi: 10.1016/j.fct.2015.05.023

Wang, Y.-j., Nie, J.-y., Yan, Z., Li, Z.-x., Cheng, Y., & Farooq, S. (2018). Multi-mycotoxin exposure and risk assessments for Chinese consumption of nuts and dried fruits. Journal of Integrative Agriculture, 17(7), 1676-1690. doi: 10.1016/S2095-3119(18)61966-5

Wijnands, L., & van Leusden, F. (2000). An overview of adverse health effects caused by mycotoxins and bioassays for their detection (pp. 99). National Institute of Public Health and the Environment. Acesso em 05 março 2020. Disponível em https://rivm.openrepository.com/bitstream/handle/10029/9410/257852004.pdf?sequence=1&isAllowed=y

Zinedine, A., Fernandez-Franzon, M., Manes, J., & Manyes, L. (2017). Multi-mycotoxin contamination of couscous semolina commercialized in Morocco. Food Chemistry, 214, 440-446. doi: 10.1016/j.foodchem.2016.07.098

Zinedine, A., Soriano, J. M., Moltó, J. C., & Mañes, J. (2007). Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Food and Chemical Toxicology, 45(1), 1-18. doi: 10.1016/j.fct.2006.07.030

Publicado

11/03/2020

Cómo citar

SAVI, G. D.; ZENAIDE, F. dos S. Micotoxinas: riesgos para la salud humana por la ingestión diaria de alimentos contaminados y su ocurrencia en muestras clínicas. Research, Society and Development, [S. l.], v. 9, n. 4, p. e24942482, 2020. DOI: 10.33448/rsd-v9i4.2482. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/2482. Acesso em: 22 nov. 2024.

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