Linfoma canino: estudio de caso controle en la Región Metropolitana de Recife-PE, Brasil

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i3.26495

Palabras clave:

Perro; Carcinógenos; Epidemiología; Georreferenciación; Neoplasia linfoide.

Resumen

El objetivo de este estudio es evaluar los aspectos epidemiológicos y la distribución espacial de los casos de linfoma canino en la Región Metropolitana de Recife-PE, Brasil. Se analizaron los datos epidemiológicos obtenidos de las historias clínicas de 178 perros, 89 casos y 89 controles. Para el análisis de los factores de riesgo, se consideró la información relacionada con el contacto con carcinógenos, la alimentación y el alojamiento del animal y para realizar el mapa se obtuvieron los puntos de georreferenciación de los municipios, barrios y códigos postales informados en las historias clínicas de los animales. Los factores de riesgo identificados consistieron en el contacto con seres humanos sometidos a quimioterapia/radioterapia (OR=13,54; p=0,014), la alimentación mixta (OR=5,59; p=0,000), el contacto del animal con pinturas y disolventes (OR=5,08; p=0,014), el hecho de vivir cerca de una avenida o calle con mucho tráfico (OR=4,86; p=0,000) y la alimentación en casa (OR=2,44; p=0,014). El mayor número de casos de linfoma se encontró en la región sur de la ciudad de Recife, así como en la región norte de Olinda. La aparición de linfomas caninos diagnosticados en la Región Metropolitana de Recife está estrechamente relacionada con la exposición a carcinógenos ambientales.

Citas

Abba, E. J. (2011). Fine aerosol and PAH carcinogenicity estimation in outdoor environment of Mumbai City, India. Internal Journal Environmental Health Research, 22, 134-49. https://doi.org/10.1080/09603123.2011.613112

Bastos, L. N. V. (2014). Indicadores de saúde ambiental e incidência do câncer infanto-juvenil em Pernambuco (Dissertação de Mestrado). https://www.arca.fiocruz.br/handle/icict/12163

Bezerra, E. L., & Zimmermann, M. (2015). Distúrbios Comportamentais em Cães: Ansiedade por Separação. Revista Científica REVET de Medicina Veterinária do UNICEPLAC, 2(1). http://revista.faciplac.edu.br/index.php/Revet/article/view/115/63

Case, L. P., & Daristotle, L. (2011). Canine of Feline Nutrition. A Resource for Companion Animal Professionals. Elsevier Editora.

Chakraborty, J. (2012). Cancer risk from exposure to hazardous air pollutants: spatial and social inequities in Tampa Bay, Florida. Internal Journal Environmental Health Research, 22, 165-183. https://doi.org/10.1080/09603123.2011.628643

Comazzi, S., Marelli, S., Cozzi, M., Rizzi, R., Finotello, R., Henriques, J., Pastor, J., Ponce, F., Rohrer-Bley, C., Rütgen B. C., & Teske E. (2018). Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study. BMC Veterinary Research, 14, 232. https://dx.doi.org/10.1186/s12917-018-1557-2.

Czeresnia, D., & Ribeiro, A. M. (2000). O conceito de espaço em epidemiologia: uma interpretação histórica e epistemológica. Cadernos de Saúde Pública, 16 (3), 595-617. https://doi.org/10.1590/S0102-311X2000000300002

Dias, J. N. R., André, A. S., Aguiar, S. I., Gil, S., Tavares, L., & Aires-da-Silva, F. (2021). Immunotherapeutic Strategies for Canine Lymphoma: Changing the Odds Against Non-Hodgkin Lymphoma. Frontiers in Veterinary Science, 8:621758. https://doi.org/10.3389/fvets.2021.621758

Dobson, J. M., Blackwood, L. B., Mcinnes, E. F., Bostock, D.E., Nicholls, P., Hoather, T. M., & Tom, B. D. M. (2001). Prognostic variables in canine multicentric lymphosarcoma. Journal of Small Animal Practice, 42, 377-384. https://doi.org/10.1111/j.1748-5827.2001.tb02485.x

Drumm, F. C., Gerhardt, A. E., Eloi, A., Fernandes, G. D., Chagas, P., Sucolotti, M. S., & Kemerich, P. D. C. (2014). Poluição atmosférica proveniente da queima de combustíveis derivados do petróleo em veículos automotores. Revista Eletrônica em Gestão, Educação e Tecnologia Digital, 18(1), 66-78. http://dx.doi.org/10.5902/2236117010537

FIEPE - Federação das Indústrias do Estado de Pernambuco (2012). FIEPE lança cadastro industrial de Pernambuco. https://www.leiaja.com/carreiras/2012/11/30/fiepe-lanca-cadastro-industrial-de-pernambuco/

Fighera, R. A., Souza, T. M., Silva, M. C., Brum, J. S., Graça, D. L., Kommers, G. D., Irigoyen, L. F., & Barros, C.S.L. (2008). Causas de morte e razões para eutanásia de cães da Mesorregião do Centro Ocidental Rio-Grandense (1965-2004). Pesquisa Veterinária Brasileira, 28 (4), 223-230. https://doi.org/10.1590/S0100-736X2008000400005

Gatto, N. M. (2021). Environmental Carcinogens and Cancer Risk. Cancers, 13, 622. https://doi.org/10.3390/cancers1304062

Gavazza, A., Presciuttini, S., Barale, R., Lubas, G., & Gugliucci, B. (2001). Association between canine malignant lymphoma, living in industrial areas, and use of chemicals by dog owners. Journal of Veterinary Internal Medicine, 15(3), 190-195. https://doi.org/10.1111/j.1939-1676.2001.tb02310.x

Giumelli, R. D., & Santos, M. C. P. (2016). Convivência com animais de estimação: um estudo fenomenológico. Revista da Abordagem Gestáltica, 22(1), 49-58. http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1809-68672016000100007&lng=pt&tlng=pt

Gouveia, N., & Prado, R. (2010). Spatial analysis of the health risks associated with solid waste incineration: a preliminary analysis. Revista Brasileira de Epidemiologia, 13(1), 3-10. https://doi.org/10.1590/S1415-790X2010000100001

Grandi, F., Beserra, L. E. O., & Costa, L. D. (2014). Citopatologia veterinária diagnóstica. MedVet Editora.

Gray, K. N., Raulston, G. L., Gleiser, C. A., & Jardine, J. H. (1984). Histologic classification as an indication of therapeutic response in malignant lymphoma of dogs. Journal of American Veterinary Medical Association, 184, 814-817. https://europepmc.org/article/med/6725115

INCA - Instituto Nacional de Câncer José Alencar Gomes da Silva (2021). Quimioterapia. https://www.inca.gov.br/tratamento/quimioterapia

Ito, D., Frantz, A. M., & Modiano, J. F. (2014). Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications. Veterinary immunology and immunopathology, 159(3-4), 192–201. https://doi.org/10.1016/j.vetimm.2014.02.016

Kimura, K. C., Zanini, D. A., Nishiya, A. T., Dias, R. A., & Dagli, M. L. Z. (2011). Morphology and immunophenotypes of canine lymphomas: a survey from the service of animal pathology School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil. Brazilian Journal of Veterinary Pathology, 4(3), 199-206. https://bjvp.org.br/wp-content/uploads/2015/09/DOWNLOAD-FULL-ARTICLE-34-20881_2011_11_13_35_59t-al.pdf

Kliucininkas, L. (2011). Indoor and outdoor concentrations of fine particles, particle-bound PAHs and volatile organic compounds in Kaunas, Lithuania. Journal of Environmental Monitoring, 1, p. 182-91, 2011. https://doi.org/10.1039/C0EM00260G

Lonsdale, T. (2007). Junk pet food and the damage done. Nexus Magazine, 14(6), 31-35.

Martini, V., Marano, G., Aresu, L., Bonfanti, U., Boracchi, P., Caniatti, M., Cian, F., Gambini, M., Marconato, L., Masserdotti, C., Nicoletti, A., Riondato, F., Roccabianca, P., Stefanello, D., Teske, E., & Comazzi, S. (2022). Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs. Journal of veterinary internal medicine, 36(1), 204–214. https://doi.org/10.1111/jvim.16326

Miranda, R. C. (2007). Biodegradation of Diesel Oil by Yeasts Isolated from the Vicinity of Suape Port in the State of Pernambuco –Brazil. Brazilian Archives of Biology and Technology, 50, 147-152. https://doi.org/10.1590/S1516-89132007000100018

Müller, A. M., Ihorst, G., Mertelsmann, R., & Engelhardt, M. (2005). Epidemiology of non-Hodgkin's lymphoma (NHL): trends, geographic distribution, and etiology. Annals of Hematology, 84, 1-12. https://doi.org/10.1007/s00277-004-0939-7

Olgivie, G.K. (2006). Nutrition and cancer: frontiers for cure. https://www.vin.com/apputil/content/defaultadv1.aspx?id=3859082&pid=11223&

Owen, L. N. (1980). TNM Classification of Tumours in Domestic Animals. https://apps.who.int/iris/handle/10665/68618

Papini, S. (2009). Vigilância em saúde ambiental: uma nova área da ecologia. Atheneu Editora.

Pastor, M., Chalvet-Monfray, K., Marchal, T., Keck, G., Magnol, J. P., Fournel – Fleury, C., & Ponce, F. (2009). Genetic and Environmental Risk Indicators in Canine Non Hodgkin’s Lymphomas: Breed Associations and Geographic Distribution of 608 Cases Diagnosed throughout France over 1 Year. Journal Veterinary Internal Medicine, 23(2), 301-310. https://doi.org/10.1111/j.1939-1676.2008.0255.x

Pinello, K. C., Santos, M., Leite-Martins, L., Niza-Ribeiro, J., & de Matos, A. J. (2017). Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke. Veterinary world, 10(11), 1307–1313. https://doi.org/10.14202/vetworld.2017.1307-1313

Pittaway, C., Schofield, I., Dobson, J., O’Neill, D. G., & Brodbelt, D. C. (2019). Incidence and risk factors for the diagnosis of lymphoma in dogs in UK primary-care practice. Journal of Small Animal Practice, 60(10), 581-588. https://doi.org/10.1111/jsap.13054

Ponce, F., Marchal, T., Magnol, J. P., Turinelli, V., Ledieu, D., Bonnefont, C., Pastor, M., Delignette, M. L., & Fournel-Fleury, C. (2010). A Morphological Study of 608 Cases of Canine Malignant Lymphoma in France With a Focus on Comparative Similarities Between Canine and Human Lymphoma Morphology. Veterinary Pathology, 47(3), 414–433. https://doi.org/10.1177/0300985810363902

Suzano, S. M. C., Sequeira, J. L., Rocha, N. S., & Pessoa, A. W. P. (2010). Classificação citológica dos linfomas caninos. Brazilian Journal of Veterinary Research and Animal Science, 47(1), 47-54. http://www.revistas.usp.br/bjvras/article/view/26848

Teske, E., & Van Heerde, P. (1996). Diagnostic value and reproducibility of fine needle aspiration cytology in canine malignant lynfoma. Veterinary Quaternaly, 18 (3), 112-115. https://doi.org/10.1080/01652176.1996.9694630

Tybjerg, A. J., Friis, S., Brown, K., Nilbert, M. C., Morch, L., & Koster, B. (2018). Updated fraction of cancer attributable to lifestyle and environmental factors in Denmark in 2018. Scientific Reports, 12, 549 (2022). https://doi.org/10.1038/s41598-021-04564-2

Vasconcelos, A., Horta. R. S., & Lavalle, G. E. (2013). Nutrição do paciente oncológico – uma visão integrativa. Cadernos Técnicos de Veterinária e Zootecnia, 70, 91-99. https://vet.ufmg.br/ARQUIVOS/FCK/file/editora/caderno%20tecnico%2070%20oncologia%20pequenos%20animais.pdf

Villamil, J. A., Henry, C. J., Hahn, A. W., Bryan, J. N., Tyler, J. W., & Caldwell, C.W. (2009). Hormonal and Sex Impact on the Epidemiology of Canine Lymphoma. Journal of Cancer Epidemiology, 2009, Article ID 591753, 7p. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859020/pdf/JCE2009-591753.pdf

Yau, P. P., Dhand, N. K., & Thomson, P. C. (2017). Retrospective study on the occurrence of canine lymphoma and associated breed risks in a population of dogs in NSW (2001-2009). Australian Veterinary Journal, 95, 149-155. https://doi.org/10.1111/avj.12576

Zandvliet, M. (2016). Canine lymphoma: a review. Veterinary Quaternaly, 36(2), 76-104. https://doi.org/10.1080/01652176.2016.1152633.

Zanini, D. A., Kimura, K. C., Nishiya, A. T., Ubukata, R., Leandro, R. M., Brito, C. P., Trombetti, M., Lagoa, A. C., Macedo, T. R., Rodrigues, L. C. S., Rosendo, J. A. S., Arndt, H. L., Dias, R. A. D., & Dagli, M. L. Z. (2013). Environmental risk factors related to the development of canine non-Hodgkin’s lymphoma. Ciência Rural, 43(7), 1302-1308. https://doi.org/10.1590/S0103-84782013005000089

Publicado

25/02/2022

Cómo citar

HOLANDA, L. C. de .; SILVA, B. P. e .; PINHEIRO JÚNIOR, J. W. .; OLIVEIRA, A. A. da F. . Linfoma canino: estudio de caso controle en la Región Metropolitana de Recife-PE, Brasil. Research, Society and Development, [S. l.], v. 11, n. 3, p. e34611326495, 2022. DOI: 10.33448/rsd-v11i3.26495. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26495. Acesso em: 26 nov. 2024.

Número

Sección

Ciencias Agrarias y Biológicas