Efectos de la suplementación con probióticos sobre el metabolismo de la glucosa y los biomarcadores inflamatorios en mujeres embarazadas con diabetes mellitus gestacional: una revisión integradora

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i5.28199

Palabras clave:

Diabetes Gestacional; Probiótico; Inflamación.

Resumen

Objetivos: La presente revisión de la literatura tiene como objetivo investigar el efecto de la suplementación con probióticos sobre el metabolismo de la glucosa y los biomarcadores inflamatorios en mujeres embarazadas con diabetes mellitus gestacional. Métodos: La recolección de datos se realizó utilizando la Biblioteca Nacional de Medicina (Medline), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (Lilacs), Biblioteca Virtual en Salud (BVS) y Biblioteca Científica Electrónica en Línea (Scielo). Se utilizaron los siguientes descriptores “diabetes gestacional”, “probiótico” e “inflamación”. Resultados: Los principales resultados destacaron la mejora de la glucosa en ayunas y la resistencia a la insulina y un menor impacto en la mejora de los marcadores inflamatorios después de la suplementación con probióticos en mujeres embarazadas con diagnóstico de diabetes mellitus gestacional. Conclusión: El uso de probióticos en gestantes con diabetes mellitus gestacional ha mostrado acciones positivas para controlar el metabolismo de la glucosa y los factores proinflamatorios, pudiendo mejorar los niveles séricos de glucosa, la sensibilidad a la insulina y la inflamación.

Citas

Bai, A. P., Ouyang, Q., Zhang, W., Wang, C. H., & Li, S. F. (2004). Probiotics inhibit TNF-α-induced interleukin-8 secretion of HT29 cells. World Journal of Gastroenterology, 10(3), 455.

Barrett, H. L., Callaway, L. K., & Nitert, M. D. (2012). Probiotics: a potential role in the prevention of gestational diabetes?. Acta diabetologica, 49(1), 1-13.

Bock, P. M., Telo, G. H., Ramalho, R., Sbaraini, M., Leivas, G., Martins, A. F., et al. (2021). The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis. Diabetologia, 64(1), 26-41.

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761-1772.

Caricilli, A. M., & Saad, M. J. (2013). The role of gut microbiota on insulin resistance. Nutrients, 5(3), 829-851.

Crusell, M. K. W., Hansen, T. H., Nielsen, T., Allin, K. H., Rühlemann, M. C., Damm, P., et al. (2018). Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum. Microbiome, 6(1), 1-19.

Dallanora, S., Medeiros de Souza, Y., Deon, R. G., Tracey, C. A., Freitas-Vilela, A. A., Wurdig Roesch, L. F., et al. (2018). Do probiotics effectively ameliorate glycemic control during gestational diabetes? A systematic review. Archives of gynecology and obstetrics, 298(3), 477-485.

Dickens, L. T., & Thomas, C. C. (2019). Updates in gestational diabetes prevalence, treatment, and health policy. Current diabetes reports, 19(6), 1-11.

Gomes, A. C., Bueno, A. A., de Souza, R. G. M., & Mota, J. F. (2014). Gut microbiota, probiotics and diabetes. Nutrition journal, 13(1), 1-13.

Hasain, Z., Mokhtar, N. M., Kamaruddin, N. A., Mohamed Ismail, N. A., Razalli, N. H., Gnanou, J. V., et al. (2020). Gut microbiota and gestational diabetes mellitus: a review of host-gut microbiota interactions and their therapeutic potential. Frontiers in cellular and infection microbiology, 188.

International Diabetes Federation. (2015). Diabetes atlas. 7ªed. Brussels (BE): IDF.

Jayashree, B., Bibin, Y. S., Prabhu, D., Shanthirani, C. S., Gokulakrishnan, K., Lakshmi, B. S., et al (2014). Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes. Molecular and cellular biochemistry, 388(1), 203-210.

Kellow, N. J., Coughlan, M. T., & Reid, C. M. (2014). Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. British Journal of Nutrition, 111(7), 1147-1161.

Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Bäckhed, H. K., et al. (2012). Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell, 150(3), 470-480.

Kuang, Y. S., Lu, J. H., Li, S. H., Li, J. H., Yuan, M. Y., He, J. R., et al. (2017). Connections between the human gut microbiome and gestational diabetes mellitus. Gigascience, 6(8), gix058.

Lain, K. Y., & Catalano, P. M. (2007). Metabolic changes in pregnancy. Clinical obstetrics and gynecology, 50(4), 938-948.

Lee, J. A., Ko, J. H., Jung, B. G., Kim, T. H., Hong, J. I., Park, Y. S., et al. (2013). Fermented Prunus mume with probiotics inhibits 7, 12-dimethylbenz [a] anthracene and 12-o-tetradecanoyl phorbol-13-acetate induced skin carcinogenesis through alleviation of oxidative stress. Asian Pacific Journal of Cancer Prevention, 14(5), 2973-2978.

Lim, S., Choi, S. H., Park, Y. J., Park, K. S., Lee, H. K., Jang, H. C., et al. (2007). Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus. Diabetes care, 30(2), 348-353.

Mendes, K. D. S., Silveira, R. C. D. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, 17, 758-764.

Palem, S. P., & Abraham, P. (2015). A study on the level of oxidative stress and inflammatory markers in type 2 diabetes mellitus patients with different treatment modalities. Journal of clinical and diagnostic research: Journal of Clinical and Diagnostic Research for doctors, 9(9), BC04.

Pantham, P., Aye, I. L. H., & Powell, T. L. (2015). Inflammation in maternal obesity and gestational diabetes mellitus. Placenta, 36(7), 709-715.

Panwar, H., Rashmi, H. M., Batish, V. K., & Grover, S. (2013). Probiotics as potential biotherapeutics in the management of type 2 diabetes–prospects and perspectives. Diabetes Metabolism Research Review, 29(2), 103-112.

Ponzo, V., Fedele, D., Goitre, I., Leone, F., Lezo, A., Monzeglio, C., et al. (2019). Diet-gut microbiota interactions and gestational diabetes mellitus (GDM). Nutrients, 11(2), 330.

Redman, M. G., Ward, E. J., & Phillips, R. S. (2014). The efficacy and safety of probiotics in people with cancer: a systematic review. Annals of Oncology, 25(10), 1919-1929.

Reid, G., Jass, J., Sebulsky, M. T., & McCormick, J. K. (2003). Potential uses of probiotics in clinical practice. Clinical microbiology reviews, 16(4), 658-672.

Sacks, D. A., Hadden, D. R., Maresh, M., Deerochanawong, C., Dyer, A. R., Metzger, B. E., et al. (2012). Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel–recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Diabetes care, 35(3), 526-528.

Schoenaker, D. A., Mishra, G. D., Callaway, L. K., & Soedamah-Muthu, S. S. (2016). The role of energy, nutrients, foods, and dietary patterns in the development of gestational diabetes mellitus: a systematic review of observational studies. Diabetes Care, 39(1), 16-23.

Prentice, A., & Williams, A. (2011). The influence of maternal, fetal and child nutrition on the development of chronic disease in later life. The Stationery Office. Scientific Advisory Committee on Nutrition.

Sociedade Brasileira De Diabetes. SBD. (2019). Diretrizes da sociedade brasileira de diabetes 2019-2020. São Paulo: Editora Clannad.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.

Murthy, K. S., Bhandiwada, A., Chandan, S. L., Gowda, S. L., & Sindhusree, G. (2018). Evaluation of oxidative stress and proinflammatory cytokines in gestational diabetes mellitus and their correlation with pregnancy outcome. Indian journal of endocrinology and metabolism, 22(1), 79.

World Health Organization. (2013). Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Genebra.

Zhang, J., Ma, S., Wu, S., Guo, C., Long, S., & Tan, H. (2019). Effects of probiotic supplement in pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes Research, 2019.

Descargas

Publicado

04/04/2022

Cómo citar

BRAGA, R. A. M. .; NOGUEIRA, M. D. de A. .; SOUSA, F. I. da S. e .; PINHEIRO, A. D. V. .; LIMA, M. R. da S. .; SOUSA, A. R. .; BATISTA, A. C. V. .; HOEFEL, A. L. Efectos de la suplementación con probióticos sobre el metabolismo de la glucosa y los biomarcadores inflamatorios en mujeres embarazadas con diabetes mellitus gestacional: una revisión integradora. Research, Society and Development, [S. l.], v. 11, n. 5, p. e22411528199, 2022. DOI: 10.33448/rsd-v11i5.28199. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/28199. Acesso em: 30 jun. 2024.

Número

Sección

Revisiones