Vía de señalización canónica de WNT en pronóstico de carcinoma de células escamosas oral

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i2.25462

Palabras clave:

β-catenina; Carcinoma oral de células escamosas; OSCC; Señalización wnt.

Resumen

El objetivo del estudio fue demostrar la expresión inmunohistoquímica de la vía wnt / b-catenina en células de carcinoma oral (COCE), a través de una revisión de la literatura. Para ello, se realizó una búsqueda en las bases de datos PubMed y SciELO con las palabras clave “β-catenina”, “carcinoma oral de células escamosas”, “OSCC” y “Señalización Wnt” con el operador booleano AND. Como criterios de inclusión se adoptaron artículos publicados en inglés, in vitro, in situ o ensayos clínicos de los años 2010 a 2021 que relacionan la vía de señalización canónica del WNT con el carcinoma oral de células escamosas y los criterios de exclusión considerados fueron artículos duplicados, revisión de la literatura y que no abordó el problema. Después de leer el título, el resumen y el contenido completo de cada uno de los estudios, se seleccionaron 110 artículos. Los compuestos de ARNc, las enzimas, los derivados de hexaclorofeno y la lignina aislados de Taiwania pudieron suprimir el crecimiento y la metástasis al inhibir la vía WNT / β-catenina. Las células madre cancerosas, las enzimas de tipo PON2, la ingesta de nicotina, la citocina TNF-α y el gen FAD1 pueden aumentar el crecimiento y la metástasis al inhibir la misma vía. Por lo tanto, la expresión de estos biomarcadores puede influir en el pronóstico de las células cancerosas y ayudar a los médicos a explorar nuevos posibles efectos terapéuticos en OSSC modulando la vía Wnt / β-catenina.

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FARRAPO, M. T. .; RIFANE, T. O. .; PINTO, D. N. .; RODRIGUES, R. E. A. .; OLIVEIRA, K. K. P. de .; MEDEIROS, S. T. C. B. .; SOUSA, L. M. de .; VASCONCELOS, L. V. .; FEITOSA , V. P. . Vía de señalización canónica de WNT en pronóstico de carcinoma de células escamosas oral. Research, Society and Development, [S. l.], v. 11, n. 2, p. e8411225462, 2022. DOI: 10.33448/rsd-v11i2.25462. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/25462. Acesso em: 22 nov. 2024.

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Derechos de autor 2022 Manuela Timbó Farrapo; Tainah Oliveira Rifane; Diego Neves Pinto; Ranyele Elis Alexandre Rodrigues; Ketelyn Kerty Pereira de Oliveira; Samara Tabata Cavalcante Braga Medeiros; Luane Macedo de Sousa; Lorena Vieira Vasconcelos; Victor Pinheiro Feitosa

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